CovidChloroV1, Main, Corpus, bibRecord, 000D71

An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants.

Identifieur interne : 000D71 ( Main/Corpus ); précédent : 000D70; suivant : 000D72

An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants.

Auteurs : Sophie Caillard ; Dany Anglicheau ; Marie Matignon ; Antoine Durrbach ; Clarisse Greze ; Luc Frimat ; Olivier Thaunat ; Tristan Legris ; Valerie Moal ; Pierre Francois Westeel ; Nassim Kamar ; Philippe Gatault ; Renaud Snanoudj ; Antoine Sicard ; Dominique Bertrand ; Charlotte Colosio ; Lionel Couzi ; Jonathan M. Chemouny ; Christophe Masset ; Gilles Blancho ; Jamal Bamoulid ; Agnes Duveau ; Nicolas Bouvier ; Nathalie Chavarot ; Philippe Grimbert ; Bruno Moulin ; Yannick Le Meur ; Marc Hazzan

Source :

Kidney international [ 1523-1755 ] ; 2020.

RBID : pubmed:32853631

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), COVID-19 (complications), COVID-19 (mortality), COVID-19 (therapy), Deprescriptions (MeSH), Female (MeSH), France (epidemiology), Humans (MeSH), Immunosuppression (MeSH), Kidney Transplantation (mortality), Male (MeSH), Middle Aged (MeSH), Pandemics (statistics & numerical data), Postoperative Complications (mortality), Postoperative Complications (virology), Registries (MeSH), Retrospective Studies (MeSH), Risk Factors (MeSH), Young Adult (MeSH).
MESH :
- geographic , epidemiology : France.
- complications : COVID-19.
- mortality : COVID-19, Kidney Transplantation, Postoperative Complications.
- statistics & numerical data : Pandemics.
- therapy : COVID-19.
- virology : Postoperative Complications.
- Adult, Aged, Aged, 80 and over, Deprescriptions, Female, Humans, Immunosuppression, Male, Middle Aged, Registries, Retrospective Studies, Risk Factors, Young Adult.

Abstract

Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational study was to explore characteristics and clinical outcomes of recipients of kidney transplants included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. Covid-19 was diagnosed in symptomatic patients who had a positive PCR assay for SARS-CoV-2 or having typical lung lesions on imaging. Clinical and laboratory characteristics, management of immunosuppression, treatment for Covid-19, and clinical outcomes (hospitalization, admission to intensive care unit, mechanical ventilation, or death) were recorded. Risk factors for severe disease or death were determined. Of the 279 patients, 243 were admitted to hospital and 36 were managed at home. The median age of hospitalized patients was 61.6 years; most had comorbidities (hypertension, 90.1%; overweight, 63.8%; diabetes, 41.3%; cardiovascular disease, 36.2%). Fever, cough, dyspnea, and diarrhea were the most common symptoms on admission. Laboratory findings revealed mild inflammation frequently accompanied by lymphopenia. Immunosuppressive drugs were generally withdrawn (calcineurin inhibitors: 28.7%; antimetabolites: 70.8%). Treatment was mainly based on hydroxychloroquine (24.7%), antiviral drugs (7.8%), and tocilizumab (5.3%). Severe Covid-19 occurred in 106 patients (46%). Forty-three hospitalized patients died (30-day mortality 22.8%). Multivariable analysis identified overweight, fever, and dyspnea as independent risk factors for severe disease, whereas age over 60 years, cardiovascular disease, and dyspnea were independently associated with mortality. Thus, Covid-19 in recipients of kidney transplants portends a high mortality rate. Proper management of immunosuppression and tailored treatment of this population remain challenging.

DOI: 10.1016/j.kint.2020.08.005
PubMed: 32853631
PubMed Central: PMC7444636

Links to Exploration step

pubmed:32853631

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants.</title>
<author><name sortKey="Caillard, Sophie" sort="Caillard, Sophie" uniqKey="Caillard S" first="Sophie" last="Caillard">Sophie Caillard</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Strasbourg University Hospital, Strasbourg, France; INSERM, IRM UMR-S 1109, University of Strasbourg, Strasbourg, France. Electronic address: Sophie.caillard@chru-strasbourg.fr.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Anglicheau, Dany" sort="Anglicheau, Dany" uniqKey="Anglicheau D" first="Dany" last="Anglicheau">Dany Anglicheau</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Necker University Hospital - APHP, Paris, France; INEM INSERM U 1151- CNRS UMR 8253, Paris University, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Matignon, Marie" sort="Matignon, Marie" uniqKey="Matignon M" first="Marie" last="Matignon">Marie Matignon</name>
<affiliation><nlm:affiliation>Department of Nephrology and Renal Transplantation, Henri-Mondor/Albert-Chenevier Hospital, AP-HP, Créteil, France; IFRNT, INSERM U 955, University of Paris-Est-Créteil, Créteil, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Durrbach, Antoine" sort="Durrbach, Antoine" uniqKey="Durrbach A" first="Antoine" last="Durrbach">Antoine Durrbach</name>
<affiliation><nlm:affiliation>Department of Nephrology and Renal Transplantation, Henri-Mondor/Albert-Chenevier Hospital, AP-HP, Créteil, France; IFRNT, INSERM U 955, University of Paris-Est-Créteil, Créteil, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Greze, Clarisse" sort="Greze, Clarisse" uniqKey="Greze C" first="Clarisse" last="Greze">Clarisse Greze</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Bichat hospital, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Frimat, Luc" sort="Frimat, Luc" uniqKey="Frimat L" first="Luc" last="Frimat">Luc Frimat</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, CHRU-Nancy, Vandoeuvre, France; INSERM CIC-EC CIE6, University of Lorraine, Nancy, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Thaunat, Olivier" sort="Thaunat, Olivier" uniqKey="Thaunat O" first="Olivier" last="Thaunat">Olivier Thaunat</name>
<affiliation><nlm:affiliation>Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital, Hospices civils de Lyon, Lyon, France; CIRI, INSERM U1111, University Claude Bernard Lyon 1, Lyon, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Legris, Tristan" sort="Legris, Tristan" uniqKey="Legris T" first="Tristan" last="Legris">Tristan Legris</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Marseille University Hospital, Conception hospital, Aix Marseille University, Marseille, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Moal, Valerie" sort="Moal, Valerie" uniqKey="Moal V" first="Valerie" last="Moal">Valerie Moal</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Marseille University Hospital, Conception hospital, Aix Marseille University, Marseille, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Westeel, Pierre Francois" sort="Westeel, Pierre Francois" uniqKey="Westeel P" first="Pierre Francois" last="Westeel">Pierre Francois Westeel</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Amiens, Amiens, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kamar, Nassim" sort="Kamar, Nassim" uniqKey="Kamar N" first="Nassim" last="Kamar">Nassim Kamar</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Toulouse, Toulouse, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gatault, Philippe" sort="Gatault, Philippe" uniqKey="Gatault P" first="Philippe" last="Gatault">Philippe Gatault</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Tours, Tours, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Snanoudj, Renaud" sort="Snanoudj, Renaud" uniqKey="Snanoudj R" first="Renaud" last="Snanoudj">Renaud Snanoudj</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Bicêtre Hospital, Le Kremlin-Bicêtre, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sicard, Antoine" sort="Sicard, Antoine" uniqKey="Sicard A" first="Antoine" last="Sicard">Antoine Sicard</name>
<affiliation><nlm:affiliation>Department of Nephrology Dialysis and Transplantation, Pasteur 2 Hospital, Nice University Hospital, Nice, France; Unité de Recherche Clinique Côte d'Azur (UR2CA), University of Côte d'Azur, Nice, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bertrand, Dominique" sort="Bertrand, Dominique" uniqKey="Bertrand D" first="Dominique" last="Bertrand">Dominique Bertrand</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Rouen, Rouen, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Colosio, Charlotte" sort="Colosio, Charlotte" uniqKey="Colosio C" first="Charlotte" last="Colosio">Charlotte Colosio</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Reims, Reims, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Couzi, Lionel" sort="Couzi, Lionel" uniqKey="Couzi L" first="Lionel" last="Couzi">Lionel Couzi</name>
<affiliation><nlm:affiliation>Department of Nephrology Dialysis, Transplantation and Apheresis, Bordeaux Pellegrin University Hospital, Bordeaux, France; Research Unit ImmunoConcEpT CNRS 5164, University of Bordeaux, Bordeaux, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chemouny, Jonathan M" sort="Chemouny, Jonathan M" uniqKey="Chemouny J" first="Jonathan M" last="Chemouny">Jonathan M. Chemouny</name>
<affiliation><nlm:affiliation>Inserm UMR_S 1085, EHESP, University of Rennes, Rennes, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Masset, Christophe" sort="Masset, Christophe" uniqKey="Masset C" first="Christophe" last="Masset">Christophe Masset</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Nantes University Hospital, Nantes, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Blancho, Gilles" sort="Blancho, Gilles" uniqKey="Blancho G" first="Gilles" last="Blancho">Gilles Blancho</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Nantes University Hospital, Nantes, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bamoulid, Jamal" sort="Bamoulid, Jamal" uniqKey="Bamoulid J" first="Jamal" last="Bamoulid">Jamal Bamoulid</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Besançon, Besançon, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Duveau, Agnes" sort="Duveau, Agnes" uniqKey="Duveau A" first="Agnes" last="Duveau">Agnes Duveau</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Angers, Angers, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bouvier, Nicolas" sort="Bouvier, Nicolas" uniqKey="Bouvier N" first="Nicolas" last="Bouvier">Nicolas Bouvier</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Caen, Caen, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chavarot, Nathalie" sort="Chavarot, Nathalie" uniqKey="Chavarot N" first="Nathalie" last="Chavarot">Nathalie Chavarot</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Necker University Hospital - APHP, Paris, France; INEM INSERM U 1151- CNRS UMR 8253, Paris University, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Grimbert, Philippe" sort="Grimbert, Philippe" uniqKey="Grimbert P" first="Philippe" last="Grimbert">Philippe Grimbert</name>
<affiliation><nlm:affiliation>Department of Nephrology and Renal Transplantation, Henri-Mondor/Albert-Chenevier Hospital, AP-HP, Créteil, France; IFRNT, INSERM U 955, University of Paris-Est-Créteil, Créteil, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Moulin, Bruno" sort="Moulin, Bruno" uniqKey="Moulin B" first="Bruno" last="Moulin">Bruno Moulin</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Strasbourg University Hospital, Strasbourg, France; INSERM, IRM UMR-S 1109, University of Strasbourg, Strasbourg, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Le Meur, Yannick" sort="Le Meur, Yannick" uniqKey="Le Meur Y" first="Yannick" last="Le Meur">Yannick Le Meur</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Brest University Hospital, Brest, France; Inserm UMR1227, University of Brest, Labex IGO, Brest, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hazzan, Marc" sort="Hazzan, Marc" uniqKey="Hazzan M" first="Marc" last="Hazzan">Marc Hazzan</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Lille, Lille, France.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32853631</idno>
<idno type="pmid">32853631</idno>
<idno type="doi">10.1016/j.kint.2020.08.005</idno>
<idno type="pmc">PMC7444636</idno>
<idno type="wicri:Area/Main/Corpus">000D71</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000D71</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants.</title>
<author><name sortKey="Caillard, Sophie" sort="Caillard, Sophie" uniqKey="Caillard S" first="Sophie" last="Caillard">Sophie Caillard</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Strasbourg University Hospital, Strasbourg, France; INSERM, IRM UMR-S 1109, University of Strasbourg, Strasbourg, France. Electronic address: Sophie.caillard@chru-strasbourg.fr.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Anglicheau, Dany" sort="Anglicheau, Dany" uniqKey="Anglicheau D" first="Dany" last="Anglicheau">Dany Anglicheau</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Necker University Hospital - APHP, Paris, France; INEM INSERM U 1151- CNRS UMR 8253, Paris University, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Matignon, Marie" sort="Matignon, Marie" uniqKey="Matignon M" first="Marie" last="Matignon">Marie Matignon</name>
<affiliation><nlm:affiliation>Department of Nephrology and Renal Transplantation, Henri-Mondor/Albert-Chenevier Hospital, AP-HP, Créteil, France; IFRNT, INSERM U 955, University of Paris-Est-Créteil, Créteil, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Durrbach, Antoine" sort="Durrbach, Antoine" uniqKey="Durrbach A" first="Antoine" last="Durrbach">Antoine Durrbach</name>
<affiliation><nlm:affiliation>Department of Nephrology and Renal Transplantation, Henri-Mondor/Albert-Chenevier Hospital, AP-HP, Créteil, France; IFRNT, INSERM U 955, University of Paris-Est-Créteil, Créteil, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Greze, Clarisse" sort="Greze, Clarisse" uniqKey="Greze C" first="Clarisse" last="Greze">Clarisse Greze</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Bichat hospital, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Frimat, Luc" sort="Frimat, Luc" uniqKey="Frimat L" first="Luc" last="Frimat">Luc Frimat</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, CHRU-Nancy, Vandoeuvre, France; INSERM CIC-EC CIE6, University of Lorraine, Nancy, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Thaunat, Olivier" sort="Thaunat, Olivier" uniqKey="Thaunat O" first="Olivier" last="Thaunat">Olivier Thaunat</name>
<affiliation><nlm:affiliation>Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital, Hospices civils de Lyon, Lyon, France; CIRI, INSERM U1111, University Claude Bernard Lyon 1, Lyon, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Legris, Tristan" sort="Legris, Tristan" uniqKey="Legris T" first="Tristan" last="Legris">Tristan Legris</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Marseille University Hospital, Conception hospital, Aix Marseille University, Marseille, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Moal, Valerie" sort="Moal, Valerie" uniqKey="Moal V" first="Valerie" last="Moal">Valerie Moal</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Marseille University Hospital, Conception hospital, Aix Marseille University, Marseille, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Westeel, Pierre Francois" sort="Westeel, Pierre Francois" uniqKey="Westeel P" first="Pierre Francois" last="Westeel">Pierre Francois Westeel</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Amiens, Amiens, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kamar, Nassim" sort="Kamar, Nassim" uniqKey="Kamar N" first="Nassim" last="Kamar">Nassim Kamar</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Toulouse, Toulouse, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gatault, Philippe" sort="Gatault, Philippe" uniqKey="Gatault P" first="Philippe" last="Gatault">Philippe Gatault</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Tours, Tours, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Snanoudj, Renaud" sort="Snanoudj, Renaud" uniqKey="Snanoudj R" first="Renaud" last="Snanoudj">Renaud Snanoudj</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Bicêtre Hospital, Le Kremlin-Bicêtre, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sicard, Antoine" sort="Sicard, Antoine" uniqKey="Sicard A" first="Antoine" last="Sicard">Antoine Sicard</name>
<affiliation><nlm:affiliation>Department of Nephrology Dialysis and Transplantation, Pasteur 2 Hospital, Nice University Hospital, Nice, France; Unité de Recherche Clinique Côte d'Azur (UR2CA), University of Côte d'Azur, Nice, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bertrand, Dominique" sort="Bertrand, Dominique" uniqKey="Bertrand D" first="Dominique" last="Bertrand">Dominique Bertrand</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Rouen, Rouen, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Colosio, Charlotte" sort="Colosio, Charlotte" uniqKey="Colosio C" first="Charlotte" last="Colosio">Charlotte Colosio</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Reims, Reims, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Couzi, Lionel" sort="Couzi, Lionel" uniqKey="Couzi L" first="Lionel" last="Couzi">Lionel Couzi</name>
<affiliation><nlm:affiliation>Department of Nephrology Dialysis, Transplantation and Apheresis, Bordeaux Pellegrin University Hospital, Bordeaux, France; Research Unit ImmunoConcEpT CNRS 5164, University of Bordeaux, Bordeaux, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chemouny, Jonathan M" sort="Chemouny, Jonathan M" uniqKey="Chemouny J" first="Jonathan M" last="Chemouny">Jonathan M. Chemouny</name>
<affiliation><nlm:affiliation>Inserm UMR_S 1085, EHESP, University of Rennes, Rennes, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Masset, Christophe" sort="Masset, Christophe" uniqKey="Masset C" first="Christophe" last="Masset">Christophe Masset</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Nantes University Hospital, Nantes, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Blancho, Gilles" sort="Blancho, Gilles" uniqKey="Blancho G" first="Gilles" last="Blancho">Gilles Blancho</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Nantes University Hospital, Nantes, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bamoulid, Jamal" sort="Bamoulid, Jamal" uniqKey="Bamoulid J" first="Jamal" last="Bamoulid">Jamal Bamoulid</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Besançon, Besançon, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Duveau, Agnes" sort="Duveau, Agnes" uniqKey="Duveau A" first="Agnes" last="Duveau">Agnes Duveau</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Angers, Angers, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bouvier, Nicolas" sort="Bouvier, Nicolas" uniqKey="Bouvier N" first="Nicolas" last="Bouvier">Nicolas Bouvier</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Caen, Caen, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chavarot, Nathalie" sort="Chavarot, Nathalie" uniqKey="Chavarot N" first="Nathalie" last="Chavarot">Nathalie Chavarot</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Necker University Hospital - APHP, Paris, France; INEM INSERM U 1151- CNRS UMR 8253, Paris University, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Grimbert, Philippe" sort="Grimbert, Philippe" uniqKey="Grimbert P" first="Philippe" last="Grimbert">Philippe Grimbert</name>
<affiliation><nlm:affiliation>Department of Nephrology and Renal Transplantation, Henri-Mondor/Albert-Chenevier Hospital, AP-HP, Créteil, France; IFRNT, INSERM U 955, University of Paris-Est-Créteil, Créteil, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Moulin, Bruno" sort="Moulin, Bruno" uniqKey="Moulin B" first="Bruno" last="Moulin">Bruno Moulin</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Strasbourg University Hospital, Strasbourg, France; INSERM, IRM UMR-S 1109, University of Strasbourg, Strasbourg, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Le Meur, Yannick" sort="Le Meur, Yannick" uniqKey="Le Meur Y" first="Yannick" last="Le Meur">Yannick Le Meur</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, Brest University Hospital, Brest, France; Inserm UMR1227, University of Brest, Labex IGO, Brest, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hazzan, Marc" sort="Hazzan, Marc" uniqKey="Hazzan M" first="Marc" last="Hazzan">Marc Hazzan</name>
<affiliation><nlm:affiliation>Department of Nephrology and Transplantation, University of Lille, Lille, France.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Kidney international</title>
<idno type="eISSN">1523-1755</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>COVID-19 (complications)</term>
<term>COVID-19 (mortality)</term>
<term>COVID-19 (therapy)</term>
<term>Deprescriptions (MeSH)</term>
<term>Female (MeSH)</term>
<term>France (epidemiology)</term>
<term>Humans (MeSH)</term>
<term>Immunosuppression (MeSH)</term>
<term>Kidney Transplantation (mortality)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (statistics & numerical data)</term>
<term>Postoperative Complications (mortality)</term>
<term>Postoperative Complications (virology)</term>
<term>Registries (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>COVID-19</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>COVID-19</term>
<term>Kidney Transplantation</term>
<term>Postoperative Complications</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Pandemics</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>COVID-19</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Postoperative Complications</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Deprescriptions</term>
<term>Female</term>
<term>Humans</term>
<term>Immunosuppression</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Registries</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Young Adult</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational study was to explore characteristics and clinical outcomes of recipients of kidney transplants included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. Covid-19 was diagnosed in symptomatic patients who had a positive PCR assay for SARS-CoV-2 or having typical lung lesions on imaging. Clinical and laboratory characteristics, management of immunosuppression, treatment for Covid-19, and clinical outcomes (hospitalization, admission to intensive care unit, mechanical ventilation, or death) were recorded. Risk factors for severe disease or death were determined. Of the 279 patients, 243 were admitted to hospital and 36 were managed at home. The median age of hospitalized patients was 61.6 years; most had comorbidities (hypertension, 90.1%; overweight, 63.8%; diabetes, 41.3%; cardiovascular disease, 36.2%). Fever, cough, dyspnea, and diarrhea were the most common symptoms on admission. Laboratory findings revealed mild inflammation frequently accompanied by lymphopenia. Immunosuppressive drugs were generally withdrawn (calcineurin inhibitors: 28.7%; antimetabolites: 70.8%). Treatment was mainly based on hydroxychloroquine (24.7%), antiviral drugs (7.8%), and tocilizumab (5.3%). Severe Covid-19 occurred in 106 patients (46%). Forty-three hospitalized patients died (30-day mortality 22.8%). Multivariable analysis identified overweight, fever, and dyspnea as independent risk factors for severe disease, whereas age over 60 years, cardiovascular disease, and dyspnea were independently associated with mortality. Thus, Covid-19 in recipients of kidney transplants portends a high mortality rate. Proper management of immunosuppression and tailored treatment of this population remain challenging.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32853631</PMID>
<DateCompleted><Year>2020</Year>
<Month>12</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2021</Year>
<Month>03</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1523-1755</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>98</Volume>
<Issue>6</Issue>
<PubDate><Year>2020</Year>
<Month>12</Month>
</PubDate>
</JournalIssue>
<Title>Kidney international</Title>
<ISOAbbreviation>Kidney Int</ISOAbbreviation>
</Journal>
<ArticleTitle>An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants.</ArticleTitle>
<Pagination><MedlinePgn>1549-1558</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0085-2538(20)30961-3</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.kint.2020.08.005</ELocationID>
<Abstract><AbstractText>Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational study was to explore characteristics and clinical outcomes of recipients of kidney transplants included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. Covid-19 was diagnosed in symptomatic patients who had a positive PCR assay for SARS-CoV-2 or having typical lung lesions on imaging. Clinical and laboratory characteristics, management of immunosuppression, treatment for Covid-19, and clinical outcomes (hospitalization, admission to intensive care unit, mechanical ventilation, or death) were recorded. Risk factors for severe disease or death were determined. Of the 279 patients, 243 were admitted to hospital and 36 were managed at home. The median age of hospitalized patients was 61.6 years; most had comorbidities (hypertension, 90.1%; overweight, 63.8%; diabetes, 41.3%; cardiovascular disease, 36.2%). Fever, cough, dyspnea, and diarrhea were the most common symptoms on admission. Laboratory findings revealed mild inflammation frequently accompanied by lymphopenia. Immunosuppressive drugs were generally withdrawn (calcineurin inhibitors: 28.7%; antimetabolites: 70.8%). Treatment was mainly based on hydroxychloroquine (24.7%), antiviral drugs (7.8%), and tocilizumab (5.3%). Severe Covid-19 occurred in 106 patients (46%). Forty-three hospitalized patients died (30-day mortality 22.8%). Multivariable analysis identified overweight, fever, and dyspnea as independent risk factors for severe disease, whereas age over 60 years, cardiovascular disease, and dyspnea were independently associated with mortality. Thus, Covid-19 in recipients of kidney transplants portends a high mortality rate. Proper management of immunosuppression and tailored treatment of this population remain challenging.</AbstractText>
<CopyrightInformation>Copyright © 2020 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Caillard</LastName>
<ForeName>Sophie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Strasbourg University Hospital, Strasbourg, France; INSERM, IRM UMR-S 1109, University of Strasbourg, Strasbourg, France. Electronic address: Sophie.caillard@chru-strasbourg.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Anglicheau</LastName>
<ForeName>Dany</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Necker University Hospital - APHP, Paris, France; INEM INSERM U 1151- CNRS UMR 8253, Paris University, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Matignon</LastName>
<ForeName>Marie</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Renal Transplantation, Henri-Mondor/Albert-Chenevier Hospital, AP-HP, Créteil, France; IFRNT, INSERM U 955, University of Paris-Est-Créteil, Créteil, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Durrbach</LastName>
<ForeName>Antoine</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Renal Transplantation, Henri-Mondor/Albert-Chenevier Hospital, AP-HP, Créteil, France; IFRNT, INSERM U 955, University of Paris-Est-Créteil, Créteil, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Greze</LastName>
<ForeName>Clarisse</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Bichat hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Frimat</LastName>
<ForeName>Luc</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, CHRU-Nancy, Vandoeuvre, France; INSERM CIC-EC CIE6, University of Lorraine, Nancy, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thaunat</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital, Hospices civils de Lyon, Lyon, France; CIRI, INSERM U1111, University Claude Bernard Lyon 1, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Legris</LastName>
<ForeName>Tristan</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Marseille University Hospital, Conception hospital, Aix Marseille University, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moal</LastName>
<ForeName>Valerie</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Marseille University Hospital, Conception hospital, Aix Marseille University, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Westeel</LastName>
<ForeName>Pierre Francois</ForeName>
<Initials>PF</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Amiens, Amiens, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kamar</LastName>
<ForeName>Nassim</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Toulouse, Toulouse, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gatault</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Tours, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Snanoudj</LastName>
<ForeName>Renaud</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Bicêtre Hospital, Le Kremlin-Bicêtre, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sicard</LastName>
<ForeName>Antoine</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology Dialysis and Transplantation, Pasteur 2 Hospital, Nice University Hospital, Nice, France; Unité de Recherche Clinique Côte d'Azur (UR2CA), University of Côte d'Azur, Nice, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bertrand</LastName>
<ForeName>Dominique</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Rouen, Rouen, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Colosio</LastName>
<ForeName>Charlotte</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Reims, Reims, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Couzi</LastName>
<ForeName>Lionel</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology Dialysis, Transplantation and Apheresis, Bordeaux Pellegrin University Hospital, Bordeaux, France; Research Unit ImmunoConcEpT CNRS 5164, University of Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chemouny</LastName>
<ForeName>Jonathan M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Inserm UMR_S 1085, EHESP, University of Rennes, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Masset</LastName>
<ForeName>Christophe</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Nantes University Hospital, Nantes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blancho</LastName>
<ForeName>Gilles</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Nantes University Hospital, Nantes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bamoulid</LastName>
<ForeName>Jamal</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Besançon, Besançon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Duveau</LastName>
<ForeName>Agnes</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Angers, Angers, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bouvier</LastName>
<ForeName>Nicolas</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Caen, Caen, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chavarot</LastName>
<ForeName>Nathalie</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Necker University Hospital - APHP, Paris, France; INEM INSERM U 1151- CNRS UMR 8253, Paris University, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grimbert</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Renal Transplantation, Henri-Mondor/Albert-Chenevier Hospital, AP-HP, Créteil, France; IFRNT, INSERM U 955, University of Paris-Est-Créteil, Créteil, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moulin</LastName>
<ForeName>Bruno</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Strasbourg University Hospital, Strasbourg, France; INSERM, IRM UMR-S 1109, University of Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Le Meur</LastName>
<ForeName>Yannick</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Brest University Hospital, Brest, France; Inserm UMR1227, University of Brest, Labex IGO, Brest, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hazzan</LastName>
<ForeName>Marc</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Lille, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>French SOT COVID Registry</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>24</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Kidney Int</MedlineTA>
<NlmUniqueID>0323470</NlmUniqueID>
<ISSNLinking>0085-2538</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Kidney Int. 2020 Dec;98(6):1618-1619</RefSource>
<PMID Version="1">33065130</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Kidney Int. 2020 Dec;98(6):1618</RefSource>
<PMID Version="1">33065132</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000069340" MajorTopicYN="N">Deprescriptions</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007165" MajorTopicYN="N">Immunosuppression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016030" MajorTopicYN="N">Kidney Transplantation</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011183" MajorTopicYN="N">Postoperative Complications</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012042" MajorTopicYN="Y">Registries</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">immunosuppression</Keyword>
<Keyword MajorTopicYN="Y">kidney transplantation</Keyword>
<Keyword MajorTopicYN="Y">mortality</Keyword>
<Keyword MajorTopicYN="Y">prognosis</Keyword>
</KeywordList>
<InvestigatorList><Investigator ValidYN="Y"><LastName>Caillard</LastName>
<ForeName>Sophie</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Moulin</LastName>
<ForeName>Bruno</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fafi-Kremer</LastName>
<ForeName>Samira</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hazzan</LastName>
<ForeName>Marc</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Anglicheau</LastName>
<ForeName>Dany</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hertig</LastName>
<ForeName>Alexandre</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tourret</LastName>
<ForeName>Jérôme</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Barrou</LastName>
<ForeName>Benoit</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Morelon</LastName>
<ForeName>Emmanuel</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Thaunat</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Couzi</LastName>
<ForeName>Lionel</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Merville</LastName>
<ForeName>Pierre</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Moal</LastName>
<ForeName>Valérie</ForeName>
<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Legris</LastName>
<ForeName>Tristan</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Westeel</LastName>
<ForeName>Pierre-François</ForeName>
<Initials>PF</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jaureguy</LastName>
<ForeName>Maïté</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Frimat</LastName>
<ForeName>Luc</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ducloux</LastName>
<ForeName>Didier</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bamoulid</LastName>
<ForeName>Jamal</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bertrand</LastName>
<ForeName>Dominique</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tsimaratos</LastName>
<ForeName>Michel</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Garaix-Gilardo</LastName>
<ForeName>Florentine</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Dumortier</LastName>
<ForeName>Jérôme</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mussot</LastName>
<ForeName>Sacha</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Roux</LastName>
<ForeName>Antoine</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sebbag</LastName>
<ForeName>Laurent</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Le Meur</LastName>
<ForeName>Yannick</ForeName>
<Initials>Y</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Blancho</LastName>
<ForeName>Gilles</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Masset</LastName>
<ForeName>Christophe</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kamar</LastName>
<ForeName>Nassim</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Francois</LastName>
<ForeName>Hélène</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rondeau</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bouvier</LastName>
<ForeName>Nicolas</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mousson</LastName>
<ForeName>Christiane</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Buchler</LastName>
<ForeName>Matthias</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Gatault</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Augusto</LastName>
<ForeName>Jean-François</ForeName>
<Initials>JF</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Duveau</LastName>
<ForeName>Agnès</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vigneau</LastName>
<ForeName>Cécile</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Morin</LastName>
<ForeName>Marie-Christine</ForeName>
<Initials>MC</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Chemouny</LastName>
<ForeName>Jonathan</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Golbin</LastName>
<ForeName>Leonard</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Grimbert</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Matignon</LastName>
<ForeName>Marie</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Durrbach</LastName>
<ForeName>Antoine</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Greze</LastName>
<ForeName>Clarisse</ForeName>
<Initials>C</Initials>
</Investigator>
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An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants.

An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants.

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