Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology.
Identifieur interne : 001268 ( Main/Exploration ); précédent : 001267; suivant : 001269Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology.
Auteurs : Maicon Falavigna [Brésil, Canada] ; Verônica Colpani [Brésil] ; Cinara Stein [Brésil] ; Luciano Cesar Pontes Azevedo [Brésil] ; Angela Maria Bagattini [Brésil] ; Gabriela Vilela De Brito [Brésil] ; José Miguel Chatkin [Brésil] ; Sergio Cimerman [Brésil] ; Mirian De Freitas Dal Ben Corradi [Brésil] ; Clovis Arns Da Cunha [Brésil] ; Flávia Cordeiro De Medeiros [Brésil] ; Haliton Alves De Oliveira Junior [Brésil] ; Leandro Genehr Fritscher [Brésil] ; Marcelo Basso Gazzana [Brésil] ; Débora Dalmas Gr F [Brésil] ; Lays Pires Marra [Brésil] ; Jessica Yumi Matuoka [Brésil] ; Michelle Silva Nunes [Brésil] ; Daniela Vianna Pachito [Brésil] ; Cássia Garcia Moraes Pagano [Brésil] ; Patrícia Do Carmo Silva Parreira [Brésil] ; Rachel Riera [Brésil] ; Amilton Silva [Brésil] ; Bruno De Melo Tavares [Brésil] ; Alexandre Prehn Zavascki [Brésil] ; Regis Goulart Rosa [Brésil] ; Felipe Dal-Pizzol [Brésil]Source :
- Revista Brasileira de terapia intensiva [ 1982-4335 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- Humains, Pandémies.
English descriptors
- KwdEn :
- MESH :
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- COVID-19, Humans, Pandemics.
Abstract
INTRODUCTION
Different therapies are currently used, considered, or proposed for the treatment of COVID-19; for many of those therapies, no appropriate assessment of effectiveness and safety was performed. This document aims to provide scientifically available evidence-based information in a transparent interpretation, to subsidize decisions related to the pharmacological therapy of COVID-19 in Brazil.
METHODS
A group of 27 experts and methodologists integrated a task-force formed by professionals from the Brazilian Association of Intensive Care Medicine (Associação de Medicina Intensiva Brasileira - AMIB), the Brazilian Society of Infectious Diseases (Sociedad Brasileira de Infectologia - SBI) and the Brazilian Society of Pulmonology and Tisiology (Sociedade Brasileira de Pneumologia e Tisiologia - SBPT). Rapid systematic reviews, updated on April 28, 2020, were conducted. The assessment of the quality of evidence and the development of recommendations followed the GRADE system. The recommendations were written on May 5, 8, and 13, 2020.
RESULTS
Eleven recommendations were issued based on low or very-low level evidence. We do not recommend the routine use of hydroxychloroquine, chloroquine, azithromycin, lopinavir/ritonavir, corticosteroids, or tocilizumab for the treatment of COVID-19. Prophylactic heparin should be used in hospitalized patients, however, no anticoagulation should be provided for patients without a specific clinical indication. Antibiotics and oseltamivir should only be considered for patients with suspected bacterial or influenza coinfection, respectively.
CONCLUSION
So far no pharmacological intervention was proven effective and safe to warrant its use in the routine treatment of COVID-19 patients; therefore such patients should ideally be treated in the context of clinical trials. The recommendations herein provided will be revised continuously aiming to capture newly generated evidence.
DOI: 10.5935/0103-507x.20200039
PubMed: 32667444
PubMed Central: PMC7405746
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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São Paulo (SP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:affiliation>Universidade Federal do Paraná - Curitiba (PR), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade Federal do Paraná - Curitiba (PR)</wicri:regionArea></affiliation></author><author><name sortKey="Medeiros, Flavia Cordeiro De" sort="Medeiros, Flavia Cordeiro De" uniqKey="Medeiros F" first="Flávia Cordeiro De" last="Medeiros">Flávia Cordeiro De Medeiros</name><affiliation wicri:level="1"><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea><wicri:noRegion>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:noRegion></affiliation></author><author><name sortKey="Oliveira Junior, Haliton Alves De" sort="Oliveira Junior, Haliton Alves De" uniqKey="Oliveira Junior H" first="Haliton Alves De" last="Oliveira Junior">Haliton Alves De Oliveira Junior</name><affiliation wicri:level="1"><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea><wicri:noRegion>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:noRegion></affiliation></author><author><name sortKey="Fritscher, Leandro Genehr" sort="Fritscher, Leandro Genehr" uniqKey="Fritscher L" first="Leandro Genehr" last="Fritscher">Leandro Genehr Fritscher</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Moinhos de Vento, Porto Alegre, RS</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS)</wicri:regionArea></affiliation></author><author><name sortKey="Gazzana, Marcelo Basso" sort="Gazzana, Marcelo Basso" uniqKey="Gazzana M" first="Marcelo Basso" last="Gazzana">Marcelo Basso Gazzana</name><affiliation wicri:level="1"><nlm:affiliation>Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS)</wicri:regionArea><wicri:noRegion>Universidade Federal do Rio Grande do Sul - Porto Alegre (RS)</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Serviço de Pneumologia e Cirurgia Torácica, Hospital Moinhos de Vento - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Serviço de Pneumologia e Cirurgia Torácica, Hospital Moinhos de Vento - Porto Alegre (RS)</wicri:regionArea><wicri:noRegion>Hospital Moinhos de Vento - Porto Alegre (RS)</wicri:noRegion></affiliation></author><author><name sortKey="Gr F, Debora Dalmas" sort="Gr F, Debora Dalmas" uniqKey="Gr F D" first="Débora Dalmas" last="Gr F">Débora Dalmas Gr F</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Moinhos de Vento, Porto Alegre, RS</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Marra, Lays Pires" sort="Marra, Lays Pires" uniqKey="Marra L" first="Lays Pires" last="Marra">Lays Pires Marra</name><affiliation wicri:level="1"><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea><wicri:noRegion>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:noRegion></affiliation></author><author><name sortKey="Matuoka, Jessica Yumi" sort="Matuoka, Jessica Yumi" uniqKey="Matuoka J" first="Jessica Yumi" last="Matuoka">Jessica Yumi Matuoka</name><affiliation wicri:level="1"><nlm:affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS)</wicri:regionArea></affiliation></author><author><name sortKey="Nunes, Michelle Silva" sort="Nunes, Michelle Silva" uniqKey="Nunes M" first="Michelle Silva" last="Nunes">Michelle Silva Nunes</name><affiliation wicri:level="1"><nlm:affiliation>Empresa Brasileira de Serviços Hospitalares - Brasília (DF), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Empresa Brasileira de Serviços Hospitalares - Brasília (DF)</wicri:regionArea></affiliation></author><author><name sortKey="Pachito, Daniela Vianna" sort="Pachito, Daniela Vianna" uniqKey="Pachito D" first="Daniela Vianna" last="Pachito">Daniela Vianna Pachito</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sírio-Libanês - São Paulo (SP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:affiliation>Fundação Getúlio Vargas - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Fundação Getúlio Vargas - São Paulo (SP)</wicri:regionArea></affiliation></author><author><name sortKey="Pagano, Cassia Garcia Moraes" sort="Pagano, Cassia Garcia Moraes" uniqKey="Pagano C" first="Cássia Garcia Moraes" last="Pagano">Cássia Garcia Moraes Pagano</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Moinhos de Vento, Porto Alegre, RS</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Parreira, Patricia Do Carmo Silva" sort="Parreira, Patricia Do Carmo Silva" uniqKey="Parreira P" first="Patrícia Do Carmo Silva" last="Parreira">Patrícia Do Carmo Silva Parreira</name><affiliation wicri:level="1"><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea><wicri:noRegion>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:noRegion></affiliation></author><author><name sortKey="Riera, Rachel" sort="Riera, Rachel" uniqKey="Riera R" first="Rachel" last="Riera">Rachel Riera</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sírio-Libanês - São Paulo (SP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:affiliation>Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP)</wicri:regionArea><wicri:noRegion>Universidade Federal de São Paulo - São Paulo (SP)</wicri:noRegion></affiliation></author><author><name sortKey="Silva, Amilton" sort="Silva, Amilton" uniqKey="Silva A" first="Amilton" last="Silva">Amilton Silva</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea></affiliation></author><author><name sortKey="Tavares, Bruno De Melo" sort="Tavares, Bruno De Melo" uniqKey="Tavares B" first="Bruno De Melo" last="Tavares">Bruno De Melo Tavares</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea></affiliation></author><author><name sortKey="Zavascki, Alexandre Prehn" sort="Zavascki, Alexandre Prehn" uniqKey="Zavascki A" first="Alexandre Prehn" last="Zavascki">Alexandre Prehn Zavascki</name><affiliation wicri:level="1"><nlm:affiliation>Serviço de Infectologia e Controle de Infecção, Hospital Moinhos de Vento - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Serviço de Infectologia e Controle de Infecção, Hospital Moinhos de Vento - Porto Alegre (RS)</wicri:regionArea><wicri:noRegion>Hospital Moinhos de Vento - Porto Alegre (RS)</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Departamento de Medicina Interna, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Medicina Interna, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS)</wicri:regionArea><wicri:noRegion>Universidade Federal do Rio Grande do Sul - Porto Alegre (RS)</wicri:noRegion></affiliation></author><author><name sortKey="Rosa, Regis Goulart" sort="Rosa, Regis Goulart" uniqKey="Rosa R" first="Regis Goulart" last="Rosa">Regis Goulart Rosa</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Moinhos de Vento, Porto Alegre, RS</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Dal Pizzol, Felipe" sort="Dal Pizzol, Felipe" uniqKey="Dal Pizzol F" first="Felipe" last="Dal-Pizzol">Felipe Dal-Pizzol</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense – Criciúma (SC), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense – Criciúma (SC)</wicri:regionArea><wicri:noRegion>Universidade do Extremo Sul Catarinense – Criciúma (SC)</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Serviço de Medicina Intensiva, Hospital São José - Criciúma (SC), Brasil</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Serviço de Medicina Intensiva, Hospital São José - Criciúma (SC)</wicri:regionArea><wicri:noRegion>Hospital São José - Criciúma (SC)</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32667444</idno><idno type="pmid">32667444</idno><idno type="doi">10.5935/0103-507x.20200039</idno><idno type="pmc">PMC7405746</idno><idno type="wicri:Area/Main/Corpus">001146</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001146</idno><idno type="wicri:Area/Main/Curation">001146</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001146</idno><idno type="wicri:Area/Main/Exploration">001146</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology.</title><author><name sortKey="Falavigna, Maicon" sort="Falavigna, Maicon" uniqKey="Falavigna M" first="Maicon" last="Falavigna">Maicon Falavigna</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Moinhos de Vento, Porto Alegre, RS</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Instituto para Avaliação de Tecnologia em Saúde, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto para Avaliação de Tecnologia em Saúde, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS)</wicri:regionArea><wicri:noRegion>Universidade Federal do Rio Grande do Sul - Porto Alegre (RS)</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Health Research Methods, Evidence, and Impact, McMaster University - Hamilton, Canadá.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Department of Health Research Methods, Evidence, and Impact, McMaster University - Hamilton</wicri:regionArea><wicri:noRegion>McMaster University - Hamilton</wicri:noRegion></affiliation></author><author><name sortKey="Colpani, Veronica" sort="Colpani, Veronica" uniqKey="Colpani V" first="Verônica" last="Colpani">Verônica Colpani</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Moinhos de Vento, Porto Alegre, RS</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS)</wicri:regionArea><wicri:noRegion>Universidade Federal do Rio Grande do Sul - Porto Alegre (RS)</wicri:noRegion></affiliation></author><author><name sortKey="Stein, Cinara" sort="Stein, Cinara" uniqKey="Stein C" first="Cinara" last="Stein">Cinara Stein</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Moinhos de Vento, Porto Alegre, RS</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Azevedo, Luciano Cesar Pontes" sort="Azevedo, Luciano Cesar Pontes" uniqKey="Azevedo L" first="Luciano Cesar Pontes" last="Azevedo">Luciano Cesar Pontes Azevedo</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sírio-Libanês - São Paulo (SP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:affiliation>Disciplina de Emergências Clínicas, Universidade de São Paulo - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Disciplina de Emergências Clínicas, Universidade de São Paulo - São Paulo (SP)</wicri:regionArea><wicri:noRegion>Universidade de São Paulo - São Paulo (SP)</wicri:noRegion></affiliation></author><author><name sortKey="Bagattini, Angela Maria" sort="Bagattini, Angela Maria" uniqKey="Bagattini A" first="Angela Maria" last="Bagattini">Angela Maria Bagattini</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sírio-Libanês - São Paulo (SP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:affiliation>Programa de Pós-Graduação em Medicina Tropical e Saúde Pública, Universidade Federal de Goiás - Goiânia (GO), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Medicina Tropical e Saúde Pública, Universidade Federal de Goiás - Goiânia (GO)</wicri:regionArea><wicri:noRegion>Universidade Federal de Goiás - Goiânia (GO)</wicri:noRegion></affiliation></author><author><name sortKey="Brito, Gabriela Vilela De" sort="Brito, Gabriela Vilela De" uniqKey="Brito G" first="Gabriela Vilela De" last="Brito">Gabriela Vilela De Brito</name><affiliation wicri:level="1"><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea><wicri:noRegion>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:noRegion></affiliation></author><author><name sortKey="Chatkin, Jose Miguel" sort="Chatkin, Jose Miguel" uniqKey="Chatkin J" first="José Miguel" last="Chatkin">José Miguel Chatkin</name><affiliation wicri:level="1"><nlm:affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:affiliation>Sociedade Brasileira de Pneumologia e Tisiologia - Brasília (DF), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Sociedade Brasileira de Pneumologia e Tisiologia - Brasília (DF)</wicri:regionArea></affiliation></author><author><name sortKey="Cimerman, Sergio" sort="Cimerman, Sergio" uniqKey="Cimerman S" first="Sergio" last="Cimerman">Sergio Cimerman</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Infectologia Emílio Ribas - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto de Infectologia Emílio Ribas - São Paulo (SP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:affiliation>Sociedade Brasileira de Infectologia - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Sociedade Brasileira de Infectologia - São Paulo (SP)</wicri:regionArea></affiliation></author><author><name sortKey="Corradi, Mirian De Freitas Dal Ben" sort="Corradi, Mirian De Freitas Dal Ben" uniqKey="Corradi M" first="Mirian De Freitas Dal Ben" last="Corradi">Mirian De Freitas Dal Ben Corradi</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sírio-Libanês - São Paulo (SP)</wicri:regionArea></affiliation></author><author><name sortKey="Cunha, Clovis Arns Da" sort="Cunha, Clovis Arns Da" uniqKey="Cunha C" first="Clovis Arns Da" last="Cunha">Clovis Arns Da Cunha</name><affiliation wicri:level="1"><nlm:affiliation>Sociedade Brasileira de Infectologia - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Sociedade Brasileira de Infectologia - São Paulo (SP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:affiliation>Universidade Federal do Paraná - Curitiba (PR), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade Federal do Paraná - Curitiba (PR)</wicri:regionArea></affiliation></author><author><name sortKey="Medeiros, Flavia Cordeiro De" sort="Medeiros, Flavia Cordeiro De" uniqKey="Medeiros F" first="Flávia Cordeiro De" last="Medeiros">Flávia Cordeiro De Medeiros</name><affiliation wicri:level="1"><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea><wicri:noRegion>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:noRegion></affiliation></author><author><name sortKey="Oliveira Junior, Haliton Alves De" sort="Oliveira Junior, Haliton Alves De" uniqKey="Oliveira Junior H" first="Haliton Alves De" last="Oliveira Junior">Haliton Alves De Oliveira Junior</name><affiliation wicri:level="1"><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea><wicri:noRegion>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:noRegion></affiliation></author><author><name sortKey="Fritscher, Leandro Genehr" sort="Fritscher, Leandro Genehr" uniqKey="Fritscher L" first="Leandro Genehr" last="Fritscher">Leandro Genehr Fritscher</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Moinhos de Vento, Porto Alegre, RS</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS)</wicri:regionArea></affiliation></author><author><name sortKey="Gazzana, Marcelo Basso" sort="Gazzana, Marcelo Basso" uniqKey="Gazzana M" first="Marcelo Basso" last="Gazzana">Marcelo Basso Gazzana</name><affiliation wicri:level="1"><nlm:affiliation>Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS)</wicri:regionArea><wicri:noRegion>Universidade Federal do Rio Grande do Sul - Porto Alegre (RS)</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Serviço de Pneumologia e Cirurgia Torácica, Hospital Moinhos de Vento - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Serviço de Pneumologia e Cirurgia Torácica, Hospital Moinhos de Vento - Porto Alegre (RS)</wicri:regionArea><wicri:noRegion>Hospital Moinhos de Vento - Porto Alegre (RS)</wicri:noRegion></affiliation></author><author><name sortKey="Gr F, Debora Dalmas" sort="Gr F, Debora Dalmas" uniqKey="Gr F D" first="Débora Dalmas" last="Gr F">Débora Dalmas Gr F</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Moinhos de Vento, Porto Alegre, RS</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Marra, Lays Pires" sort="Marra, Lays Pires" uniqKey="Marra L" first="Lays Pires" last="Marra">Lays Pires Marra</name><affiliation wicri:level="1"><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea><wicri:noRegion>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:noRegion></affiliation></author><author><name sortKey="Matuoka, Jessica Yumi" sort="Matuoka, Jessica Yumi" uniqKey="Matuoka J" first="Jessica Yumi" last="Matuoka">Jessica Yumi Matuoka</name><affiliation wicri:level="1"><nlm:affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS)</wicri:regionArea></affiliation></author><author><name sortKey="Nunes, Michelle Silva" sort="Nunes, Michelle Silva" uniqKey="Nunes M" first="Michelle Silva" last="Nunes">Michelle Silva Nunes</name><affiliation wicri:level="1"><nlm:affiliation>Empresa Brasileira de Serviços Hospitalares - Brasília (DF), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Empresa Brasileira de Serviços Hospitalares - Brasília (DF)</wicri:regionArea></affiliation></author><author><name sortKey="Pachito, Daniela Vianna" sort="Pachito, Daniela Vianna" uniqKey="Pachito D" first="Daniela Vianna" last="Pachito">Daniela Vianna Pachito</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sírio-Libanês - São Paulo (SP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:affiliation>Fundação Getúlio Vargas - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Fundação Getúlio Vargas - São Paulo (SP)</wicri:regionArea></affiliation></author><author><name sortKey="Pagano, Cassia Garcia Moraes" sort="Pagano, Cassia Garcia Moraes" uniqKey="Pagano C" first="Cássia Garcia Moraes" last="Pagano">Cássia Garcia Moraes Pagano</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Moinhos de Vento, Porto Alegre, RS</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Parreira, Patricia Do Carmo Silva" sort="Parreira, Patricia Do Carmo Silva" uniqKey="Parreira P" first="Patrícia Do Carmo Silva" last="Parreira">Patrícia Do Carmo Silva Parreira</name><affiliation wicri:level="1"><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea><wicri:noRegion>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:noRegion></affiliation></author><author><name sortKey="Riera, Rachel" sort="Riera, Rachel" uniqKey="Riera R" first="Rachel" last="Riera">Rachel Riera</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sírio-Libanês - São Paulo (SP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:affiliation>Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP)</wicri:regionArea><wicri:noRegion>Universidade Federal de São Paulo - São Paulo (SP)</wicri:noRegion></affiliation></author><author><name sortKey="Silva, Amilton" sort="Silva, Amilton" uniqKey="Silva A" first="Amilton" last="Silva">Amilton Silva</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea></affiliation></author><author><name sortKey="Tavares, Bruno De Melo" sort="Tavares, Bruno De Melo" uniqKey="Tavares B" first="Bruno De Melo" last="Tavares">Bruno De Melo Tavares</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Alemão Oswaldo Cruz - São Paulo (SP)</wicri:regionArea></affiliation></author><author><name sortKey="Zavascki, Alexandre Prehn" sort="Zavascki, Alexandre Prehn" uniqKey="Zavascki A" first="Alexandre Prehn" last="Zavascki">Alexandre Prehn Zavascki</name><affiliation wicri:level="1"><nlm:affiliation>Serviço de Infectologia e Controle de Infecção, Hospital Moinhos de Vento - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Serviço de Infectologia e Controle de Infecção, Hospital Moinhos de Vento - Porto Alegre (RS)</wicri:regionArea><wicri:noRegion>Hospital Moinhos de Vento - Porto Alegre (RS)</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Departamento de Medicina Interna, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Medicina Interna, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS)</wicri:regionArea><wicri:noRegion>Universidade Federal do Rio Grande do Sul - Porto Alegre (RS)</wicri:noRegion></affiliation></author><author><name sortKey="Rosa, Regis Goulart" sort="Rosa, Regis Goulart" uniqKey="Rosa R" first="Regis Goulart" last="Rosa">Regis Goulart Rosa</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Moinhos de Vento, Porto Alegre, RS</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Dal Pizzol, Felipe" sort="Dal Pizzol, Felipe" uniqKey="Dal Pizzol F" first="Felipe" last="Dal-Pizzol">Felipe Dal-Pizzol</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense – Criciúma (SC), Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense – Criciúma (SC)</wicri:regionArea><wicri:noRegion>Universidade do Extremo Sul Catarinense – Criciúma (SC)</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Serviço de Medicina Intensiva, Hospital São José - Criciúma (SC), Brasil</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Serviço de Medicina Intensiva, Hospital São José - Criciúma (SC)</wicri:regionArea><wicri:noRegion>Hospital São José - Criciúma (SC)</wicri:noRegion></affiliation></author></analytic><series><title level="j">Revista Brasileira de terapia intensiva</title><idno type="eISSN">1982-4335</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>COVID-19 (MeSH)</term><term>Coronavirus Infections (drug therapy)</term><term>Humans (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (drug therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains (MeSH)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (traitement médicamenteux)</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>COVID-19</term><term>Humans</term><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Pandémies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Different therapies are currently used, considered, or proposed for the treatment of COVID-19; for many of those therapies, no appropriate assessment of effectiveness and safety was performed. This document aims to provide scientifically available evidence-based information in a transparent interpretation, to subsidize decisions related to the pharmacological therapy of COVID-19 in Brazil.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A group of 27 experts and methodologists integrated a task-force formed by professionals from the Brazilian Association of Intensive Care Medicine (Associação de Medicina Intensiva Brasileira - AMIB), the Brazilian Society of Infectious Diseases (Sociedad Brasileira de Infectologia - SBI) and the Brazilian Society of Pulmonology and Tisiology (Sociedade Brasileira de Pneumologia e Tisiologia - SBPT). Rapid systematic reviews, updated on April 28, 2020, were conducted. The assessment of the quality of evidence and the development of recommendations followed the GRADE system. The recommendations were written on May 5, 8, and 13, 2020.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Eleven recommendations were issued based on low or very-low level evidence. We do not recommend the routine use of hydroxychloroquine, chloroquine, azithromycin, lopinavir/ritonavir, corticosteroids, or tocilizumab for the treatment of COVID-19. Prophylactic heparin should be used in hospitalized patients, however, no anticoagulation should be provided for patients without a specific clinical indication. Antibiotics and oseltamivir should only be considered for patients with suspected bacterial or influenza coinfection, respectively.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>So far no pharmacological intervention was proven effective and safe to warrant its use in the routine treatment of COVID-19 patients; therefore such patients should ideally be treated in the context of clinical trials. The recommendations herein provided will be revised continuously aiming to capture newly generated evidence.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32667444</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>29</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1982-4335</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>2</Issue><PubDate><Year>2020</Year><Month>06</Month></PubDate></JournalIssue><Title>Revista Brasileira de terapia intensiva</Title><ISOAbbreviation>Rev Bras Ter Intensiva</ISOAbbreviation></Journal><ArticleTitle>Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology.</ArticleTitle><Pagination><MedlinePgn>166-196</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0103-507X2020000200166</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.5935/0103-507x.20200039</ELocationID><Abstract><AbstractText Label="INTRODUCTION">Different therapies are currently used, considered, or proposed for the treatment of COVID-19; for many of those therapies, no appropriate assessment of effectiveness and safety was performed. This document aims to provide scientifically available evidence-based information in a transparent interpretation, to subsidize decisions related to the pharmacological therapy of COVID-19 in Brazil.</AbstractText><AbstractText Label="METHODS">A group of 27 experts and methodologists integrated a task-force formed by professionals from the Brazilian Association of Intensive Care Medicine (Associação de Medicina Intensiva Brasileira - AMIB), the Brazilian Society of Infectious Diseases (Sociedad Brasileira de Infectologia - SBI) and the Brazilian Society of Pulmonology and Tisiology (Sociedade Brasileira de Pneumologia e Tisiologia - SBPT). Rapid systematic reviews, updated on April 28, 2020, were conducted. The assessment of the quality of evidence and the development of recommendations followed the GRADE system. The recommendations were written on May 5, 8, and 13, 2020.</AbstractText><AbstractText Label="RESULTS">Eleven recommendations were issued based on low or very-low level evidence. We do not recommend the routine use of hydroxychloroquine, chloroquine, azithromycin, lopinavir/ritonavir, corticosteroids, or tocilizumab for the treatment of COVID-19. Prophylactic heparin should be used in hospitalized patients, however, no anticoagulation should be provided for patients without a specific clinical indication. Antibiotics and oseltamivir should only be considered for patients with suspected bacterial or influenza coinfection, respectively.</AbstractText><AbstractText Label="CONCLUSION">So far no pharmacological intervention was proven effective and safe to warrant its use in the routine treatment of COVID-19 patients; therefore such patients should ideally be treated in the context of clinical trials. The recommendations herein provided will be revised continuously aiming to capture newly generated evidence.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Falavigna</LastName><ForeName>Maicon</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Instituto para Avaliação de Tecnologia em Saúde, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Health Research Methods, Evidence, and Impact, McMaster University - Hamilton, Canadá.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colpani</LastName><ForeName>Verônica</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stein</LastName><ForeName>Cinara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Azevedo</LastName><ForeName>Luciano Cesar Pontes</ForeName><Initials>LCP</Initials><AffiliationInfo><Affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Disciplina de Emergências Clínicas, Universidade de São Paulo - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bagattini</LastName><ForeName>Angela Maria</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Medicina Tropical e Saúde Pública, Universidade Federal de Goiás - Goiânia (GO), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brito</LastName><ForeName>Gabriela Vilela de</ForeName><Initials>GV</Initials><AffiliationInfo><Affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chatkin</LastName><ForeName>José Miguel</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sociedade Brasileira de Pneumologia e Tisiologia - Brasília (DF), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cimerman</LastName><ForeName>Sergio</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Instituto de Infectologia Emílio Ribas - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sociedade Brasileira de Infectologia - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corradi</LastName><ForeName>Mirian de Freitas Dal Ben</ForeName><Initials>MFDB</Initials><AffiliationInfo><Affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cunha</LastName><ForeName>Clovis Arns da</ForeName><Initials>CAD</Initials><AffiliationInfo><Affiliation>Sociedade Brasileira de Infectologia - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Universidade Federal do Paraná - Curitiba (PR), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Medeiros</LastName><ForeName>Flávia Cordeiro de</ForeName><Initials>FC</Initials><AffiliationInfo><Affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oliveira Junior</LastName><ForeName>Haliton Alves de</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fritscher</LastName><ForeName>Leandro Genehr</ForeName><Initials>LG</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gazzana</LastName><ForeName>Marcelo Basso</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Serviço de Pneumologia e Cirurgia Torácica, Hospital Moinhos de Vento - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gräf</LastName><ForeName>Débora Dalmas</ForeName><Initials>DD</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marra</LastName><ForeName>Lays Pires</ForeName><Initials>LP</Initials><AffiliationInfo><Affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matuoka</LastName><ForeName>Jessica Yumi</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nunes</LastName><ForeName>Michelle Silva</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Empresa Brasileira de Serviços Hospitalares - Brasília (DF), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pachito</LastName><ForeName>Daniela Vianna</ForeName><Initials>DV</Initials><AffiliationInfo><Affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Fundação Getúlio Vargas - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pagano</LastName><ForeName>Cássia Garcia Moraes</ForeName><Initials>CGM</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parreira</LastName><ForeName>Patrícia do Carmo Silva</ForeName><Initials>PCS</Initials><AffiliationInfo><Affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riera</LastName><ForeName>Rachel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silva</LastName><ForeName>Amilton</ForeName><Initials>A</Initials><Suffix>Júnior</Suffix><AffiliationInfo><Affiliation>Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tavares</LastName><ForeName>Bruno de Melo</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zavascki</LastName><ForeName>Alexandre Prehn</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Serviço de Infectologia e Controle de Infecção, Hospital Moinhos de Vento - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Departamento de Medicina Interna, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosa</LastName><ForeName>Regis Goulart</ForeName><Initials>RG</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dal-Pizzol</LastName><ForeName>Felipe</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense – Criciúma (SC), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Serviço de Medicina Intensiva, Hospital São José - Criciúma (SC), Brasil</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><Language>por</Language><PublicationTypeList><PublicationType UI="D016446">Consensus Development Conference</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017065">Practice Guideline</PublicationType></PublicationTypeList><VernacularTitle>Diretrizes para o tratamento farmacológico da COVID-19. 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Carmo Silva" last="Parreira">Patrícia Do Carmo Silva Parreira</name><name sortKey="Riera, Rachel" sort="Riera, Rachel" uniqKey="Riera R" first="Rachel" last="Riera">Rachel Riera</name><name sortKey="Riera, Rachel" sort="Riera, Rachel" uniqKey="Riera R" first="Rachel" last="Riera">Rachel Riera</name><name sortKey="Rosa, Regis Goulart" sort="Rosa, Regis Goulart" uniqKey="Rosa R" first="Regis Goulart" last="Rosa">Regis Goulart Rosa</name><name sortKey="Silva, Amilton" sort="Silva, Amilton" uniqKey="Silva A" first="Amilton" last="Silva">Amilton Silva</name><name sortKey="Stein, Cinara" sort="Stein, Cinara" uniqKey="Stein C" first="Cinara" last="Stein">Cinara Stein</name><name sortKey="Tavares, Bruno De Melo" sort="Tavares, Bruno De Melo" uniqKey="Tavares B" first="Bruno De Melo" last="Tavares">Bruno De Melo Tavares</name><name sortKey="Zavascki, Alexandre Prehn" sort="Zavascki, Alexandre Prehn" uniqKey="Zavascki A" first="Alexandre Prehn" last="Zavascki">Alexandre Prehn Zavascki</name><name sortKey="Zavascki, Alexandre Prehn" sort="Zavascki, Alexandre Prehn" uniqKey="Zavascki A" first="Alexandre Prehn" last="Zavascki">Alexandre Prehn Zavascki</name></country><country name="Canada"><noRegion><name sortKey="Falavigna, Maicon" sort="Falavigna, Maicon" uniqKey="Falavigna M" first="Maicon" last="Falavigna">Maicon Falavigna</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Sante
|area= CovidChloroV1
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|type= RBID
|clé= pubmed:32667444
|texte= Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology.
}}
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