A Case of Breakthrough COVID-19 during Hydroxychloroquine Maintenance.
Identifieur interne : 001A41 ( Main/Exploration ); précédent : 001A40; suivant : 001A42A Case of Breakthrough COVID-19 during Hydroxychloroquine Maintenance.
Auteurs : Byeong Yun Ahn [Corée du Sud] ; Chang Kyung Kang [Corée du Sud] ; Jong Do Seo [Corée du Sud] ; Pyoeng Gyun Choe [Corée du Sud] ; Sang Hoon Song [Corée du Sud] ; Wan Beom Park [Corée du Sud] ; Sang Won Park [Corée du Sud] ; Nam Joong Kim [Corée du Sud] ; Myoung Don Oh [Corée du Sud]Source :
- Journal of Korean medical science [ 1598-6357 ] ; 2020.
Descripteurs français
- KwdFr :
- AMP (analogues et dérivés), AMP (usage thérapeutique), Adulte d'âge moyen (MeSH), Alanine (analogues et dérivés), Alanine (usage thérapeutique), Antiviraux (usage thérapeutique), Azithromycine (usage thérapeutique), Betacoronavirus (effets des médicaments et des substances chimiques), Femelle (MeSH), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Infections à coronavirus (prévention et contrôle), Infections à coronavirus (traitement médicamenteux), Pandémies (prévention et contrôle), Pneumopathie virale (prévention et contrôle), Pneumopathie virale (traitement médicamenteux), Prévention primaire (méthodes).
- MESH :
- analogues et dérivés : AMP, Alanine.
- effets des médicaments et des substances chimiques : Betacoronavirus.
- méthodes : Prévention primaire.
- prévention et contrôle : Infections à coronavirus, Pandémies, Pneumopathie virale.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : AMP, Alanine, Antiviraux, Azithromycine, Hydroxychloroquine.
- Adulte d'âge moyen, Femelle, Humains.
English descriptors
- KwdEn :
- Adenosine Monophosphate (analogs & derivatives), Adenosine Monophosphate (therapeutic use), Alanine (analogs & derivatives), Alanine (therapeutic use), Antiviral Agents (therapeutic use), Azithromycin (therapeutic use), Betacoronavirus (drug effects), COVID-19 (MeSH), Coronavirus Infections (drug therapy), Coronavirus Infections (prevention & control), Female (MeSH), Humans (MeSH), Hydroxychloroquine (therapeutic use), Middle Aged (MeSH), Pandemics (prevention & control), Pneumonia, Viral (drug therapy), Pneumonia, Viral (prevention & control), Primary Prevention (methods), SARS-CoV-2 (MeSH).
- MESH :
- chemical , analogs & derivatives : Adenosine Monophosphate, Alanine.
- chemical , therapeutic use : Adenosine Monophosphate, Alanine, Antiviral Agents, Azithromycin, Hydroxychloroquine.
- drug effects : Betacoronavirus.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- methods : Primary Prevention.
- prevention & control : Coronavirus Infections, Pandemics, Pneumonia, Viral.
- COVID-19, Female, Humans, Middle Aged, SARS-CoV-2.
Abstract
There have been controversies on the prophylactic effect of hydroxychloroquine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We describe a patient, 60-year old Korean woman, with coronavirus disease 2019 (COVID-19) who had been taking hydroxychloroquine for 6 months. Her serum and saliva concentrations of hydroxychloroquine were 280 μg/L and 4,890 μg/L, respectively. The present case raises concerns on hydroxychloroquine's role as a prophylactic agent for COVID-19.
DOI: 10.3346/jkms.2020.35.e231
PubMed: 32567262
PubMed Central: PMC7308141
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Alanine (therapeutic use)</term>
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<term>Azithromycin (therapeutic use)</term>
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<front><div type="abstract" xml:lang="en">There have been controversies on the prophylactic effect of hydroxychloroquine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We describe a patient, 60-year old Korean woman, with coronavirus disease 2019 (COVID-19) who had been taking hydroxychloroquine for 6 months. Her serum and saliva concentrations of hydroxychloroquine were 280 μg/L and 4,890 μg/L, respectively. The present case raises concerns on hydroxychloroquine's role as a prophylactic agent for COVID-19.</div>
</front>
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<DateCompleted><Year>2020</Year>
<Month>06</Month>
<Day>29</Day>
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<DateRevised><Year>2020</Year>
<Month>12</Month>
<Day>18</Day>
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<Issue>24</Issue>
<PubDate><Year>2020</Year>
<Month>Jun</Month>
<Day>22</Day>
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<Title>Journal of Korean medical science</Title>
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<ArticleTitle>A Case of Breakthrough COVID-19 during Hydroxychloroquine Maintenance.</ArticleTitle>
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<ELocationID EIdType="doi" ValidYN="Y">10.3346/jkms.2020.35.e231</ELocationID>
<Abstract><AbstractText>There have been controversies on the prophylactic effect of hydroxychloroquine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We describe a patient, 60-year old Korean woman, with coronavirus disease 2019 (COVID-19) who had been taking hydroxychloroquine for 6 months. Her serum and saliva concentrations of hydroxychloroquine were 280 μg/L and 4,890 μg/L, respectively. The present case raises concerns on hydroxychloroquine's role as a prophylactic agent for COVID-19.</AbstractText>
<CopyrightInformation>© 2020 The Korean Academy of Medical Sciences.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Ahn</LastName>
<ForeName>Byeong Yun</ForeName>
<Initials>BY</Initials>
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<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y" EqualContrib="Y"><LastName>Kang</LastName>
<ForeName>Chang Kyung</ForeName>
<Initials>CK</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Seo</LastName>
<ForeName>Jong Do</ForeName>
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<AffiliationInfo><Affiliation>Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Choe</LastName>
<ForeName>Pyoeng Gyun</ForeName>
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<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Sang Hoon</ForeName>
<Initials>SH</Initials>
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<AffiliationInfo><Affiliation>Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Wan Beom</ForeName>
<Initials>WB</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-0022-9625</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Sang Won</ForeName>
<Initials>SW</Initials>
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<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. njkmd@snu.ac.kr.</Affiliation>
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<ForeName>Myoung Don</ForeName>
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<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
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<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>06</Month>
<Day>22</Day>
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<CoiStatement>The authors have no potential conflicts of interest to disclose.</CoiStatement>
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<affiliations><list><country><li>Corée du Sud</li>
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<tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Ahn, Byeong Yun" sort="Ahn, Byeong Yun" uniqKey="Ahn B" first="Byeong Yun" last="Ahn">Byeong Yun Ahn</name>
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<name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name>
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<name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name>
<name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name>
<name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name>
<name sortKey="Seo, Jong Do" sort="Seo, Jong Do" uniqKey="Seo J" first="Jong Do" last="Seo">Jong Do Seo</name>
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