Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives.
Identifieur interne : 000E63 ( Main/Exploration ); précédent : 000E62; suivant : 000E64Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives.
Auteurs : Xiao-Lei Zhang [République populaire de Chine] ; Zhuo-Ming Li [République populaire de Chine] ; Jian-Tao Ye [République populaire de Chine] ; Jing Lu [République populaire de Chine] ; Lingyu Linda Ye [République populaire de Chine] ; Chun-Xiang Zhang [République populaire de Chine] ; Pei-Qing Liu [République populaire de Chine] ; Dayue D. Duan [République populaire de Chine]Source :
- Acta pharmacologica Sinica [ 1745-7254 ] ; 2020.
Descripteurs français
- KwdFr :
- Antiviraux (pharmacologie), Chloroquine (analogues et dérivés), Chloroquine (pharmacologie), Chloroquine (usage thérapeutique), Humains (MeSH), Infections à coronavirus (complications), Infections à coronavirus (traitement médicamenteux), Maladies cardiovasculaires (complications), Pandémies (MeSH), Pneumopathie virale (complications), Pneumopathie virale (traitement médicamenteux).
- MESH :
- analogues et dérivés : Chloroquine.
- pharmacologie : Antiviraux, Chloroquine, Infections à coronavirus, Maladies cardiovasculaires, Pneumopathie virale.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Chloroquine.
- Humains, Pandémies.
English descriptors
- KwdEn :
- Antiviral Agents (pharmacology), COVID-19 (MeSH), Cardiovascular Diseases (complications), Chloroquine (analogs & derivatives), Chloroquine (pharmacology), Chloroquine (therapeutic use), Coronavirus Infections (complications), Coronavirus Infections (drug therapy), Humans (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (drug therapy).
- MESH :
- chemical , analogs & derivatives : Chloroquine.
- chemical , pharmacology : Antiviral Agents, Chloroquine.
- complications : Cardiovascular Diseases, Coronavirus Infections, Pneumonia, Viral.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- chemical , therapeutic use : Chloroquine.
- COVID-19, Humans, Pandemics.
Abstract
The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. Therefore, chloroquine phosphate was first used in the treatment of COVID-19 in China. Later, under a limited emergency-use authorization from the FDA, hydroxychloroquine in combination with azithromycin was used to treat COVID-19 patients in the USA, although the mechanisms of the anti-COVID-19 effects remain unclear. Preliminary outcomes from clinical trials in several countries have generated controversial results. The desperation to control the pandemic overrode the concerns regarding the serious adverse effects of chloroquine derivatives and combination drugs, including lethal arrhythmias and cardiomyopathy. The risks of these treatments have become more complex as a result of findings that COVID-19 is actually a multisystem disease. While respiratory symptoms are the major clinical manifestations, cardiovascular abnormalities, including arrhythmias, myocarditis, heart failure, and ischemic stroke, have been reported in a significant number of COVID-19 patients. Patients with preexisting cardiovascular conditions (hypertension, arrhythmias, etc.) are at increased risk of severe COVID-19 and death. From pharmacological and cardiovascular perspectives, therefore, the treatment of COVID-19 with chloroquine and its derivatives should be systematically evaluated, and patients should be routinely monitored for cardiovascular conditions to prevent lethal adverse events.
DOI: 10.1038/s41401-020-00519-x
PubMed: 32968208
PubMed Central: PMC7509225
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Chloroquine (analogs & derivatives)</term>
<term>Chloroquine (pharmacology)</term>
<term>Chloroquine (therapeutic use)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Humans (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (drug therapy)</term>
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<term>Chloroquine (analogues et dérivés)</term>
<term>Chloroquine (pharmacologie)</term>
<term>Chloroquine (usage thérapeutique)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (complications)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Maladies cardiovasculaires (complications)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (complications)</term>
<term>Pneumopathie virale (traitement médicamenteux)</term>
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<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Chloroquine</term>
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<term>Chloroquine</term>
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<front><div type="abstract" xml:lang="en">The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. Therefore, chloroquine phosphate was first used in the treatment of COVID-19 in China. Later, under a limited emergency-use authorization from the FDA, hydroxychloroquine in combination with azithromycin was used to treat COVID-19 patients in the USA, although the mechanisms of the anti-COVID-19 effects remain unclear. Preliminary outcomes from clinical trials in several countries have generated controversial results. The desperation to control the pandemic overrode the concerns regarding the serious adverse effects of chloroquine derivatives and combination drugs, including lethal arrhythmias and cardiomyopathy. The risks of these treatments have become more complex as a result of findings that COVID-19 is actually a multisystem disease. While respiratory symptoms are the major clinical manifestations, cardiovascular abnormalities, including arrhythmias, myocarditis, heart failure, and ischemic stroke, have been reported in a significant number of COVID-19 patients. Patients with preexisting cardiovascular conditions (hypertension, arrhythmias, etc.) are at increased risk of severe COVID-19 and death. From pharmacological and cardiovascular perspectives, therefore, the treatment of COVID-19 with chloroquine and its derivatives should be systematically evaluated, and patients should be routinely monitored for cardiovascular conditions to prevent lethal adverse events.</div>
</front>
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<DateCompleted><Year>2020</Year>
<Month>11</Month>
<Day>05</Day>
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<DateRevised><Year>2021</Year>
<Month>04</Month>
<Day>27</Day>
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<Title>Acta pharmacologica Sinica</Title>
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<ArticleTitle>Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives.</ArticleTitle>
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<Abstract><AbstractText>The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. Therefore, chloroquine phosphate was first used in the treatment of COVID-19 in China. Later, under a limited emergency-use authorization from the FDA, hydroxychloroquine in combination with azithromycin was used to treat COVID-19 patients in the USA, although the mechanisms of the anti-COVID-19 effects remain unclear. Preliminary outcomes from clinical trials in several countries have generated controversial results. The desperation to control the pandemic overrode the concerns regarding the serious adverse effects of chloroquine derivatives and combination drugs, including lethal arrhythmias and cardiomyopathy. The risks of these treatments have become more complex as a result of findings that COVID-19 is actually a multisystem disease. While respiratory symptoms are the major clinical manifestations, cardiovascular abnormalities, including arrhythmias, myocarditis, heart failure, and ischemic stroke, have been reported in a significant number of COVID-19 patients. Patients with preexisting cardiovascular conditions (hypertension, arrhythmias, etc.) are at increased risk of severe COVID-19 and death. From pharmacological and cardiovascular perspectives, therefore, the treatment of COVID-19 with chloroquine and its derivatives should be systematically evaluated, and patients should be routinely monitored for cardiovascular conditions to prevent lethal adverse events.</AbstractText>
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<ForeName>Xiao-Lei</ForeName>
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<ForeName>Zhuo-Ming</ForeName>
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<ForeName>Jing</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drug Evaluation, Guangdong Engineering Laboratory of Druggability and New Drug Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ye</LastName>
<ForeName>Lingyu Linda</ForeName>
<Initials>LL</Initials>
<AffiliationInfo><Affiliation>Center for Phenomics of Traditional Chinese Medicine of the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Chun-Xiang</ForeName>
<Initials>CX</Initials>
<AffiliationInfo><Affiliation>Institute of Cardiovascular Research and the Affiliated Hospital, Southwest Medical University, Luzhou, 646000, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Pei-Qing</ForeName>
<Initials>PQ</Initials>
<AffiliationInfo><Affiliation>Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drug Evaluation, Guangdong Engineering Laboratory of Druggability and New Drug Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China. liupq@mail.sysu.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Duan</LastName>
<ForeName>Dayue D</ForeName>
<Initials>DD</Initials>
<AffiliationInfo><Affiliation>Center for Phenomics of Traditional Chinese Medicine of the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, China. dduan@swmu.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
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<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>09</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Acta Pharmacol Sin</MedlineTA>
<NlmUniqueID>100956087</NlmUniqueID>
<ISSNLinking>1671-4083</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
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<NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance>
</Chemical>
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<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName>
<QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
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<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
</MeshHeadingList>
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<Keyword MajorTopicYN="N">arrhythmias</Keyword>
<Keyword MajorTopicYN="N">cardiomyopathy</Keyword>
<Keyword MajorTopicYN="N">chloroquine</Keyword>
<Keyword MajorTopicYN="N">hydroxychloroquine</Keyword>
<Keyword MajorTopicYN="N">toxicity</Keyword>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>05</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>08</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>9</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>11</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>9</Month>
<Day>24</Day>
<Hour>5</Hour>
<Minute>31</Minute>
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<affiliations><list><country><li>République populaire de Chine</li>
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<name sortKey="Duan, Dayue D" sort="Duan, Dayue D" uniqKey="Duan D" first="Dayue D" last="Duan">Dayue D. Duan</name>
<name sortKey="Li, Zhuo Ming" sort="Li, Zhuo Ming" uniqKey="Li Z" first="Zhuo-Ming" last="Li">Zhuo-Ming Li</name>
<name sortKey="Liu, Pei Qing" sort="Liu, Pei Qing" uniqKey="Liu P" first="Pei-Qing" last="Liu">Pei-Qing Liu</name>
<name sortKey="Lu, Jing" sort="Lu, Jing" uniqKey="Lu J" first="Jing" last="Lu">Jing Lu</name>
<name sortKey="Ye, Jian Tao" sort="Ye, Jian Tao" uniqKey="Ye J" first="Jian-Tao" last="Ye">Jian-Tao Ye</name>
<name sortKey="Ye, Lingyu Linda" sort="Ye, Lingyu Linda" uniqKey="Ye L" first="Lingyu Linda" last="Ye">Lingyu Linda Ye</name>
<name sortKey="Zhang, Chun Xiang" sort="Zhang, Chun Xiang" uniqKey="Zhang C" first="Chun-Xiang" last="Zhang">Chun-Xiang Zhang</name>
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