Treating COVID-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind Randomized Controlled Trial in Hospitalized Patients.
Identifieur interne : 000906 ( Main/Corpus ); précédent : 000905; suivant : 000907Treating COVID-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind Randomized Controlled Trial in Hospitalized Patients.
Auteurs : Robert J. Ulrich ; Andrea B. Troxel ; Ellie Carmody ; Jaishvi Eapen ; Martin B Cker ; Jack A. Dehovitz ; Prithiv J. Prasad ; Yi Li ; Camila Delgado ; Morris Jrada ; Gabriel A. Robbins ; Brooklyn Henderson ; Alexander Hrycko ; Dinuli Delpachitra ; Vanessa Raabe ; Jonathan S. Austrian ; Yanina Dubrovskaya ; Mark J. MulliganSource :
- Open forum infectious diseases [ 2328-8957 ] ; 2020.
Abstract
Background
Effective therapies to combat coronavirus 2019 (COVID-19) are urgently needed. Hydroxychloroquine (HCQ) has in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the clinical benefit of HCQ in treating COVID-19 is unclear. Randomized controlled trials are needed to determine the safety and efficacy of HCQ for the treatment of hospitalized patients with COVID-19.
Methods
We conducted a multicenter, double-blind randomized clinical trial of HCQ among patients hospitalized with laboratory-confirmed COVID-19. Subjects were randomized in a 1:1 ratio to HCQ or placebo for 5 days and followed for 30 days. The primary efficacy outcome was a severe disease progression composite end point (death, intensive care unit admission, mechanical ventilation, extracorporeal membrane oxygenation, and/or vasopressor use) at day 14.
Results
A total of 128 patients were included in the intention-to-treat analysis. Baseline demographic, clinical, and laboratory characteristics were similar between the HCQ (n = 67) and placebo (n = 61) arms. At day 14, 11 (16.4%) subjects assigned to HCQ and 6 (9.8%) subjects assigned to placebo met the severe disease progression end point, but this did not achieve statistical significance (
Conclusions
In hospitalized patients with COVID-19, our data suggest that HCQ does not prevent severe outcomes or improve clinical scores. However, our conclusions are limited by a relatively small sample size, and larger randomized controlled trials or pooled analyses are needed.
DOI: 10.1093/ofid/ofaa446
PubMed: 33134417
PubMed Central: PMC7543602
Links to Exploration step
pubmed:33134417Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treating COVID-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind Randomized Controlled Trial in Hospitalized Patients.</title><author><name sortKey="Ulrich, Robert J" sort="Ulrich, Robert J" uniqKey="Ulrich R" first="Robert J" last="Ulrich">Robert J. Ulrich</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Troxel, Andrea B" sort="Troxel, Andrea B" uniqKey="Troxel A" first="Andrea B" last="Troxel">Andrea B. Troxel</name><affiliation><nlm:affiliation>Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carmody, Ellie" sort="Carmody, Ellie" uniqKey="Carmody E" first="Ellie" last="Carmody">Ellie Carmody</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Eapen, Jaishvi" sort="Eapen, Jaishvi" uniqKey="Eapen J" first="Jaishvi" last="Eapen">Jaishvi Eapen</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="B Cker, Martin" sort="B Cker, Martin" uniqKey="B Cker M" first="Martin" last="B Cker">Martin B Cker</name><affiliation><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dehovitz, Jack A" sort="Dehovitz, Jack A" uniqKey="Dehovitz J" first="Jack A" last="Dehovitz">Jack A. Dehovitz</name><affiliation><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Prasad, Prithiv J" sort="Prasad, Prithiv J" uniqKey="Prasad P" first="Prithiv J" last="Prasad">Prithiv J. Prasad</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yi" sort="Li, Yi" uniqKey="Li Y" first="Yi" last="Li">Yi Li</name><affiliation><nlm:affiliation>Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Delgado, Camila" sort="Delgado, Camila" uniqKey="Delgado C" first="Camila" last="Delgado">Camila Delgado</name><affiliation><nlm:affiliation>New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jrada, Morris" sort="Jrada, Morris" uniqKey="Jrada M" first="Morris" last="Jrada">Morris Jrada</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Robbins, Gabriel A" sort="Robbins, Gabriel A" uniqKey="Robbins G" first="Gabriel A" last="Robbins">Gabriel A. Robbins</name><affiliation><nlm:affiliation>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Pediatric Hematology-Oncology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Henderson, Brooklyn" sort="Henderson, Brooklyn" uniqKey="Henderson B" first="Brooklyn" last="Henderson">Brooklyn Henderson</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hrycko, Alexander" sort="Hrycko, Alexander" uniqKey="Hrycko A" first="Alexander" last="Hrycko">Alexander Hrycko</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Delpachitra, Dinuli" sort="Delpachitra, Dinuli" uniqKey="Delpachitra D" first="Dinuli" last="Delpachitra">Dinuli Delpachitra</name><affiliation><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Raabe, Vanessa" sort="Raabe, Vanessa" uniqKey="Raabe V" first="Vanessa" last="Raabe">Vanessa Raabe</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Divison of Pediatric Infectious Diseases, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Austrian, Jonathan S" sort="Austrian, Jonathan S" uniqKey="Austrian J" first="Jonathan S" last="Austrian">Jonathan S. Austrian</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dubrovskaya, Yanina" sort="Dubrovskaya, Yanina" uniqKey="Dubrovskaya Y" first="Yanina" last="Dubrovskaya">Yanina Dubrovskaya</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Pharmacy, NYU Langone Health, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mulligan, Mark J" sort="Mulligan, Mark J" uniqKey="Mulligan M" first="Mark J" last="Mulligan">Mark J. Mulligan</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33134417</idno><idno type="pmid">33134417</idno><idno type="doi">10.1093/ofid/ofaa446</idno><idno type="pmc">PMC7543602</idno><idno type="wicri:Area/Main/Corpus">000906</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000906</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Treating COVID-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind Randomized Controlled Trial in Hospitalized Patients.</title><author><name sortKey="Ulrich, Robert J" sort="Ulrich, Robert J" uniqKey="Ulrich R" first="Robert J" last="Ulrich">Robert J. Ulrich</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Troxel, Andrea B" sort="Troxel, Andrea B" uniqKey="Troxel A" first="Andrea B" last="Troxel">Andrea B. Troxel</name><affiliation><nlm:affiliation>Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carmody, Ellie" sort="Carmody, Ellie" uniqKey="Carmody E" first="Ellie" last="Carmody">Ellie Carmody</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Eapen, Jaishvi" sort="Eapen, Jaishvi" uniqKey="Eapen J" first="Jaishvi" last="Eapen">Jaishvi Eapen</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="B Cker, Martin" sort="B Cker, Martin" uniqKey="B Cker M" first="Martin" last="B Cker">Martin B Cker</name><affiliation><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dehovitz, Jack A" sort="Dehovitz, Jack A" uniqKey="Dehovitz J" first="Jack A" last="Dehovitz">Jack A. Dehovitz</name><affiliation><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Prasad, Prithiv J" sort="Prasad, Prithiv J" uniqKey="Prasad P" first="Prithiv J" last="Prasad">Prithiv J. Prasad</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yi" sort="Li, Yi" uniqKey="Li Y" first="Yi" last="Li">Yi Li</name><affiliation><nlm:affiliation>Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Delgado, Camila" sort="Delgado, Camila" uniqKey="Delgado C" first="Camila" last="Delgado">Camila Delgado</name><affiliation><nlm:affiliation>New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jrada, Morris" sort="Jrada, Morris" uniqKey="Jrada M" first="Morris" last="Jrada">Morris Jrada</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Robbins, Gabriel A" sort="Robbins, Gabriel A" uniqKey="Robbins G" first="Gabriel A" last="Robbins">Gabriel A. Robbins</name><affiliation><nlm:affiliation>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Pediatric Hematology-Oncology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Henderson, Brooklyn" sort="Henderson, Brooklyn" uniqKey="Henderson B" first="Brooklyn" last="Henderson">Brooklyn Henderson</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hrycko, Alexander" sort="Hrycko, Alexander" uniqKey="Hrycko A" first="Alexander" last="Hrycko">Alexander Hrycko</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Delpachitra, Dinuli" sort="Delpachitra, Dinuli" uniqKey="Delpachitra D" first="Dinuli" last="Delpachitra">Dinuli Delpachitra</name><affiliation><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Raabe, Vanessa" sort="Raabe, Vanessa" uniqKey="Raabe V" first="Vanessa" last="Raabe">Vanessa Raabe</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Divison of Pediatric Infectious Diseases, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Austrian, Jonathan S" sort="Austrian, Jonathan S" uniqKey="Austrian J" first="Jonathan S" last="Austrian">Jonathan S. Austrian</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dubrovskaya, Yanina" sort="Dubrovskaya, Yanina" uniqKey="Dubrovskaya Y" first="Yanina" last="Dubrovskaya">Yanina Dubrovskaya</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Pharmacy, NYU Langone Health, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mulligan, Mark J" sort="Mulligan, Mark J" uniqKey="Mulligan M" first="Mark J" last="Mulligan">Mark J. Mulligan</name><affiliation><nlm:affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Open forum infectious diseases</title><idno type="ISSN">2328-8957</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background</b></p><p>Effective therapies to combat coronavirus 2019 (COVID-19) are urgently needed. Hydroxychloroquine (HCQ) has in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the clinical benefit of HCQ in treating COVID-19 is unclear. Randomized controlled trials are needed to determine the safety and efficacy of HCQ for the treatment of hospitalized patients with COVID-19.</p></div><div type="abstract" xml:lang="en"><p><b>Methods</b></p><p>We conducted a multicenter, double-blind randomized clinical trial of HCQ among patients hospitalized with laboratory-confirmed COVID-19. Subjects were randomized in a 1:1 ratio to HCQ or placebo for 5 days and followed for 30 days. The primary efficacy outcome was a severe disease progression composite end point (death, intensive care unit admission, mechanical ventilation, extracorporeal membrane oxygenation, and/or vasopressor use) at day 14.</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>A total of 128 patients were included in the intention-to-treat analysis. Baseline demographic, clinical, and laboratory characteristics were similar between the HCQ (n = 67) and placebo (n = 61) arms. At day 14, 11 (16.4%) subjects assigned to HCQ and 6 (9.8%) subjects assigned to placebo met the severe disease progression end point, but this did not achieve statistical significance (</p></div><div type="abstract" xml:lang="en"><p><b>Conclusions</b></p><p>In hospitalized patients with COVID-19, our data suggest that HCQ does not prevent severe outcomes or improve clinical scores. However, our conclusions are limited by a relatively small sample size, and larger randomized controlled trials or pooled analyses are needed.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33134417</PMID><DateRevised><Year>2021</Year><Month>04</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2328-8957</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><Issue>10</Issue><PubDate><Year>2020</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Open forum infectious diseases</Title><ISOAbbreviation>Open Forum Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Treating COVID-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind Randomized Controlled Trial in Hospitalized Patients.</ArticleTitle><Pagination><MedlinePgn>ofaa446</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/ofid/ofaa446</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Effective therapies to combat coronavirus 2019 (COVID-19) are urgently needed. Hydroxychloroquine (HCQ) has in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the clinical benefit of HCQ in treating COVID-19 is unclear. Randomized controlled trials are needed to determine the safety and efficacy of HCQ for the treatment of hospitalized patients with COVID-19.</AbstractText><AbstractText Label="Methods" NlmCategory="UNASSIGNED">We conducted a multicenter, double-blind randomized clinical trial of HCQ among patients hospitalized with laboratory-confirmed COVID-19. Subjects were randomized in a 1:1 ratio to HCQ or placebo for 5 days and followed for 30 days. The primary efficacy outcome was a severe disease progression composite end point (death, intensive care unit admission, mechanical ventilation, extracorporeal membrane oxygenation, and/or vasopressor use) at day 14.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">A total of 128 patients were included in the intention-to-treat analysis. Baseline demographic, clinical, and laboratory characteristics were similar between the HCQ (n = 67) and placebo (n = 61) arms. At day 14, 11 (16.4%) subjects assigned to HCQ and 6 (9.8%) subjects assigned to placebo met the severe disease progression end point, but this did not achieve statistical significance (<i>P</i> = .350). There were no significant differences in COVID-19 clinical scores, number of oxygen-free days, SARS-CoV-2 clearance, or adverse events between HCQ and placebo. HCQ was associated with a slight increase in mean corrected QT interval, an increased D-dimer, and a trend toward an increased length of stay.</AbstractText><AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">In hospitalized patients with COVID-19, our data suggest that HCQ does not prevent severe outcomes or improve clinical scores. However, our conclusions are limited by a relatively small sample size, and larger randomized controlled trials or pooled analyses are needed.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ulrich</LastName><ForeName>Robert J</ForeName><Initials>RJ</Initials><Identifier Source="ORCID">0000-0002-3217-5062</Identifier><AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Troxel</LastName><ForeName>Andrea B</ForeName><Initials>AB</Initials><AffiliationInfo><Affiliation>Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carmody</LastName><ForeName>Ellie</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eapen</LastName><ForeName>Jaishvi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bäcker</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DeHovitz</LastName><ForeName>Jack A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prasad</LastName><ForeName>Prithiv J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Biostatistics, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delgado</LastName><ForeName>Camila</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jrada</LastName><ForeName>Morris</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robbins</LastName><ForeName>Gabriel A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Pediatric Hematology-Oncology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henderson</LastName><ForeName>Brooklyn</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hrycko</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delpachitra</LastName><ForeName>Dinuli</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, NYU Long Island School of Medicine, Mineola, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raabe</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials><Identifier Source="ORCID">0000-0003-2579-1104</Identifier><AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Divison of Pediatric Infectious Diseases, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Austrian</LastName><ForeName>Jonathan S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dubrovskaya</LastName><ForeName>Yanina</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pharmacy, NYU Langone Health, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mulligan</LastName><ForeName>Mark J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>UL1 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