Incidence of COVID-19 in patients under chronic treatment with hydroxychloroquine.
Identifieur interne : 000380 ( Main/Exploration ); précédent : 000379; suivant : 000381Incidence of COVID-19 in patients under chronic treatment with hydroxychloroquine.
Auteurs : Francisco Tejada Cifuentes [Espagne] ; Ángeles Lloret Callejo [Espagne] ; María José Tirado Peláez [Espagne] ; Olga Rubio Pulido [Espagne] ; Marta Ruiz-Morote Arag N [Espagne] ; Rocío Fernández Urrusuno [Espagne] ; María Isabel Mu Oz Carreras [Espagne] ; María Isabel Méndez Esteban [Espagne] ; Victoria Maestre Sánchez [Espagne] ; Antonio García Bonilla [Espagne] ; José Manuel Paredero Dominguez [Espagne] ; Virginia Arroyo Pineda [Espagne] ; Esther Marco Tej N [Espagne] ; Gregorio Romero Candel [Espagne] ; Ana Isabel Fernández Marchante [Espagne] ; José Marco Del Rio [Espagne] ; Teresa Ortiz Martín [Espagne] ; Piedad L Pez Sánchez [Espagne]Source :
- Medicina clinica (English ed.) [ 2387-0206 ] ; 2021.
Abstract
Objective
To analyze the incidence of Covid-19 in patients who are chronic users of hydroxychloroquine.
Patients and methods
Cross-sectional retrospective observational multicenter study in health areas and districts from Castilla La-Mancha and Andalucia. Of the 4451 participants included in the first recruitment, 3817 with valid data were selected. The main variable of the study is the presence or absence of Covid-19 infection by clinical, serological or polymerase chain reaction diagnosis. Sociodemographic and clinical variables and treatment and concomitant comorbidities were recorded.
Results
169 (4,45%) patients had Covid-19 infection, of which 12 (7.1 %) died and 32 (18.9%) required hospital admission. Previous respiratory pathology was related to Covid-19 infection (
Conclusion
There is no relationship between chronic use of hydroxychloroquine and the incidence of Covid-19.
DOI: 10.1016/j.medcle.2020.10.012
PubMed: 33521293
PubMed Central: PMC7825965
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Primaria de Toledo, Toledo</wicri:regionArea><wicri:noRegion>Toledo</wicri:noRegion></affiliation></author><author><name sortKey="Ruiz Morote Arag N, Marta" sort="Ruiz Morote Arag N, Marta" uniqKey="Ruiz Morote Arag N M" first="Marta" last="Ruiz-Morote Arag N">Marta Ruiz-Morote Arag N</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Puertollano, Puertollan, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Puertollano, Puertollan</wicri:regionArea><wicri:noRegion>Puertollan</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Urrusuno, Rocio" sort="Fernandez Urrusuno, Rocio" uniqKey="Fernandez Urrusuno R" first="Rocío" last="Fernández Urrusuno">Rocío Fernández Urrusuno</name><affiliation wicri:level="1"><nlm:affiliation>Distrito Sanitario Aljarafe, Sevilla, Spain.</nlm:affiliation><country 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de Gibraltar, Cádiz, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Área de Gestión Sanitaria Campo de Gibraltar, Cádiz</wicri:regionArea><wicri:noRegion>Cádiz</wicri:noRegion></affiliation></author><author><name sortKey="Maestre Sanchez, Victoria" sort="Maestre Sanchez, Victoria" uniqKey="Maestre Sanchez V" first="Victoria" last="Maestre Sánchez">Victoria Maestre Sánchez</name><affiliation wicri:level="1"><nlm:affiliation>Distrito Sanitario Condado Campiña, Huelva, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Distrito Sanitario Condado Campiña, Huelva</wicri:regionArea><wicri:noRegion>Huelva</wicri:noRegion></affiliation></author><author><name sortKey="Garcia Bonilla, Antonio" sort="Garcia Bonilla, Antonio" uniqKey="Garcia Bonilla A" first="Antonio" last="García Bonilla">Antonio García Bonilla</name><affiliation wicri:level="1"><nlm:affiliation>Área de Gestión Sanitaria Jerez, Costa Noroeste y Sierra de Cádiz, Jerez, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Área de Gestión Sanitaria Jerez, Costa Noroeste y Sierra de Cádiz, Jerez</wicri:regionArea><wicri:noRegion>Jerez</wicri:noRegion></affiliation></author><author><name sortKey="Paredero Dominguez, Jose Manuel" sort="Paredero Dominguez, Jose Manuel" uniqKey="Paredero Dominguez J" first="José Manuel" last="Paredero Dominguez">José Manuel Paredero Dominguez</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada, de Guadalajara, Guadalajara, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada, de Guadalajara, Guadalajara</wicri:regionArea><wicri:noRegion>Guadalajara</wicri:noRegion></affiliation></author><author><name sortKey="Arroyo Pineda, Virginia" sort="Arroyo Pineda, Virginia" uniqKey="Arroyo Pineda V" first="Virginia" last="Arroyo Pineda">Virginia Arroyo Pineda</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada Talavera de la Reina, Talavera de la Reina, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada Talavera de la Reina, Talavera de la Reina</wicri:regionArea><wicri:noRegion>Talavera de la Reina</wicri:noRegion></affiliation></author><author><name sortKey="Marco Tej N, Esther" sort="Marco Tej N, Esther" uniqKey="Marco Tej N E" first="Esther" last="Marco Tej N">Esther Marco Tej N</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Cuenca, Cuenca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Cuenca, Cuenca</wicri:regionArea><wicri:noRegion>Cuenca</wicri:noRegion></affiliation></author><author><name sortKey="Romero Candel, Gregorio" sort="Romero Candel, Gregorio" uniqKey="Romero Candel G" first="Gregorio" last="Romero Candel">Gregorio Romero Candel</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Hellín, Hellín, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Hellín, Hellín</wicri:regionArea><wicri:noRegion>Hellín</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Marchante, Ana Isabel" sort="Fernandez Marchante, Ana Isabel" uniqKey="Fernandez Marchante A" first="Ana Isabel" last="Fernández Marchante">Ana Isabel Fernández Marchante</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Villarrobledo, Villarrobledo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Villarrobledo, Villarrobledo</wicri:regionArea><wicri:noRegion>Villarrobledo</wicri:noRegion></affiliation></author><author><name sortKey="Marco Del Rio, Jose" sort="Marco Del Rio, Jose" uniqKey="Marco Del Rio J" first="José" last="Marco Del Rio">José Marco Del Rio</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Almansa, Almansa, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Almansa, Almansa</wicri:regionArea><wicri:noRegion>Almansa</wicri:noRegion></affiliation></author><author><name sortKey="Ortiz Martin, Teresa" sort="Ortiz Martin, Teresa" uniqKey="Ortiz Martin T" first="Teresa" last="Ortiz Martín">Teresa Ortiz Martín</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Valdepeñas, Valdepeñas, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Valdepeñas, Valdepeñas</wicri:regionArea><wicri:noRegion>Valdepeñas</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Sanchez, Piedad" sort="L Pez Sanchez, Piedad" uniqKey="L Pez Sanchez P" first="Piedad" last="L Pez Sánchez">Piedad L Pez Sánchez</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Tomelloso, Tomelloso, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Tomelloso, Tomelloso</wicri:regionArea><wicri:noRegion>Tomelloso</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33521293</idno><idno type="pmid">33521293</idno><idno type="doi">10.1016/j.medcle.2020.10.012</idno><idno type="pmc">PMC7825965</idno><idno type="wicri:Area/Main/Corpus">000414</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000414</idno><idno type="wicri:Area/Main/Curation">000414</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000414</idno><idno type="wicri:Area/Main/Exploration">000414</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Incidence of COVID-19 in patients under chronic treatment with hydroxychloroquine.</title><author><name sortKey="Tejada Cifuentes, Francisco" sort="Tejada Cifuentes, Francisco" uniqKey="Tejada Cifuentes F" first="Francisco" last="Tejada Cifuentes">Francisco Tejada Cifuentes</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Albacete, Albacete, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Albacete, Albacete</wicri:regionArea><wicri:noRegion>Albacete</wicri:noRegion></affiliation></author><author><name sortKey="Lloret Callejo, Angeles" sort="Lloret Callejo, Angeles" uniqKey="Lloret Callejo A" first="Ángeles" last="Lloret Callejo">Ángeles Lloret Callejo</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Albacete, Albacete, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Albacete, Albacete</wicri:regionArea><wicri:noRegion>Albacete</wicri:noRegion></affiliation></author><author><name sortKey="Tirado Pelaez, Maria Jose" sort="Tirado Pelaez, Maria Jose" uniqKey="Tirado Pelaez M" first="María José" last="Tirado Peláez">María José Tirado Peláez</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Albacete, Albacete, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Albacete, Albacete</wicri:regionArea><wicri:noRegion>Albacete</wicri:noRegion></affiliation></author><author><name sortKey="Rubio Pulido, Olga" sort="Rubio Pulido, Olga" uniqKey="Rubio Pulido O" first="Olga" last="Rubio Pulido">Olga Rubio Pulido</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Primaria de Toledo, Toledo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Primaria de Toledo, Toledo</wicri:regionArea><wicri:noRegion>Toledo</wicri:noRegion></affiliation></author><author><name sortKey="Ruiz Morote Arag N, Marta" sort="Ruiz Morote Arag N, Marta" uniqKey="Ruiz Morote Arag N M" first="Marta" last="Ruiz-Morote Arag N">Marta Ruiz-Morote Arag N</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Puertollano, Puertollan, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Puertollano, Puertollan</wicri:regionArea><wicri:noRegion>Puertollan</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Urrusuno, Rocio" sort="Fernandez Urrusuno, Rocio" uniqKey="Fernandez Urrusuno R" first="Rocío" last="Fernández Urrusuno">Rocío Fernández Urrusuno</name><affiliation wicri:level="1"><nlm:affiliation>Distrito Sanitario Aljarafe, Sevilla, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Distrito Sanitario Aljarafe, Sevilla</wicri:regionArea><wicri:noRegion>Sevilla</wicri:noRegion></affiliation></author><author><name sortKey="Mu Oz Carreras, Maria Isabel" sort="Mu Oz Carreras, Maria Isabel" uniqKey="Mu Oz Carreras M" first="María Isabel" last="Mu Oz Carreras">María Isabel Mu Oz Carreras</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada, Alcázar de San Juan, Alcázar de San Juan, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada, Alcázar de San Juan, Alcázar de San Juan</wicri:regionArea><wicri:noRegion>Alcázar de San Juan</wicri:noRegion></affiliation></author><author><name sortKey="Mendez Esteban, Maria Isabel" sort="Mendez Esteban, Maria Isabel" uniqKey="Mendez Esteban M" first="María Isabel" last="Méndez Esteban">María Isabel Méndez Esteban</name><affiliation wicri:level="1"><nlm:affiliation>Área de Gestión Sanitaria Campo de Gibraltar, Cádiz, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Área de Gestión Sanitaria Campo de Gibraltar, Cádiz</wicri:regionArea><wicri:noRegion>Cádiz</wicri:noRegion></affiliation></author><author><name sortKey="Maestre Sanchez, Victoria" sort="Maestre Sanchez, Victoria" uniqKey="Maestre Sanchez V" first="Victoria" last="Maestre Sánchez">Victoria Maestre Sánchez</name><affiliation wicri:level="1"><nlm:affiliation>Distrito Sanitario Condado Campiña, Huelva, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Distrito Sanitario Condado Campiña, Huelva</wicri:regionArea><wicri:noRegion>Huelva</wicri:noRegion></affiliation></author><author><name sortKey="Garcia Bonilla, Antonio" sort="Garcia Bonilla, Antonio" uniqKey="Garcia Bonilla A" first="Antonio" last="García Bonilla">Antonio García Bonilla</name><affiliation wicri:level="1"><nlm:affiliation>Área de Gestión Sanitaria Jerez, Costa Noroeste y Sierra de Cádiz, Jerez, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Área de Gestión Sanitaria Jerez, Costa Noroeste y Sierra de Cádiz, Jerez</wicri:regionArea><wicri:noRegion>Jerez</wicri:noRegion></affiliation></author><author><name sortKey="Paredero Dominguez, Jose Manuel" sort="Paredero Dominguez, Jose Manuel" uniqKey="Paredero Dominguez J" first="José Manuel" last="Paredero Dominguez">José Manuel Paredero Dominguez</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada, de Guadalajara, Guadalajara, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada, de Guadalajara, Guadalajara</wicri:regionArea><wicri:noRegion>Guadalajara</wicri:noRegion></affiliation></author><author><name sortKey="Arroyo Pineda, Virginia" sort="Arroyo Pineda, Virginia" uniqKey="Arroyo Pineda V" first="Virginia" last="Arroyo Pineda">Virginia Arroyo Pineda</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada Talavera de la Reina, Talavera de la Reina, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada Talavera de la Reina, Talavera de la Reina</wicri:regionArea><wicri:noRegion>Talavera de la Reina</wicri:noRegion></affiliation></author><author><name sortKey="Marco Tej N, Esther" sort="Marco Tej N, Esther" uniqKey="Marco Tej N E" first="Esther" last="Marco Tej N">Esther Marco Tej N</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Cuenca, Cuenca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Cuenca, Cuenca</wicri:regionArea><wicri:noRegion>Cuenca</wicri:noRegion></affiliation></author><author><name sortKey="Romero Candel, Gregorio" sort="Romero Candel, Gregorio" uniqKey="Romero Candel G" first="Gregorio" last="Romero Candel">Gregorio Romero Candel</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Hellín, Hellín, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Hellín, Hellín</wicri:regionArea><wicri:noRegion>Hellín</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Marchante, Ana Isabel" sort="Fernandez Marchante, Ana Isabel" uniqKey="Fernandez Marchante A" first="Ana Isabel" last="Fernández Marchante">Ana Isabel Fernández Marchante</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Villarrobledo, Villarrobledo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Villarrobledo, Villarrobledo</wicri:regionArea><wicri:noRegion>Villarrobledo</wicri:noRegion></affiliation></author><author><name sortKey="Marco Del Rio, Jose" sort="Marco Del Rio, Jose" uniqKey="Marco Del Rio J" first="José" last="Marco Del Rio">José Marco Del Rio</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Almansa, Almansa, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Almansa, Almansa</wicri:regionArea><wicri:noRegion>Almansa</wicri:noRegion></affiliation></author><author><name sortKey="Ortiz Martin, Teresa" sort="Ortiz Martin, Teresa" uniqKey="Ortiz Martin T" first="Teresa" last="Ortiz Martín">Teresa Ortiz Martín</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Valdepeñas, Valdepeñas, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Valdepeñas, Valdepeñas</wicri:regionArea><wicri:noRegion>Valdepeñas</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Sanchez, Piedad" sort="L Pez Sanchez, Piedad" uniqKey="L Pez Sanchez P" first="Piedad" last="L Pez Sánchez">Piedad L Pez Sánchez</name><affiliation wicri:level="1"><nlm:affiliation>Gerencia de Atención Integrada de Tomelloso, Tomelloso, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Gerencia de Atención Integrada de Tomelloso, Tomelloso</wicri:regionArea><wicri:noRegion>Tomelloso</wicri:noRegion></affiliation></author></analytic><series><title level="j">Medicina clinica (English ed.)</title><idno type="eISSN">2387-0206</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Objective</b></p><p>To analyze the incidence of Covid-19 in patients who are chronic users of hydroxychloroquine.</p></div><div type="abstract" xml:lang="en"><p><b>Patients and methods</b></p><p>Cross-sectional retrospective observational multicenter study in health areas and districts from Castilla La-Mancha and Andalucia. Of the 4451 participants included in the first recruitment, 3817 with valid data were selected. The main variable of the study is the presence or absence of Covid-19 infection by clinical, serological or polymerase chain reaction diagnosis. Sociodemographic and clinical variables and treatment and concomitant comorbidities were recorded.</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>169 (4,45%) patients had Covid-19 infection, of which 12 (7.1 %) died and 32 (18.9%) required hospital admission. Previous respiratory pathology was related to Covid-19 infection (</p></div><div type="abstract" xml:lang="en"><p><b>Conclusion</b></p><p>There is no relationship between chronic use of hydroxychloroquine and the incidence of Covid-19.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33521293</PMID><DateRevised><Year>2021</Year><Month>02</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2387-0206</ISSN><JournalIssue CitedMedium="Internet"><Volume>156</Volume><Issue>4</Issue><PubDate><Year>2021</Year><Month>Feb</Month><Day>26</Day></PubDate></JournalIssue><Title>Medicina clinica (English ed.)</Title><ISOAbbreviation>Med Clin (Engl Ed)</ISOAbbreviation></Journal><ArticleTitle>Incidence of COVID-19 in patients under chronic treatment with hydroxychloroquine.</ArticleTitle><Pagination><MedlinePgn>166-171</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.medcle.2020.10.012</ELocationID><Abstract><AbstractText Label="Objective" NlmCategory="UNASSIGNED">To analyze the incidence of Covid-19 in patients who are chronic users of hydroxychloroquine.</AbstractText><AbstractText Label="Patients and methods" NlmCategory="UNASSIGNED">Cross-sectional retrospective observational multicenter study in health areas and districts from Castilla La-Mancha and Andalucia. Of the 4451 participants included in the first recruitment, 3817 with valid data were selected. The main variable of the study is the presence or absence of Covid-19 infection by clinical, serological or polymerase chain reaction diagnosis. Sociodemographic and clinical variables and treatment and concomitant comorbidities were recorded.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">169 (4,45%) patients had Covid-19 infection, of which 12 (7.1 %) died and 32 (18.9%) required hospital admission. Previous respiratory pathology was related to Covid-19 infection (<i>P</i> < .05). Maculopathy appears in 5.3% of patients and is significantly related to the dose of hydroxychloroquine consumed (<i>P</i> < .05).</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">There is no relationship between chronic use of hydroxychloroquine and the incidence of Covid-19.</AbstractText><CopyrightInformation>© 2020 Elsevier España, S.L.U. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tejada Cifuentes</LastName><ForeName>Francisco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada de Albacete, Albacete, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lloret Callejo</LastName><ForeName>Ángeles</ForeName><Initials>Á</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada de Albacete, Albacete, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tirado Peláez</LastName><ForeName>María José</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada de Albacete, Albacete, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rubio Pulido</LastName><ForeName>Olga</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Primaria de Toledo, Toledo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruiz-Morote Aragón</LastName><ForeName>Marta</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada de Puertollano, Puertollan, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández Urrusuno</LastName><ForeName>Rocío</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Distrito Sanitario Aljarafe, Sevilla, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muñoz Carreras</LastName><ForeName>María Isabel</ForeName><Initials>MI</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada, Alcázar de San Juan, Alcázar de San Juan, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Méndez Esteban</LastName><ForeName>María Isabel</ForeName><Initials>MI</Initials><AffiliationInfo><Affiliation>Área de Gestión Sanitaria Campo de Gibraltar, Cádiz, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maestre Sánchez</LastName><ForeName>Victoria</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Distrito Sanitario Condado Campiña, Huelva, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García Bonilla</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Área de Gestión Sanitaria Jerez, Costa Noroeste y Sierra de Cádiz, Jerez, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paredero Dominguez</LastName><ForeName>José Manuel</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada, de Guadalajara, Guadalajara, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arroyo Pineda</LastName><ForeName>Virginia</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada Talavera de la Reina, Talavera de la Reina, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marco Tejón</LastName><ForeName>Esther</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada de Cuenca, Cuenca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romero Candel</LastName><ForeName>Gregorio</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada de Hellín, Hellín, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández Marchante</LastName><ForeName>Ana Isabel</ForeName><Initials>AI</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada de Villarrobledo, Villarrobledo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marco Del Rio</LastName><ForeName>José</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada de Almansa, Almansa, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ortiz Martín</LastName><ForeName>Teresa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada de Valdepeñas, Valdepeñas, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López Sánchez</LastName><ForeName>Piedad</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Gerencia de Atención Integrada de Tomelloso, Tomelloso, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>01</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>Spain</Country><MedlineTA>Med Clin (Engl Ed)</MedlineTA><NlmUniqueID>101711190</NlmUniqueID><ISSNLinking>2387-0206</ISSNLinking></MedlineJournalInfo><OtherAbstract Type="Publisher" Language="spa"><AbstractText Label="Objetivo" NlmCategory="UNASSIGNED">Analizar la incidencia de la enfermedad del coronavirus 19 (COVID-19) en pacientes consumidores crónicos de hidroxicloroquina.</AbstractText><AbstractText Label="Pacientes y métodos" NlmCategory="UNASSIGNED">Estudio multicéntrico observacional retrospectivo transversal en Áreas de Salud de Castilla La-Mancha y distritos sanitarios de Andalucía. De los 4.451 participantes incluidos en el primer reclutamiento se seleccionaron 3.817 sujetos con datos válidos. La variable principal del estudio ha sido la presencia o ausencia de infección por la COVID-19 por diagnóstico clínico, serológico o por reacción en cadena de la polimerasa. Se registraron variables sociodemográficas, clínicas y tratamientos y comorbilidades concomitantes.</AbstractText><AbstractText Label="Resultados" NlmCategory="UNASSIGNED">Ciento sesenta y nueve (4,45%) pacientes presentaron infección por la COVID-19, de los cuales fallecieron 12 (7,1%) y 32 (18,9%) requirieron ingreso hospitalario. La enfermedad respiratoria previa se relacionó con la infección por la COVID-19 (p < 0,05). La maculopatía aparece en un 5,3% de los pacientes y está relacionada significativamente con la dosis de hidroxicloroquina consumida (p < 0,05).</AbstractText><AbstractText Label="Conclusión" NlmCategory="UNASSIGNED">No existe relación entre consumo crónico de hidroxicloroquina e incidencia de la COVID-19.</AbstractText></OtherAbstract><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Coronavirus</Keyword><Keyword MajorTopicYN="N">Hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">Incidence</Keyword><Keyword MajorTopicYN="N">Treatment</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>10</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>2</Month><Day>1</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33521293</ArticleId><ArticleId IdType="doi">10.1016/j.medcle.2020.10.012</ArticleId><ArticleId IdType="pii">S2387-0206(21)00020-6</ArticleId><ArticleId IdType="pmc">PMC7825965</ArticleId></ArticleIdList><pmc-dir>pmcsd</pmc-dir>
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IdType="pubmed">32171062</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Tejada Cifuentes, Francisco" sort="Tejada Cifuentes, Francisco" uniqKey="Tejada Cifuentes F" first="Francisco" last="Tejada Cifuentes">Francisco Tejada Cifuentes</name></noRegion><name sortKey="Arroyo Pineda, Virginia" sort="Arroyo Pineda, Virginia" uniqKey="Arroyo Pineda V" first="Virginia" last="Arroyo Pineda">Virginia Arroyo Pineda</name><name sortKey="Fernandez Marchante, Ana Isabel" sort="Fernandez Marchante, Ana Isabel" uniqKey="Fernandez Marchante A" first="Ana Isabel" last="Fernández Marchante">Ana Isabel Fernández Marchante</name><name sortKey="Fernandez Urrusuno, Rocio" sort="Fernandez Urrusuno, Rocio" uniqKey="Fernandez Urrusuno R" first="Rocío" last="Fernández Urrusuno">Rocío Fernández Urrusuno</name><name sortKey="Garcia Bonilla, Antonio" sort="Garcia Bonilla, Antonio" uniqKey="Garcia Bonilla A" first="Antonio" last="García Bonilla">Antonio García Bonilla</name><name sortKey="L Pez Sanchez, Piedad" sort="L Pez Sanchez, Piedad" uniqKey="L Pez Sanchez P" first="Piedad" last="L Pez Sánchez">Piedad L Pez Sánchez</name><name sortKey="Lloret Callejo, Angeles" sort="Lloret Callejo, Angeles" uniqKey="Lloret Callejo A" first="Ángeles" last="Lloret Callejo">Ángeles Lloret Callejo</name><name sortKey="Maestre Sanchez, Victoria" sort="Maestre Sanchez, Victoria" uniqKey="Maestre Sanchez V" first="Victoria" last="Maestre Sánchez">Victoria Maestre Sánchez</name><name sortKey="Marco Del Rio, Jose" sort="Marco Del Rio, Jose" uniqKey="Marco Del Rio J" first="José" last="Marco Del Rio">José Marco Del Rio</name><name sortKey="Marco Tej N, Esther" sort="Marco Tej N, Esther" uniqKey="Marco Tej N E" first="Esther" last="Marco Tej N">Esther Marco Tej N</name><name sortKey="Mendez Esteban, Maria Isabel" sort="Mendez Esteban, Maria Isabel" uniqKey="Mendez Esteban M" first="María Isabel" last="Méndez Esteban">María Isabel Méndez Esteban</name><name sortKey="Mu Oz Carreras, Maria Isabel" sort="Mu Oz Carreras, Maria Isabel" uniqKey="Mu Oz Carreras M" first="María Isabel" last="Mu Oz Carreras">María Isabel Mu Oz Carreras</name><name sortKey="Ortiz Martin, Teresa" sort="Ortiz Martin, Teresa" uniqKey="Ortiz Martin T" first="Teresa" last="Ortiz Martín">Teresa Ortiz Martín</name><name sortKey="Paredero Dominguez, Jose Manuel" sort="Paredero Dominguez, Jose Manuel" uniqKey="Paredero Dominguez J" first="José Manuel" last="Paredero Dominguez">José Manuel Paredero Dominguez</name><name sortKey="Romero Candel, Gregorio" sort="Romero Candel, Gregorio" uniqKey="Romero Candel G" first="Gregorio" last="Romero Candel">Gregorio Romero Candel</name><name sortKey="Rubio Pulido, Olga" sort="Rubio Pulido, Olga" uniqKey="Rubio Pulido O" first="Olga" last="Rubio Pulido">Olga Rubio Pulido</name><name sortKey="Ruiz Morote Arag N, Marta" sort="Ruiz Morote Arag N, Marta" uniqKey="Ruiz Morote Arag N M" first="Marta" last="Ruiz-Morote Arag N">Marta Ruiz-Morote Arag N</name><name sortKey="Tirado Pelaez, Maria Jose" sort="Tirado Pelaez, Maria Jose" uniqKey="Tirado Pelaez M" first="María José" last="Tirado Peláez">María José Tirado Peláez</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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