SAFETY PROFILE OF TREATMENTS ADMINISTERED IN COVID 19 INFECTION IN PREGNANT WOMEN.
Identifieur interne : 000178 ( Main/Exploration ); précédent : 000177; suivant : 000179SAFETY PROFILE OF TREATMENTS ADMINISTERED IN COVID 19 INFECTION IN PREGNANT WOMEN.
Auteurs : N. Martínez-Sánchez [Espagne] ; M. De La Calle Fernández-Miranda [Espagne] ; J L Bartha [Espagne]Source :
- Clinica e investigacion en ginecologia y obstetricia [ 0210-573X ] ; 2021.
Abstract
SARS-CoV-2 infection has unexpectedly arrived in our society. In pregnant women, the situation has been similar to general population. Some drugs have been used empirically, and obstetricians have to consider whether the same treatments used in the general population were valid for pregnant women with severe disease, according to their safety profile for both the mother and the foetus. There has been a wide experience with the use of hydroxychloroquine and lopinavir/ritonavir in pregnant women. Tocilizumab and interferon beta could be used if benefits exceed risks. There is no experience using remdesivir in pregnancy.
DOI: 10.1016/j.gine.2021.01.004
PubMed: 33654337
PubMed Central: PMC7906532
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SAFETY PROFILE OF TREATMENTS ADMINISTERED IN COVID 19 INFECTION IN PREGNANT WOMEN.</title><author><name sortKey="Martinez Sanchez, N" sort="Martinez Sanchez, N" uniqKey="Martinez Sanchez N" first="N" last="Martínez-Sánchez">N. Martínez-Sánchez</name><affiliation wicri:level="3"><nlm:affiliation>Specialist in Obstetric Medicine and High Risk Pregnancy. Obstetrics and Gynecology, Department. University Hospital La Paz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Specialist in Obstetric Medicine and High Risk Pregnancy. Obstetrics and Gynecology, Department. University Hospital La Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="De La Calle Fernandez Miranda, M" sort="De La Calle Fernandez Miranda, M" uniqKey="De La Calle Fernandez Miranda M" first="M" last="De La Calle Fernández-Miranda">M. De La Calle Fernández-Miranda</name><affiliation wicri:level="3"><nlm:affiliation>Head of Obstetric Medicine and High Risk Pregnancy Unit. Obstetrics and Gynecology, Department. University Hospital La Paz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Head of Obstetric Medicine and High Risk Pregnancy Unit. Obstetrics and Gynecology, Department. University Hospital La Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bartha, J L" sort="Bartha, J L" uniqKey="Bartha J" first="J L" last="Bartha">J L Bartha</name><affiliation wicri:level="3"><nlm:affiliation>Head of Obstetrics and Gynecology Department. University Hospital La Paz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Head of Obstetrics and Gynecology Department. University Hospital La Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33654337</idno><idno type="pmid">33654337</idno><idno type="doi">10.1016/j.gine.2021.01.004</idno><idno type="pmc">PMC7906532</idno><idno type="wicri:Area/Main/Corpus">000287</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000287</idno><idno type="wicri:Area/Main/Curation">000287</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000287</idno><idno type="wicri:Area/Main/Exploration">000287</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">SAFETY PROFILE OF TREATMENTS ADMINISTERED IN COVID 19 INFECTION IN PREGNANT WOMEN.</title><author><name sortKey="Martinez Sanchez, N" sort="Martinez Sanchez, N" uniqKey="Martinez Sanchez N" first="N" last="Martínez-Sánchez">N. Martínez-Sánchez</name><affiliation wicri:level="3"><nlm:affiliation>Specialist in Obstetric Medicine and High Risk Pregnancy. Obstetrics and Gynecology, Department. University Hospital La Paz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Specialist in Obstetric Medicine and High Risk Pregnancy. Obstetrics and Gynecology, Department. University Hospital La Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="De La Calle Fernandez Miranda, M" sort="De La Calle Fernandez Miranda, M" uniqKey="De La Calle Fernandez Miranda M" first="M" last="De La Calle Fernández-Miranda">M. De La Calle Fernández-Miranda</name><affiliation wicri:level="3"><nlm:affiliation>Head of Obstetric Medicine and High Risk Pregnancy Unit. Obstetrics and Gynecology, Department. University Hospital La Paz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Head of Obstetric Medicine and High Risk Pregnancy Unit. Obstetrics and Gynecology, Department. University Hospital La Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bartha, J L" sort="Bartha, J L" uniqKey="Bartha J" first="J L" last="Bartha">J L Bartha</name><affiliation wicri:level="3"><nlm:affiliation>Head of Obstetrics and Gynecology Department. University Hospital La Paz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Head of Obstetrics and Gynecology Department. University Hospital La Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j">Clinica e investigacion en ginecologia y obstetricia</title><idno type="ISSN">0210-573X</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">SARS-CoV-2 infection has unexpectedly arrived in our society. In pregnant women, the situation has been similar to general population. Some drugs have been used empirically, and obstetricians have to consider whether the same treatments used in the general population were valid for pregnant women with severe disease, according to their safety profile for both the mother and the foetus. There has been a wide experience with the use of hydroxychloroquine and lopinavir/ritonavir in pregnant women. Tocilizumab and interferon beta could be used if benefits exceed risks. There is no experience using remdesivir in pregnancy.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33654337</PMID><DateRevised><Year>2021</Year><Month>05</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0210-573X</ISSN><JournalIssue CitedMedium="Print"><PubDate><Year>2021</Year><Month>Feb</Month><Day>25</Day></PubDate></JournalIssue><Title>Clinica e investigacion en ginecologia y obstetricia</Title><ISOAbbreviation>Clin Invest Ginecol Obstet</ISOAbbreviation></Journal><ArticleTitle>SAFETY PROFILE OF TREATMENTS ADMINISTERED IN COVID 19 INFECTION IN PREGNANT WOMEN.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.gine.2021.01.004</ELocationID><Abstract><AbstractText>SARS-CoV-2 infection has unexpectedly arrived in our society. In pregnant women, the situation has been similar to general population. Some drugs have been used empirically, and obstetricians have to consider whether the same treatments used in the general population were valid for pregnant women with severe disease, according to their safety profile for both the mother and the foetus. There has been a wide experience with the use of hydroxychloroquine and lopinavir/ritonavir in pregnant women. Tocilizumab and interferon beta could be used if benefits exceed risks. There is no experience using remdesivir in pregnancy.</AbstractText><CopyrightInformation>© 2021 Published by Elsevier España, S.L.U.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martínez-Sánchez</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Specialist in Obstetric Medicine and High Risk Pregnancy. Obstetrics and Gynecology, Department. University Hospital La Paz, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De la Calle Fernández-Miranda</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Head of Obstetric Medicine and High Risk Pregnancy Unit. Obstetrics and Gynecology, Department. University Hospital La Paz, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bartha</LastName><ForeName>J L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Head of Obstetrics and Gynecology Department. University Hospital La Paz, Madrid, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>02</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>Spain</Country><MedlineTA>Clin Invest Ginecol Obstet</MedlineTA><NlmUniqueID>8110102</NlmUniqueID><ISSNLinking>0210-573X</ISSNLinking></MedlineJournalInfo><OtherAbstract Type="Publisher" Language="spa"><AbstractText>La infección por SARS-CoV-2 ha llegado a nuestra sociedad de forma inesperada. En las mujeres embarazadas, la situación ha sido similar a la de la población general. Algunos fármacos se han utilizado de forma empírica y los obstetras deben considerar si los mismos tratamientos utilizados en la población general son válidos para mujeres embarazadas con enfermedad grave de acuerdo con su perfil de seguridad tanto para la madre como para el feto. Existe una amplia experiencia con el uso de hidroxicloroquina y lopinavir / ritonavir en mujeres embarazadas. Se podrían usar tocilizumab e interferón beta si los beneficios superan los riesgos. No hay experiencia en el embarazo con remdesivir.</AbstractText></OtherAbstract><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">coronavirus disease</Keyword><Keyword MajorTopicYN="N">drugs</Keyword><Keyword MajorTopicYN="N">pregnancy</Keyword><Keyword MajorTopicYN="N">treatment</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>10</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2021</Year><Month>01</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>3</Month><Day>3</Day><Hour>5</Hour><Minute>46</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>3</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>3</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33654337</ArticleId><ArticleId IdType="doi">10.1016/j.gine.2021.01.004</ArticleId><ArticleId IdType="pii">S0210-573X(21)00007-1</ArticleId><ArticleId IdType="pmc">PMC7906532</ArticleId></ArticleIdList><pmc-dir>pmcsd</pmc-dir>
<ReferenceList><Reference><Citation>N Engl J Med. 2020 May 7;382(19):1787-1799</Citation><ArticleIdList><ArticleId IdType="pubmed">32187464</ArticleId></ArticleIdList></Reference><Reference><Citation>Ther Adv Neurol Disord. 2018 Nov 03;11:1756286418804760</Citation><ArticleIdList><ArticleId IdType="pubmed">30542374</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Obstet Gynecol MFM. 2020 Aug;2(3):100159</Citation><ArticleIdList><ArticleId IdType="pubmed">32838264</ArticleId></ArticleIdList></Reference><Reference><Citation>Open Forum Infect Dis. 2020 Mar 23;7(4):ofaa105</Citation><ArticleIdList><ArticleId IdType="pubmed">32284951</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ Open. 2014 May 12;4(5):e004536</Citation><ArticleIdList><ArticleId IdType="pubmed">24821713</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pediatr. 2015 Oct;167(4):881-5</Citation><ArticleIdList><ArticleId IdType="pubmed">26130112</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2005 Jul 15;106(2):401-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15811953</ArticleId></ArticleIdList></Reference><Reference><Citation>Semin Immunopathol. 2017 Jul;39(5):529-539</Citation><ArticleIdList><ArticleId IdType="pubmed">28466096</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Virol. 2020 Jun;92(6):556-563</Citation><ArticleIdList><ArticleId IdType="pubmed">32104907</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 15;395(10223):497-506</Citation><ArticleIdList><ArticleId IdType="pubmed">31986264</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Obstet Gynecol MFM. 2020 May;2(2):100107</Citation><ArticleIdList><ArticleId IdType="pubmed">32292902</ArticleId></ArticleIdList></Reference><Reference><Citation>Pract Neurol. 2019 Apr;19(2):106-114</Citation><ArticleIdList><ArticleId IdType="pubmed">30612100</ArticleId></ArticleIdList></Reference><Reference><Citation>Rheumatology (Oxford). 2016 Sep;55(9):1698-702</Citation><ArticleIdList><ArticleId IdType="pubmed">26750125</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2012 May;12(5):388-96</Citation><ArticleIdList><ArticleId IdType="pubmed">22169409</ArticleId></ArticleIdList></Reference><Reference><Citation>Gastroenterology. 2019 Apr;156(5):1508-1524</Citation><ArticleIdList><ArticleId IdType="pubmed">30658060</ArticleId></ArticleIdList></Reference><Reference><Citation>Enferm Infecc Microbiol Clin. 2014 May;32(5):310.e1-310.e33</Citation><ArticleIdList><ArticleId IdType="pubmed">24484733</ArticleId></ArticleIdList></Reference><Reference><Citation>Arthritis Rheum. 2003 Nov;48(11):3207-11</Citation><ArticleIdList><ArticleId IdType="pubmed">14613284</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacoepidemiol Drug Saf. 2015 Dec;24(12):1241-8</Citation><ArticleIdList><ArticleId IdType="pubmed">26513406</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 May 23;395(10237):e92</Citation><ArticleIdList><ArticleId IdType="pubmed">32410758</ArticleId></ArticleIdList></Reference><Reference><Citation>Biosci Trends. 2020 Mar 16;14(1):69-71</Citation><ArticleIdList><ArticleId IdType="pubmed">31996494</ArticleId></ArticleIdList></Reference><Reference><Citation>Reproduction. 2019 Sep;158(3):237-245</Citation><ArticleIdList><ArticleId IdType="pubmed">31247590</ArticleId></ArticleIdList></Reference><Reference><Citation>J Microbiol Immunol Infect. 2019 Jun;52(3):501-503</Citation><ArticleIdList><ArticleId IdType="pubmed">29907538</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Infect Dis. 2016 Feb 04;16:65</Citation><ArticleIdList><ArticleId IdType="pubmed">26847625</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Rheum Dis. 2016 May;75(5):795-810</Citation><ArticleIdList><ArticleId IdType="pubmed">26888948</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2014 Jun 5;370(23):2211-8</Citation><ArticleIdList><ArticleId IdType="pubmed">24897084</ArticleId></ArticleIdList></Reference><Reference><Citation>Arthritis Res Ther. 2006;8(3):209</Citation><ArticleIdList><ArticleId IdType="pubmed">16712713</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2019 Dec 12;381(24):2293-2303</Citation><ArticleIdList><ArticleId IdType="pubmed">31774950</ArticleId></ArticleIdList></Reference><Reference><Citation>Respirology. 2015 Jul;20(5):799-804</Citation><ArticleIdList><ArticleId IdType="pubmed">25728265</ArticleId></ArticleIdList></Reference><Reference><Citation>Ultrasound Obstet Gynecol. 2020 Jun;55(6):848-862</Citation><ArticleIdList><ArticleId IdType="pubmed">32356590</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Aug 13;383(7):697</Citation><ArticleIdList><ArticleId IdType="pubmed">32790270</ArticleId></ArticleIdList></Reference><Reference><Citation>Birth Defects Res. 2019 Nov 15;111(19):1487-1493</Citation><ArticleIdList><ArticleId IdType="pubmed">31397112</ArticleId></ArticleIdList></Reference><Reference><Citation>Reumatol Clin. 2021 Feb;17(2):61-66</Citation><ArticleIdList><ArticleId IdType="pubmed">31784396</ArticleId></ArticleIdList></Reference><Reference><Citation>Semin Arthritis Rheum. 2016 Oct;46(2):238-245</Citation><ArticleIdList><ArticleId IdType="pubmed">27346577</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 15;395(10223):507-513</Citation><ArticleIdList><ArticleId IdType="pubmed">32007143</ArticleId></ArticleIdList></Reference><Reference><Citation>Rheumatology (Oxford). 2019 Sep 1;58(9):1694-1695</Citation><ArticleIdList><ArticleId IdType="pubmed">31329987</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Opin Drug Saf. 2017 May;16(5):523-534</Citation><ArticleIdList><ArticleId IdType="pubmed">28333552</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Endocrinol (Oxf). 1997 Feb;46(2):161-6</Citation><ArticleIdList><ArticleId IdType="pubmed">9135697</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Haematol. 2020 May;7(5):e362-e363</Citation><ArticleIdList><ArticleId IdType="pubmed">32278361</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2006 Feb;6(2):67-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16439323</ArticleId></ArticleIdList></Reference><Reference><Citation>Antimicrob Agents Chemother. 2020 Apr 21;64(5):</Citation><ArticleIdList><ArticleId IdType="pubmed">32152082</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Antimicrob Agents. 2020 Jul;56(1):105949</Citation><ArticleIdList><ArticleId IdType="pubmed">32205204</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Martinez Sanchez, N" sort="Martinez Sanchez, N" uniqKey="Martinez Sanchez N" first="N" last="Martínez-Sánchez">N. Martínez-Sánchez</name></region><name sortKey="Bartha, J L" sort="Bartha, J L" uniqKey="Bartha J" first="J L" last="Bartha">J L Bartha</name><name sortKey="De La Calle Fernandez Miranda, M" sort="De La Calle Fernandez Miranda, M" uniqKey="De La Calle Fernandez Miranda M" first="M" last="De La Calle Fernández-Miranda">M. De La Calle Fernández-Miranda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000178 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000178 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidChloroV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:33654337
|texte= SAFETY PROFILE OF TREATMENTS ADMINISTERED IN COVID 19 INFECTION IN PREGNANT WOMEN.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:33654337" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidChloroV1
| This area was generated with Dilib version V0.6.38. |  |