Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet
Identifieur interne : 000801 ( Istex/Checkpoint ); précédent : 000800; suivant : 000802Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet
Auteurs : M. A. Medinsky [États-Unis] ; J. A. Popp [États-Unis] ; T. E. Hamm [États-Unis] ; J. G. Dent [États-Unis]Source :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1982.
English descriptors
- Teeft :
- Acid deficiencies, American institute, Bieri, Bioserve diet, Blox, Body weights, Chemical pathology, Chlorinated insecticides, Control diet, Diet, Error bars, Female rats, Food consumption, Food efficiency, Growth rates, Hemorrhagic, Hemorrhagic lesions, Hepatic, Hepatic lesions, Hepatic lipidosis, Hepatocytes, Laboratory animals, Lesion, Lipid, Lipid accumulation, Lipidosis, Liver tissue, Male rats, Medinsky, Nutritional studies, Open formula diet, Percentage weight ratios, Periportal, Periportal hepatocytes, Periportal lipidosis, Portal triads, Present formulation, Rat, Weight ratios, Zeigler, Zeigler bros, Zeigler diet.
Abstract
Abstract: The suitability of the AIN-76A diet for Fischer-344 rats was investigated. This diet, proposed by the American Institute of Nutrition for use when a purified diet composed of refined ingredients and added vitamins and minerals is required, was tested in Sprague-Dawley rats. Male weanling Fischer-344 rats were fed three different lots of the AIN-76A diet from two suppliers. Increase in body weights and food consumption were compared to animals fed a cereal-based control diet. Animals were sacrificed at various intervals and tissues were taken for histopathological observation. By 8 weeks moderate to marked periportal lipidosis developed in livers of all rats fed the AIN-76A diet. Liver-body weight ratios over the 8-week period were significantly higher in rats fed AIN-76A diets compared to rats fed the control diet. However, growth rates of rats fed the AIN-76A diet were similar to growth rates of controls. Some rats fed the AIN-76A diet developed severe hemorrhagic lesions. The AIN-76A diet in its present form is not suitable for use with male Fischer-344 rats.
Url:
DOI: 10.1016/0041-008X(82)90107-7
Affiliations:
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This diet, proposed by the American Institute of Nutrition for use when a purified diet composed of refined ingredients and added vitamins and minerals is required, was tested in Sprague-Dawley rats. Male weanling Fischer-344 rats were fed three different lots of the AIN-76A diet from two suppliers. Increase in body weights and food consumption were compared to animals fed a cereal-based control diet. Animals were sacrificed at various intervals and tissues were taken for histopathological observation. By 8 weeks moderate to marked periportal lipidosis developed in livers of all rats fed the AIN-76A diet. Liver-body weight ratios over the 8-week period were significantly higher in rats fed AIN-76A diets compared to rats fed the control diet. However, growth rates of rats fed the AIN-76A diet were similar to growth rates of controls. Some rats fed the AIN-76A diet developed severe hemorrhagic lesions. The AIN-76A diet in its present form is not suitable for use with male Fischer-344 rats.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Medinsky, M A" sort="Medinsky, M A" uniqKey="Medinsky M" first="M. A." last="Medinsky">M. A. Medinsky</name></region><name sortKey="Dent, J G" sort="Dent, J G" uniqKey="Dent J" first="J. G." last="Dent">J. G. Dent</name><name sortKey="Hamm, T E" sort="Hamm, T E" uniqKey="Hamm T" first="T. E." last="Hamm">T. E. Hamm</name><name sortKey="Popp, J A" sort="Popp, J A" uniqKey="Popp J" first="J. A." last="Popp">J. A. Popp</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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