CovidChloroV1, Main, Corpus, bibRecord, 000835

Recent progress of antiviral therapy for coronavirus disease 2019.

Identifieur interne : 000835 ( Main/Corpus ); précédent : 000834; suivant : 000836

Recent progress of antiviral therapy for coronavirus disease 2019.

Auteurs : Mengmeng Zhao ; Jishou Zhang ; Hanli Li ; Zhen Luo ; Jing Ye ; Yao Xu ; Zhen Wang ; Di Ye ; Jianfang Liu ; Dan Li ; Menglong Wang ; Jun Wan

Source :

European journal of pharmacology [ 1879-0712 ] ; 2021.

RBID : pubmed:33190802

English descriptors

KwdEn :
- Animals (MeSH), Antiviral Agents (therapeutic use), COVID-19 (drug therapy), Humans (MeSH), SARS-CoV-2 (MeSH).
MESH :
- chemical , therapeutic use : Antiviral Agents.
- drug therapy : COVID-19.
- Animals, Humans, SARS-CoV-2.

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has become a global public health crisis, for which antiviral treatments are considered mainstream therapeutic approaches. With the development of this pandemic, the number of clinical studies on antiviral therapy, including remdesivir, chloroquine and hydroxychloroquine, lopinavir/ritonavir, ribavirin, arbidol, interferon, favipiravir, oseltamivir, nitazoxanide, nelfinavir, and camostat mesylate, has been increasing. However, the efficacy of these antiviral drugs for COVID-19 remains controversial. In this review, we summarize the recent progress and findings on antiviral therapies, aiming to provide clinical support for the management of COVID-19. In addition, we analyze the causes of controversy in antiviral drug research and discuss the quality of current studies on antiviral treatments. High-quality randomized clinical trials are required to demonstrate the efficacy and safety of antiviral drugs for the treatment of COVID-19.

DOI: 10.1016/j.ejphar.2020.173646
PubMed: 33190802
PubMed Central: PMC7584884

Links to Exploration step

pubmed:33190802

Le document en format XML

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<affiliation><nlm:affiliation>Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China; Cardiovascular Research Institute, Wuhan University, Wuhan, China; Hubei Key Laboratory of Cardiology, Wuhan, China.</nlm:affiliation>
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<front><div type="abstract" xml:lang="en">The coronavirus disease 2019 (COVID-19) pandemic has become a global public health crisis, for which antiviral treatments are considered mainstream therapeutic approaches. With the development of this pandemic, the number of clinical studies on antiviral therapy, including remdesivir, chloroquine and hydroxychloroquine, lopinavir/ritonavir, ribavirin, arbidol, interferon, favipiravir, oseltamivir, nitazoxanide, nelfinavir, and camostat mesylate, has been increasing. However, the efficacy of these antiviral drugs for COVID-19 remains controversial. In this review, we summarize the recent progress and findings on antiviral therapies, aiming to provide clinical support for the management of COVID-19. In addition, we analyze the causes of controversy in antiviral drug research and discuss the quality of current studies on antiviral treatments. High-quality randomized clinical trials are required to demonstrate the efficacy and safety of antiviral drugs for the treatment of COVID-19.</div>
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<Abstract><AbstractText>The coronavirus disease 2019 (COVID-19) pandemic has become a global public health crisis, for which antiviral treatments are considered mainstream therapeutic approaches. With the development of this pandemic, the number of clinical studies on antiviral therapy, including remdesivir, chloroquine and hydroxychloroquine, lopinavir/ritonavir, ribavirin, arbidol, interferon, favipiravir, oseltamivir, nitazoxanide, nelfinavir, and camostat mesylate, has been increasing. However, the efficacy of these antiviral drugs for COVID-19 remains controversial. In this review, we summarize the recent progress and findings on antiviral therapies, aiming to provide clinical support for the management of COVID-19. In addition, we analyze the causes of controversy in antiviral drug research and discuss the quality of current studies on antiviral treatments. High-quality randomized clinical trials are required to demonstrate the efficacy and safety of antiviral drugs for the treatment of COVID-19.</AbstractText>
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Recent progress of antiviral therapy for coronavirus disease 2019.

Recent progress of antiviral therapy for coronavirus disease 2019.

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