Treating COVID-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind Randomized Controlled Trial in Hospitalized Patients.
Identifieur interne : 000A56 ( Main/Exploration ); précédent : 000A55; suivant : 000A57Treating COVID-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind Randomized Controlled Trial in Hospitalized Patients.
Auteurs : Robert J. Ulrich [États-Unis] ; Andrea B. Troxel [États-Unis] ; Ellie Carmody [États-Unis] ; Jaishvi Eapen [États-Unis] ; Martin B Cker [États-Unis] ; Jack A. Dehovitz [États-Unis] ; Prithiv J. Prasad [États-Unis] ; Yi Li [États-Unis] ; Camila Delgado [États-Unis] ; Morris Jrada [États-Unis] ; Gabriel A. Robbins [États-Unis] ; Brooklyn Henderson [États-Unis] ; Alexander Hrycko [États-Unis] ; Dinuli Delpachitra [États-Unis] ; Vanessa Raabe [États-Unis] ; Jonathan S. Austrian [États-Unis] ; Yanina Dubrovskaya [États-Unis] ; Mark J. Mulligan [États-Unis]Source :
- Open forum infectious diseases [ 2328-8957 ] ; 2020.
Abstract
Background
Effective therapies to combat coronavirus 2019 (COVID-19) are urgently needed. Hydroxychloroquine (HCQ) has in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the clinical benefit of HCQ in treating COVID-19 is unclear. Randomized controlled trials are needed to determine the safety and efficacy of HCQ for the treatment of hospitalized patients with COVID-19.
Methods
We conducted a multicenter, double-blind randomized clinical trial of HCQ among patients hospitalized with laboratory-confirmed COVID-19. Subjects were randomized in a 1:1 ratio to HCQ or placebo for 5 days and followed for 30 days. The primary efficacy outcome was a severe disease progression composite end point (death, intensive care unit admission, mechanical ventilation, extracorporeal membrane oxygenation, and/or vasopressor use) at day 14.
Results
A total of 128 patients were included in the intention-to-treat analysis. Baseline demographic, clinical, and laboratory characteristics were similar between the HCQ (n = 67) and placebo (n = 61) arms. At day 14, 11 (16.4%) subjects assigned to HCQ and 6 (9.8%) subjects assigned to placebo met the severe disease progression end point, but this did not achieve statistical significance (
Conclusions
In hospitalized patients with COVID-19, our data suggest that HCQ does not prevent severe outcomes or improve clinical scores. However, our conclusions are limited by a relatively small sample size, and larger randomized controlled trials or pooled analyses are needed.
DOI: 10.1093/ofid/ofaa446
PubMed: 33134417
PubMed Central: PMC7543602
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treating COVID-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind Randomized Controlled Trial in Hospitalized Patients.</title>
<author><name sortKey="Ulrich, Robert J" sort="Ulrich, Robert J" uniqKey="Ulrich R" first="Robert J" last="Ulrich">Robert J. Ulrich</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Troxel, Andrea B" sort="Troxel, Andrea B" uniqKey="Troxel A" first="Andrea B" last="Troxel">Andrea B. Troxel</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Population Health, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carmody, Ellie" sort="Carmody, Ellie" uniqKey="Carmody E" first="Ellie" last="Carmody">Ellie Carmody</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eapen, Jaishvi" sort="Eapen, Jaishvi" uniqKey="Eapen J" first="Jaishvi" last="Eapen">Jaishvi Eapen</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="B Cker, Martin" sort="B Cker, Martin" uniqKey="B Cker M" first="Martin" last="B Cker">Martin B Cker</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dehovitz, Jack A" sort="Dehovitz, Jack A" uniqKey="Dehovitz J" first="Jack A" last="Dehovitz">Jack A. Dehovitz</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prasad, Prithiv J" sort="Prasad, Prithiv J" uniqKey="Prasad P" first="Prithiv J" last="Prasad">Prithiv J. Prasad</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Yi" sort="Li, Yi" uniqKey="Li Y" first="Yi" last="Li">Yi Li</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Population Health, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delgado, Camila" sort="Delgado, Camila" uniqKey="Delgado C" first="Camila" last="Delgado">Camila Delgado</name>
<affiliation wicri:level="2"><nlm:affiliation>New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jrada, Morris" sort="Jrada, Morris" uniqKey="Jrada M" first="Morris" last="Jrada">Morris Jrada</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robbins, Gabriel A" sort="Robbins, Gabriel A" uniqKey="Robbins G" first="Gabriel A" last="Robbins">Gabriel A. Robbins</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Pediatric Hematology-Oncology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Pediatric Hematology-Oncology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Henderson, Brooklyn" sort="Henderson, Brooklyn" uniqKey="Henderson B" first="Brooklyn" last="Henderson">Brooklyn Henderson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hrycko, Alexander" sort="Hrycko, Alexander" uniqKey="Hrycko A" first="Alexander" last="Hrycko">Alexander Hrycko</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delpachitra, Dinuli" sort="Delpachitra, Dinuli" uniqKey="Delpachitra D" first="Dinuli" last="Delpachitra">Dinuli Delpachitra</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raabe, Vanessa" sort="Raabe, Vanessa" uniqKey="Raabe V" first="Vanessa" last="Raabe">Vanessa Raabe</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Divison of Pediatric Infectious Diseases, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Divison of Pediatric Infectious Diseases, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Austrian, Jonathan S" sort="Austrian, Jonathan S" uniqKey="Austrian J" first="Jonathan S" last="Austrian">Jonathan S. Austrian</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dubrovskaya, Yanina" sort="Dubrovskaya, Yanina" uniqKey="Dubrovskaya Y" first="Yanina" last="Dubrovskaya">Yanina Dubrovskaya</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacy, NYU Langone Health, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacy, NYU Langone Health, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mulligan, Mark J" sort="Mulligan, Mark J" uniqKey="Mulligan M" first="Mark J" last="Mulligan">Mark J. Mulligan</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:33134417</idno>
<idno type="pmid">33134417</idno>
<idno type="doi">10.1093/ofid/ofaa446</idno>
<idno type="pmc">PMC7543602</idno>
<idno type="wicri:Area/Main/Corpus">000906</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000906</idno>
<idno type="wicri:Area/Main/Curation">000906</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000906</idno>
<idno type="wicri:Area/Main/Exploration">000906</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Treating COVID-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind Randomized Controlled Trial in Hospitalized Patients.</title>
<author><name sortKey="Ulrich, Robert J" sort="Ulrich, Robert J" uniqKey="Ulrich R" first="Robert J" last="Ulrich">Robert J. Ulrich</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Troxel, Andrea B" sort="Troxel, Andrea B" uniqKey="Troxel A" first="Andrea B" last="Troxel">Andrea B. Troxel</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Population Health, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carmody, Ellie" sort="Carmody, Ellie" uniqKey="Carmody E" first="Ellie" last="Carmody">Ellie Carmody</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eapen, Jaishvi" sort="Eapen, Jaishvi" uniqKey="Eapen J" first="Jaishvi" last="Eapen">Jaishvi Eapen</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="B Cker, Martin" sort="B Cker, Martin" uniqKey="B Cker M" first="Martin" last="B Cker">Martin B Cker</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dehovitz, Jack A" sort="Dehovitz, Jack A" uniqKey="Dehovitz J" first="Jack A" last="Dehovitz">Jack A. Dehovitz</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prasad, Prithiv J" sort="Prasad, Prithiv J" uniqKey="Prasad P" first="Prithiv J" last="Prasad">Prithiv J. Prasad</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Yi" sort="Li, Yi" uniqKey="Li Y" first="Yi" last="Li">Yi Li</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Population Health, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delgado, Camila" sort="Delgado, Camila" uniqKey="Delgado C" first="Camila" last="Delgado">Camila Delgado</name>
<affiliation wicri:level="2"><nlm:affiliation>New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jrada, Morris" sort="Jrada, Morris" uniqKey="Jrada M" first="Morris" last="Jrada">Morris Jrada</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robbins, Gabriel A" sort="Robbins, Gabriel A" uniqKey="Robbins G" first="Gabriel A" last="Robbins">Gabriel A. Robbins</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Pediatric Hematology-Oncology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Pediatric Hematology-Oncology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Henderson, Brooklyn" sort="Henderson, Brooklyn" uniqKey="Henderson B" first="Brooklyn" last="Henderson">Brooklyn Henderson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hrycko, Alexander" sort="Hrycko, Alexander" uniqKey="Hrycko A" first="Alexander" last="Hrycko">Alexander Hrycko</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delpachitra, Dinuli" sort="Delpachitra, Dinuli" uniqKey="Delpachitra D" first="Dinuli" last="Delpachitra">Dinuli Delpachitra</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raabe, Vanessa" sort="Raabe, Vanessa" uniqKey="Raabe V" first="Vanessa" last="Raabe">Vanessa Raabe</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Divison of Pediatric Infectious Diseases, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Divison of Pediatric Infectious Diseases, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Austrian, Jonathan S" sort="Austrian, Jonathan S" uniqKey="Austrian J" first="Jonathan S" last="Austrian">Jonathan S. Austrian</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dubrovskaya, Yanina" sort="Dubrovskaya, Yanina" uniqKey="Dubrovskaya Y" first="Yanina" last="Dubrovskaya">Yanina Dubrovskaya</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacy, NYU Langone Health, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacy, NYU Langone Health, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mulligan, Mark J" sort="Mulligan, Mark J" uniqKey="Mulligan M" first="Mark J" last="Mulligan">Mark J. Mulligan</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Open forum infectious diseases</title>
<idno type="ISSN">2328-8957</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>Background</b>
</p>
<p>Effective therapies to combat coronavirus 2019 (COVID-19) are urgently needed. Hydroxychloroquine (HCQ) has in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the clinical benefit of HCQ in treating COVID-19 is unclear. Randomized controlled trials are needed to determine the safety and efficacy of HCQ for the treatment of hospitalized patients with COVID-19.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Methods</b>
</p>
<p>We conducted a multicenter, double-blind randomized clinical trial of HCQ among patients hospitalized with laboratory-confirmed COVID-19. Subjects were randomized in a 1:1 ratio to HCQ or placebo for 5 days and followed for 30 days. The primary efficacy outcome was a severe disease progression composite end point (death, intensive care unit admission, mechanical ventilation, extracorporeal membrane oxygenation, and/or vasopressor use) at day 14.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Results</b>
</p>
<p>A total of 128 patients were included in the intention-to-treat analysis. Baseline demographic, clinical, and laboratory characteristics were similar between the HCQ (n = 67) and placebo (n = 61) arms. At day 14, 11 (16.4%) subjects assigned to HCQ and 6 (9.8%) subjects assigned to placebo met the severe disease progression end point, but this did not achieve statistical significance (</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Conclusions</b>
</p>
<p>In hospitalized patients with COVID-19, our data suggest that HCQ does not prevent severe outcomes or improve clinical scores. However, our conclusions are limited by a relatively small sample size, and larger randomized controlled trials or pooled analyses are needed.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33134417</PMID>
<DateRevised><Year>2021</Year>
<Month>04</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2328-8957</ISSN>
<JournalIssue CitedMedium="Print"><Volume>7</Volume>
<Issue>10</Issue>
<PubDate><Year>2020</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Open forum infectious diseases</Title>
<ISOAbbreviation>Open Forum Infect Dis</ISOAbbreviation>
</Journal>
<ArticleTitle>Treating COVID-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind Randomized Controlled Trial in Hospitalized Patients.</ArticleTitle>
<Pagination><MedlinePgn>ofaa446</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/ofid/ofaa446</ELocationID>
<Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Effective therapies to combat coronavirus 2019 (COVID-19) are urgently needed. Hydroxychloroquine (HCQ) has in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the clinical benefit of HCQ in treating COVID-19 is unclear. Randomized controlled trials are needed to determine the safety and efficacy of HCQ for the treatment of hospitalized patients with COVID-19.</AbstractText>
<AbstractText Label="Methods" NlmCategory="UNASSIGNED">We conducted a multicenter, double-blind randomized clinical trial of HCQ among patients hospitalized with laboratory-confirmed COVID-19. Subjects were randomized in a 1:1 ratio to HCQ or placebo for 5 days and followed for 30 days. The primary efficacy outcome was a severe disease progression composite end point (death, intensive care unit admission, mechanical ventilation, extracorporeal membrane oxygenation, and/or vasopressor use) at day 14.</AbstractText>
<AbstractText Label="Results" NlmCategory="UNASSIGNED">A total of 128 patients were included in the intention-to-treat analysis. Baseline demographic, clinical, and laboratory characteristics were similar between the HCQ (n = 67) and placebo (n = 61) arms. At day 14, 11 (16.4%) subjects assigned to HCQ and 6 (9.8%) subjects assigned to placebo met the severe disease progression end point, but this did not achieve statistical significance (<i>P</i>
= .350). There were no significant differences in COVID-19 clinical scores, number of oxygen-free days, SARS-CoV-2 clearance, or adverse events between HCQ and placebo. HCQ was associated with a slight increase in mean corrected QT interval, an increased D-dimer, and a trend toward an increased length of stay.</AbstractText>
<AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">In hospitalized patients with COVID-19, our data suggest that HCQ does not prevent severe outcomes or improve clinical scores. However, our conclusions are limited by a relatively small sample size, and larger randomized controlled trials or pooled analyses are needed.</AbstractText>
<CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ulrich</LastName>
<ForeName>Robert J</ForeName>
<Initials>RJ</Initials>
<Identifier Source="ORCID">0000-0002-3217-5062</Identifier>
<AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Troxel</LastName>
<ForeName>Andrea B</ForeName>
<Initials>AB</Initials>
<AffiliationInfo><Affiliation>Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carmody</LastName>
<ForeName>Ellie</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eapen</LastName>
<ForeName>Jaishvi</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bäcker</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>DeHovitz</LastName>
<ForeName>Jack A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Prasad</LastName>
<ForeName>Prithiv J</ForeName>
<Initials>PJ</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yi</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Delgado</LastName>
<ForeName>Camila</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jrada</LastName>
<ForeName>Morris</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Robbins</LastName>
<ForeName>Gabriel A</ForeName>
<Initials>GA</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Pediatric Hematology-Oncology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Henderson</LastName>
<ForeName>Brooklyn</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hrycko</LastName>
<ForeName>Alexander</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Delpachitra</LastName>
<ForeName>Dinuli</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Raabe</LastName>
<ForeName>Vanessa</ForeName>
<Initials>V</Initials>
<Identifier Source="ORCID">0000-0003-2579-1104</Identifier>
<AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Divison of Pediatric Infectious Diseases, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Austrian</LastName>
<ForeName>Jonathan S</ForeName>
<Initials>JS</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dubrovskaya</LastName>
<ForeName>Yanina</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pharmacy, NYU Langone Health, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mulligan</LastName>
<ForeName>Mark J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>UL1 TR001445</GrantID>
<Acronym>TR</Acronym>
<Agency>NCATS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>09</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Open Forum Infect Dis</MedlineTA>
<NlmUniqueID>101637045</NlmUniqueID>
<ISSNLinking>2328-8957</ISSNLinking>
</MedlineJournalInfo>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="N">hydroxychloroquine</Keyword>
<Keyword MajorTopicYN="N">randomized controlled trial</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>09</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>09</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>11</Month>
<Day>2</Day>
<Hour>6</Hour>
<Minute>21</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>11</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>11</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>1</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">33134417</ArticleId>
<ArticleId IdType="doi">10.1093/ofid/ofaa446</ArticleId>
<ArticleId IdType="pii">ofaa446</ArticleId>
<ArticleId IdType="pmc">PMC7543602</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Thromb Thrombolysis. 2020 Oct;50(3):548-557</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32524516</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Intern Med. 2020 Aug 18;173(4):287-296</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32459529</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):732-739</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32150618</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Travel Med Infect Dis. 2020 Jul - Aug;36:101791</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32593867</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Discov. 2020 Mar 18;6:16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32194981</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Jun 23;323(24):2493-2502</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32392282</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Thromb Res. 2020 Nov;195:95-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32682004</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2020 May;20(5):533-534</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32087114</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Rheumatol. 1997 Jan;24(1):55-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9002011</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Expert Opin Drug Saf. 2011 Sep;10(5):705-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21417950</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Res Vet Sci. 1986 Jan;40(1):1-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3010408</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2020 May 14;369:m1849</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32409561</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Aug 11;324(6):543-545</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32717043</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Mar 17;323(11):1061-1069</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32031570</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Kidney J. 2013 Feb;6(1):8-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27818745</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Res. 2020 Mar;30(3):269-271</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32020029</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Infect Dis. 2020 Aug;97:396-403</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32623082</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Apr 27;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32338708</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Clin Nutr. 2007 Oct;86(4):1054-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17921384</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2019 Feb 4;37(6):863-868</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30639461</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Rheum Dis. 2019 Jun;78(6):736-745</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30926722</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Jun 18;382(25):2411-2418</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32379955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Infect Dis. 2020 Jul;96:467-474</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32425643</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Nov 19;383(21):2041-2052</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32706953</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Res Ther. 2017 Aug 9;19(1):183</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28793932</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Cardiol. 2020 Sep 1;5(9):1036-1041</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32936252</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Rheum. 1999 Feb;42(2):357-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10025931</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pharmacol Res Perspect. 2017 Jan 23;5(1):e00293</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28596841</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2020 Jul;56(1):105949</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32205204</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Ulrich, Robert J" sort="Ulrich, Robert J" uniqKey="Ulrich R" first="Robert J" last="Ulrich">Robert J. Ulrich</name>
</region>
<name sortKey="Austrian, Jonathan S" sort="Austrian, Jonathan S" uniqKey="Austrian J" first="Jonathan S" last="Austrian">Jonathan S. Austrian</name>
<name sortKey="B Cker, Martin" sort="B Cker, Martin" uniqKey="B Cker M" first="Martin" last="B Cker">Martin B Cker</name>
<name sortKey="Carmody, Ellie" sort="Carmody, Ellie" uniqKey="Carmody E" first="Ellie" last="Carmody">Ellie Carmody</name>
<name sortKey="Carmody, Ellie" sort="Carmody, Ellie" uniqKey="Carmody E" first="Ellie" last="Carmody">Ellie Carmody</name>
<name sortKey="Dehovitz, Jack A" sort="Dehovitz, Jack A" uniqKey="Dehovitz J" first="Jack A" last="Dehovitz">Jack A. Dehovitz</name>
<name sortKey="Delgado, Camila" sort="Delgado, Camila" uniqKey="Delgado C" first="Camila" last="Delgado">Camila Delgado</name>
<name sortKey="Delpachitra, Dinuli" sort="Delpachitra, Dinuli" uniqKey="Delpachitra D" first="Dinuli" last="Delpachitra">Dinuli Delpachitra</name>
<name sortKey="Dubrovskaya, Yanina" sort="Dubrovskaya, Yanina" uniqKey="Dubrovskaya Y" first="Yanina" last="Dubrovskaya">Yanina Dubrovskaya</name>
<name sortKey="Dubrovskaya, Yanina" sort="Dubrovskaya, Yanina" uniqKey="Dubrovskaya Y" first="Yanina" last="Dubrovskaya">Yanina Dubrovskaya</name>
<name sortKey="Dubrovskaya, Yanina" sort="Dubrovskaya, Yanina" uniqKey="Dubrovskaya Y" first="Yanina" last="Dubrovskaya">Yanina Dubrovskaya</name>
<name sortKey="Eapen, Jaishvi" sort="Eapen, Jaishvi" uniqKey="Eapen J" first="Jaishvi" last="Eapen">Jaishvi Eapen</name>
<name sortKey="Eapen, Jaishvi" sort="Eapen, Jaishvi" uniqKey="Eapen J" first="Jaishvi" last="Eapen">Jaishvi Eapen</name>
<name sortKey="Henderson, Brooklyn" sort="Henderson, Brooklyn" uniqKey="Henderson B" first="Brooklyn" last="Henderson">Brooklyn Henderson</name>
<name sortKey="Henderson, Brooklyn" sort="Henderson, Brooklyn" uniqKey="Henderson B" first="Brooklyn" last="Henderson">Brooklyn Henderson</name>
<name sortKey="Hrycko, Alexander" sort="Hrycko, Alexander" uniqKey="Hrycko A" first="Alexander" last="Hrycko">Alexander Hrycko</name>
<name sortKey="Hrycko, Alexander" sort="Hrycko, Alexander" uniqKey="Hrycko A" first="Alexander" last="Hrycko">Alexander Hrycko</name>
<name sortKey="Jrada, Morris" sort="Jrada, Morris" uniqKey="Jrada M" first="Morris" last="Jrada">Morris Jrada</name>
<name sortKey="Li, Yi" sort="Li, Yi" uniqKey="Li Y" first="Yi" last="Li">Yi Li</name>
<name sortKey="Li, Yi" sort="Li, Yi" uniqKey="Li Y" first="Yi" last="Li">Yi Li</name>
<name sortKey="Mulligan, Mark J" sort="Mulligan, Mark J" uniqKey="Mulligan M" first="Mark J" last="Mulligan">Mark J. Mulligan</name>
<name sortKey="Mulligan, Mark J" sort="Mulligan, Mark J" uniqKey="Mulligan M" first="Mark J" last="Mulligan">Mark J. Mulligan</name>
<name sortKey="Prasad, Prithiv J" sort="Prasad, Prithiv J" uniqKey="Prasad P" first="Prithiv J" last="Prasad">Prithiv J. Prasad</name>
<name sortKey="Prasad, Prithiv J" sort="Prasad, Prithiv J" uniqKey="Prasad P" first="Prithiv J" last="Prasad">Prithiv J. Prasad</name>
<name sortKey="Raabe, Vanessa" sort="Raabe, Vanessa" uniqKey="Raabe V" first="Vanessa" last="Raabe">Vanessa Raabe</name>
<name sortKey="Raabe, Vanessa" sort="Raabe, Vanessa" uniqKey="Raabe V" first="Vanessa" last="Raabe">Vanessa Raabe</name>
<name sortKey="Raabe, Vanessa" sort="Raabe, Vanessa" uniqKey="Raabe V" first="Vanessa" last="Raabe">Vanessa Raabe</name>
<name sortKey="Raabe, Vanessa" sort="Raabe, Vanessa" uniqKey="Raabe V" first="Vanessa" last="Raabe">Vanessa Raabe</name>
<name sortKey="Robbins, Gabriel A" sort="Robbins, Gabriel A" uniqKey="Robbins G" first="Gabriel A" last="Robbins">Gabriel A. Robbins</name>
<name sortKey="Robbins, Gabriel A" sort="Robbins, Gabriel A" uniqKey="Robbins G" first="Gabriel A" last="Robbins">Gabriel A. Robbins</name>
<name sortKey="Troxel, Andrea B" sort="Troxel, Andrea B" uniqKey="Troxel A" first="Andrea B" last="Troxel">Andrea B. Troxel</name>
<name sortKey="Troxel, Andrea B" sort="Troxel, Andrea B" uniqKey="Troxel A" first="Andrea B" last="Troxel">Andrea B. Troxel</name>
<name sortKey="Ulrich, Robert J" sort="Ulrich, Robert J" uniqKey="Ulrich R" first="Robert J" last="Ulrich">Robert J. Ulrich</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A56 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A56 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= CovidChloroV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:33134417 |texte= Treating COVID-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind Randomized Controlled Trial in Hospitalized Patients. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:33134417" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a CovidChloroV1
![]() | This area was generated with Dilib version V0.6.38. | ![]() |