Efficacy of corticosteroids in non-intensive care unit patients with COVID-19 pneumonia from the New York Metropolitan region.
Identifieur interne : 000618 ( Main/Exploration ); précédent : 000617; suivant : 000619Efficacy of corticosteroids in non-intensive care unit patients with COVID-19 pneumonia from the New York Metropolitan region.
Auteurs : Monil Majmundar [États-Unis] ; Tikal Kansara [États-Unis] ; Joanna Marta Lenik [États-Unis] ; Hansang Park [États-Unis] ; Kuldeep Ghosh [États-Unis] ; Rajkumar Doshi [États-Unis] ; Palak Shah [États-Unis] ; Ashish Kumar [Inde] ; Hossam Amin [États-Unis] ; Shobhana Chaudhari [États-Unis] ; Imnett Habtes [États-Unis]Source :
- PloS one [ 1932-6203 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Betacoronavirus (isolement et purification), Estimation de Kaplan-Meier (MeSH), Femelle (MeSH), Hormones corticosurrénaliennes (usage thérapeutique), Humains (MeSH), Infections à coronavirus (mortalité), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Modèles des risques proportionnels (MeSH), Mortalité hospitalière (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (mortalité), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (virologie), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Syndrome de détresse respiratoire de l'adulte (diagnostic), Syndrome de détresse respiratoire de l'adulte (étiologie), Unités de soins intensifs (MeSH), État de New York (MeSH), Études rétrospectives (MeSH).
- MESH :
- diagnostic : Syndrome de détresse respiratoire de l'adulte.
- isolement et purification : Betacoronavirus.
- mortalité : Infections à coronavirus, Pneumopathie virale.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Hormones corticosurrénaliennes.
- virologie : Infections à coronavirus, Pneumopathie virale.
- étiologie : Syndrome de détresse respiratoire de l'adulte.
- Adulte, Adulte d'âge moyen, Estimation de Kaplan-Meier, Femelle, Humains, Modèles des risques proportionnels, Mortalité hospitalière, Mâle, Pandémies, Résultat thérapeutique, Sujet âgé, Unités de soins intensifs, État de New York, Études rétrospectives.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (therapeutic use), Adult (MeSH), Aged (MeSH), Betacoronavirus (isolation & purification), Coronavirus Infections (drug therapy), Coronavirus Infections (mortality), Coronavirus Infections (virology), Female (MeSH), Hospital Mortality (MeSH), Humans (MeSH), Intensive Care Units (MeSH), Kaplan-Meier Estimate (MeSH), Male (MeSH), Middle Aged (MeSH), New York (MeSH), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (mortality), Pneumonia, Viral (virology), Proportional Hazards Models (MeSH), Respiratory Distress Syndrome, Adult (diagnosis), Respiratory Distress Syndrome, Adult (etiology), Retrospective Studies (MeSH), Treatment Outcome (MeSH).
- MESH :
- chemical , therapeutic use : Adrenal Cortex Hormones.
- geographic : New York.
- diagnosis : Respiratory Distress Syndrome, Adult.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- etiology : Respiratory Distress Syndrome, Adult.
- isolation & purification : Betacoronavirus.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Adult, Aged, Female, Hospital Mortality, Humans, Intensive Care Units, Kaplan-Meier Estimate, Male, Middle Aged, Pandemics, Proportional Hazards Models, Retrospective Studies, Treatment Outcome.
Abstract
INTRODUCTION
The role of systemic corticosteroid as a therapeutic agent for patients with COVID-19 pneumonia is controversial.
OBJECTIVE
The purpose of this study was to evaluate the effect of corticosteroids in non-intensive care unit (ICU) patients with COVID-19 pneumonia complicated by acute hypoxemic respiratory failure (AHRF).
METHODS
This was a single-center retrospective cohort study, from 16th March, 2020 to 30th April, 2020; final follow-up on 10th May, 2020. 265 patients consecutively admitted to the non-ICU wards with laboratory-confirmed COVID-19 pneumonia were screened for inclusion. 205 patients who developed AHRF (SpO2/FiO2 ≤ 440 or PaO2/FiO2 ≤ 300) were only included in the final study. Direct admission to the Intensive care unit (ICU), patients developing composite primary outcome within 24 hours of admission, and patients who never became hypoxic during their stay in the hospital were excluded. Patients were divided into two cohorts based on corticosteroid. The primary outcome was a composite of ICU transfer, intubation, or in-hospital mortality. Secondary outcomes were ICU transfer, intubation, in-hospital mortality, discharge, length of stay, and daily trend of SpO2/FiO2 (SF) ratio from the index date. Cox-proportional hazard regression was implemented to analyze the time to event outcomes.
RESULT
Among 205 patients, 60 (29.27%) were treated with corticosteroid. The mean age was ~57 years, and ~75% were men. Thirteen patients (22.41%) developed a primary composite outcome in the corticosteroid cohort vs. 54 (37.5%) patients in the non-corticosteroid cohort (P = 0.039). The adjusted hazard ratio (HR) for the development of the composite primary outcome was 0.15 (95% CI, 0.07-0.33; P <0.001). The adjusted hazard ratio for ICU transfer was 0.16 (95% CI, 0.07 to 0.34; P < 0.001), intubation was 0.31 (95% CI, 0.14 to 0.70; P- 0.005), death was 0.53 (95% CI, 0.22 to 1.31; P- 0.172), composite of death or intubation was 0.31 (95% CI, 0.15 to 0.66; P- 0.002) and discharge was 3.65 (95% CI, 2.20 to 6.06; P<0.001). The corticosteroid cohort had increasing SpO2/FiO2 over time compared to the non-corticosteroid cohort who experience decreasing SpO2/FiO2 over time.
CONCLUSION
Among non-ICU patients hospitalized with COVID-19 pneumonia complicated by AHRF, treatment with corticosteroid was associated with a significantly lower risk of the primary composite outcome of ICU transfer, intubation, or in-hospital death, composite of intubation or death and individual components of the primary outcome.
DOI: 10.1371/journal.pone.0238827
PubMed: 32903258
PubMed Central: PMC7480842
Affiliations:
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Medical College, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kansara, Tikal" sort="Kansara, Tikal" uniqKey="Kansara T" first="Tikal" last="Kansara">Tikal Kansara</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lenik, Joanna Marta" sort="Lenik, Joanna Marta" uniqKey="Lenik J" first="Joanna Marta" last="Lenik">Joanna Marta Lenik</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New 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last="Ghosh">Kuldeep Ghosh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Doshi, Rajkumar" sort="Doshi, Rajkumar" uniqKey="Doshi R" first="Rajkumar" last="Doshi">Rajkumar Doshi</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Reno School of Medicine, University of Nevada, Reno, NV, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Reno School of Medicine, University of Nevada, Reno, NV</wicri:regionArea><placeName><region type="state">Nevada</region></placeName></affiliation></author><author><name sortKey="Shah, Palak" sort="Shah, Palak" uniqKey="Shah P" first="Palak" last="Shah">Palak Shah</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kumar, Ashish" sort="Kumar, Ashish" uniqKey="Kumar A" first="Ashish" last="Kumar">Ashish Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, St John's Medical College Hospital, Bengaluru, Karnataka, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Critical Care Medicine, St John's Medical College Hospital, Bengaluru, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Amin, Hossam" sort="Amin, Hossam" uniqKey="Amin H" first="Hossam" last="Amin">Hossam Amin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Division of Pulmonary and Critical Care, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Division of Pulmonary and Critical Care, Metropolitan Hospital, New York Medical College, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Chaudhari, Shobhana" sort="Chaudhari, Shobhana" uniqKey="Chaudhari S" first="Shobhana" last="Chaudhari">Shobhana Chaudhari</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Habtes, Imnett" sort="Habtes, Imnett" uniqKey="Habtes I" first="Imnett" last="Habtes">Imnett Habtes</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Division of Pulmonary and Critical Care, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Division of Pulmonary and Critical Care, Metropolitan Hospital, New York Medical College, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex Hormones (therapeutic use)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Betacoronavirus (isolation & purification)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (virology)</term><term>Female (MeSH)</term><term>Hospital Mortality (MeSH)</term><term>Humans (MeSH)</term><term>Intensive Care Units (MeSH)</term><term>Kaplan-Meier Estimate (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>New York (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (drug therapy)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (virology)</term><term>Proportional Hazards Models (MeSH)</term><term>Respiratory Distress Syndrome, Adult (diagnosis)</term><term>Respiratory Distress Syndrome, Adult (etiology)</term><term>Retrospective Studies (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Betacoronavirus (isolement et purification)</term><term>Estimation de Kaplan-Meier (MeSH)</term><term>Femelle (MeSH)</term><term>Hormones corticosurrénaliennes (usage thérapeutique)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Modèles des risques proportionnels (MeSH)</term><term>Mortalité hospitalière (MeSH)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (mortalité)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Pneumopathie virale (virologie)</term><term>Résultat thérapeutique (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Syndrome de détresse respiratoire de l'adulte (diagnostic)</term><term>Syndrome de détresse respiratoire de l'adulte (étiologie)</term><term>Unités de soins intensifs (MeSH)</term><term>État de New York (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>New York</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Hormones corticosurrénaliennes</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Hospital Mortality</term><term>Humans</term><term>Intensive Care Units</term><term>Kaplan-Meier Estimate</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Proportional Hazards Models</term><term>Retrospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Humains</term><term>Modèles des risques proportionnels</term><term>Mortalité hospitalière</term><term>Mâle</term><term>Pandémies</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Unités de soins intensifs</term><term>État de New York</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>The role of systemic corticosteroid as a therapeutic agent for patients with COVID-19 pneumonia is controversial.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>The purpose of this study was to evaluate the effect of corticosteroids in non-intensive care unit (ICU) patients with COVID-19 pneumonia complicated by acute hypoxemic respiratory failure (AHRF).</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>This was a single-center retrospective cohort study, from 16th March, 2020 to 30th April, 2020; final follow-up on 10th May, 2020. 265 patients consecutively admitted to the non-ICU wards with laboratory-confirmed COVID-19 pneumonia were screened for inclusion. 205 patients who developed AHRF (SpO2/FiO2 ≤ 440 or PaO2/FiO2 ≤ 300) were only included in the final study. Direct admission to the Intensive care unit (ICU), patients developing composite primary outcome within 24 hours of admission, and patients who never became hypoxic during their stay in the hospital were excluded. Patients were divided into two cohorts based on corticosteroid. The primary outcome was a composite of ICU transfer, intubation, or in-hospital mortality. Secondary outcomes were ICU transfer, intubation, in-hospital mortality, discharge, length of stay, and daily trend of SpO2/FiO2 (SF) ratio from the index date. Cox-proportional hazard regression was implemented to analyze the time to event outcomes.</p></div><div type="abstract" xml:lang="en"><p><b>RESULT</b></p><p>Among 205 patients, 60 (29.27%) were treated with corticosteroid. The mean age was ~57 years, and ~75% were men. Thirteen patients (22.41%) developed a primary composite outcome in the corticosteroid cohort vs. 54 (37.5%) patients in the non-corticosteroid cohort (P = 0.039). The adjusted hazard ratio (HR) for the development of the composite primary outcome was 0.15 (95% CI, 0.07-0.33; P <0.001). The adjusted hazard ratio for ICU transfer was 0.16 (95% CI, 0.07 to 0.34; P < 0.001), intubation was 0.31 (95% CI, 0.14 to 0.70; P- 0.005), death was 0.53 (95% CI, 0.22 to 1.31; P- 0.172), composite of death or intubation was 0.31 (95% CI, 0.15 to 0.66; P- 0.002) and discharge was 3.65 (95% CI, 2.20 to 6.06; P<0.001). The corticosteroid cohort had increasing SpO2/FiO2 over time compared to the non-corticosteroid cohort who experience decreasing SpO2/FiO2 over time.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Among non-ICU patients hospitalized with COVID-19 pneumonia complicated by AHRF, treatment with corticosteroid was associated with a significantly lower risk of the primary composite outcome of ICU transfer, intubation, or in-hospital death, composite of intubation or death and individual components of the primary outcome.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32903258</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>23</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>9</Issue><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS One</ISOAbbreviation></Journal><ArticleTitle>Efficacy of corticosteroids in non-intensive care unit patients with COVID-19 pneumonia from the New York Metropolitan region.</ArticleTitle><Pagination><MedlinePgn>e0238827</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0238827</ELocationID><Abstract><AbstractText Label="INTRODUCTION">The role of systemic corticosteroid as a therapeutic agent for patients with COVID-19 pneumonia is controversial.</AbstractText><AbstractText Label="OBJECTIVE">The purpose of this study was to evaluate the effect of corticosteroids in non-intensive care unit (ICU) patients with COVID-19 pneumonia complicated by acute hypoxemic respiratory failure (AHRF).</AbstractText><AbstractText Label="METHODS">This was a single-center retrospective cohort study, from 16th March, 2020 to 30th April, 2020; final follow-up on 10th May, 2020. 265 patients consecutively admitted to the non-ICU wards with laboratory-confirmed COVID-19 pneumonia were screened for inclusion. 205 patients who developed AHRF (SpO2/FiO2 ≤ 440 or PaO2/FiO2 ≤ 300) were only included in the final study. Direct admission to the Intensive care unit (ICU), patients developing composite primary outcome within 24 hours of admission, and patients who never became hypoxic during their stay in the hospital were excluded. Patients were divided into two cohorts based on corticosteroid. The primary outcome was a composite of ICU transfer, intubation, or in-hospital mortality. Secondary outcomes were ICU transfer, intubation, in-hospital mortality, discharge, length of stay, and daily trend of SpO2/FiO2 (SF) ratio from the index date. Cox-proportional hazard regression was implemented to analyze the time to event outcomes.</AbstractText><AbstractText Label="RESULT">Among 205 patients, 60 (29.27%) were treated with corticosteroid. The mean age was ~57 years, and ~75% were men. Thirteen patients (22.41%) developed a primary composite outcome in the corticosteroid cohort vs. 54 (37.5%) patients in the non-corticosteroid cohort (P = 0.039). The adjusted hazard ratio (HR) for the development of the composite primary outcome was 0.15 (95% CI, 0.07-0.33; P <0.001). The adjusted hazard ratio for ICU transfer was 0.16 (95% CI, 0.07 to 0.34; P < 0.001), intubation was 0.31 (95% CI, 0.14 to 0.70; P- 0.005), death was 0.53 (95% CI, 0.22 to 1.31; P- 0.172), composite of death or intubation was 0.31 (95% CI, 0.15 to 0.66; P- 0.002) and discharge was 3.65 (95% CI, 2.20 to 6.06; P<0.001). The corticosteroid cohort had increasing SpO2/FiO2 over time compared to the non-corticosteroid cohort who experience decreasing SpO2/FiO2 over time.</AbstractText><AbstractText Label="CONCLUSION">Among non-ICU patients hospitalized with COVID-19 pneumonia complicated by AHRF, treatment with corticosteroid was associated with a significantly lower risk of the primary composite outcome of ICU transfer, intubation, or in-hospital death, composite of intubation or death and individual components of the primary outcome.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Majmundar</LastName><ForeName>Monil</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-5389-5878</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kansara</LastName><ForeName>Tikal</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lenik</LastName><ForeName>Joanna Marta</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Hansang</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghosh</LastName><ForeName>Kuldeep</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doshi</LastName><ForeName>Rajkumar</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Reno School of Medicine, University of Nevada, Reno, NV, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shah</LastName><ForeName>Palak</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>Ashish</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0003-4249-0055</Identifier><AffiliationInfo><Affiliation>Department of Critical Care Medicine, St John's Medical College Hospital, Bengaluru, Karnataka, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amin</LastName><ForeName>Hossam</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Pulmonary and Critical Care, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chaudhari</LastName><ForeName>Shobhana</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Habtes</LastName><ForeName>Imnett</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Pulmonary and Critical Care, Metropolitan Hospital, New York Medical College, New York, NY, United States of America.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000305" MajorTopicYN="N">Adrenal Cortex Hormones</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053208" MajorTopicYN="N">Kaplan-Meier Estimate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009518" MajorTopicYN="N" Type="Geographic">New York</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><CoiStatement>The authors have declared that no competing interests exist.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>14</Day></PubMedPubDate><PubMedPubDate 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Apr;17(4):233-247</Citation><ArticleIdList><ArticleId IdType="pubmed">28192415</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Inde</li><li>États-Unis</li></country><region><li>Nevada</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Majmundar, Monil" sort="Majmundar, Monil" uniqKey="Majmundar M" first="Monil" last="Majmundar">Monil Majmundar</name></region><name sortKey="Amin, Hossam" sort="Amin, Hossam" uniqKey="Amin H" first="Hossam" last="Amin">Hossam Amin</name><name sortKey="Chaudhari, Shobhana" sort="Chaudhari, Shobhana" uniqKey="Chaudhari S" first="Shobhana" last="Chaudhari">Shobhana Chaudhari</name><name sortKey="Doshi, Rajkumar" sort="Doshi, Rajkumar" uniqKey="Doshi R" first="Rajkumar" last="Doshi">Rajkumar Doshi</name><name sortKey="Ghosh, Kuldeep" sort="Ghosh, Kuldeep" uniqKey="Ghosh K" first="Kuldeep" last="Ghosh">Kuldeep Ghosh</name><name sortKey="Habtes, Imnett" sort="Habtes, Imnett" uniqKey="Habtes I" first="Imnett" last="Habtes">Imnett Habtes</name><name sortKey="Kansara, Tikal" sort="Kansara, Tikal" uniqKey="Kansara T" first="Tikal" last="Kansara">Tikal Kansara</name><name sortKey="Lenik, Joanna Marta" sort="Lenik, Joanna Marta" uniqKey="Lenik J" first="Joanna Marta" last="Lenik">Joanna Marta Lenik</name><name sortKey="Park, Hansang" sort="Park, Hansang" uniqKey="Park H" first="Hansang" last="Park">Hansang Park</name><name sortKey="Shah, Palak" sort="Shah, Palak" uniqKey="Shah P" first="Palak" last="Shah">Palak Shah</name></country><country name="Inde"><noRegion><name sortKey="Kumar, Ashish" sort="Kumar, Ashish" uniqKey="Kumar A" first="Ashish" last="Kumar">Ashish Kumar</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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