Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial.
Identifieur interne : 001128 ( Main/Corpus ); précédent : 001127; suivant : 001129Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial.
Auteurs : Oriol Mitjà ; Marc Corbacho-Monné ; Maria Ubals ; Cristian Tebe ; Judith Pe Afiel ; Aurelio Tobias ; Ester Ballana ; Andrea Alemany ; Núria Riera-Martí ; Carla A. Pérez ; Clara Su Er ; Pep Laporte ; Pol Admella ; Jordi Mitjà ; Mireia Clua ; Laia Bertran ; Maria Sarquella ; Sergi Gavilán ; Jordi Ara ; Josep M. Argimon ; Jordi Casabona ; Gabriel Cuatrecasas ; Paz Ca Adas ; Aleix Elizalde-Torrent ; Robert Fabregat ; Magí Farré ; Anna Forcada ; Gemma Flores-Mateo ; Esteve Muntada ; Núria Nadal ; Silvia Narejos ; Aroa N. Gil-Ortega ; Nuria Prat ; Jordi Puig ; Carles Qui Ones ; Juliana Reyes-Ure A ; Ferran Ramírez-Viaplana ; Lidia Ruiz ; Eva Riveira-Mu Oz ; Alba Sierra ; César Velasco ; Rosa Maria Vivanco-Hidalgo ; Alexis Sentís ; Camila G-Beiras ; Bonaventura Clotet ; Martí Vall-MayansSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2020.
Abstract
BACKGROUND
No therapeutics have yet been proven effective for the treatment of mild-illness caused by SARS-CoV-2. We aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be more efficacious than no-treatment for outpatients with mild Covid-19.
METHODS
We conducted a multicenter, open label, randomized controlled trial in Catalonia (Spain) between March 17, and May 26, 2020. Eligible Covid-19 cases were non-hospitalized adult patients with recently confirmed SARS-CoV-2 infection and less than five days of symptoms. Patients were assigned to receive HCQ (800 mg on day 1, followed by 400 mg once daily for 6 days) or no antiviral treatment (not-placebo controlled). Study outcomes were the reduction of viral RNA load in nasopharyngeal swabs up to 7 days after treatment start, patient disease progression using the WHO scale up to 28 days, and time to complete resolution of symptoms. Adverse events were assessed up to 28 days.
RESULTS
A total of 293 patients were eligible for intention-to-treat analysis: 157 in the control arm and 136 in the intervention arm. The mean age was 41.6 years (SD 12.6), mean viral load at baseline was 7.90 (SD 1.82) Log10 copies/mL, and median time from symptom onset to randomization was 3 days. No significant differences were found in the mean reduction of viral load at day 3 (-1.41 vs. -1.41 Log10 copies/mL in the control and intervention arm, respectively; difference 0.01 [95% CI -0.28;0.29]) or at day 7 (-3.37 vs. -3.44; d -0.07 [-0.44;0.29]). This treatment regimen did not reduce risk of hospitalization (7.1%, control vs. 5.9%, intervention; RR 0.75 [0.32;1.77]) nor shortened the time to complete resolution of symptoms (12 days, control vs. 10 days, intervention; p = 0.38). No relevant treatment-related AEs were reported.
CONCLUSIONS
In patients with mild Covid-19, no benefit was observed with HCQ beyond the usual care.
DOI: 10.1093/cid/ciaa1009
PubMed: 32674126
PubMed Central: PMC7454406
Links to Exploration step
pubmed:32674126Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial.</title><author><name sortKey="Mitja, Oriol" sort="Mitja, Oriol" uniqKey="Mitja O" first="Oriol" last="Mitjà">Oriol Mitjà</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Lihir Medical Centre - InternationalSOS, Lihir Island, Papua New Guinea.</nlm:affiliation></affiliation></author><author><name sortKey="Corbacho Monne, Marc" sort="Corbacho Monne, Marc" uniqKey="Corbacho Monne M" first="Marc" last="Corbacho-Monné">Marc Corbacho-Monné</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ubals, Maria" sort="Ubals, Maria" uniqKey="Ubals M" first="Maria" last="Ubals">Maria Ubals</name><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tebe, Cristian" sort="Tebe, Cristian" uniqKey="Tebe C" first="Cristian" last="Tebe">Cristian Tebe</name><affiliation><nlm:affiliation>Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Pe Afiel, Judith" sort="Pe Afiel, Judith" uniqKey="Pe Afiel J" first="Judith" last="Pe Afiel">Judith Pe Afiel</name><affiliation><nlm:affiliation>Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tobias, Aurelio" sort="Tobias, Aurelio" uniqKey="Tobias A" first="Aurelio" last="Tobias">Aurelio Tobias</name><affiliation><nlm:affiliation>Institute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ballana, Ester" sort="Ballana, Ester" uniqKey="Ballana E" first="Ester" last="Ballana">Ester Ballana</name><affiliation><nlm:affiliation>IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Alemany, Andrea" sort="Alemany, Andrea" uniqKey="Alemany A" first="Andrea" last="Alemany">Andrea Alemany</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Riera Marti, Nuria" sort="Riera Marti, Nuria" uniqKey="Riera Marti N" first="Núria" last="Riera-Martí">Núria Riera-Martí</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Perez, Carla A" sort="Perez, Carla A" uniqKey="Perez C" first="Carla A" last="Pérez">Carla A. Pérez</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Su Er, Clara" sort="Su Er, Clara" uniqKey="Su Er C" first="Clara" last="Su Er">Clara Su Er</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Laporte, Pep" sort="Laporte, Pep" uniqKey="Laporte P" first="Pep" last="Laporte">Pep Laporte</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Admella, Pol" sort="Admella, Pol" uniqKey="Admella P" first="Pol" last="Admella">Pol Admella</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mitja, Jordi" sort="Mitja, Jordi" uniqKey="Mitja J" first="Jordi" last="Mitjà">Jordi Mitjà</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Clua, Mireia" sort="Clua, Mireia" uniqKey="Clua M" first="Mireia" last="Clua">Mireia Clua</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bertran, Laia" sort="Bertran, Laia" uniqKey="Bertran L" first="Laia" last="Bertran">Laia Bertran</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sarquella, Maria" sort="Sarquella, Maria" uniqKey="Sarquella M" first="Maria" last="Sarquella">Maria Sarquella</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gavilan, Sergi" sort="Gavilan, Sergi" uniqKey="Gavilan S" first="Sergi" last="Gavilán">Sergi Gavilán</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ara, Jordi" sort="Ara, Jordi" uniqKey="Ara J" first="Jordi" last="Ara">Jordi Ara</name><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Argimon, Josep M" sort="Argimon, Josep M" uniqKey="Argimon J" first="Josep M" last="Argimon">Josep M. Argimon</name><affiliation><nlm:affiliation>Direcció-gerència, Institut Català de la Salut, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Casabona, Jordi" sort="Casabona, Jordi" uniqKey="Casabona J" first="Jordi" last="Casabona">Jordi Casabona</name><affiliation><nlm:affiliation>Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Catalan Institute of Oncology (ICO)-Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cuatrecasas, Gabriel" sort="Cuatrecasas, Gabriel" uniqKey="Cuatrecasas G" first="Gabriel" last="Cuatrecasas">Gabriel Cuatrecasas</name><affiliation><nlm:affiliation>Equip d'atenció primària de Sarria, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ca Adas, Paz" sort="Ca Adas, Paz" uniqKey="Ca Adas P" first="Paz" last="Ca Adas">Paz Ca Adas</name><affiliation><nlm:affiliation>SYNLAB, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Elizalde Torrent, Aleix" sort="Elizalde Torrent, Aleix" uniqKey="Elizalde Torrent A" first="Aleix" last="Elizalde-Torrent">Aleix Elizalde-Torrent</name><affiliation><nlm:affiliation>IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fabregat, Robert" sort="Fabregat, Robert" uniqKey="Fabregat R" first="Robert" last="Fabregat">Robert Fabregat</name><affiliation><nlm:affiliation>Direcció General de Recerca i Innovació en Salut, Generalitat de Catalunya, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Farre, Magi" sort="Farre, Magi" uniqKey="Farre M" first="Magí" last="Farré">Magí Farré</name><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Forcada, Anna" sort="Forcada, Anna" uniqKey="Forcada A" first="Anna" last="Forcada">Anna Forcada</name><affiliation><nlm:affiliation>Gerència territorial de Catalunya Central, Institut Català de la Salut, St Fruitós del Bages, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Flores Mateo, Gemma" sort="Flores Mateo, Gemma" uniqKey="Flores Mateo G" first="Gemma" last="Flores-Mateo">Gemma Flores-Mateo</name><affiliation><nlm:affiliation>Xarxa Sanitària i Social Santa Tecla, Tarragona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Muntada, Esteve" sort="Muntada, Esteve" uniqKey="Muntada E" first="Esteve" last="Muntada">Esteve Muntada</name><affiliation><nlm:affiliation>Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Catalan Institute of Oncology (ICO)-Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Nadal, Nuria" sort="Nadal, Nuria" uniqKey="Nadal N" first="Núria" last="Nadal">Núria Nadal</name><affiliation><nlm:affiliation>Gerència territorial de Barcelona, Institut Català de la Salut, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Narejos, Silvia" sort="Narejos, Silvia" uniqKey="Narejos S" first="Silvia" last="Narejos">Silvia Narejos</name><affiliation><nlm:affiliation>Entitat de Base Asociativa Centelles- Atenció Primària, Centelles, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gil Ortega, Aroa N" sort="Gil Ortega, Aroa N" uniqKey="Gil Ortega A" first="Aroa N" last="Gil-Ortega">Aroa N. Gil-Ortega</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Prat, Nuria" sort="Prat, Nuria" uniqKey="Prat N" first="Nuria" last="Prat">Nuria Prat</name><affiliation><nlm:affiliation>Gerència territorial de Àmbit Metropolità nord, Institut Català de la Salut, Sabadell, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Puig, Jordi" sort="Puig, Jordi" uniqKey="Puig J" first="Jordi" last="Puig">Jordi Puig</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Qui Ones, Carles" sort="Qui Ones, Carles" uniqKey="Qui Ones C" first="Carles" last="Qui Ones">Carles Qui Ones</name><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Reyes Ure A, Juliana" sort="Reyes Ure A, Juliana" uniqKey="Reyes Ure A J" first="Juliana" last="Reyes-Ure A">Juliana Reyes-Ure A</name><affiliation><nlm:affiliation>Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Catalan Institute of Oncology (ICO)-Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ramirez Viaplana, Ferran" sort="Ramirez Viaplana, Ferran" uniqKey="Ramirez Viaplana F" first="Ferran" last="Ramírez-Viaplana">Ferran Ramírez-Viaplana</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ruiz, Lidia" sort="Ruiz, Lidia" uniqKey="Ruiz L" first="Lidia" last="Ruiz">Lidia Ruiz</name><affiliation><nlm:affiliation>IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Riveira Mu Oz, Eva" sort="Riveira Mu Oz, Eva" uniqKey="Riveira Mu Oz E" first="Eva" last="Riveira-Mu Oz">Eva Riveira-Mu Oz</name><affiliation><nlm:affiliation>IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sierra, Alba" sort="Sierra, Alba" uniqKey="Sierra A" first="Alba" last="Sierra">Alba Sierra</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Velasco, Cesar" sort="Velasco, Cesar" uniqKey="Velasco C" first="César" last="Velasco">César Velasco</name><affiliation><nlm:affiliation>Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Vivanco Hidalgo, Rosa Maria" sort="Vivanco Hidalgo, Rosa Maria" uniqKey="Vivanco Hidalgo R" first="Rosa Maria" last="Vivanco-Hidalgo">Rosa Maria Vivanco-Hidalgo</name><affiliation><nlm:affiliation>Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sentis, Alexis" sort="Sentis, Alexis" uniqKey="Sentis A" first="Alexis" last="Sentís">Alexis Sentís</name><affiliation><nlm:affiliation>Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Catalan Institute of Oncology (ICO)-Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="G Beiras, Camila" sort="G Beiras, Camila" uniqKey="G Beiras C" first="Camila" last="G-Beiras">Camila G-Beiras</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Clotet, Bonaventura" sort="Clotet, Bonaventura" uniqKey="Clotet B" first="Bonaventura" last="Clotet">Bonaventura Clotet</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Universitat de Vic-Universitat Central de Catalunya (UVIC-UCC), Vic, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Vall Mayans, Marti" sort="Vall Mayans, Marti" uniqKey="Vall Mayans M" first="Martí" last="Vall-Mayans">Martí Vall-Mayans</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32674126</idno><idno type="pmid">32674126</idno><idno type="doi">10.1093/cid/ciaa1009</idno><idno type="pmc">PMC7454406</idno><idno type="wicri:Area/Main/Corpus">001128</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001128</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial.</title><author><name sortKey="Mitja, Oriol" sort="Mitja, Oriol" uniqKey="Mitja O" first="Oriol" last="Mitjà">Oriol Mitjà</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Lihir Medical Centre - InternationalSOS, Lihir Island, Papua New Guinea.</nlm:affiliation></affiliation></author><author><name sortKey="Corbacho Monne, Marc" sort="Corbacho Monne, Marc" uniqKey="Corbacho Monne M" first="Marc" last="Corbacho-Monné">Marc Corbacho-Monné</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ubals, Maria" sort="Ubals, Maria" uniqKey="Ubals M" first="Maria" last="Ubals">Maria Ubals</name><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tebe, Cristian" sort="Tebe, Cristian" uniqKey="Tebe C" first="Cristian" last="Tebe">Cristian Tebe</name><affiliation><nlm:affiliation>Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Pe Afiel, Judith" sort="Pe Afiel, Judith" uniqKey="Pe Afiel J" first="Judith" last="Pe Afiel">Judith Pe Afiel</name><affiliation><nlm:affiliation>Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tobias, Aurelio" sort="Tobias, Aurelio" uniqKey="Tobias A" first="Aurelio" last="Tobias">Aurelio Tobias</name><affiliation><nlm:affiliation>Institute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ballana, Ester" sort="Ballana, Ester" uniqKey="Ballana E" first="Ester" last="Ballana">Ester Ballana</name><affiliation><nlm:affiliation>IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Alemany, Andrea" sort="Alemany, Andrea" uniqKey="Alemany A" first="Andrea" last="Alemany">Andrea Alemany</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Riera Marti, Nuria" sort="Riera Marti, Nuria" uniqKey="Riera Marti N" first="Núria" last="Riera-Martí">Núria Riera-Martí</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Perez, Carla A" sort="Perez, Carla A" uniqKey="Perez C" first="Carla A" last="Pérez">Carla A. Pérez</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Su Er, Clara" sort="Su Er, Clara" uniqKey="Su Er C" first="Clara" last="Su Er">Clara Su Er</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Laporte, Pep" sort="Laporte, Pep" uniqKey="Laporte P" first="Pep" last="Laporte">Pep Laporte</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Admella, Pol" sort="Admella, Pol" uniqKey="Admella P" first="Pol" last="Admella">Pol Admella</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mitja, Jordi" sort="Mitja, Jordi" uniqKey="Mitja J" first="Jordi" last="Mitjà">Jordi Mitjà</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Clua, Mireia" sort="Clua, Mireia" uniqKey="Clua M" first="Mireia" last="Clua">Mireia Clua</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bertran, Laia" sort="Bertran, Laia" uniqKey="Bertran L" first="Laia" last="Bertran">Laia Bertran</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sarquella, Maria" sort="Sarquella, Maria" uniqKey="Sarquella M" first="Maria" last="Sarquella">Maria Sarquella</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gavilan, Sergi" sort="Gavilan, Sergi" uniqKey="Gavilan S" first="Sergi" last="Gavilán">Sergi Gavilán</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ara, Jordi" sort="Ara, Jordi" uniqKey="Ara J" first="Jordi" last="Ara">Jordi Ara</name><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Argimon, Josep M" sort="Argimon, Josep M" uniqKey="Argimon J" first="Josep M" last="Argimon">Josep M. Argimon</name><affiliation><nlm:affiliation>Direcció-gerència, Institut Català de la Salut, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Casabona, Jordi" sort="Casabona, Jordi" uniqKey="Casabona J" first="Jordi" last="Casabona">Jordi Casabona</name><affiliation><nlm:affiliation>Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Catalan Institute of Oncology (ICO)-Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cuatrecasas, Gabriel" sort="Cuatrecasas, Gabriel" uniqKey="Cuatrecasas G" first="Gabriel" last="Cuatrecasas">Gabriel Cuatrecasas</name><affiliation><nlm:affiliation>Equip d'atenció primària de Sarria, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ca Adas, Paz" sort="Ca Adas, Paz" uniqKey="Ca Adas P" first="Paz" last="Ca Adas">Paz Ca Adas</name><affiliation><nlm:affiliation>SYNLAB, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Elizalde Torrent, Aleix" sort="Elizalde Torrent, Aleix" uniqKey="Elizalde Torrent A" first="Aleix" last="Elizalde-Torrent">Aleix Elizalde-Torrent</name><affiliation><nlm:affiliation>IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fabregat, Robert" sort="Fabregat, Robert" uniqKey="Fabregat R" first="Robert" last="Fabregat">Robert Fabregat</name><affiliation><nlm:affiliation>Direcció General de Recerca i Innovació en Salut, Generalitat de Catalunya, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Farre, Magi" sort="Farre, Magi" uniqKey="Farre M" first="Magí" last="Farré">Magí Farré</name><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Forcada, Anna" sort="Forcada, Anna" uniqKey="Forcada A" first="Anna" last="Forcada">Anna Forcada</name><affiliation><nlm:affiliation>Gerència territorial de Catalunya Central, Institut Català de la Salut, St Fruitós del Bages, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Flores Mateo, Gemma" sort="Flores Mateo, Gemma" uniqKey="Flores Mateo G" first="Gemma" last="Flores-Mateo">Gemma Flores-Mateo</name><affiliation><nlm:affiliation>Xarxa Sanitària i Social Santa Tecla, Tarragona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Muntada, Esteve" sort="Muntada, Esteve" uniqKey="Muntada E" first="Esteve" last="Muntada">Esteve Muntada</name><affiliation><nlm:affiliation>Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Catalan Institute of Oncology (ICO)-Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Nadal, Nuria" sort="Nadal, Nuria" uniqKey="Nadal N" first="Núria" last="Nadal">Núria Nadal</name><affiliation><nlm:affiliation>Gerència territorial de Barcelona, Institut Català de la Salut, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Narejos, Silvia" sort="Narejos, Silvia" uniqKey="Narejos S" first="Silvia" last="Narejos">Silvia Narejos</name><affiliation><nlm:affiliation>Entitat de Base Asociativa Centelles- Atenció Primària, Centelles, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gil Ortega, Aroa N" sort="Gil Ortega, Aroa N" uniqKey="Gil Ortega A" first="Aroa N" last="Gil-Ortega">Aroa N. Gil-Ortega</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Prat, Nuria" sort="Prat, Nuria" uniqKey="Prat N" first="Nuria" last="Prat">Nuria Prat</name><affiliation><nlm:affiliation>Gerència territorial de Àmbit Metropolità nord, Institut Català de la Salut, Sabadell, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Puig, Jordi" sort="Puig, Jordi" uniqKey="Puig J" first="Jordi" last="Puig">Jordi Puig</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Qui Ones, Carles" sort="Qui Ones, Carles" uniqKey="Qui Ones C" first="Carles" last="Qui Ones">Carles Qui Ones</name><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Reyes Ure A, Juliana" sort="Reyes Ure A, Juliana" uniqKey="Reyes Ure A J" first="Juliana" last="Reyes-Ure A">Juliana Reyes-Ure A</name><affiliation><nlm:affiliation>Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Catalan Institute of Oncology (ICO)-Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ramirez Viaplana, Ferran" sort="Ramirez Viaplana, Ferran" uniqKey="Ramirez Viaplana F" first="Ferran" last="Ramírez-Viaplana">Ferran Ramírez-Viaplana</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ruiz, Lidia" sort="Ruiz, Lidia" uniqKey="Ruiz L" first="Lidia" last="Ruiz">Lidia Ruiz</name><affiliation><nlm:affiliation>IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Riveira Mu Oz, Eva" sort="Riveira Mu Oz, Eva" uniqKey="Riveira Mu Oz E" first="Eva" last="Riveira-Mu Oz">Eva Riveira-Mu Oz</name><affiliation><nlm:affiliation>IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sierra, Alba" sort="Sierra, Alba" uniqKey="Sierra A" first="Alba" last="Sierra">Alba Sierra</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Velasco, Cesar" sort="Velasco, Cesar" uniqKey="Velasco C" first="César" last="Velasco">César Velasco</name><affiliation><nlm:affiliation>Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Vivanco Hidalgo, Rosa Maria" sort="Vivanco Hidalgo, Rosa Maria" uniqKey="Vivanco Hidalgo R" first="Rosa Maria" last="Vivanco-Hidalgo">Rosa Maria Vivanco-Hidalgo</name><affiliation><nlm:affiliation>Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sentis, Alexis" sort="Sentis, Alexis" uniqKey="Sentis A" first="Alexis" last="Sentís">Alexis Sentís</name><affiliation><nlm:affiliation>Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Catalan Institute of Oncology (ICO)-Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="G Beiras, Camila" sort="G Beiras, Camila" uniqKey="G Beiras C" first="Camila" last="G-Beiras">Camila G-Beiras</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Clotet, Bonaventura" sort="Clotet, Bonaventura" uniqKey="Clotet B" first="Bonaventura" last="Clotet">Bonaventura Clotet</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Universitat de Vic-Universitat Central de Catalunya (UVIC-UCC), Vic, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Vall Mayans, Marti" sort="Vall Mayans, Marti" uniqKey="Vall Mayans M" first="Martí" last="Vall-Mayans">Martí Vall-Mayans</name><affiliation><nlm:affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>No therapeutics have yet been proven effective for the treatment of mild-illness caused by SARS-CoV-2. We aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be more efficacious than no-treatment for outpatients with mild Covid-19.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We conducted a multicenter, open label, randomized controlled trial in Catalonia (Spain) between March 17, and May 26, 2020. Eligible Covid-19 cases were non-hospitalized adult patients with recently confirmed SARS-CoV-2 infection and less than five days of symptoms. Patients were assigned to receive HCQ (800 mg on day 1, followed by 400 mg once daily for 6 days) or no antiviral treatment (not-placebo controlled). Study outcomes were the reduction of viral RNA load in nasopharyngeal swabs up to 7 days after treatment start, patient disease progression using the WHO scale up to 28 days, and time to complete resolution of symptoms. Adverse events were assessed up to 28 days.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>A total of 293 patients were eligible for intention-to-treat analysis: 157 in the control arm and 136 in the intervention arm. The mean age was 41.6 years (SD 12.6), mean viral load at baseline was 7.90 (SD 1.82) Log10 copies/mL, and median time from symptom onset to randomization was 3 days. No significant differences were found in the mean reduction of viral load at day 3 (-1.41 vs. -1.41 Log10 copies/mL in the control and intervention arm, respectively; difference 0.01 [95% CI -0.28;0.29]) or at day 7 (-3.37 vs. -3.44; d -0.07 [-0.44;0.29]). This treatment regimen did not reduce risk of hospitalization (7.1%, control vs. 5.9%, intervention; RR 0.75 [0.32;1.77]) nor shortened the time to complete resolution of symptoms (12 days, control vs. 10 days, intervention; p = 0.38). No relevant treatment-related AEs were reported.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>In patients with mild Covid-19, no benefit was observed with HCQ beyond the usual care.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32674126</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jul</Month><Day>16</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">ciaa1009</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/ciaa1009</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">No therapeutics have yet been proven effective for the treatment of mild-illness caused by SARS-CoV-2. We aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be more efficacious than no-treatment for outpatients with mild Covid-19.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a multicenter, open label, randomized controlled trial in Catalonia (Spain) between March 17, and May 26, 2020. Eligible Covid-19 cases were non-hospitalized adult patients with recently confirmed SARS-CoV-2 infection and less than five days of symptoms. Patients were assigned to receive HCQ (800 mg on day 1, followed by 400 mg once daily for 6 days) or no antiviral treatment (not-placebo controlled). Study outcomes were the reduction of viral RNA load in nasopharyngeal swabs up to 7 days after treatment start, patient disease progression using the WHO scale up to 28 days, and time to complete resolution of symptoms. Adverse events were assessed up to 28 days.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 293 patients were eligible for intention-to-treat analysis: 157 in the control arm and 136 in the intervention arm. The mean age was 41.6 years (SD 12.6), mean viral load at baseline was 7.90 (SD 1.82) Log10 copies/mL, and median time from symptom onset to randomization was 3 days. No significant differences were found in the mean reduction of viral load at day 3 (-1.41 vs. -1.41 Log10 copies/mL in the control and intervention arm, respectively; difference 0.01 [95% CI -0.28;0.29]) or at day 7 (-3.37 vs. -3.44; d -0.07 [-0.44;0.29]). This treatment regimen did not reduce risk of hospitalization (7.1%, control vs. 5.9%, intervention; RR 0.75 [0.32;1.77]) nor shortened the time to complete resolution of symptoms (12 days, control vs. 10 days, intervention; p = 0.38). No relevant treatment-related AEs were reported.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In patients with mild Covid-19, no benefit was observed with HCQ beyond the usual care.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mitjà</LastName><ForeName>Oriol</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Lihir Medical Centre - InternationalSOS, Lihir Island, Papua New Guinea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corbacho-Monné</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ubals</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tebe</LastName><ForeName>Cristian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peñafiel</LastName><ForeName>Judith</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tobias</LastName><ForeName>Aurelio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ballana</LastName><ForeName>Ester</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alemany</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riera-Martí</LastName><ForeName>Núria</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pérez</LastName><ForeName>Carla A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suñer</LastName><ForeName>Clara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laporte</LastName><ForeName>Pep</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Admella</LastName><ForeName>Pol</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitjà</LastName><ForeName>Jordi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clua</LastName><ForeName>Mireia</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bertran</LastName><ForeName>Laia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sarquella</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gavilán</LastName><ForeName>Sergi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ara</LastName><ForeName>Jordi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Argimon</LastName><ForeName>Josep M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Direcció-gerència, Institut Català de la Salut, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casabona</LastName><ForeName>Jordi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Catalan Institute of Oncology (ICO)-Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cuatrecasas</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Equip d'atenció primària de Sarria, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cañadas</LastName><ForeName>Paz</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>SYNLAB, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elizalde-Torrent</LastName><ForeName>Aleix</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fabregat</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Direcció General de Recerca i Innovació en Salut, Generalitat de Catalunya, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farré</LastName><ForeName>Magí</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Forcada</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Gerència territorial de Catalunya Central, Institut Català de la Salut, St Fruitós del Bages, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flores-Mateo</LastName><ForeName>Gemma</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Xarxa Sanitària i Social Santa Tecla, Tarragona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muntada</LastName><ForeName>Esteve</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Catalan Institute of Oncology (ICO)-Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nadal</LastName><ForeName>Núria</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Gerència territorial de Barcelona, Institut Català de la Salut, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Narejos</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Entitat de Base Asociativa Centelles- Atenció Primària, Centelles, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gil-Ortega</LastName><ForeName>Aroa N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prat</LastName><ForeName>Nuria</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Gerència territorial de Àmbit Metropolità nord, Institut Català de la Salut, Sabadell, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Puig</LastName><ForeName>Jordi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quiñones</LastName><ForeName>Carles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reyes-Ureña</LastName><ForeName>Juliana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Catalan Institute of Oncology (ICO)-Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramírez-Viaplana</LastName><ForeName>Ferran</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruiz</LastName><ForeName>Lidia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riveira-Muñoz</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sierra</LastName><ForeName>Alba</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Velasco</LastName><ForeName>César</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vivanco-Hidalgo</LastName><ForeName>Rosa Maria</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sentís</LastName><ForeName>Alexis</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Catalan Institute of Oncology (ICO)-Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>G-Beiras</LastName><ForeName>Camila</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clotet</LastName><ForeName>Bonaventura</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Universitat de Vic-Universitat Central de Catalunya (UVIC-UCC), Vic, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vall-Mayans</LastName><ForeName>Martí</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Fight AIDS and Infectious Diseases Foundation, Badalona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hospital Universitari Germans Trias i Pujol, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>BCN PEP-CoV-2 RESEARCH GROUP</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Infect Dis</MedlineTA><NlmUniqueID>9203213</NlmUniqueID><ISSNLinking>1058-4838</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Covid-19</Keyword><Keyword MajorTopicYN="N">Hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">Randomized Controlled Trial</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">Therapy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32674126</ArticleId><ArticleId IdType="pii">5872589</ArticleId><ArticleId IdType="doi">10.1093/cid/ciaa1009</ArticleId><ArticleId IdType="pmc">PMC7454406</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001128 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001128 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidChloroV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:32674126
|texte= Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:32674126" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a CovidChloroV1
| This area was generated with Dilib version V0.6.38. |  |