Characteristics and outcomes of acute respiratory distress syndrome related to COVID-19 in Belgian and French intensive care units according to antiviral strategies: the COVADIS multicentre observational study.
Identifieur interne : 000A85 ( Main/Corpus ); précédent : 000A84; suivant : 000A86Characteristics and outcomes of acute respiratory distress syndrome related to COVID-19 in Belgian and French intensive care units according to antiviral strategies: the COVADIS multicentre observational study.
Auteurs : David Grimaldi ; Nadia Aissaoui ; Gauthier Blonz ; Giuseppe Carbutti ; Romain Courcelle ; Stephane Gaudry ; Aurelie Gaultier ; Alain D'Hondt ; Julien Higny ; Geoffrey Horlait ; Sami Hraiech ; Laurent Lefebvre ; Francois Lejeune ; Andre Ly ; Michael Piagnerelli ; Bertrand Sauneuf ; Nicolas Serck ; Thibaud Soumagne ; Piotr Szychowiak ; Julien Textoris ; Benoit Vandenbunder ; Christophe Vinsonneau ; Jean- Baptiste LascarrouSource :
- Annals of intensive care [ 2110-5820 ] ; 2020.
Abstract
BACKGROUND
Limited data are available regarding antiviral therapy efficacy in most severe patients under mechanical ventilation for Covid-19-related acute respiratory distress syndrome (ARDS).
METHODS
Comparison of antiviral strategies (none, hydroxychloroquine (OHQ), lopinavir/ritonavir (L/R), others (combination or remdesivir) in an observational multicentre cohort of patients with moderate-to-severe Covid-19 ARDS. The primary endpoint was the number of day 28 ventilator-free days (VFD). Patients who died before d28 were considered as having 0 VFD. The variable was dichotomized into "patients still ventilated or dead at day 28" versus "patients weaned and alive at day 28".
RESULTS
We analyzed 415 patients (85 treated with standard of care (SOC), 57 with L/R, 220 with OHQ, and 53 others). The median number of d28-VFD was 0 (IQR 0-13) and differed between groups (P = 0.03), SOC patients having the highest d28-VFD. After adjustment for age, sex, Charlson Comorbidity Index, PaO
CONCLUSION
In this multicentre observational study of moderate-to-severe Covid-19 ARDS patients, we did not observe any benefit among patients treated with OHQ or L/R compared with SOC. The use of L/R treatment was associated with an increased need for RRT. Take home message Neither hydroxychloroquine nor lopinavir/ritonavir as COVID-19 antiviral treatment is associated with higher ventilator-free days at day 28 when compared with standard of care (no antiviral treatment) in ICU patients under invasive mechanical ventilation. Lopinavir/ritonavir is associated with an increased risk of renal replacement therapy requirement. Tweet COVID-19: Insights from ARDS cohort: no signal of efficacy of any antiviral drugs. Lopinavir/ritonavir may be associated with need for RRT.
DOI: 10.1186/s13613-020-00751-y
PubMed: 33025225
PubMed Central: PMC7537971
Links to Exploration step
pubmed:33025225Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characteristics and outcomes of acute respiratory distress syndrome related to COVID-19 in Belgian and French intensive care units according to antiviral strategies: the COVADIS multicentre observational study.</title><author><name sortKey="Grimaldi, David" sort="Grimaldi, David" uniqKey="Grimaldi D" first="David" last="Grimaldi">David Grimaldi</name><affiliation><nlm:affiliation>Soins IntensifsHôpital Erasme, ULB, Route de Lennik 808, 1070, Bruxelles, Belgium. david.grimaldi@erasme.ulb.ac.be.</nlm:affiliation></affiliation></author><author><name sortKey="Aissaoui, Nadia" sort="Aissaoui, Nadia" uniqKey="Aissaoui N" first="Nadia" last="Aissaoui">Nadia Aissaoui</name><affiliation><nlm:affiliation>Medecine Intensive Reanimation, Hôpital Européen Georges Pompidou, Paris centre U 970 PARCC, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blonz, Gauthier" sort="Blonz, Gauthier" uniqKey="Blonz G" first="Gauthier" last="Blonz">Gauthier Blonz</name><affiliation><nlm:affiliation>District Hospital Center, Boulevard Stephane Moreau, Medecine Intensive Reanimation, 85000, La Roche Sur Yon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Carbutti, Giuseppe" sort="Carbutti, Giuseppe" uniqKey="Carbutti G" first="Giuseppe" last="Carbutti">Giuseppe Carbutti</name><affiliation><nlm:affiliation>Unité de Soins Intensifs, CHR Mons-Hainaut, Mons, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Courcelle, Romain" sort="Courcelle, Romain" uniqKey="Courcelle R" first="Romain" last="Courcelle">Romain Courcelle</name><affiliation><nlm:affiliation>Unité de Soins Intensifs, Centres Hospitaliers de Jolimont, La Louvière, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Gaudry, Stephane" sort="Gaudry, Stephane" uniqKey="Gaudry S" first="Stephane" last="Gaudry">Stephane Gaudry</name><affiliation><nlm:affiliation>Réanimation médico-Chirurgicale CHU Avicennes, Université Sorbonne Paris Nord, Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gaultier, Aurelie" sort="Gaultier, Aurelie" uniqKey="Gaultier A" first="Aurelie" last="Gaultier">Aurelie Gaultier</name><affiliation><nlm:affiliation>Plateforme de Méthodologie Et Biostatistique, CHU Nantes, 1 Places Alexis Ricordeau, 44093, Nantes Cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="D Hondt, Alain" sort="D Hondt, Alain" uniqKey="D Hondt A" first="Alain" last="D'Hondt">Alain D'Hondt</name><affiliation><nlm:affiliation>Unité de Soins Intensifs, CHU Ambroise Paré, Mons, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Higny, Julien" sort="Higny, Julien" uniqKey="Higny J" first="Julien" last="Higny">Julien Higny</name><affiliation><nlm:affiliation>Unité de Soins Intensifs, CHU Dinant Godinne, site Dinant, Dinant, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Horlait, Geoffrey" sort="Horlait, Geoffrey" uniqKey="Horlait G" first="Geoffrey" last="Horlait">Geoffrey Horlait</name><affiliation><nlm:affiliation>Unité de Soins Intensifs, CHU Dinant Godinne, site Godinne, Godinne, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Hraiech, Sami" sort="Hraiech, Sami" uniqKey="Hraiech S" first="Sami" last="Hraiech">Sami Hraiech</name><affiliation><nlm:affiliation>Médecine Intensive Réanimation, Assistance Publique - Hôpitaux de Marseille, Hôpital Nord, 13015, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre D'Etudes Et de Recherches Sur Les Services de Santé Et qualité de Vie EA 3279, Aix- Faculté de médecine, Marseille Université, 13005, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lefebvre, Laurent" sort="Lefebvre, Laurent" uniqKey="Lefebvre L" first="Laurent" last="Lefebvre">Laurent Lefebvre</name><affiliation><nlm:affiliation>Réanimation Polyvalente Centre Hospitalier du Pays D'Aix, Aix en Provence, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lejeune, Francois" sort="Lejeune, Francois" uniqKey="Lejeune F" first="Francois" last="Lejeune">Francois Lejeune</name><affiliation><nlm:affiliation>Unité de Soins Intensifs, Clinique Notre Dame de Grâce, Gosselies, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Ly, Andre" sort="Ly, Andre" uniqKey="Ly A" first="Andre" last="Ly">Andre Ly</name><affiliation><nlm:affiliation>Service d'anesthésie-réanimation chirurgicale Unité de réanimation chirurgicale polyvalente, Hôpitaux Universitaires Henri Mondor, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Piagnerelli, Michael" sort="Piagnerelli, Michael" uniqKey="Piagnerelli M" first="Michael" last="Piagnerelli">Michael Piagnerelli</name><affiliation><nlm:affiliation>Intensive Care. CHU-Charleroi, Marie Curie, Université Libre de Bruxelles, 140, chaussée de Bruxelles, 6042, Charleroi, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Sauneuf, Bertrand" sort="Sauneuf, Bertrand" uniqKey="Sauneuf B" first="Bertrand" last="Sauneuf">Bertrand Sauneuf</name><affiliation><nlm:affiliation>Réanimation - Médecine Intensive, Centre Hospitalier Public du Cotentin, BP208, 50102, Cherbourg-en-Cotentin, France.</nlm:affiliation></affiliation></author><author><name sortKey="Serck, Nicolas" sort="Serck, Nicolas" uniqKey="Serck N" first="Nicolas" last="Serck">Nicolas Serck</name><affiliation><nlm:affiliation>Unité de soins intensifs, Clinique Saint Pierre, Ottignies, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Soumagne, Thibaud" sort="Soumagne, Thibaud" uniqKey="Soumagne T" first="Thibaud" last="Soumagne">Thibaud Soumagne</name><affiliation><nlm:affiliation>Médecine Intensive Réanimation, CHU Besançon, 3 Boulevard FLEMING, 25030, Besançon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Szychowiak, Piotr" sort="Szychowiak, Piotr" uniqKey="Szychowiak P" first="Piotr" last="Szychowiak">Piotr Szychowiak</name><affiliation><nlm:affiliation>Médecine Intensive Réanimation, CHRU Tours, Tours, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>INSERM CIC 1415, CHRU Tours, Tours, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>CRICS-TriggerSEP research network, Tours, France.</nlm:affiliation></affiliation></author><author><name sortKey="Textoris, Julien" sort="Textoris, Julien" uniqKey="Textoris J" first="Julien" last="Textoris">Julien Textoris</name><affiliation><nlm:affiliation>Service de réanimation, Hospices Civils de Lyon, 5 Place D'Arsonval, Lyon, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Laboratoire Commun de Recherche bioMérieux-Hospices Civils de Lyon-Université de Lyon 1, EA7426 PI3, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vandenbunder, Benoit" sort="Vandenbunder, Benoit" uniqKey="Vandenbunder B" first="Benoit" last="Vandenbunder">Benoit Vandenbunder</name><affiliation><nlm:affiliation>Groupe des anesthésistes réanimateurs, Hôpital Privé d'Antony, Antony, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vinsonneau, Christophe" sort="Vinsonneau, Christophe" uniqKey="Vinsonneau C" first="Christophe" last="Vinsonneau">Christophe Vinsonneau</name><affiliation><nlm:affiliation>Service de Médecine Intensive Réanimation Unité de Sevrage Ventilatoire et Réhabilitation Centre Hospitalier de BETHUNE, 27 Rue Delbecque, 62660, Beuvry, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lascarrou, Jean Baptiste" sort="Lascarrou, Jean Baptiste" uniqKey="Lascarrou J" first="Jean- Baptiste" last="Lascarrou">Jean- Baptiste Lascarrou</name><affiliation><nlm:affiliation>CRICS-TriggerSEP research network, Tours, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Medecine Intensive Reanimation, CHU Nantes, 30 Boulevard Jean Monnet, 44093, Nantes Cedex 9, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33025225</idno><idno type="pmid">33025225</idno><idno type="doi">10.1186/s13613-020-00751-y</idno><idno type="pmc">PMC7537971</idno><idno type="wicri:Area/Main/Corpus">000A85</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000A85</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characteristics and outcomes of acute respiratory distress syndrome related to COVID-19 in Belgian and French intensive care units according to antiviral strategies: the COVADIS multicentre observational study.</title><author><name sortKey="Grimaldi, David" sort="Grimaldi, David" uniqKey="Grimaldi D" first="David" last="Grimaldi">David Grimaldi</name><affiliation><nlm:affiliation>Soins IntensifsHôpital Erasme, ULB, Route de Lennik 808, 1070, Bruxelles, Belgium. david.grimaldi@erasme.ulb.ac.be.</nlm:affiliation></affiliation></author><author><name sortKey="Aissaoui, Nadia" sort="Aissaoui, Nadia" uniqKey="Aissaoui N" first="Nadia" last="Aissaoui">Nadia Aissaoui</name><affiliation><nlm:affiliation>Medecine Intensive Reanimation, Hôpital Européen Georges Pompidou, Paris centre U 970 PARCC, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blonz, Gauthier" sort="Blonz, Gauthier" uniqKey="Blonz G" first="Gauthier" last="Blonz">Gauthier Blonz</name><affiliation><nlm:affiliation>District Hospital Center, Boulevard Stephane Moreau, Medecine Intensive Reanimation, 85000, La Roche Sur Yon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Carbutti, Giuseppe" sort="Carbutti, Giuseppe" uniqKey="Carbutti G" first="Giuseppe" last="Carbutti">Giuseppe Carbutti</name><affiliation><nlm:affiliation>Unité de Soins Intensifs, CHR Mons-Hainaut, Mons, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Courcelle, Romain" sort="Courcelle, Romain" uniqKey="Courcelle R" first="Romain" last="Courcelle">Romain Courcelle</name><affiliation><nlm:affiliation>Unité de Soins Intensifs, Centres Hospitaliers de Jolimont, La Louvière, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Gaudry, Stephane" sort="Gaudry, Stephane" uniqKey="Gaudry S" first="Stephane" last="Gaudry">Stephane Gaudry</name><affiliation><nlm:affiliation>Réanimation médico-Chirurgicale CHU Avicennes, Université Sorbonne Paris Nord, Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gaultier, Aurelie" sort="Gaultier, Aurelie" uniqKey="Gaultier A" first="Aurelie" last="Gaultier">Aurelie Gaultier</name><affiliation><nlm:affiliation>Plateforme de Méthodologie Et Biostatistique, CHU Nantes, 1 Places Alexis Ricordeau, 44093, Nantes Cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="D Hondt, Alain" sort="D Hondt, Alain" uniqKey="D Hondt A" first="Alain" last="D'Hondt">Alain D'Hondt</name><affiliation><nlm:affiliation>Unité de Soins Intensifs, CHU Ambroise Paré, Mons, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Higny, Julien" sort="Higny, Julien" uniqKey="Higny J" first="Julien" last="Higny">Julien Higny</name><affiliation><nlm:affiliation>Unité de Soins Intensifs, CHU Dinant Godinne, site Dinant, Dinant, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Horlait, Geoffrey" sort="Horlait, Geoffrey" uniqKey="Horlait G" first="Geoffrey" last="Horlait">Geoffrey Horlait</name><affiliation><nlm:affiliation>Unité de Soins Intensifs, CHU Dinant Godinne, site Godinne, Godinne, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Hraiech, Sami" sort="Hraiech, Sami" uniqKey="Hraiech S" first="Sami" last="Hraiech">Sami Hraiech</name><affiliation><nlm:affiliation>Médecine Intensive Réanimation, Assistance Publique - Hôpitaux de Marseille, Hôpital Nord, 13015, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre D'Etudes Et de Recherches Sur Les Services de Santé Et qualité de Vie EA 3279, Aix- Faculté de médecine, Marseille Université, 13005, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lefebvre, Laurent" sort="Lefebvre, Laurent" uniqKey="Lefebvre L" first="Laurent" last="Lefebvre">Laurent Lefebvre</name><affiliation><nlm:affiliation>Réanimation Polyvalente Centre Hospitalier du Pays D'Aix, Aix en Provence, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lejeune, Francois" sort="Lejeune, Francois" uniqKey="Lejeune F" first="Francois" last="Lejeune">Francois Lejeune</name><affiliation><nlm:affiliation>Unité de Soins Intensifs, Clinique Notre Dame de Grâce, Gosselies, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Ly, Andre" sort="Ly, Andre" uniqKey="Ly A" first="Andre" last="Ly">Andre Ly</name><affiliation><nlm:affiliation>Service d'anesthésie-réanimation chirurgicale Unité de réanimation chirurgicale polyvalente, Hôpitaux Universitaires Henri Mondor, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Piagnerelli, Michael" sort="Piagnerelli, Michael" uniqKey="Piagnerelli M" first="Michael" last="Piagnerelli">Michael Piagnerelli</name><affiliation><nlm:affiliation>Intensive Care. CHU-Charleroi, Marie Curie, Université Libre de Bruxelles, 140, chaussée de Bruxelles, 6042, Charleroi, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Sauneuf, Bertrand" sort="Sauneuf, Bertrand" uniqKey="Sauneuf B" first="Bertrand" last="Sauneuf">Bertrand Sauneuf</name><affiliation><nlm:affiliation>Réanimation - Médecine Intensive, Centre Hospitalier Public du Cotentin, BP208, 50102, Cherbourg-en-Cotentin, France.</nlm:affiliation></affiliation></author><author><name sortKey="Serck, Nicolas" sort="Serck, Nicolas" uniqKey="Serck N" first="Nicolas" last="Serck">Nicolas Serck</name><affiliation><nlm:affiliation>Unité de soins intensifs, Clinique Saint Pierre, Ottignies, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Soumagne, Thibaud" sort="Soumagne, Thibaud" uniqKey="Soumagne T" first="Thibaud" last="Soumagne">Thibaud Soumagne</name><affiliation><nlm:affiliation>Médecine Intensive Réanimation, CHU Besançon, 3 Boulevard FLEMING, 25030, Besançon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Szychowiak, Piotr" sort="Szychowiak, Piotr" uniqKey="Szychowiak P" first="Piotr" last="Szychowiak">Piotr Szychowiak</name><affiliation><nlm:affiliation>Médecine Intensive Réanimation, CHRU Tours, Tours, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>INSERM CIC 1415, CHRU Tours, Tours, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>CRICS-TriggerSEP research network, Tours, France.</nlm:affiliation></affiliation></author><author><name sortKey="Textoris, Julien" sort="Textoris, Julien" uniqKey="Textoris J" first="Julien" last="Textoris">Julien Textoris</name><affiliation><nlm:affiliation>Service de réanimation, Hospices Civils de Lyon, 5 Place D'Arsonval, Lyon, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Laboratoire Commun de Recherche bioMérieux-Hospices Civils de Lyon-Université de Lyon 1, EA7426 PI3, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vandenbunder, Benoit" sort="Vandenbunder, Benoit" uniqKey="Vandenbunder B" first="Benoit" last="Vandenbunder">Benoit Vandenbunder</name><affiliation><nlm:affiliation>Groupe des anesthésistes réanimateurs, Hôpital Privé d'Antony, Antony, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vinsonneau, Christophe" sort="Vinsonneau, Christophe" uniqKey="Vinsonneau C" first="Christophe" last="Vinsonneau">Christophe Vinsonneau</name><affiliation><nlm:affiliation>Service de Médecine Intensive Réanimation Unité de Sevrage Ventilatoire et Réhabilitation Centre Hospitalier de BETHUNE, 27 Rue Delbecque, 62660, Beuvry, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lascarrou, Jean Baptiste" sort="Lascarrou, Jean Baptiste" uniqKey="Lascarrou J" first="Jean- Baptiste" last="Lascarrou">Jean- Baptiste Lascarrou</name><affiliation><nlm:affiliation>CRICS-TriggerSEP research network, Tours, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Medecine Intensive Reanimation, CHU Nantes, 30 Boulevard Jean Monnet, 44093, Nantes Cedex 9, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Annals of intensive care</title><idno type="ISSN">2110-5820</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Limited data are available regarding antiviral therapy efficacy in most severe patients under mechanical ventilation for Covid-19-related acute respiratory distress syndrome (ARDS).</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Comparison of antiviral strategies (none, hydroxychloroquine (OHQ), lopinavir/ritonavir (L/R), others (combination or remdesivir) in an observational multicentre cohort of patients with moderate-to-severe Covid-19 ARDS. The primary endpoint was the number of day 28 ventilator-free days (VFD). Patients who died before d28 were considered as having 0 VFD. The variable was dichotomized into "patients still ventilated or dead at day 28" versus "patients weaned and alive at day 28".</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We analyzed 415 patients (85 treated with standard of care (SOC), 57 with L/R, 220 with OHQ, and 53 others). The median number of d28-VFD was 0 (IQR 0-13) and differed between groups (P = 0.03), SOC patients having the highest d28-VFD. After adjustment for age, sex, Charlson Comorbidity Index, PaO</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>In this multicentre observational study of moderate-to-severe Covid-19 ARDS patients, we did not observe any benefit among patients treated with OHQ or L/R compared with SOC. The use of L/R treatment was associated with an increased need for RRT. Take home message Neither hydroxychloroquine nor lopinavir/ritonavir as COVID-19 antiviral treatment is associated with higher ventilator-free days at day 28 when compared with standard of care (no antiviral treatment) in ICU patients under invasive mechanical ventilation. Lopinavir/ritonavir is associated with an increased risk of renal replacement therapy requirement. Tweet COVID-19: Insights from ARDS cohort: no signal of efficacy of any antiviral drugs. Lopinavir/ritonavir may be associated with need for RRT.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33025225</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>09</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2110-5820</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Oct</Month><Day>06</Day></PubDate></JournalIssue><Title>Annals of intensive care</Title><ISOAbbreviation>Ann Intensive Care</ISOAbbreviation></Journal><ArticleTitle>Characteristics and outcomes of acute respiratory distress syndrome related to COVID-19 in Belgian and French intensive care units according to antiviral strategies: the COVADIS multicentre observational study.</ArticleTitle><Pagination><MedlinePgn>131</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13613-020-00751-y</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Limited data are available regarding antiviral therapy efficacy in most severe patients under mechanical ventilation for Covid-19-related acute respiratory distress syndrome (ARDS).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Comparison of antiviral strategies (none, hydroxychloroquine (OHQ), lopinavir/ritonavir (L/R), others (combination or remdesivir) in an observational multicentre cohort of patients with moderate-to-severe Covid-19 ARDS. The primary endpoint was the number of day 28 ventilator-free days (VFD). Patients who died before d28 were considered as having 0 VFD. The variable was dichotomized into "patients still ventilated or dead at day 28" versus "patients weaned and alive at day 28".</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We analyzed 415 patients (85 treated with standard of care (SOC), 57 with L/R, 220 with OHQ, and 53 others). The median number of d28-VFD was 0 (IQR 0-13) and differed between groups (P = 0.03), SOC patients having the highest d28-VFD. After adjustment for age, sex, Charlson Comorbidity Index, PaO<sub>2</sub>/FiO<sub>2</sub> ratio and plateau pressure and accounting for center effect with a generalized linear mixed model, none of the antiviral strategies increased the chance of being alive and weaned from MV at day 28 compared to the SOC strategy (OR 0.48 CI95% (0.18-1.25); OR 0.96 (0.47-2.02) and OR 1.43 (0.53-4.04) for L/R, OHQ and other treatments, respectively). Acute kidney injury during ICU stay was frequent (55%); its incidence was higher in patients receiving lopinavir (66 vs 53%, P = 0.03). After adjustment for age, sex, BMI, chronic hypertension and chronic renal disease, the use of L/R was associated with an increased risk of renal replacement therapy (RRT). (OR 2.52 CI95% 1.16-5.59).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In this multicentre observational study of moderate-to-severe Covid-19 ARDS patients, we did not observe any benefit among patients treated with OHQ or L/R compared with SOC. The use of L/R treatment was associated with an increased need for RRT. Take home message Neither hydroxychloroquine nor lopinavir/ritonavir as COVID-19 antiviral treatment is associated with higher ventilator-free days at day 28 when compared with standard of care (no antiviral treatment) in ICU patients under invasive mechanical ventilation. Lopinavir/ritonavir is associated with an increased risk of renal replacement therapy requirement. Tweet COVID-19: Insights from ARDS cohort: no signal of efficacy of any antiviral drugs. Lopinavir/ritonavir may be associated with need for RRT.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Grimaldi</LastName><ForeName>David</ForeName><Initials>D</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-8428-065X</Identifier><AffiliationInfo><Affiliation>Soins IntensifsHôpital Erasme, ULB, Route de Lennik 808, 1070, Bruxelles, Belgium. david.grimaldi@erasme.ulb.ac.be.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aissaoui</LastName><ForeName>Nadia</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Medecine Intensive Reanimation, Hôpital Européen Georges Pompidou, Paris centre U 970 PARCC, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blonz</LastName><ForeName>Gauthier</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>District Hospital Center, Boulevard Stephane Moreau, Medecine Intensive Reanimation, 85000, La Roche Sur Yon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carbutti</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Unité de Soins Intensifs, CHR Mons-Hainaut, Mons, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Courcelle</LastName><ForeName>Romain</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Unité de Soins Intensifs, Centres Hospitaliers de Jolimont, La Louvière, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaudry</LastName><ForeName>Stephane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Réanimation médico-Chirurgicale CHU Avicennes, Université Sorbonne Paris Nord, Bobigny, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaultier</LastName><ForeName>Aurelie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Plateforme de Méthodologie Et Biostatistique, CHU Nantes, 1 Places Alexis Ricordeau, 44093, Nantes Cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'hondt</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unité de Soins Intensifs, CHU Ambroise Paré, Mons, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Higny</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Unité de Soins Intensifs, CHU Dinant Godinne, site Dinant, Dinant, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horlait</LastName><ForeName>Geoffrey</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Unité de Soins Intensifs, CHU Dinant Godinne, site Godinne, Godinne, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hraiech</LastName><ForeName>Sami</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Médecine Intensive Réanimation, Assistance Publique - Hôpitaux de Marseille, Hôpital Nord, 13015, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre D'Etudes Et de Recherches Sur Les Services de Santé Et qualité de Vie EA 3279, Aix- Faculté de médecine, Marseille Université, 13005, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lefebvre</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Réanimation Polyvalente Centre Hospitalier du Pays D'Aix, Aix en Provence, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lejeune</LastName><ForeName>Francois</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Unité de Soins Intensifs, Clinique Notre Dame de Grâce, Gosselies, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ly</LastName><ForeName>Andre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Service d'anesthésie-réanimation chirurgicale Unité de réanimation chirurgicale polyvalente, Hôpitaux Universitaires Henri Mondor, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piagnerelli</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Intensive Care. CHU-Charleroi, Marie Curie, Université Libre de Bruxelles, 140, chaussée de Bruxelles, 6042, Charleroi, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sauneuf</LastName><ForeName>Bertrand</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Réanimation - Médecine Intensive, Centre Hospitalier Public du Cotentin, BP208, 50102, Cherbourg-en-Cotentin, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Serck</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Unité de soins intensifs, Clinique Saint Pierre, Ottignies, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soumagne</LastName><ForeName>Thibaud</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Médecine Intensive Réanimation, CHU Besançon, 3 Boulevard FLEMING, 25030, Besançon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Szychowiak</LastName><ForeName>Piotr</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Médecine Intensive Réanimation, CHRU Tours, Tours, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM CIC 1415, CHRU Tours, Tours, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CRICS-TriggerSEP research network, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Textoris</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Service de réanimation, Hospices Civils de Lyon, 5 Place D'Arsonval, Lyon, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratoire Commun de Recherche bioMérieux-Hospices Civils de Lyon-Université de Lyon 1, EA7426 PI3, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vandenbunder</LastName><ForeName>Benoit</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Groupe des anesthésistes réanimateurs, Hôpital Privé d'Antony, Antony, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vinsonneau</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Service de Médecine Intensive Réanimation Unité de Sevrage Ventilatoire et Réhabilitation Centre Hospitalier de BETHUNE, 27 Rue Delbecque, 62660, Beuvry, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lascarrou</LastName><ForeName>Jean- Baptiste</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>CRICS-TriggerSEP research network, Tours, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medecine Intensive Reanimation, CHU Nantes, 30 Boulevard Jean Monnet, 44093, Nantes Cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>COVADIS study group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Ann Intensive Care</MedlineTA><NlmUniqueID>101562873</NlmUniqueID><ISSNLinking>2110-5820</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute kidney injury</Keyword><Keyword MajorTopicYN="N">Hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">Lopinavir</Keyword><Keyword MajorTopicYN="N">Remdesivir</Keyword><Keyword MajorTopicYN="N">Renal replacement therapy</Keyword><Keyword MajorTopicYN="N">Ritonavir</Keyword></KeywordList><InvestigatorList><Investigator ValidYN="Y"><LastName>Biston</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Colin</LastName><ForeName>Gwenhael</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>de Maere</LastName><ForeName>Oriane</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ebstein</LastName><ForeName>Nathan</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ehrmann</LastName><ForeName>Stephan</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Foret</LastName><ForeName>Frederic</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Haentjens</LastName><ForeName>Lionel</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Helbert</LastName><ForeName>Thibault</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mesland</LastName><ForeName>Jean-Baptiste</ForeName><Initials>JB</Initials></Investigator><Investigator 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