Nasopharyngeal SARS-CoV-2 Viral Load Response among COVID-19 Patients Receiving Favipiravir.
Identifieur interne : 000420 ( Main/Corpus ); précédent : 000419; suivant : 000421Nasopharyngeal SARS-CoV-2 Viral Load Response among COVID-19 Patients Receiving Favipiravir.
Auteurs : Weerawat Manosuthi ; Somlerk Jeungsmarn ; Pilailuk Okada ; Pawita Suwanvattana ; Warawan Wongboot ; Unchana Thawornwan ; Lantharita Charoenpong ; Surasak Wiboonchutikul ; Sumonmal Uttayamakul ; Wannarat A. Pongpirul ; Apichat Wachirapan ; Paijit WarachitSource :
- Japanese journal of infectious diseases [ 1884-2836 ] ; 2021.
Abstract
We retrospectively studied nasopharyngeal SARS-CoV-2 viral load in the COVID-19 patients who were hospitalized between 13 January and 1 April 2020. Quantitative real-time reverse transcription-PCR were conducted with primers and probes targeting the ORF1ab and N genes. All patients were classified as Group 1: Received favipiravir + chloroquine or hydroxychloroquine + lopinavir/ritonavir or darunavir/ritonavir for 5-10 days, Group 2: Received chloroquine or hydroxychloroquine + lopinavir/ritonavir or darunavir/ritonavir for 5-10 days and Group 3: no anti-viral medication. Of 115 patients, 38 (33%), 54 (47%), and 23 (20%) patients were in Group 1, 2, and 3, respectively. Median (IQR) baseline viral loads at days 0 of Group 1, 2, and 3 were 7.2 (6.0-8.1), 6.9 (5.8-7.8), and 6.9 (5.8-7.6) log10 copies/mL, respectively. The reductions of mean viral loads at day 3 from baseline were 2.41, 1.38,and 2.19 log10 copies/mL in the corresponding groups (P <0.05). There were no differences in reductions of mean viral loads from baseline among three groups at days 5 and 10 (P >0.05). By multiple logistic regression analysis, receiving favipiravir was associated with nasopharyngeal viral load reduction at three days (P=0.001). Significant nasopharyngeal SARS-CoV-2 viral load reduction was achieved in the COVID-19 patients who received favipiravir-containing regimen.
DOI: 10.7883/yoken.JJID.2020.827
PubMed: 33518623
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Pongpirul</name><affiliation><nlm:affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Wachirapan, Apichat" sort="Wachirapan, Apichat" uniqKey="Wachirapan A" first="Apichat" last="Wachirapan">Apichat Wachirapan</name><affiliation><nlm:affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Warachit, Paijit" sort="Warachit, Paijit" uniqKey="Warachit P" first="Paijit" last="Warachit">Paijit Warachit</name><affiliation><nlm:affiliation>Office of the Permanent Secretary, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33518623</idno><idno type="pmid">33518623</idno><idno type="doi">10.7883/yoken.JJID.2020.827</idno><idno type="wicri:Area/Main/Corpus">000420</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000420</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nasopharyngeal SARS-CoV-2 Viral Load Response among COVID-19 Patients Receiving Favipiravir.</title><author><name sortKey="Manosuthi, Weerawat" sort="Manosuthi, Weerawat" uniqKey="Manosuthi W" first="Weerawat" last="Manosuthi">Weerawat Manosuthi</name><affiliation><nlm:affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Jeungsmarn, Somlerk" sort="Jeungsmarn, Somlerk" uniqKey="Jeungsmarn S" first="Somlerk" last="Jeungsmarn">Somlerk Jeungsmarn</name><affiliation><nlm:affiliation>Department of Medical Sciences, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Okada, Pilailuk" sort="Okada, Pilailuk" uniqKey="Okada P" first="Pilailuk" last="Okada">Pilailuk Okada</name><affiliation><nlm:affiliation>Department of Medical Sciences, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Suwanvattana, Pawita" sort="Suwanvattana, Pawita" uniqKey="Suwanvattana P" first="Pawita" last="Suwanvattana">Pawita Suwanvattana</name><affiliation><nlm:affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Wongboot, Warawan" sort="Wongboot, Warawan" uniqKey="Wongboot W" first="Warawan" last="Wongboot">Warawan Wongboot</name><affiliation><nlm:affiliation>Department of Medical Sciences, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Thawornwan, Unchana" sort="Thawornwan, Unchana" uniqKey="Thawornwan U" first="Unchana" last="Thawornwan">Unchana Thawornwan</name><affiliation><nlm:affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Charoenpong, Lantharita" sort="Charoenpong, Lantharita" uniqKey="Charoenpong L" first="Lantharita" last="Charoenpong">Lantharita Charoenpong</name><affiliation><nlm:affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Wiboonchutikul, Surasak" sort="Wiboonchutikul, Surasak" uniqKey="Wiboonchutikul S" first="Surasak" last="Wiboonchutikul">Surasak Wiboonchutikul</name><affiliation><nlm:affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Uttayamakul, Sumonmal" sort="Uttayamakul, Sumonmal" uniqKey="Uttayamakul S" first="Sumonmal" last="Uttayamakul">Sumonmal Uttayamakul</name><affiliation><nlm:affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Pongpirul, Wannarat A" sort="Pongpirul, Wannarat A" uniqKey="Pongpirul W" first="Wannarat A" last="Pongpirul">Wannarat A. Pongpirul</name><affiliation><nlm:affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Wachirapan, Apichat" sort="Wachirapan, Apichat" uniqKey="Wachirapan A" first="Apichat" last="Wachirapan">Apichat Wachirapan</name><affiliation><nlm:affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Warachit, Paijit" sort="Warachit, Paijit" uniqKey="Warachit P" first="Paijit" last="Warachit">Paijit Warachit</name><affiliation><nlm:affiliation>Office of the Permanent Secretary, Ministry of Public Health, Thailand.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Japanese journal of infectious diseases</title><idno type="eISSN">1884-2836</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We retrospectively studied nasopharyngeal SARS-CoV-2 viral load in the COVID-19 patients who were hospitalized between 13 January and 1 April 2020. Quantitative real-time reverse transcription-PCR were conducted with primers and probes targeting the ORF1ab and N genes. All patients were classified as Group 1: Received favipiravir + chloroquine or hydroxychloroquine + lopinavir/ritonavir or darunavir/ritonavir for 5-10 days, Group 2: Received chloroquine or hydroxychloroquine + lopinavir/ritonavir or darunavir/ritonavir for 5-10 days and Group 3: no anti-viral medication. Of 115 patients, 38 (33%), 54 (47%), and 23 (20%) patients were in Group 1, 2, and 3, respectively. Median (IQR) baseline viral loads at days 0 of Group 1, 2, and 3 were 7.2 (6.0-8.1), 6.9 (5.8-7.8), and 6.9 (5.8-7.6) log<sub>10</sub> copies/mL, respectively. The reductions of mean viral loads at day 3 from baseline were 2.41, 1.38,and 2.19 log<sub>10</sub> copies/mL in the corresponding groups (P <0.05). There were no differences in reductions of mean viral loads from baseline among three groups at days 5 and 10 (P >0.05). By multiple logistic regression analysis, receiving favipiravir was associated with nasopharyngeal viral load reduction at three days (P=0.001). Significant nasopharyngeal SARS-CoV-2 viral load reduction was achieved in the COVID-19 patients who received favipiravir-containing regimen.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33518623</PMID><DateRevised><Year>2021</Year><Month>02</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1884-2836</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2021</Year><Month>Jan</Month><Day>29</Day></PubDate></JournalIssue><Title>Japanese journal of infectious diseases</Title><ISOAbbreviation>Jpn J Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Nasopharyngeal SARS-CoV-2 Viral Load Response among COVID-19 Patients Receiving Favipiravir.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.7883/yoken.JJID.2020.827</ELocationID><Abstract><AbstractText>We retrospectively studied nasopharyngeal SARS-CoV-2 viral load in the COVID-19 patients who were hospitalized between 13 January and 1 April 2020. Quantitative real-time reverse transcription-PCR were conducted with primers and probes targeting the ORF1ab and N genes. All patients were classified as Group 1: Received favipiravir + chloroquine or hydroxychloroquine + lopinavir/ritonavir or darunavir/ritonavir for 5-10 days, Group 2: Received chloroquine or hydroxychloroquine + lopinavir/ritonavir or darunavir/ritonavir for 5-10 days and Group 3: no anti-viral medication. Of 115 patients, 38 (33%), 54 (47%), and 23 (20%) patients were in Group 1, 2, and 3, respectively. Median (IQR) baseline viral loads at days 0 of Group 1, 2, and 3 were 7.2 (6.0-8.1), 6.9 (5.8-7.8), and 6.9 (5.8-7.6) log<sub>10</sub> copies/mL, respectively. The reductions of mean viral loads at day 3 from baseline were 2.41, 1.38,and 2.19 log<sub>10</sub> copies/mL in the corresponding groups (P <0.05). There were no differences in reductions of mean viral loads from baseline among three groups at days 5 and 10 (P >0.05). By multiple logistic regression analysis, receiving favipiravir was associated with nasopharyngeal viral load reduction at three days (P=0.001). Significant nasopharyngeal SARS-CoV-2 viral load reduction was achieved in the COVID-19 patients who received favipiravir-containing regimen.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Manosuthi</LastName><ForeName>Weerawat</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeungsmarn</LastName><ForeName>Somlerk</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Ministry of Public Health, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Okada</LastName><ForeName>Pilailuk</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Ministry of Public Health, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suwanvattana</LastName><ForeName>Pawita</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wongboot</LastName><ForeName>Warawan</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Ministry of Public Health, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thawornwan</LastName><ForeName>Unchana</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Charoenpong</LastName><ForeName>Lantharita</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wiboonchutikul</LastName><ForeName>Surasak</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uttayamakul</LastName><ForeName>Sumonmal</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pongpirul</LastName><ForeName>Wannarat A</ForeName><Initials>WA</Initials><AffiliationInfo><Affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wachirapan</LastName><ForeName>Apichat</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warachit</LastName><ForeName>Paijit</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Office of the Permanent Secretary, Ministry of Public Health, Thailand.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>01</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Jpn J Infect Dis</MedlineTA><NlmUniqueID>100893704</NlmUniqueID><ISSNLinking>1344-6304</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Favipiravir</Keyword><Keyword MajorTopicYN="N">treatment</Keyword><Keyword MajorTopicYN="N">viral load</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>2</Month><Day>1</Day><Hour>5</Hour><Minute>49</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33518623</ArticleId><ArticleId IdType="doi">10.7883/yoken.JJID.2020.827</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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