Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology.
Identifieur interne : 001146 ( Main/Corpus ); précédent : 001145; suivant : 001147Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology.
Auteurs : Maicon Falavigna ; Verônica Colpani ; Cinara Stein ; Luciano Cesar Pontes Azevedo ; Angela Maria Bagattini ; Gabriela Vilela De Brito ; José Miguel Chatkin ; Sergio Cimerman ; Mirian De Freitas Dal Ben Corradi ; Clovis Arns Da Cunha ; Flávia Cordeiro De Medeiros ; Haliton Alves De Oliveira Junior ; Leandro Genehr Fritscher ; Marcelo Basso Gazzana ; Débora Dalmas Gr F ; Lays Pires Marra ; Jessica Yumi Matuoka ; Michelle Silva Nunes ; Daniela Vianna Pachito ; Cássia Garcia Moraes Pagano ; Patrícia Do Carmo Silva Parreira ; Rachel Riera ; Amilton Silva ; Bruno De Melo Tavares ; Alexandre Prehn Zavascki ; Regis Goulart Rosa ; Felipe Dal-PizzolSource :
- Revista Brasileira de terapia intensiva [ 1982-4335 ] ; 2020.
English descriptors
- KwdEn :
- MESH :
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- COVID-19, Humans, Pandemics.
Abstract
INTRODUCTION
Different therapies are currently used, considered, or proposed for the treatment of COVID-19; for many of those therapies, no appropriate assessment of effectiveness and safety was performed. This document aims to provide scientifically available evidence-based information in a transparent interpretation, to subsidize decisions related to the pharmacological therapy of COVID-19 in Brazil.
METHODS
A group of 27 experts and methodologists integrated a task-force formed by professionals from the Brazilian Association of Intensive Care Medicine (Associação de Medicina Intensiva Brasileira - AMIB), the Brazilian Society of Infectious Diseases (Sociedad Brasileira de Infectologia - SBI) and the Brazilian Society of Pulmonology and Tisiology (Sociedade Brasileira de Pneumologia e Tisiologia - SBPT). Rapid systematic reviews, updated on April 28, 2020, were conducted. The assessment of the quality of evidence and the development of recommendations followed the GRADE system. The recommendations were written on May 5, 8, and 13, 2020.
RESULTS
Eleven recommendations were issued based on low or very-low level evidence. We do not recommend the routine use of hydroxychloroquine, chloroquine, azithromycin, lopinavir/ritonavir, corticosteroids, or tocilizumab for the treatment of COVID-19. Prophylactic heparin should be used in hospitalized patients, however, no anticoagulation should be provided for patients without a specific clinical indication. Antibiotics and oseltamivir should only be considered for patients with suspected bacterial or influenza coinfection, respectively.
CONCLUSION
So far no pharmacological intervention was proven effective and safe to warrant its use in the routine treatment of COVID-19 patients; therefore such patients should ideally be treated in the context of clinical trials. The recommendations herein provided will be revised continuously aiming to capture newly generated evidence.
DOI: 10.5935/0103-507x.20200039
PubMed: 32667444
PubMed Central: PMC7405746
Links to Exploration step
pubmed:32667444Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology.</title><author><name sortKey="Falavigna, Maicon" sort="Falavigna, Maicon" uniqKey="Falavigna M" first="Maicon" last="Falavigna">Maicon Falavigna</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Instituto para Avaliação de Tecnologia em Saúde, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Health Research Methods, Evidence, and Impact, McMaster University - Hamilton, Canadá.</nlm:affiliation></affiliation></author><author><name sortKey="Colpani, Veronica" sort="Colpani, Veronica" uniqKey="Colpani V" first="Verônica" last="Colpani">Verônica Colpani</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Stein, Cinara" sort="Stein, Cinara" uniqKey="Stein C" first="Cinara" last="Stein">Cinara Stein</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Azevedo, Luciano Cesar Pontes" sort="Azevedo, Luciano Cesar Pontes" uniqKey="Azevedo L" first="Luciano Cesar Pontes" last="Azevedo">Luciano Cesar Pontes Azevedo</name><affiliation><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Disciplina de Emergências Clínicas, Universidade de São Paulo - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Bagattini, Angela Maria" sort="Bagattini, Angela Maria" uniqKey="Bagattini A" first="Angela Maria" last="Bagattini">Angela Maria Bagattini</name><affiliation><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Programa de Pós-Graduação em Medicina Tropical e Saúde Pública, Universidade Federal de Goiás - Goiânia (GO), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Brito, Gabriela Vilela De" sort="Brito, Gabriela Vilela De" uniqKey="Brito G" first="Gabriela Vilela De" last="Brito">Gabriela Vilela De Brito</name><affiliation><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Chatkin, Jose Miguel" sort="Chatkin, Jose Miguel" uniqKey="Chatkin J" first="José Miguel" last="Chatkin">José Miguel Chatkin</name><affiliation><nlm:affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Sociedade Brasileira de Pneumologia e Tisiologia - Brasília (DF), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Cimerman, Sergio" sort="Cimerman, Sergio" uniqKey="Cimerman S" first="Sergio" last="Cimerman">Sergio Cimerman</name><affiliation><nlm:affiliation>Instituto de Infectologia Emílio Ribas - São Paulo (SP), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Sociedade Brasileira de Infectologia - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Corradi, Mirian De Freitas Dal Ben" sort="Corradi, Mirian De Freitas Dal Ben" uniqKey="Corradi M" first="Mirian De Freitas Dal Ben" last="Corradi">Mirian De Freitas Dal Ben Corradi</name><affiliation><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Cunha, Clovis Arns Da" sort="Cunha, Clovis Arns Da" uniqKey="Cunha C" first="Clovis Arns Da" last="Cunha">Clovis Arns Da Cunha</name><affiliation><nlm:affiliation>Sociedade Brasileira de Infectologia - São Paulo (SP), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Universidade Federal do Paraná - Curitiba (PR), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Medeiros, Flavia Cordeiro De" sort="Medeiros, Flavia Cordeiro De" uniqKey="Medeiros F" first="Flávia Cordeiro De" last="Medeiros">Flávia Cordeiro De Medeiros</name><affiliation><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Oliveira Junior, Haliton Alves De" sort="Oliveira Junior, Haliton Alves De" uniqKey="Oliveira Junior H" first="Haliton Alves De" last="Oliveira Junior">Haliton Alves De Oliveira Junior</name><affiliation><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Fritscher, Leandro Genehr" sort="Fritscher, Leandro Genehr" uniqKey="Fritscher L" first="Leandro Genehr" last="Fritscher">Leandro Genehr Fritscher</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Gazzana, Marcelo Basso" sort="Gazzana, Marcelo Basso" uniqKey="Gazzana M" first="Marcelo Basso" last="Gazzana">Marcelo Basso Gazzana</name><affiliation><nlm:affiliation>Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Serviço de Pneumologia e Cirurgia Torácica, Hospital Moinhos de Vento - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Gr F, Debora Dalmas" sort="Gr F, Debora Dalmas" uniqKey="Gr F D" first="Débora Dalmas" last="Gr F">Débora Dalmas Gr F</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Marra, Lays Pires" sort="Marra, Lays Pires" uniqKey="Marra L" first="Lays Pires" last="Marra">Lays Pires Marra</name><affiliation><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Matuoka, Jessica Yumi" sort="Matuoka, Jessica Yumi" uniqKey="Matuoka J" first="Jessica Yumi" last="Matuoka">Jessica Yumi Matuoka</name><affiliation><nlm:affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Nunes, Michelle Silva" sort="Nunes, Michelle Silva" uniqKey="Nunes M" first="Michelle Silva" last="Nunes">Michelle Silva Nunes</name><affiliation><nlm:affiliation>Empresa Brasileira de Serviços Hospitalares - Brasília (DF), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Pachito, Daniela Vianna" sort="Pachito, Daniela Vianna" uniqKey="Pachito D" first="Daniela Vianna" last="Pachito">Daniela Vianna Pachito</name><affiliation><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Fundação Getúlio Vargas - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Pagano, Cassia Garcia Moraes" sort="Pagano, Cassia Garcia Moraes" uniqKey="Pagano C" first="Cássia Garcia Moraes" last="Pagano">Cássia Garcia Moraes Pagano</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Parreira, Patricia Do Carmo Silva" sort="Parreira, Patricia Do Carmo Silva" uniqKey="Parreira P" first="Patrícia Do Carmo Silva" last="Parreira">Patrícia Do Carmo Silva Parreira</name><affiliation><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Riera, Rachel" sort="Riera, Rachel" uniqKey="Riera R" first="Rachel" last="Riera">Rachel Riera</name><affiliation><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Silva, Amilton" sort="Silva, Amilton" uniqKey="Silva A" first="Amilton" last="Silva">Amilton Silva</name><affiliation><nlm:affiliation>Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Tavares, Bruno De Melo" sort="Tavares, Bruno De Melo" uniqKey="Tavares B" first="Bruno De Melo" last="Tavares">Bruno De Melo Tavares</name><affiliation><nlm:affiliation>Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Zavascki, Alexandre Prehn" sort="Zavascki, Alexandre Prehn" uniqKey="Zavascki A" first="Alexandre Prehn" last="Zavascki">Alexandre Prehn Zavascki</name><affiliation><nlm:affiliation>Serviço de Infectologia e Controle de Infecção, Hospital Moinhos de Vento - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Departamento de Medicina Interna, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Rosa, Regis Goulart" sort="Rosa, Regis Goulart" uniqKey="Rosa R" first="Regis Goulart" last="Rosa">Regis Goulart Rosa</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Dal Pizzol, Felipe" sort="Dal Pizzol, Felipe" uniqKey="Dal Pizzol F" first="Felipe" last="Dal-Pizzol">Felipe Dal-Pizzol</name><affiliation><nlm:affiliation>Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense – Criciúma (SC), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Serviço de Medicina Intensiva, Hospital São José - Criciúma (SC), Brasil</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32667444</idno><idno type="pmid">32667444</idno><idno type="doi">10.5935/0103-507x.20200039</idno><idno type="pmc">PMC7405746</idno><idno type="wicri:Area/Main/Corpus">001146</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001146</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology.</title><author><name sortKey="Falavigna, Maicon" sort="Falavigna, Maicon" uniqKey="Falavigna M" first="Maicon" last="Falavigna">Maicon Falavigna</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Instituto para Avaliação de Tecnologia em Saúde, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Health Research Methods, Evidence, and Impact, McMaster University - Hamilton, Canadá.</nlm:affiliation></affiliation></author><author><name sortKey="Colpani, Veronica" sort="Colpani, Veronica" uniqKey="Colpani V" first="Verônica" last="Colpani">Verônica Colpani</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Stein, Cinara" sort="Stein, Cinara" uniqKey="Stein C" first="Cinara" last="Stein">Cinara Stein</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Azevedo, Luciano Cesar Pontes" sort="Azevedo, Luciano Cesar Pontes" uniqKey="Azevedo L" first="Luciano Cesar Pontes" last="Azevedo">Luciano Cesar Pontes Azevedo</name><affiliation><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Disciplina de Emergências Clínicas, Universidade de São Paulo - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Bagattini, Angela Maria" sort="Bagattini, Angela Maria" uniqKey="Bagattini A" first="Angela Maria" last="Bagattini">Angela Maria Bagattini</name><affiliation><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Programa de Pós-Graduação em Medicina Tropical e Saúde Pública, Universidade Federal de Goiás - Goiânia (GO), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Brito, Gabriela Vilela De" sort="Brito, Gabriela Vilela De" uniqKey="Brito G" first="Gabriela Vilela De" last="Brito">Gabriela Vilela De Brito</name><affiliation><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Chatkin, Jose Miguel" sort="Chatkin, Jose Miguel" uniqKey="Chatkin J" first="José Miguel" last="Chatkin">José Miguel Chatkin</name><affiliation><nlm:affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Sociedade Brasileira de Pneumologia e Tisiologia - Brasília (DF), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Cimerman, Sergio" sort="Cimerman, Sergio" uniqKey="Cimerman S" first="Sergio" last="Cimerman">Sergio Cimerman</name><affiliation><nlm:affiliation>Instituto de Infectologia Emílio Ribas - São Paulo (SP), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Sociedade Brasileira de Infectologia - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Corradi, Mirian De Freitas Dal Ben" sort="Corradi, Mirian De Freitas Dal Ben" uniqKey="Corradi M" first="Mirian De Freitas Dal Ben" last="Corradi">Mirian De Freitas Dal Ben Corradi</name><affiliation><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Cunha, Clovis Arns Da" sort="Cunha, Clovis Arns Da" uniqKey="Cunha C" first="Clovis Arns Da" last="Cunha">Clovis Arns Da Cunha</name><affiliation><nlm:affiliation>Sociedade Brasileira de Infectologia - São Paulo (SP), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Universidade Federal do Paraná - Curitiba (PR), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Medeiros, Flavia Cordeiro De" sort="Medeiros, Flavia Cordeiro De" uniqKey="Medeiros F" first="Flávia Cordeiro De" last="Medeiros">Flávia Cordeiro De Medeiros</name><affiliation><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Oliveira Junior, Haliton Alves De" sort="Oliveira Junior, Haliton Alves De" uniqKey="Oliveira Junior H" first="Haliton Alves De" last="Oliveira Junior">Haliton Alves De Oliveira Junior</name><affiliation><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Fritscher, Leandro Genehr" sort="Fritscher, Leandro Genehr" uniqKey="Fritscher L" first="Leandro Genehr" last="Fritscher">Leandro Genehr Fritscher</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Gazzana, Marcelo Basso" sort="Gazzana, Marcelo Basso" uniqKey="Gazzana M" first="Marcelo Basso" last="Gazzana">Marcelo Basso Gazzana</name><affiliation><nlm:affiliation>Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Serviço de Pneumologia e Cirurgia Torácica, Hospital Moinhos de Vento - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Gr F, Debora Dalmas" sort="Gr F, Debora Dalmas" uniqKey="Gr F D" first="Débora Dalmas" last="Gr F">Débora Dalmas Gr F</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Marra, Lays Pires" sort="Marra, Lays Pires" uniqKey="Marra L" first="Lays Pires" last="Marra">Lays Pires Marra</name><affiliation><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Matuoka, Jessica Yumi" sort="Matuoka, Jessica Yumi" uniqKey="Matuoka J" first="Jessica Yumi" last="Matuoka">Jessica Yumi Matuoka</name><affiliation><nlm:affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Nunes, Michelle Silva" sort="Nunes, Michelle Silva" uniqKey="Nunes M" first="Michelle Silva" last="Nunes">Michelle Silva Nunes</name><affiliation><nlm:affiliation>Empresa Brasileira de Serviços Hospitalares - Brasília (DF), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Pachito, Daniela Vianna" sort="Pachito, Daniela Vianna" uniqKey="Pachito D" first="Daniela Vianna" last="Pachito">Daniela Vianna Pachito</name><affiliation><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Fundação Getúlio Vargas - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Pagano, Cassia Garcia Moraes" sort="Pagano, Cassia Garcia Moraes" uniqKey="Pagano C" first="Cássia Garcia Moraes" last="Pagano">Cássia Garcia Moraes Pagano</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Parreira, Patricia Do Carmo Silva" sort="Parreira, Patricia Do Carmo Silva" uniqKey="Parreira P" first="Patrícia Do Carmo Silva" last="Parreira">Patrícia Do Carmo Silva Parreira</name><affiliation><nlm:affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Riera, Rachel" sort="Riera, Rachel" uniqKey="Riera R" first="Rachel" last="Riera">Rachel Riera</name><affiliation><nlm:affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Silva, Amilton" sort="Silva, Amilton" uniqKey="Silva A" first="Amilton" last="Silva">Amilton Silva</name><affiliation><nlm:affiliation>Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Tavares, Bruno De Melo" sort="Tavares, Bruno De Melo" uniqKey="Tavares B" first="Bruno De Melo" last="Tavares">Bruno De Melo Tavares</name><affiliation><nlm:affiliation>Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Zavascki, Alexandre Prehn" sort="Zavascki, Alexandre Prehn" uniqKey="Zavascki A" first="Alexandre Prehn" last="Zavascki">Alexandre Prehn Zavascki</name><affiliation><nlm:affiliation>Serviço de Infectologia e Controle de Infecção, Hospital Moinhos de Vento - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Departamento de Medicina Interna, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Rosa, Regis Goulart" sort="Rosa, Regis Goulart" uniqKey="Rosa R" first="Regis Goulart" last="Rosa">Regis Goulart Rosa</name><affiliation><nlm:affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</nlm:affiliation></affiliation></author><author><name sortKey="Dal Pizzol, Felipe" sort="Dal Pizzol, Felipe" uniqKey="Dal Pizzol F" first="Felipe" last="Dal-Pizzol">Felipe Dal-Pizzol</name><affiliation><nlm:affiliation>Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense – Criciúma (SC), Brasil.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Serviço de Medicina Intensiva, Hospital São José - Criciúma (SC), Brasil</nlm:affiliation></affiliation></author></analytic><series><title level="j">Revista Brasileira de terapia intensiva</title><idno type="eISSN">1982-4335</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>COVID-19 (MeSH)</term><term>Coronavirus Infections (drug therapy)</term><term>Humans (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (drug therapy)</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>COVID-19</term><term>Humans</term><term>Pandemics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Different therapies are currently used, considered, or proposed for the treatment of COVID-19; for many of those therapies, no appropriate assessment of effectiveness and safety was performed. This document aims to provide scientifically available evidence-based information in a transparent interpretation, to subsidize decisions related to the pharmacological therapy of COVID-19 in Brazil.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A group of 27 experts and methodologists integrated a task-force formed by professionals from the Brazilian Association of Intensive Care Medicine (Associação de Medicina Intensiva Brasileira - AMIB), the Brazilian Society of Infectious Diseases (Sociedad Brasileira de Infectologia - SBI) and the Brazilian Society of Pulmonology and Tisiology (Sociedade Brasileira de Pneumologia e Tisiologia - SBPT). Rapid systematic reviews, updated on April 28, 2020, were conducted. The assessment of the quality of evidence and the development of recommendations followed the GRADE system. The recommendations were written on May 5, 8, and 13, 2020.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Eleven recommendations were issued based on low or very-low level evidence. We do not recommend the routine use of hydroxychloroquine, chloroquine, azithromycin, lopinavir/ritonavir, corticosteroids, or tocilizumab for the treatment of COVID-19. Prophylactic heparin should be used in hospitalized patients, however, no anticoagulation should be provided for patients without a specific clinical indication. Antibiotics and oseltamivir should only be considered for patients with suspected bacterial or influenza coinfection, respectively.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>So far no pharmacological intervention was proven effective and safe to warrant its use in the routine treatment of COVID-19 patients; therefore such patients should ideally be treated in the context of clinical trials. The recommendations herein provided will be revised continuously aiming to capture newly generated evidence.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32667444</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>29</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1982-4335</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>2</Issue><PubDate><Year>2020</Year><Month>06</Month></PubDate></JournalIssue><Title>Revista Brasileira de terapia intensiva</Title><ISOAbbreviation>Rev Bras Ter Intensiva</ISOAbbreviation></Journal><ArticleTitle>Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology.</ArticleTitle><Pagination><MedlinePgn>166-196</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0103-507X2020000200166</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.5935/0103-507x.20200039</ELocationID><Abstract><AbstractText Label="INTRODUCTION">Different therapies are currently used, considered, or proposed for the treatment of COVID-19; for many of those therapies, no appropriate assessment of effectiveness and safety was performed. This document aims to provide scientifically available evidence-based information in a transparent interpretation, to subsidize decisions related to the pharmacological therapy of COVID-19 in Brazil.</AbstractText><AbstractText Label="METHODS">A group of 27 experts and methodologists integrated a task-force formed by professionals from the Brazilian Association of Intensive Care Medicine (Associação de Medicina Intensiva Brasileira - AMIB), the Brazilian Society of Infectious Diseases (Sociedad Brasileira de Infectologia - SBI) and the Brazilian Society of Pulmonology and Tisiology (Sociedade Brasileira de Pneumologia e Tisiologia - SBPT). Rapid systematic reviews, updated on April 28, 2020, were conducted. The assessment of the quality of evidence and the development of recommendations followed the GRADE system. The recommendations were written on May 5, 8, and 13, 2020.</AbstractText><AbstractText Label="RESULTS">Eleven recommendations were issued based on low or very-low level evidence. We do not recommend the routine use of hydroxychloroquine, chloroquine, azithromycin, lopinavir/ritonavir, corticosteroids, or tocilizumab for the treatment of COVID-19. Prophylactic heparin should be used in hospitalized patients, however, no anticoagulation should be provided for patients without a specific clinical indication. Antibiotics and oseltamivir should only be considered for patients with suspected bacterial or influenza coinfection, respectively.</AbstractText><AbstractText Label="CONCLUSION">So far no pharmacological intervention was proven effective and safe to warrant its use in the routine treatment of COVID-19 patients; therefore such patients should ideally be treated in the context of clinical trials. The recommendations herein provided will be revised continuously aiming to capture newly generated evidence.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Falavigna</LastName><ForeName>Maicon</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Instituto para Avaliação de Tecnologia em Saúde, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Health Research Methods, Evidence, and Impact, McMaster University - Hamilton, Canadá.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colpani</LastName><ForeName>Verônica</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stein</LastName><ForeName>Cinara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Azevedo</LastName><ForeName>Luciano Cesar Pontes</ForeName><Initials>LCP</Initials><AffiliationInfo><Affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Disciplina de Emergências Clínicas, Universidade de São Paulo - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bagattini</LastName><ForeName>Angela Maria</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Medicina Tropical e Saúde Pública, Universidade Federal de Goiás - Goiânia (GO), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brito</LastName><ForeName>Gabriela Vilela de</ForeName><Initials>GV</Initials><AffiliationInfo><Affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chatkin</LastName><ForeName>José Miguel</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sociedade Brasileira de Pneumologia e Tisiologia - Brasília (DF), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cimerman</LastName><ForeName>Sergio</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Instituto de Infectologia Emílio Ribas - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sociedade Brasileira de Infectologia - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corradi</LastName><ForeName>Mirian de Freitas Dal Ben</ForeName><Initials>MFDB</Initials><AffiliationInfo><Affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cunha</LastName><ForeName>Clovis Arns da</ForeName><Initials>CAD</Initials><AffiliationInfo><Affiliation>Sociedade Brasileira de Infectologia - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Universidade Federal do Paraná - Curitiba (PR), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Medeiros</LastName><ForeName>Flávia Cordeiro de</ForeName><Initials>FC</Initials><AffiliationInfo><Affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oliveira Junior</LastName><ForeName>Haliton Alves de</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fritscher</LastName><ForeName>Leandro Genehr</ForeName><Initials>LG</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gazzana</LastName><ForeName>Marcelo Basso</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Serviço de Pneumologia e Cirurgia Torácica, Hospital Moinhos de Vento - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gräf</LastName><ForeName>Débora Dalmas</ForeName><Initials>DD</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marra</LastName><ForeName>Lays Pires</ForeName><Initials>LP</Initials><AffiliationInfo><Affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matuoka</LastName><ForeName>Jessica Yumi</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Pontifícia Universidade Católica do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nunes</LastName><ForeName>Michelle Silva</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Empresa Brasileira de Serviços Hospitalares - Brasília (DF), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pachito</LastName><ForeName>Daniela Vianna</ForeName><Initials>DV</Initials><AffiliationInfo><Affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Fundação Getúlio Vargas - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pagano</LastName><ForeName>Cássia Garcia Moraes</ForeName><Initials>CGM</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parreira</LastName><ForeName>Patrícia do Carmo Silva</ForeName><Initials>PCS</Initials><AffiliationInfo><Affiliation>Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riera</LastName><ForeName>Rachel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Hospital Sírio-Libanês - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silva</LastName><ForeName>Amilton</ForeName><Initials>A</Initials><Suffix>Júnior</Suffix><AffiliationInfo><Affiliation>Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tavares</LastName><ForeName>Bruno de Melo</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Hospital Alemão Oswaldo Cruz - São Paulo (SP), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zavascki</LastName><ForeName>Alexandre Prehn</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Serviço de Infectologia e Controle de Infecção, Hospital Moinhos de Vento - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Departamento de Medicina Interna, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosa</LastName><ForeName>Regis Goulart</ForeName><Initials>RG</Initials><AffiliationInfo><Affiliation>Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dal-Pizzol</LastName><ForeName>Felipe</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense – Criciúma (SC), Brasil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Serviço de Medicina Intensiva, Hospital São José - Criciúma (SC), Brasil</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><Language>por</Language><PublicationTypeList><PublicationType UI="D016446">Consensus Development Conference</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017065">Practice Guideline</PublicationType></PublicationTypeList><VernacularTitle>Diretrizes para o tratamento farmacológico da COVID-19. Consenso da Associação de Medicina Intensiva Brasileira, da Sociedade Brasileira de Infectologia e da Sociedade Brasileira de Pneumologia e Tisiologia.</VernacularTitle><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Brazil</Country><MedlineTA>Rev Bras Ter Intensiva</MedlineTA><NlmUniqueID>9506692</NlmUniqueID><ISSNLinking>0103-507X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>05</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32667444</ArticleId><ArticleId IdType="pii">S0103-507X2020000200166</ArticleId><ArticleId IdType="doi">10.5935/0103-507x.20200039</ArticleId><ArticleId IdType="pmc">PMC7405746</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Med (N Y). 2020 Jun 5;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32838355</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood Adv. 2019 Dec 10;3(23):3898-3944</Citation><ArticleIdList><ArticleId IdType="pubmed">31794602</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2020 May 19;24(1):241</Citation><ArticleIdList><ArticleId IdType="pubmed">32430057</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Virol. 2020 Jul;92(7):814-818</Citation><ArticleIdList><ArticleId IdType="pubmed">32253759</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 May 19;323(19):1897-1898</Citation><ArticleIdList><ArticleId IdType="pubmed">32208486</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Epidemiol. 2017 Nov;91:47-53</Citation><ArticleIdList><ArticleId IdType="pubmed">28911999</ArticleId></ArticleIdList></Reference><Reference><Citation>Cochrane Database Syst Rev. 2019 Oct 3;10:ED000142</Citation><ArticleIdList><ArticleId IdType="pubmed">31643080</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2020 Mar;8(3):267-276</Citation><ArticleIdList><ArticleId IdType="pubmed">32043986</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Jun 18;382(25):2411-2418</Citation><ArticleIdList><ArticleId IdType="pubmed">32379955</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2020 May;18(5):1094-1099</Citation><ArticleIdList><ArticleId IdType="pubmed">32220112</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Intern Med. 2020 Jul 1;180(7):934-943</Citation><ArticleIdList><ArticleId IdType="pubmed">32167524</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 15;395(10223):507-513</Citation><ArticleIdList><ArticleId IdType="pubmed">32007143</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 May 7;382(19):1787-1799</Citation><ArticleIdList><ArticleId IdType="pubmed">32187464</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2020 May 14;369:m1849</Citation><ArticleIdList><ArticleId IdType="pubmed">32409561</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccines (Basel). 2018 May 21;6(2):</Citation><ArticleIdList><ArticleId IdType="pubmed">29883414</ArticleId></ArticleIdList></Reference><Reference><Citation>Health Res Policy Syst. 2018 Jul 13;16(1):63</Citation><ArticleIdList><ArticleId IdType="pubmed">30005679</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 May 30;395(10238):1695-1704</Citation><ArticleIdList><ArticleId IdType="pubmed">32401715</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 Apr 28;323(16):1574-1581</Citation><ArticleIdList><ArticleId IdType="pubmed">32250385</ArticleId></ArticleIdList></Reference><Reference><Citation>Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(2):215-219</Citation><ArticleIdList><ArticleId IdType="pubmed">32391667</ArticleId></ArticleIdList></Reference><Reference><Citation>Med (N Y). 2020 May 19;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32838353</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Feb 20;382(8):727-733</Citation><ArticleIdList><ArticleId IdType="pubmed">31978945</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect. 2020 Jul;81(1):e21-e23</Citation><ArticleIdList><ArticleId IdType="pubmed">32283143</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Apr 30;382(18):1708-1720</Citation><ArticleIdList><ArticleId IdType="pubmed">32109013</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2008 Apr 26;336(7650):924-6</Citation><ArticleIdList><ArticleId IdType="pubmed">18436948</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Coll Cardiol. 2020 Jun 16;75(23):2992-2993</Citation><ArticleIdList><ArticleId IdType="pubmed">32330546</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 May 26;323(20):2052-2059</Citation><ArticleIdList><ArticleId IdType="pubmed">32320003</ArticleId></ArticleIdList></Reference><Reference><Citation>J Allergy Clin Immunol. 2020 Jul;146(1):110-118</Citation><ArticleIdList><ArticleId IdType="pubmed">32294485</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Heart Assoc. 2020 Jun 16;9(12):e017144</Citation><ArticleIdList><ArticleId IdType="pubmed">32463348</ArticleId></ArticleIdList></Reference><Reference><Citation>Travel Med Infect Dis. 2020 Mar - Apr;34:101663</Citation><ArticleIdList><ArticleId IdType="pubmed">32289548</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 May 16;395(10236):1569-1578</Citation><ArticleIdList><ArticleId IdType="pubmed">32423584</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Jul 16;383(3):e12</Citation><ArticleIdList><ArticleId IdType="pubmed">32343505</ArticleId></ArticleIdList></Reference><Reference><Citation>Chest. 2020 Sep;158(3):864-865</Citation><ArticleIdList><ArticleId IdType="pubmed">32387517</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Soc Nephrol. 2020 Jun;31(6):1150-1156</Citation><ArticleIdList><ArticleId IdType="pubmed">32317402</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2020 Oct;20(10):1135-1140</Citation><ArticleIdList><ArticleId IdType="pubmed">32526193</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2017 Sep 21;358:j4008</Citation><ArticleIdList><ArticleId IdType="pubmed">28935701</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Netw Open. 2020 Apr 24;3(4):e208857</Citation><ArticleIdList><ArticleId IdType="pubmed">32330277</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2016 Oct 12;355:i4919</Citation><ArticleIdList><ArticleId IdType="pubmed">27733354</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Transl Sci. 2020 Sep 3;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32881340</ArticleId></ArticleIdList></Reference><Reference><Citation>Travel Med Infect Dis. 2020 May - Jun;35:101738</Citation><ArticleIdList><ArticleId IdType="pubmed">32387409</ArticleId></ArticleIdList></Reference><Reference><Citation>Syst Rev. 2015 Jan 14;4:4</Citation><ArticleIdList><ArticleId IdType="pubmed">25589399</ArticleId></ArticleIdList></Reference><Reference><Citation>Med Mal Infect. 2020 Jun;50(4):384</Citation><ArticleIdList><ArticleId IdType="pubmed">32240719</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacol Res. 2020 Jul;157:104874</Citation><ArticleIdList><ArticleId IdType="pubmed">32360581</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2015 May 2;385(9979):1729-1737</Citation><ArticleIdList><ArticleId IdType="pubmed">25640810</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975</Citation><ArticleIdList><ArticleId IdType="pubmed">32350134</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2019 Mar 5;68(6):e1-e47</Citation><ArticleIdList><ArticleId IdType="pubmed">30566567</ArticleId></ArticleIdList></Reference><Reference><Citation>Signal Transduct Target Ther. 2020 Feb 21;5(1):18</Citation><ArticleIdList><ArticleId IdType="pubmed">32296012</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9490-9496</Citation><ArticleIdList><ArticleId IdType="pubmed">32253318</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Cardiol. 2020 Sep 1;5(9):1036-1041</Citation><ArticleIdList><ArticleId IdType="pubmed">32936252</ArticleId></ArticleIdList></Reference><Reference><Citation>MMWR Morb Mortal Wkly Rep. 2020 Feb 21;69(7):177-182</Citation><ArticleIdList><ArticleId IdType="pubmed">32078591</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Antimicrob Agents. 2020 Jul;56(1):105949</Citation><ArticleIdList><ArticleId IdType="pubmed">32205204</ArticleId></ArticleIdList></Reference><Reference><Citation>Leukemia. 2020 Jun;34(6):1503-1511</Citation><ArticleIdList><ArticleId IdType="pubmed">32372026</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology.
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