Serveur d'exploration sur la COVID chez les séniors

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Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID-19 patients with pneumonia.

Identifieur interne : 000575 ( Main/Exploration ); précédent : 000574; suivant : 000576

Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID-19 patients with pneumonia.

Auteurs : Sara De Biasi [Italie] ; Domenico Lo Tartaro [Italie] ; Marianna Meschiari [Italie] ; Lara Gibellini [Italie] ; Caterina Bellinazzi [Italie] ; Rebecca Borella [Italie] ; Lucia Fidanza [Italie] ; Marco Mattioli [Italie] ; Annamaria Paolini [Italie] ; Licia Gozzi [Italie] ; Dina Jaacoub [Italie] ; Matteo Faltoni [Italie] ; Sara Volpi [Italie] ; Jovana Mili [Italie] ; Marco Sita [Italie] ; Mario Sarti [Italie] ; Carlo Pucillo [Italie] ; Massimo Girardis [Italie] ; Giovanni Guaraldi [Italie] ; Cristina Mussini [Italie] ; Andrea Cossarizza [Italie]

Source :

RBID : pubmed:32910469

Descripteurs français

English descriptors

Abstract

Studies on the interactions between SARS-CoV-2 and humoral immunity are fundamental to elaborate effective therapies including vaccines. We used polychromatic flow cytometry, coupled with unsupervised data analysis and principal component analysis (PCA), to interrogate B cells in untreated patients with COVID-19 pneumonia. COVID-19 patients displayed normal plasma levels of the main immunoglobulin classes, of antibodies against common antigens or against antigens present in common vaccines. However, we found a decreased number of total and naïve B cells, along with decreased percentages and numbers of memory switched and unswitched B cells. On the contrary, IgM+ and IgM- plasmablasts were significantly increased. In vitro cell activation revealed that B lymphocytes showed a normal proliferation index and number of dividing cells per cycle. PCA indicated that B-cell number, naive and memory B cells but not plasmablasts clustered with patients who were discharged, while plasma IgM level, C-reactive protein, D-dimer, and SOFA score with those who died. In patients with pneumonia, the derangement of the B-cell compartment could be one of the causes of the immunological failure to control SARS-Cov2, have a relevant influence on several pathways, organs and systems, and must be considered to develop vaccine strategies.

DOI: 10.1002/eji.202048838
PubMed: 32910469


Affiliations:


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Le document en format XML

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<name sortKey="Bellinazzi, Caterina" sort="Bellinazzi, Caterina" uniqKey="Bellinazzi C" first="Caterina" last="Bellinazzi">Caterina Bellinazzi</name>
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<name sortKey="Fidanza, Lucia" sort="Fidanza, Lucia" uniqKey="Fidanza L" first="Lucia" last="Fidanza">Lucia Fidanza</name>
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<name sortKey="Paolini, Annamaria" sort="Paolini, Annamaria" uniqKey="Paolini A" first="Annamaria" last="Paolini">Annamaria Paolini</name>
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<name sortKey="Gozzi, Licia" sort="Gozzi, Licia" uniqKey="Gozzi L" first="Licia" last="Gozzi">Licia Gozzi</name>
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<name sortKey="Faltoni, Matteo" sort="Faltoni, Matteo" uniqKey="Faltoni M" first="Matteo" last="Faltoni">Matteo Faltoni</name>
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<name sortKey="Volpi, Sara" sort="Volpi, Sara" uniqKey="Volpi S" first="Sara" last="Volpi">Sara Volpi</name>
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<name sortKey="Mili, Jovana" sort="Mili, Jovana" uniqKey="Mili J" first="Jovana" last="Mili">Jovana Mili</name>
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<name sortKey="Sita, Marco" sort="Sita, Marco" uniqKey="Sita M" first="Marco" last="Sita">Marco Sita</name>
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<name sortKey="Sarti, Mario" sort="Sarti, Mario" uniqKey="Sarti M" first="Mario" last="Sarti">Mario Sarti</name>
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<name sortKey="Pucillo, Carlo" sort="Pucillo, Carlo" uniqKey="Pucillo C" first="Carlo" last="Pucillo">Carlo Pucillo</name>
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<nlm:affiliation>Laboratory of Immunology, Department of Medicine, University of Udine, Udine, Italy.</nlm:affiliation>
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<wicri:regionArea>Laboratory of Immunology, Department of Medicine, University of Udine, Udine</wicri:regionArea>
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<name sortKey="Girardis, Massimo" sort="Girardis, Massimo" uniqKey="Girardis M" first="Massimo" last="Girardis">Massimo Girardis</name>
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<name sortKey="Guaraldi, Giovanni" sort="Guaraldi, Giovanni" uniqKey="Guaraldi G" first="Giovanni" last="Guaraldi">Giovanni Guaraldi</name>
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<name sortKey="Mussini, Cristina" sort="Mussini, Cristina" uniqKey="Mussini C" first="Cristina" last="Mussini">Cristina Mussini</name>
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<name sortKey="Cossarizza, Andrea" sort="Cossarizza, Andrea" uniqKey="Cossarizza A" first="Andrea" last="Cossarizza">Andrea Cossarizza</name>
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<nlm:affiliation>National Institute for Cardiovascular Research, Bologna, Italy.</nlm:affiliation>
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<title xml:lang="en">Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID-19 patients with pneumonia.</title>
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<name sortKey="De Biasi, Sara" sort="De Biasi, Sara" uniqKey="De Biasi S" first="Sara" last="De Biasi">Sara De Biasi</name>
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<nlm:affiliation>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena</wicri:regionArea>
<wicri:noRegion>Modena</wicri:noRegion>
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<name sortKey="Lo Tartaro, Domenico" sort="Lo Tartaro, Domenico" uniqKey="Lo Tartaro D" first="Domenico" last="Lo Tartaro">Domenico Lo Tartaro</name>
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<nlm:affiliation>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena</wicri:regionArea>
<wicri:noRegion>Modena</wicri:noRegion>
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<name sortKey="Meschiari, Marianna" sort="Meschiari, Marianna" uniqKey="Meschiari M" first="Marianna" last="Meschiari">Marianna Meschiari</name>
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<name sortKey="Gibellini, Lara" sort="Gibellini, Lara" uniqKey="Gibellini L" first="Lara" last="Gibellini">Lara Gibellini</name>
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<nlm:affiliation>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy.</nlm:affiliation>
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<name sortKey="Bellinazzi, Caterina" sort="Bellinazzi, Caterina" uniqKey="Bellinazzi C" first="Caterina" last="Bellinazzi">Caterina Bellinazzi</name>
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<nlm:affiliation>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy.</nlm:affiliation>
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<wicri:regionArea>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena</wicri:regionArea>
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<name sortKey="Borella, Rebecca" sort="Borella, Rebecca" uniqKey="Borella R" first="Rebecca" last="Borella">Rebecca Borella</name>
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<nlm:affiliation>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy.</nlm:affiliation>
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<wicri:regionArea>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena</wicri:regionArea>
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<name sortKey="Fidanza, Lucia" sort="Fidanza, Lucia" uniqKey="Fidanza L" first="Lucia" last="Fidanza">Lucia Fidanza</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena</wicri:regionArea>
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<name sortKey="Mattioli, Marco" sort="Mattioli, Marco" uniqKey="Mattioli M" first="Marco" last="Mattioli">Marco Mattioli</name>
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<nlm:affiliation>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena</wicri:regionArea>
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<name sortKey="Paolini, Annamaria" sort="Paolini, Annamaria" uniqKey="Paolini A" first="Annamaria" last="Paolini">Annamaria Paolini</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena</wicri:regionArea>
<wicri:noRegion>Modena</wicri:noRegion>
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<name sortKey="Gozzi, Licia" sort="Gozzi, Licia" uniqKey="Gozzi L" first="Licia" last="Gozzi">Licia Gozzi</name>
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<nlm:affiliation>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena</wicri:regionArea>
<wicri:noRegion>Modena</wicri:noRegion>
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<name sortKey="Jaacoub, Dina" sort="Jaacoub, Dina" uniqKey="Jaacoub D" first="Dina" last="Jaacoub">Dina Jaacoub</name>
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<nlm:affiliation>Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena</wicri:regionArea>
<wicri:noRegion>Modena</wicri:noRegion>
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<name sortKey="Faltoni, Matteo" sort="Faltoni, Matteo" uniqKey="Faltoni M" first="Matteo" last="Faltoni">Matteo Faltoni</name>
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<nlm:affiliation>Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena</wicri:regionArea>
<wicri:noRegion>Modena</wicri:noRegion>
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<name sortKey="Volpi, Sara" sort="Volpi, Sara" uniqKey="Volpi S" first="Sara" last="Volpi">Sara Volpi</name>
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<nlm:affiliation>Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena</wicri:regionArea>
<wicri:noRegion>Modena</wicri:noRegion>
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<name sortKey="Mili, Jovana" sort="Mili, Jovana" uniqKey="Mili J" first="Jovana" last="Mili">Jovana Mili</name>
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<nlm:affiliation>Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena</wicri:regionArea>
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<nlm:affiliation>Laboratory of Immunology, Department of Medicine, University of Udine, Udine, Italy.</nlm:affiliation>
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<nlm:affiliation>Department of Anesthesia and Intensive Care, AOU Policlinico and University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation>
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</affiliation>
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<nlm:affiliation>Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation>
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<wicri:regionArea>Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena</wicri:regionArea>
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<name sortKey="Cossarizza, Andrea" sort="Cossarizza, Andrea" uniqKey="Cossarizza A" first="Andrea" last="Cossarizza">Andrea Cossarizza</name>
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<wicri:regionArea>Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena</wicri:regionArea>
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<nlm:affiliation>National Institute for Cardiovascular Research, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
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<title level="j">European journal of immunology</title>
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<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibodies, Viral (classification)</term>
<term>B-Lymphocytes (immunology)</term>
<term>B-Lymphocytes (virology)</term>
<term>Betacoronavirus (immunology)</term>
<term>Betacoronavirus (pathogenicity)</term>
<term>C-Reactive Protein (immunology)</term>
<term>Case-Control Studies (MeSH)</term>
<term>Cell Proliferation (MeSH)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (pathology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Cross-Sectional Studies (MeSH)</term>
<term>Cytokines (genetics)</term>
<term>Cytokines (immunology)</term>
<term>Female (MeSH)</term>
<term>Fibrin Fibrinogen Degradation Products (immunology)</term>
<term>Humans (MeSH)</term>
<term>Immunity, Humoral (MeSH)</term>
<term>Immunoglobulin Isotypes (blood)</term>
<term>Immunologic Memory (MeSH)</term>
<term>Lung (immunology)</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Lymphocyte Activation (MeSH)</term>
<term>Lymphocyte Count (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Organ Dysfunction Scores (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (pathology)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Primary Cell Culture (MeSH)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Survival Analysis (MeSH)</term>
</keywords>
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<term>Activation des lymphocytes (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse de survie (MeSH)</term>
<term>Anticorps antiviraux (classification)</term>
<term>Anticorps antiviraux (sang)</term>
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<term>Betacoronavirus (pathogénicité)</term>
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<term>Cytokines (génétique)</term>
<term>Cytokines (immunologie)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunité humorale (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
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<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (mortalité)</term>
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<term>Isotypes des immunoglobulines (sang)</term>
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<term>Lymphocytes B (virologie)</term>
<term>Mâle (MeSH)</term>
<term>Mémoire immunologique (MeSH)</term>
<term>Numération des lymphocytes (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (anatomopathologie)</term>
<term>Pneumopathie virale (immunologie)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (virologie)</term>
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<term>Poumon (immunologie)</term>
<term>Poumon (virologie)</term>
<term>Produits de dégradation de la fibrine et du fibrinogène (immunologie)</term>
<term>Prolifération cellulaire (MeSH)</term>
<term>Protéine C-réactive (immunologie)</term>
<term>Scores de dysfonction d'organes (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Études cas-témoins (MeSH)</term>
<term>Études transversales (MeSH)</term>
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<term>Antibodies, Viral</term>
<term>Immunoglobulin Isotypes</term>
</keywords>
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<term>Antibodies, Viral</term>
</keywords>
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</keywords>
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<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Poumon</term>
</keywords>
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<term>Anticorps antiviraux</term>
</keywords>
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<term>Cytokines</term>
</keywords>
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<term>Betacoronavirus</term>
<term>Cytokines</term>
<term>Infections à coronavirus</term>
<term>Lymphocytes B</term>
<term>Pneumopathie virale</term>
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<term>Produits de dégradation de la fibrine et du fibrinogène</term>
<term>Protéine C-réactive</term>
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<term>B-Lymphocytes</term>
<term>Betacoronavirus</term>
<term>C-Reactive Protein</term>
<term>Coronavirus Infections</term>
<term>Cytokines</term>
<term>Fibrin Fibrinogen Degradation Products</term>
<term>Lung</term>
<term>Pneumonia, Viral</term>
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<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
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<term>Pneumopathie virale</term>
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</keywords>
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<term>Anticorps antiviraux</term>
<term>Isotypes des immunoglobulines</term>
</keywords>
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<term>Infections à coronavirus</term>
<term>Lymphocytes B</term>
<term>Pneumopathie virale</term>
<term>Poumon</term>
</keywords>
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<term>B-Lymphocytes</term>
<term>Coronavirus Infections</term>
<term>Lung</term>
<term>Pneumonia, Viral</term>
</keywords>
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<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Cell Proliferation</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Immunity, Humoral</term>
<term>Immunologic Memory</term>
<term>Lymphocyte Activation</term>
<term>Lymphocyte Count</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Organ Dysfunction Scores</term>
<term>Pandemics</term>
<term>Primary Cell Culture</term>
<term>Severity of Illness Index</term>
<term>Survival Analysis</term>
</keywords>
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<term>Activation des lymphocytes</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Culture de cellules primaires</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunité humorale</term>
<term>Indice de gravité de la maladie</term>
<term>Mâle</term>
<term>Mémoire immunologique</term>
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<term>Prolifération cellulaire</term>
<term>Scores de dysfonction d'organes</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
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<front>
<div type="abstract" xml:lang="en">Studies on the interactions between SARS-CoV-2 and humoral immunity are fundamental to elaborate effective therapies including vaccines. We used polychromatic flow cytometry, coupled with unsupervised data analysis and principal component analysis (PCA), to interrogate B cells in untreated patients with COVID-19 pneumonia. COVID-19 patients displayed normal plasma levels of the main immunoglobulin classes, of antibodies against common antigens or against antigens present in common vaccines. However, we found a decreased number of total and naïve B cells, along with decreased percentages and numbers of memory switched and unswitched B cells. On the contrary, IgM
<sup>+</sup>
and IgM
<sup>-</sup>
plasmablasts were significantly increased. In vitro cell activation revealed that B lymphocytes showed a normal proliferation index and number of dividing cells per cycle. PCA indicated that B-cell number, naive and memory B cells but not plasmablasts clustered with patients who were discharged, while plasma IgM level, C-reactive protein, D-dimer, and SOFA score with those who died. In patients with pneumonia, the derangement of the B-cell compartment could be one of the causes of the immunological failure to control SARS-Cov2, have a relevant influence on several pathways, organs and systems, and must be considered to develop vaccine strategies.</div>
</front>
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<DateCompleted>
<Year>2020</Year>
<Month>09</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised>
<Year>2020</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
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<Volume>50</Volume>
<Issue>9</Issue>
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<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>European journal of immunology</Title>
<ISOAbbreviation>Eur J Immunol</ISOAbbreviation>
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<ArticleTitle>Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID-19 patients with pneumonia.</ArticleTitle>
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<AbstractText>Studies on the interactions between SARS-CoV-2 and humoral immunity are fundamental to elaborate effective therapies including vaccines. We used polychromatic flow cytometry, coupled with unsupervised data analysis and principal component analysis (PCA), to interrogate B cells in untreated patients with COVID-19 pneumonia. COVID-19 patients displayed normal plasma levels of the main immunoglobulin classes, of antibodies against common antigens or against antigens present in common vaccines. However, we found a decreased number of total and naïve B cells, along with decreased percentages and numbers of memory switched and unswitched B cells. On the contrary, IgM
<sup>+</sup>
and IgM
<sup>-</sup>
plasmablasts were significantly increased. In vitro cell activation revealed that B lymphocytes showed a normal proliferation index and number of dividing cells per cycle. PCA indicated that B-cell number, naive and memory B cells but not plasmablasts clustered with patients who were discharged, while plasma IgM level, C-reactive protein, D-dimer, and SOFA score with those who died. In patients with pneumonia, the derangement of the B-cell compartment could be one of the causes of the immunological failure to control SARS-Cov2, have a relevant influence on several pathways, organs and systems, and must be considered to develop vaccine strategies.</AbstractText>
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