Pediatric liver transplantation and COVID-19: a case report.
Identifieur interne : 000A89 ( Main/Corpus ); précédent : 000A88; suivant : 000A90Pediatric liver transplantation and COVID-19: a case report.
Auteurs : Hamed Nikoupour ; Kourosh Kazemi ; Peyman Arasteh ; Saba Ghazimoghadam ; Hesameddin Eghlimi ; Naghi Dara ; Siavash Gholami ; Saman NikeghbalianSource :
- BMC surgery [ 1471-2482 ] ; 2020.
English descriptors
- KwdEn :
- MESH :
- complications : Coronavirus Infections, Pneumonia, Viral.
- etiology : Multiple Organ Failure.
- COVID-19, Child, Preschool, Humans, Intensive Care Units, Liver Transplantation, Male, Pandemics.
Abstract
BACKGROUND
Immunosuppressed patients, including individuals with organ transplantation, have been among susceptible groups with regard to COVID-19, on the other hand pediatric patients more commonly undergo a mild clinical course after acquiring COVID-19. To the best of the authors knowledge, to this date very little data exists on COVID-19 in a pediatric patient with liver transplantation.
CASE PRESENTATION
We report a three year-old boy who had liver transplantation at 18 months old. He was admitted due to dyspnea with impression of acute respiratory distress syndrome and was then transferred to the intensive care unit. Chest X-ray at admission showed bilateral infiltration. Vancomycin, meropenem, azithromycin, voriconazole and co-trimoxazole were started from the first day of admission. On day 4 of admission, with suspicion of COVID-19, hydroxychloroquine, lopinavir/ritonavir and oseltamivir were added to the antibiotic regimen. PCR was positive for COVID-19. The patient developed multi-organ failure and died on day 6 of admission.
CONCLUSIONS
For pediatric patients with organ transplantations, extreme caution should be taken, to limit and prevent their contact with COVID-19 during the outbreak, as these patients are highly susceptible to severe forms of the disease.
DOI: 10.1186/s12893-020-00878-6
PubMed: 33023552
PubMed Central: PMC7538038
Links to Exploration step
pubmed:33023552Le document en format XML
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<author><name sortKey="Nikoupour, Hamed" sort="Nikoupour, Hamed" uniqKey="Nikoupour H" first="Hamed" last="Nikoupour">Hamed Nikoupour</name>
<affiliation><nlm:affiliation>Shiraz Transplant Center, Abu Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.</nlm:affiliation>
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<author><name sortKey="Kazemi, Kourosh" sort="Kazemi, Kourosh" uniqKey="Kazemi K" first="Kourosh" last="Kazemi">Kourosh Kazemi</name>
<affiliation><nlm:affiliation>Shiraz Transplant Center, Abu Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.</nlm:affiliation>
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<author><name sortKey="Arasteh, Peyman" sort="Arasteh, Peyman" uniqKey="Arasteh P" first="Peyman" last="Arasteh">Peyman Arasteh</name>
<affiliation><nlm:affiliation>Shiraz Transplant Center, Abu Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.</nlm:affiliation>
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<author><name sortKey="Ghazimoghadam, Saba" sort="Ghazimoghadam, Saba" uniqKey="Ghazimoghadam S" first="Saba" last="Ghazimoghadam">Saba Ghazimoghadam</name>
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<author><name sortKey="Eghlimi, Hesameddin" sort="Eghlimi, Hesameddin" uniqKey="Eghlimi H" first="Hesameddin" last="Eghlimi">Hesameddin Eghlimi</name>
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<author><name sortKey="Dara, Naghi" sort="Dara, Naghi" uniqKey="Dara N" first="Naghi" last="Dara">Naghi Dara</name>
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<author><name sortKey="Gholami, Siavash" sort="Gholami, Siavash" uniqKey="Gholami S" first="Siavash" last="Gholami">Siavash Gholami</name>
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<author><name sortKey="Nikeghbalian, Saman" sort="Nikeghbalian, Saman" uniqKey="Nikeghbalian S" first="Saman" last="Nikeghbalian">Saman Nikeghbalian</name>
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<author><name sortKey="Kazemi, Kourosh" sort="Kazemi, Kourosh" uniqKey="Kazemi K" first="Kourosh" last="Kazemi">Kourosh Kazemi</name>
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<author><name sortKey="Arasteh, Peyman" sort="Arasteh, Peyman" uniqKey="Arasteh P" first="Peyman" last="Arasteh">Peyman Arasteh</name>
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<author><name sortKey="Ghazimoghadam, Saba" sort="Ghazimoghadam, Saba" uniqKey="Ghazimoghadam S" first="Saba" last="Ghazimoghadam">Saba Ghazimoghadam</name>
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<author><name sortKey="Eghlimi, Hesameddin" sort="Eghlimi, Hesameddin" uniqKey="Eghlimi H" first="Hesameddin" last="Eghlimi">Hesameddin Eghlimi</name>
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<author><name sortKey="Dara, Naghi" sort="Dara, Naghi" uniqKey="Dara N" first="Naghi" last="Dara">Naghi Dara</name>
<affiliation><nlm:affiliation>Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</nlm:affiliation>
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<author><name sortKey="Gholami, Siavash" sort="Gholami, Siavash" uniqKey="Gholami S" first="Siavash" last="Gholami">Siavash Gholami</name>
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<author><name sortKey="Nikeghbalian, Saman" sort="Nikeghbalian, Saman" uniqKey="Nikeghbalian S" first="Saman" last="Nikeghbalian">Saman Nikeghbalian</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>COVID-19 (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Coronavirus Infections (complications)</term>
<term>Humans (MeSH)</term>
<term>Intensive Care Units (MeSH)</term>
<term>Liver Transplantation (MeSH)</term>
<term>Male (MeSH)</term>
<term>Multiple Organ Failure (etiology)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
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<term>Pneumonia, Viral</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Immunosuppressed patients, including individuals with organ transplantation, have been among susceptible groups with regard to COVID-19, on the other hand pediatric patients more commonly undergo a mild clinical course after acquiring COVID-19. To the best of the authors knowledge, to this date very little data exists on COVID-19 in a pediatric patient with liver transplantation.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CASE PRESENTATION</b>
</p>
<p>We report a three year-old boy who had liver transplantation at 18 months old. He was admitted due to dyspnea with impression of acute respiratory distress syndrome and was then transferred to the intensive care unit. Chest X-ray at admission showed bilateral infiltration. Vancomycin, meropenem, azithromycin, voriconazole and co-trimoxazole were started from the first day of admission. On day 4 of admission, with suspicion of COVID-19, hydroxychloroquine, lopinavir/ritonavir and oseltamivir were added to the antibiotic regimen. PCR was positive for COVID-19. The patient developed multi-organ failure and died on day 6 of admission.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>For pediatric patients with organ transplantations, extreme caution should be taken, to limit and prevent their contact with COVID-19 during the outbreak, as these patients are highly susceptible to severe forms of the disease.</p>
</div>
</front>
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<AbstractText Label="CASE PRESENTATION" NlmCategory="METHODS">We report a three year-old boy who had liver transplantation at 18 months old. He was admitted due to dyspnea with impression of acute respiratory distress syndrome and was then transferred to the intensive care unit. Chest X-ray at admission showed bilateral infiltration. Vancomycin, meropenem, azithromycin, voriconazole and co-trimoxazole were started from the first day of admission. On day 4 of admission, with suspicion of COVID-19, hydroxychloroquine, lopinavir/ritonavir and oseltamivir were added to the antibiotic regimen. PCR was positive for COVID-19. The patient developed multi-organ failure and died on day 6 of admission.</AbstractText>
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