COVID-19 in Turkey: A tertiary center experience.
Identifieur interne : 000836 ( Main/Corpus ); précédent : 000835; suivant : 000837COVID-19 in Turkey: A tertiary center experience.
Auteurs : P Nar Önal ; Ay E Ayz T K L Nç ; Fatih Aygün ; Cansu Durak ; Haluk Çoku RaSource :
- Pediatrics international : official journal of the Japan Pediatric Society [ 1442-200X ] ; 2020.
Abstract
BACKGROUND
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a serious epidemic in our country and all over the world since December 2019 and has become a global health problem. The disease caused by the SARS-CoV-2 virus has been named as coronavirus disease 19 (COVID-19).
METHODS
We report on the epidemiological and clinical features of 37 children diagnosed with COVID-19.
RESULTS
The median age was of the children was 10 years and 57.1% were male. In addition, 78.3% of the children had a history of contact with adult patients who had been diagnosed with COVID-19, and 27.0% had coexisting medical conditions. We found that 40.5% of our patients had mild infection, while 32.4% had moderate infection, and 27.1% had developed severe or critical illness. The most common abnormal laboratory findings in our patients were decreased lymphocytes (45.9%) and increased D-dimer values (43.2%), while abnormal radiological findings were detected in 56.7% of the children. In addition, 64.8% of the children had received azithromycin, 59.4% had received oseltamivir, and hydroxychloroquine was used in combination with azithromycin in 35.1% of the children. Non-invasive mechanical ventilation was required in 27.0% of the children.
CONCLUSIONS
Although COVID-19 infection is usually mild in children, severe illness can be seen in children with comorbidities, or even in children who were previously healthy.
DOI: 10.1111/ped.14549
PubMed: 33190342
PubMed Central: PMC7753277
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">COVID-19 in Turkey: A tertiary center experience.</title><author><name sortKey="Onal, P Nar" sort="Onal, P Nar" uniqKey="Onal P" first="P Nar" last="Önal">P Nar Önal</name><affiliation><nlm:affiliation>Department of Pediatric Infectious Diseases, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="K L Nc, Ay E Ayz T" sort="K L Nc, Ay E Ayz T" uniqKey="K L Nc A" first="Ay E Ayz T" last="K L Nç">Ay E Ayz T K L Nç</name><affiliation><nlm:affiliation>Department of Pediatric Pulmonology, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Aygun, Fatih" sort="Aygun, Fatih" uniqKey="Aygun F" first="Fatih" last="Aygün">Fatih Aygün</name><affiliation><nlm:affiliation>Department of Pediatric Intensive Care, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Durak, Cansu" sort="Durak, Cansu" uniqKey="Durak C" first="Cansu" last="Durak">Cansu Durak</name><affiliation><nlm:affiliation>Department of Pediatric Intensive Care, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Coku Ra, Haluk" sort="Coku Ra, Haluk" uniqKey="Coku Ra H" first="Haluk" last="Çoku Ra">Haluk Çoku Ra</name><affiliation><nlm:affiliation>Department of Pediatric Infectious Diseases, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33190342</idno><idno type="pmid">33190342</idno><idno type="doi">10.1111/ped.14549</idno><idno type="pmc">PMC7753277</idno><idno type="wicri:Area/Main/Corpus">000836</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000836</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19 in Turkey: A tertiary center experience.</title><author><name sortKey="Onal, P Nar" sort="Onal, P Nar" uniqKey="Onal P" first="P Nar" last="Önal">P Nar Önal</name><affiliation><nlm:affiliation>Department of Pediatric Infectious Diseases, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="K L Nc, Ay E Ayz T" sort="K L Nc, Ay E Ayz T" uniqKey="K L Nc A" first="Ay E Ayz T" last="K L Nç">Ay E Ayz T K L Nç</name><affiliation><nlm:affiliation>Department of Pediatric Pulmonology, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Aygun, Fatih" sort="Aygun, Fatih" uniqKey="Aygun F" first="Fatih" last="Aygün">Fatih Aygün</name><affiliation><nlm:affiliation>Department of Pediatric Intensive Care, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Durak, Cansu" sort="Durak, Cansu" uniqKey="Durak C" first="Cansu" last="Durak">Cansu Durak</name><affiliation><nlm:affiliation>Department of Pediatric Intensive Care, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Coku Ra, Haluk" sort="Coku Ra, Haluk" uniqKey="Coku Ra H" first="Haluk" last="Çoku Ra">Haluk Çoku Ra</name><affiliation><nlm:affiliation>Department of Pediatric Infectious Diseases, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Pediatrics international : official journal of the Japan Pediatric Society</title><idno type="eISSN">1442-200X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a serious epidemic in our country and all over the world since December 2019 and has become a global health problem. The disease caused by the SARS-CoV-2 virus has been named as coronavirus disease 19 (COVID-19).</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We report on the epidemiological and clinical features of 37 children diagnosed with COVID-19.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The median age was of the children was 10 years and 57.1% were male. In addition, 78.3% of the children had a history of contact with adult patients who had been diagnosed with COVID-19, and 27.0% had coexisting medical conditions. We found that 40.5% of our patients had mild infection, while 32.4% had moderate infection, and 27.1% had developed severe or critical illness. The most common abnormal laboratory findings in our patients were decreased lymphocytes (45.9%) and increased D-dimer values (43.2%), while abnormal radiological findings were detected in 56.7% of the children. In addition, 64.8% of the children had received azithromycin, 59.4% had received oseltamivir, and hydroxychloroquine was used in combination with azithromycin in 35.1% of the children. Non-invasive mechanical ventilation was required in 27.0% of the children.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Although COVID-19 infection is usually mild in children, severe illness can be seen in children with comorbidities, or even in children who were previously healthy.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33190342</PMID><DateRevised><Year>2021</Year><Month>04</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1442-200X</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Nov</Month><Day>15</Day></PubDate></JournalIssue><Title>Pediatrics international : official journal of the Japan Pediatric Society</Title><ISOAbbreviation>Pediatr Int</ISOAbbreviation></Journal><ArticleTitle>COVID-19 in Turkey: A tertiary center experience.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/ped.14549</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a serious epidemic in our country and all over the world since December 2019 and has become a global health problem. The disease caused by the SARS-CoV-2 virus has been named as coronavirus disease 19 (COVID-19).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We report on the epidemiological and clinical features of 37 children diagnosed with COVID-19.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The median age was of the children was 10 years and 57.1% were male. In addition, 78.3% of the children had a history of contact with adult patients who had been diagnosed with COVID-19, and 27.0% had coexisting medical conditions. We found that 40.5% of our patients had mild infection, while 32.4% had moderate infection, and 27.1% had developed severe or critical illness. The most common abnormal laboratory findings in our patients were decreased lymphocytes (45.9%) and increased D-dimer values (43.2%), while abnormal radiological findings were detected in 56.7% of the children. In addition, 64.8% of the children had received azithromycin, 59.4% had received oseltamivir, and hydroxychloroquine was used in combination with azithromycin in 35.1% of the children. Non-invasive mechanical ventilation was required in 27.0% of the children.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Although COVID-19 infection is usually mild in children, severe illness can be seen in children with comorbidities, or even in children who were previously healthy.</AbstractText><CopyrightInformation>© 2020 Japan Pediatric Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Önal</LastName><ForeName>Pınar</ForeName><Initials>P</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-7143-3132</Identifier><AffiliationInfo><Affiliation>Department of Pediatric Infectious Diseases, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kılınç</LastName><ForeName>Ayşe Ayzıt</ForeName><Initials>AA</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-2879-8910</Identifier><AffiliationInfo><Affiliation>Department of Pediatric Pulmonology, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aygün</LastName><ForeName>Fatih</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Pediatric Intensive Care, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Durak</LastName><ForeName>Cansu</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pediatric Intensive Care, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Çokuğraş</LastName><ForeName>Haluk</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pediatric Infectious Diseases, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>11</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>Australia</Country><MedlineTA>Pediatr Int</MedlineTA><NlmUniqueID>100886002</NlmUniqueID><ISSNLinking>1328-8067</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">children</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>10</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>11</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>11</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>11</Month><Day>15</Day><Hour>20</Hour><Minute>38</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33190342</ArticleId><ArticleId IdType="doi">10.1111/ped.14549</ArticleId><ArticleId IdType="pmc">PMC7753277</ArticleId></ArticleIdList><ReferenceList><Title>References</Title><Reference><Citation>De Wit E, Van Doremalen N, Falzarano D, Munster VJ. 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