Nasopharyngeal SARS-CoV-2 Viral Load Response among COVID-19 Patients Receiving Favipiravir.
Identifieur interne : 000312 ( Main/Exploration ); précédent : 000311; suivant : 000313Nasopharyngeal SARS-CoV-2 Viral Load Response among COVID-19 Patients Receiving Favipiravir.
Auteurs : Weerawat Manosuthi [Thaïlande] ; Somlerk Jeungsmarn [Thaïlande] ; Pilailuk Okada [Thaïlande] ; Pawita Suwanvattana [Thaïlande] ; Warawan Wongboot [Thaïlande] ; Unchana Thawornwan [Thaïlande] ; Lantharita Charoenpong [Thaïlande] ; Surasak Wiboonchutikul [Thaïlande] ; Sumonmal Uttayamakul [Thaïlande] ; Wannarat A. Pongpirul [Thaïlande] ; Apichat Wachirapan [Thaïlande] ; Paijit Warachit [Thaïlande]Source :
- Japanese journal of infectious diseases [ 1884-2836 ] ; 2021.
Abstract
We retrospectively studied nasopharyngeal SARS-CoV-2 viral load in the COVID-19 patients who were hospitalized between 13 January and 1 April 2020. Quantitative real-time reverse transcription-PCR were conducted with primers and probes targeting the ORF1ab and N genes. All patients were classified as Group 1: Received favipiravir + chloroquine or hydroxychloroquine + lopinavir/ritonavir or darunavir/ritonavir for 5-10 days, Group 2: Received chloroquine or hydroxychloroquine + lopinavir/ritonavir or darunavir/ritonavir for 5-10 days and Group 3: no anti-viral medication. Of 115 patients, 38 (33%), 54 (47%), and 23 (20%) patients were in Group 1, 2, and 3, respectively. Median (IQR) baseline viral loads at days 0 of Group 1, 2, and 3 were 7.2 (6.0-8.1), 6.9 (5.8-7.8), and 6.9 (5.8-7.6) log10 copies/mL, respectively. The reductions of mean viral loads at day 3 from baseline were 2.41, 1.38,and 2.19 log10 copies/mL in the corresponding groups (P <0.05). There were no differences in reductions of mean viral loads from baseline among three groups at days 5 and 10 (P >0.05). By multiple logistic regression analysis, receiving favipiravir was associated with nasopharyngeal viral load reduction at three days (P=0.001). Significant nasopharyngeal SARS-CoV-2 viral load reduction was achieved in the COVID-19 patients who received favipiravir-containing regimen.
DOI: 10.7883/yoken.JJID.2020.827
PubMed: 33518623
Affiliations:
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<front><div type="abstract" xml:lang="en">We retrospectively studied nasopharyngeal SARS-CoV-2 viral load in the COVID-19 patients who were hospitalized between 13 January and 1 April 2020. Quantitative real-time reverse transcription-PCR were conducted with primers and probes targeting the ORF1ab and N genes. All patients were classified as Group 1: Received favipiravir + chloroquine or hydroxychloroquine + lopinavir/ritonavir or darunavir/ritonavir for 5-10 days, Group 2: Received chloroquine or hydroxychloroquine + lopinavir/ritonavir or darunavir/ritonavir for 5-10 days and Group 3: no anti-viral medication. Of 115 patients, 38 (33%), 54 (47%), and 23 (20%) patients were in Group 1, 2, and 3, respectively. Median (IQR) baseline viral loads at days 0 of Group 1, 2, and 3 were 7.2 (6.0-8.1), 6.9 (5.8-7.8), and 6.9 (5.8-7.6) log<sub>10</sub>
copies/mL, respectively. The reductions of mean viral loads at day 3 from baseline were 2.41, 1.38,and 2.19 log<sub>10</sub>
copies/mL in the corresponding groups (P <0.05). There were no differences in reductions of mean viral loads from baseline among three groups at days 5 and 10 (P >0.05). By multiple logistic regression analysis, receiving favipiravir was associated with nasopharyngeal viral load reduction at three days (P=0.001). Significant nasopharyngeal SARS-CoV-2 viral load reduction was achieved in the COVID-19 patients who received favipiravir-containing regimen.</div>
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<Abstract><AbstractText>We retrospectively studied nasopharyngeal SARS-CoV-2 viral load in the COVID-19 patients who were hospitalized between 13 January and 1 April 2020. Quantitative real-time reverse transcription-PCR were conducted with primers and probes targeting the ORF1ab and N genes. All patients were classified as Group 1: Received favipiravir + chloroquine or hydroxychloroquine + lopinavir/ritonavir or darunavir/ritonavir for 5-10 days, Group 2: Received chloroquine or hydroxychloroquine + lopinavir/ritonavir or darunavir/ritonavir for 5-10 days and Group 3: no anti-viral medication. Of 115 patients, 38 (33%), 54 (47%), and 23 (20%) patients were in Group 1, 2, and 3, respectively. Median (IQR) baseline viral loads at days 0 of Group 1, 2, and 3 were 7.2 (6.0-8.1), 6.9 (5.8-7.8), and 6.9 (5.8-7.6) log<sub>10</sub>
copies/mL, respectively. The reductions of mean viral loads at day 3 from baseline were 2.41, 1.38,and 2.19 log<sub>10</sub>
copies/mL in the corresponding groups (P <0.05). There were no differences in reductions of mean viral loads from baseline among three groups at days 5 and 10 (P >0.05). By multiple logistic regression analysis, receiving favipiravir was associated with nasopharyngeal viral load reduction at three days (P=0.001). Significant nasopharyngeal SARS-CoV-2 viral load reduction was achieved in the COVID-19 patients who received favipiravir-containing regimen.</AbstractText>
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<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2021</Year>
<Month>2</Month>
<Day>1</Day>
<Hour>5</Hour>
<Minute>49</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2021</Year>
<Month>2</Month>
<Day>2</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2021</Year>
<Month>2</Month>
<Day>2</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>aheadofprint</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">33518623</ArticleId>
<ArticleId IdType="doi">10.7883/yoken.JJID.2020.827</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Thaïlande</li>
</country>
</list>
<tree><country name="Thaïlande"><noRegion><name sortKey="Manosuthi, Weerawat" sort="Manosuthi, Weerawat" uniqKey="Manosuthi W" first="Weerawat" last="Manosuthi">Weerawat Manosuthi</name>
</noRegion>
<name sortKey="Charoenpong, Lantharita" sort="Charoenpong, Lantharita" uniqKey="Charoenpong L" first="Lantharita" last="Charoenpong">Lantharita Charoenpong</name>
<name sortKey="Jeungsmarn, Somlerk" sort="Jeungsmarn, Somlerk" uniqKey="Jeungsmarn S" first="Somlerk" last="Jeungsmarn">Somlerk Jeungsmarn</name>
<name sortKey="Okada, Pilailuk" sort="Okada, Pilailuk" uniqKey="Okada P" first="Pilailuk" last="Okada">Pilailuk Okada</name>
<name sortKey="Pongpirul, Wannarat A" sort="Pongpirul, Wannarat A" uniqKey="Pongpirul W" first="Wannarat A" last="Pongpirul">Wannarat A. Pongpirul</name>
<name sortKey="Suwanvattana, Pawita" sort="Suwanvattana, Pawita" uniqKey="Suwanvattana P" first="Pawita" last="Suwanvattana">Pawita Suwanvattana</name>
<name sortKey="Thawornwan, Unchana" sort="Thawornwan, Unchana" uniqKey="Thawornwan U" first="Unchana" last="Thawornwan">Unchana Thawornwan</name>
<name sortKey="Uttayamakul, Sumonmal" sort="Uttayamakul, Sumonmal" uniqKey="Uttayamakul S" first="Sumonmal" last="Uttayamakul">Sumonmal Uttayamakul</name>
<name sortKey="Wachirapan, Apichat" sort="Wachirapan, Apichat" uniqKey="Wachirapan A" first="Apichat" last="Wachirapan">Apichat Wachirapan</name>
<name sortKey="Warachit, Paijit" sort="Warachit, Paijit" uniqKey="Warachit P" first="Paijit" last="Warachit">Paijit Warachit</name>
<name sortKey="Wiboonchutikul, Surasak" sort="Wiboonchutikul, Surasak" uniqKey="Wiboonchutikul S" first="Surasak" last="Wiboonchutikul">Surasak Wiboonchutikul</name>
<name sortKey="Wongboot, Warawan" sort="Wongboot, Warawan" uniqKey="Wongboot W" first="Warawan" last="Wongboot">Warawan Wongboot</name>
</country>
</tree>
</affiliations>
</record>
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