Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19).
Identifieur interne : 000623 ( Main/Exploration ); précédent : 000622; suivant : 000624Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19).
Auteurs : Masoumeh Asgharpour [Iran] ; Hamed Mehdinezhad [Iran] ; Masoumeh Bayani [Iran] ; Mahmoud Sadeghi Haddad Zavareh [Iran] ; Seyed Hossein Hamidi [Iran] ; Roghayeh Akbari [Iran] ; Reza Ghadimi [Iran] ; Ali Bijani [Iran] ; Simin Mouodi [Iran]Source :
- BMC nephrology [ 1471-2369 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Circulation extracorporelle (méthodes), Femelle (MeSH), Humains (MeSH), Hémofiltration (méthodes), Infections à coronavirus (diagnostic), Infections à coronavirus (sang), Infections à coronavirus (thérapie), Interleukine-6 (sang), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (diagnostic), Pneumopathie virale (sang), Pneumopathie virale (thérapie), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Traitement substitutif de l'insuffisance rénale (méthodes).
- MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- méthodes : Circulation extracorporelle, Hémofiltration, Traitement substitutif de l'insuffisance rénale.
- sang : Infections à coronavirus, Interleukine-6, Pneumopathie virale.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- Adulte, Adulte d'âge moyen, Betacoronavirus, Femelle, Humains, Mâle, Pandémies, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Betacoronavirus (MeSH), Coronavirus Infections (blood), Coronavirus Infections (diagnosis), Coronavirus Infections (therapy), Extracorporeal Circulation (methods), Female (MeSH), Hemofiltration (methods), Humans (MeSH), Interleukin-6 (blood), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (diagnosis), Pneumonia, Viral (therapy), Renal Replacement Therapy (methods), Treatment Outcome (MeSH).
- MESH :
- chemical , blood : Interleukin-6.
- blood : Coronavirus Infections, Pneumonia, Viral.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- methods : Extracorporeal Circulation, Hemofiltration, Renal Replacement Therapy.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Adult, Aged, Aged, 80 and over, Betacoronavirus, Female, Humans, Male, Middle Aged, Pandemics, Treatment Outcome.
Abstract
BACKGROUND
Extracorporeal blood purification has been proposed as one of the therapeutic approaches in patients with coronavirus infection, because of its beneficial impact on elimination of inflammatory cytokines.
METHODS
This controlled trial has been conducted on critically ill COVID-19 patients admitted in the state hospital affiliated to Babol University of Medical Sciences, Iran who received different antiviral and antibacterial drugs, and different modalities of respiratory treatments and did not have positive clinical improvement. No randomization and blindness was considered. All of the participants underwent three sessions of resin-directed hemoperfusion using continuous renal replacement therapy with a mode of continuous venovenous hemofiltration (CVVH).
RESULTS
Five men and five women with a mean age of 57.30 ± 18.07 years have been enrolled in the study; and six of them have improved after the intervention. Peripheral capillary oxygen saturation (SpO2) changed after each session. Mean SpO2 before the three sessions of hemoperfusion was 89.60% ± 3.94% and increased to 92.13% ± 3.28% after them (p < 0.001). Serum IL-6 showed a reduction from 139.70 ± 105.62 to 72.06 ± 65.87 pg/mL (p = 0.073); and c-reactive protein decreased from 136.25 ± 84.39 to 78.25 ± 38.67 mg/L (P = 0.016).
CONCLUSIONS
Extracorporeal hemoadsorption could improve the general condition in most of recruited patients with severe coronavirus disease; however, large prospective multicenter trials in carefully selected patients are needed to definitely evaluate the efficacy of hemoperfusion in COVID-19 patients.
TRIAL REGISTRATION
The research protocol has been registered in the website of Iranian Registry of Clinical Trials with the reference number IRCT20150704023055N2 .
DOI: 10.1186/s12882-020-02020-3
PubMed: 32819292
PubMed Central: PMC7439633
Affiliations:
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Mehdinezhad</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Internal Medicine, Rouhani Hospital, Babol University of Medical Sciences, Babol</wicri:regionArea><wicri:noRegion>Babol</wicri:noRegion></affiliation></author><author><name sortKey="Bayani, Masoumeh" sort="Bayani, Masoumeh" uniqKey="Bayani M" first="Masoumeh" last="Bayani">Masoumeh Bayani</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol</wicri:regionArea><wicri:noRegion>Babol</wicri:noRegion></affiliation></author><author><name sortKey="Zavareh, Mahmoud Sadeghi Haddad" sort="Zavareh, Mahmoud Sadeghi Haddad" uniqKey="Zavareh M" first="Mahmoud Sadeghi Haddad" last="Zavareh">Mahmoud Sadeghi Haddad Zavareh</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol</wicri:regionArea><wicri:noRegion>Babol</wicri:noRegion></affiliation></author><author><name sortKey="Hamidi, Seyed Hossein" sort="Hamidi, Seyed Hossein" uniqKey="Hamidi S" first="Seyed Hossein" last="Hamidi">Seyed Hossein Hamidi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Anesthesiology, School of Medicine, Babol University of Medical Sciences, Babol</wicri:regionArea><wicri:noRegion>Babol</wicri:noRegion></affiliation></author><author><name sortKey="Akbari, Roghayeh" sort="Akbari, Roghayeh" uniqKey="Akbari R" first="Roghayeh" last="Akbari">Roghayeh Akbari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Internal Medicine, Babol University of Medical Sciences, Babol</wicri:regionArea><wicri:noRegion>Babol</wicri:noRegion></affiliation></author><author><name sortKey="Ghadimi, Reza" sort="Ghadimi, Reza" uniqKey="Ghadimi R" first="Reza" last="Ghadimi">Reza Ghadimi</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Ganjafrooz Street, Babol, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Ganjafrooz Street, Babol</wicri:regionArea><wicri:noRegion>Babol</wicri:noRegion></affiliation></author><author><name sortKey="Bijani, Ali" sort="Bijani, Ali" uniqKey="Bijani A" first="Ali" last="Bijani">Ali Bijani</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Ganjafrooz Street, Babol, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Ganjafrooz Street, Babol</wicri:regionArea><wicri:noRegion>Babol</wicri:noRegion></affiliation></author><author><name sortKey="Mouodi, Simin" sort="Mouodi, Simin" uniqKey="Mouodi S" first="Simin" last="Mouodi">Simin Mouodi</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Ganjafrooz Street, Babol, Iran. dr.mouodi@gmail.com.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Ganjafrooz Street, Babol</wicri:regionArea><wicri:noRegion>Babol</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC nephrology</title><idno type="eISSN">1471-2369</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (blood)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (therapy)</term><term>Extracorporeal Circulation (methods)</term><term>Female (MeSH)</term><term>Hemofiltration (methods)</term><term>Humans (MeSH)</term><term>Interleukin-6 (blood)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (blood)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (therapy)</term><term>Renal Replacement Therapy (methods)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Circulation extracorporelle (méthodes)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Hémofiltration (méthodes)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (sang)</term><term>Infections à coronavirus (thérapie)</term><term>Interleukine-6 (sang)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (sang)</term><term>Pneumopathie virale (thérapie)</term><term>Résultat thérapeutique (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Traitement substitutif de l'insuffisance rénale (méthodes)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Interleukin-6</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Extracorporeal Circulation</term><term>Hemofiltration</term><term>Renal Replacement Therapy</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Circulation extracorporelle</term><term>Hémofiltration</term><term>Traitement substitutif de l'insuffisance rénale</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Infections à coronavirus</term><term>Interleukine-6</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Betacoronavirus</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pandémies</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Extracorporeal blood purification has been proposed as one of the therapeutic approaches in patients with coronavirus infection, because of its beneficial impact on elimination of inflammatory cytokines.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>This controlled trial has been conducted on critically ill COVID-19 patients admitted in the state hospital affiliated to Babol University of Medical Sciences, Iran who received different antiviral and antibacterial drugs, and different modalities of respiratory treatments and did not have positive clinical improvement. No randomization and blindness was considered. All of the participants underwent three sessions of resin-directed hemoperfusion using continuous renal replacement therapy with a mode of continuous venovenous hemofiltration (CVVH).</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Five men and five women with a mean age of 57.30 ± 18.07 years have been enrolled in the study; and six of them have improved after the intervention. Peripheral capillary oxygen saturation (SpO2) changed after each session. Mean SpO2 before the three sessions of hemoperfusion was 89.60% ± 3.94% and increased to 92.13% ± 3.28% after them (p < 0.001). Serum IL-6 showed a reduction from 139.70 ± 105.62 to 72.06 ± 65.87 pg/mL (p = 0.073); and c-reactive protein decreased from 136.25 ± 84.39 to 78.25 ± 38.67 mg/L (P = 0.016).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Extracorporeal hemoadsorption could improve the general condition in most of recruited patients with severe coronavirus disease; however, large prospective multicenter trials in carefully selected patients are needed to definitely evaluate the efficacy of hemoperfusion in COVID-19 patients.</p></div><div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION</b></p><p>The research protocol has been registered in the website of Iranian Registry of Clinical Trials with the reference number IRCT20150704023055N2 .</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32819292</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>02</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>02</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2369</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>08</Month><Day>20</Day></PubDate></JournalIssue><Title>BMC nephrology</Title><ISOAbbreviation>BMC Nephrol</ISOAbbreviation></Journal><ArticleTitle>Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19).</ArticleTitle><Pagination><MedlinePgn>356</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12882-020-02020-3</ELocationID><Abstract><AbstractText Label="BACKGROUND">Extracorporeal blood purification has been proposed as one of the therapeutic approaches in patients with coronavirus infection, because of its beneficial impact on elimination of inflammatory cytokines.</AbstractText><AbstractText Label="METHODS">This controlled trial has been conducted on critically ill COVID-19 patients admitted in the state hospital affiliated to Babol University of Medical Sciences, Iran who received different antiviral and antibacterial drugs, and different modalities of respiratory treatments and did not have positive clinical improvement. No randomization and blindness was considered. All of the participants underwent three sessions of resin-directed hemoperfusion using continuous renal replacement therapy with a mode of continuous venovenous hemofiltration (CVVH).</AbstractText><AbstractText Label="RESULTS">Five men and five women with a mean age of 57.30 ± 18.07 years have been enrolled in the study; and six of them have improved after the intervention. Peripheral capillary oxygen saturation (SpO2) changed after each session. Mean SpO2 before the three sessions of hemoperfusion was 89.60% ± 3.94% and increased to 92.13% ± 3.28% after them (p < 0.001). Serum IL-6 showed a reduction from 139.70 ± 105.62 to 72.06 ± 65.87 pg/mL (p = 0.073); and c-reactive protein decreased from 136.25 ± 84.39 to 78.25 ± 38.67 mg/L (P = 0.016).</AbstractText><AbstractText Label="CONCLUSIONS">Extracorporeal hemoadsorption could improve the general condition in most of recruited patients with severe coronavirus disease; however, large prospective multicenter trials in carefully selected patients are needed to definitely evaluate the efficacy of hemoperfusion in COVID-19 patients.</AbstractText><AbstractText Label="TRIAL REGISTRATION">The research protocol has been registered in the website of Iranian Registry of Clinical Trials with the reference number IRCT20150704023055N2 .</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Asgharpour</LastName><ForeName>Masoumeh</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-5504-4612</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mehdinezhad</LastName><ForeName>Hamed</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0002-1049-1267</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bayani</LastName><ForeName>Masoumeh</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0003-3044-1168</Identifier><AffiliationInfo><Affiliation>Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zavareh</LastName><ForeName>Mahmoud Sadeghi Haddad</ForeName><Initials>MSH</Initials><Identifier Source="ORCID">0000-0001-8701-7267</Identifier><AffiliationInfo><Affiliation>Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamidi</LastName><ForeName>Seyed Hossein</ForeName><Initials>SH</Initials><Identifier Source="ORCID">0000-0002-7542-7936</Identifier><AffiliationInfo><Affiliation>Department of Anesthesiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akbari</LastName><ForeName>Roghayeh</ForeName><Initials>R</Initials><Identifier Source="ORCID">0000-0002-3720-3077</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghadimi</LastName><ForeName>Reza</ForeName><Initials>R</Initials><Identifier Source="ORCID">0000-0002-4296-2836</Identifier><AffiliationInfo><Affiliation>Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Ganjafrooz Street, Babol, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bijani</LastName><ForeName>Ali</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0003-2233-8726</Identifier><AffiliationInfo><Affiliation>Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Ganjafrooz Street, Babol, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mouodi</LastName><ForeName>Simin</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0001-7868-9360</Identifier><AffiliationInfo><Affiliation>Social Determinants of Health Research Center, Health Research Institute, Babol University 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name="Iran"><noRegion><name sortKey="Asgharpour, Masoumeh" sort="Asgharpour, Masoumeh" uniqKey="Asgharpour M" first="Masoumeh" last="Asgharpour">Masoumeh Asgharpour</name></noRegion><name sortKey="Akbari, Roghayeh" sort="Akbari, Roghayeh" uniqKey="Akbari R" first="Roghayeh" last="Akbari">Roghayeh Akbari</name><name sortKey="Bayani, Masoumeh" sort="Bayani, Masoumeh" uniqKey="Bayani M" first="Masoumeh" last="Bayani">Masoumeh Bayani</name><name sortKey="Bijani, Ali" sort="Bijani, Ali" uniqKey="Bijani A" first="Ali" last="Bijani">Ali Bijani</name><name sortKey="Ghadimi, Reza" sort="Ghadimi, Reza" uniqKey="Ghadimi R" first="Reza" last="Ghadimi">Reza Ghadimi</name><name sortKey="Hamidi, Seyed Hossein" sort="Hamidi, Seyed Hossein" uniqKey="Hamidi S" first="Seyed Hossein" last="Hamidi">Seyed Hossein Hamidi</name><name sortKey="Mehdinezhad, Hamed" sort="Mehdinezhad, Hamed" uniqKey="Mehdinezhad H" first="Hamed" last="Mehdinezhad">Hamed Mehdinezhad</name><name sortKey="Mouodi, Simin" sort="Mouodi, Simin" uniqKey="Mouodi S" first="Simin" last="Mouodi">Simin Mouodi</name><name sortKey="Zavareh, Mahmoud Sadeghi Haddad" sort="Zavareh, Mahmoud Sadeghi Haddad" uniqKey="Zavareh M" first="Mahmoud Sadeghi Haddad" last="Zavareh">Mahmoud Sadeghi Haddad Zavareh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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