Chloroquine and hydroxychloroquine in the context of COVID-19.
Identifieur interne : 001780 ( Main/Corpus ); précédent : 001779; suivant : 001781Chloroquine and hydroxychloroquine in the context of COVID-19.
Auteurs : Ashutosh M. Shukla ; Lennox K. Archibald ; Aparna Wagle Shukla ; Hiren J. Mehta ; Kartikeya CherabuddiSource :
- Drugs in context [ 1745-1981 ] ; 2020.
Abstract
Chloroquine and closely related structural analogs, employed initially for the treatment of malaria, are now gaining worldwide attention due to the rapidly spreading pandemic caused by severe acute respiratory syndrome-coronavirus-2, named coronavirus disease (COVID) of 2019 (COVID-19). Although much of this attention has a mechanistic basis, the hard efficacy data for chloroquine/hydroxychloroquine in the management of the clinical syndrome of COVID-19 have been limited thus far. This review aims to present the available in vitro and clinical data for the role of chloroquine/hydroxychloroquine in COVID-19 and attempts to put them into perspective, especially in relation to the different risks/benefits particular to each patient who may require treatment.
DOI: 10.7573/dic.2020-4-5
PubMed: 32373183
PubMed Central: PMC7192209
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chloroquine and hydroxychloroquine in the context of COVID-19.</title><author><name sortKey="Shukla, Ashutosh M" sort="Shukla, Ashutosh M" uniqKey="Shukla A" first="Ashutosh M" last="Shukla">Ashutosh M. Shukla</name><affiliation><nlm:affiliation>North Florida South Georgia VHS, Gainesville, FL, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Medicine, University of Florida, Gainesville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Archibald, Lennox K" sort="Archibald, Lennox K" uniqKey="Archibald L" first="Lennox K" last="Archibald">Lennox K. Archibald</name><affiliation><nlm:affiliation>North Florida South Georgia VHS, Gainesville, FL, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Medicine, University of Florida, Gainesville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wagle Shukla, Aparna" sort="Wagle Shukla, Aparna" uniqKey="Wagle Shukla A" first="Aparna" last="Wagle Shukla">Aparna Wagle Shukla</name><affiliation><nlm:affiliation>Department of Neurology, University of Florida, Gainesville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mehta, Hiren J" sort="Mehta, Hiren J" uniqKey="Mehta H" first="Hiren J" last="Mehta">Hiren J. Mehta</name><affiliation><nlm:affiliation>Department of Medicine, University of Florida, Gainesville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cherabuddi, Kartikeya" sort="Cherabuddi, Kartikeya" uniqKey="Cherabuddi K" first="Kartikeya" last="Cherabuddi">Kartikeya Cherabuddi</name><affiliation><nlm:affiliation>Department of Medicine, University of Florida, Gainesville, FL, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32373183</idno><idno type="pmid">32373183</idno><idno type="doi">10.7573/dic.2020-4-5</idno><idno type="pmc">PMC7192209</idno><idno type="wicri:Area/Main/Corpus">001780</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001780</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chloroquine and hydroxychloroquine in the context of COVID-19.</title><author><name sortKey="Shukla, Ashutosh M" sort="Shukla, Ashutosh M" uniqKey="Shukla A" first="Ashutosh M" last="Shukla">Ashutosh M. Shukla</name><affiliation><nlm:affiliation>North Florida South Georgia VHS, Gainesville, FL, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Medicine, University of Florida, Gainesville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Archibald, Lennox K" sort="Archibald, Lennox K" uniqKey="Archibald L" first="Lennox K" last="Archibald">Lennox K. Archibald</name><affiliation><nlm:affiliation>North Florida South Georgia VHS, Gainesville, FL, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Medicine, University of Florida, Gainesville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wagle Shukla, Aparna" sort="Wagle Shukla, Aparna" uniqKey="Wagle Shukla A" first="Aparna" last="Wagle Shukla">Aparna Wagle Shukla</name><affiliation><nlm:affiliation>Department of Neurology, University of Florida, Gainesville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mehta, Hiren J" sort="Mehta, Hiren J" uniqKey="Mehta H" first="Hiren J" last="Mehta">Hiren J. Mehta</name><affiliation><nlm:affiliation>Department of Medicine, University of Florida, Gainesville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cherabuddi, Kartikeya" sort="Cherabuddi, Kartikeya" uniqKey="Cherabuddi K" first="Kartikeya" last="Cherabuddi">Kartikeya Cherabuddi</name><affiliation><nlm:affiliation>Department of Medicine, University of Florida, Gainesville, FL, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Drugs in context</title><idno type="ISSN">1745-1981</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chloroquine and closely related structural analogs, employed initially for the treatment of malaria, are now gaining worldwide attention due to the rapidly spreading pandemic caused by severe acute respiratory syndrome-coronavirus-2, named coronavirus disease (COVID) of 2019 (COVID-19). Although much of this attention has a mechanistic basis, the hard efficacy data for chloroquine/hydroxychloroquine in the management of the clinical syndrome of COVID-19 have been limited thus far. This review aims to present the available <i>in vitro</i> and clinical data for the role of chloroquine/hydroxychloroquine in COVID-19 and attempts to put them into perspective, especially in relation to the different risks/benefits particular to each patient who may require treatment.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32373183</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1745-1981</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Drugs in context</Title><ISOAbbreviation>Drugs Context</ISOAbbreviation></Journal><ArticleTitle>Chloroquine and hydroxychloroquine in the context of COVID-19.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">2020-4-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.7573/dic.2020-4-5</ELocationID><Abstract><AbstractText>Chloroquine and closely related structural analogs, employed initially for the treatment of malaria, are now gaining worldwide attention due to the rapidly spreading pandemic caused by severe acute respiratory syndrome-coronavirus-2, named coronavirus disease (COVID) of 2019 (COVID-19). Although much of this attention has a mechanistic basis, the hard efficacy data for chloroquine/hydroxychloroquine in the management of the clinical syndrome of COVID-19 have been limited thus far. This review aims to present the available <i>in vitro</i> and clinical data for the role of chloroquine/hydroxychloroquine in COVID-19 and attempts to put them into perspective, especially in relation to the different risks/benefits particular to each patient who may require treatment.</AbstractText><CopyrightInformation>Copyright © 2020 Shukla AM, Archibald LK, Wagle Shukla A, Mehta HJ, Cherabuddi K.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shukla</LastName><ForeName>Ashutosh M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>North Florida South Georgia VHS, Gainesville, FL, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, University of Florida, Gainesville, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Archibald</LastName><ForeName>Lennox K</ForeName><Initials>LK</Initials><AffiliationInfo><Affiliation>North Florida South Georgia VHS, Gainesville, FL, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, University of Florida, Gainesville, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wagle Shukla</LastName><ForeName>Aparna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Florida, Gainesville, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mehta</LastName><ForeName>Hiren J</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Florida, Gainesville, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cherabuddi</LastName><ForeName>Kartikeya</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Florida, Gainesville, FL, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>I01 CX001661</GrantID><Acronym>CX</Acronym><Agency>CSRD VA</Agency><Country>United States</Country></Grant><Grant><GrantID>I01 HX002639</GrantID><Acronym>HX</Acronym><Agency>HSRD VA</Agency><Country>United States</Country></Grant><Grant><GrantID>K23 NS092957</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Drugs Context</MedlineTA><NlmUniqueID>101262187</NlmUniqueID><ISSNLinking>1740-4398</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword><Keyword MajorTopicYN="Y">anti-inflammatory</Keyword><Keyword MajorTopicYN="Y">antimalarial</Keyword><Keyword MajorTopicYN="Y">antiviral</Keyword><Keyword MajorTopicYN="Y">chloroquine</Keyword><Keyword MajorTopicYN="Y">hydroxychloroquine</Keyword><Keyword MajorTopicYN="Y">immunomodulatory</Keyword><Keyword MajorTopicYN="Y">pandemic</Keyword></KeywordList><CoiStatement>Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest relevant to this manuscript. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2020/04/dic.2020-4-5-COI.pdf</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>04</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>5</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>5</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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