Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2.
Identifieur interne : 000749 ( Main/Corpus ); précédent : 000748; suivant : 000750Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2.
Auteurs : Dipankar BhattacharyyaSource :
- Medical hypotheses [ 1532-2777 ] ; 2020.
English descriptors
- KwdEn :
- Acetates (therapeutic use), Anti-Asthmatic Agents (therapeutic use), Antiviral Agents (therapeutic use), COVID-19 (drug therapy), Cetirizine (therapeutic use), Clinical Trials as Topic (MeSH), Drug Repositioning (MeSH), Histamine H1 Antagonists, Non-Sedating (therapeutic use), Humans (MeSH), Hypersensitivity (drug therapy), Models, Theoretical (MeSH), Patient Safety (MeSH), Quinolines (therapeutic use), Taste (MeSH).
- MESH :
- chemical , therapeutic use : Acetates, Anti-Asthmatic Agents, Antiviral Agents, Cetirizine, Histamine H1 Antagonists, Non-Sedating, Quinolines.
- drug therapy : COVID-19, Hypersensitivity.
- Clinical Trials as Topic, Drug Repositioning, Humans, Models, Theoretical, Patient Safety, Taste.
Abstract
It has been hypothesised that antiallergic medications (AAMs) like montelukast and levocetirizine both the two bitter chloro compounds could be repurposed either alone or combinedly as an antiviral against SARS-CoV-2, like chloroquine/hydroxychloroquine (CQ/HCQ), another two bitter chloro compounds. Both AAMs and CQ/HCQ are bitter tasted chloro compounds. Depending on their these two similar physical properties and the safety and efficacy of AAMs by controlling over post viral episodes as comparing with viral inhibitory activities including SARS-CoV-2 by CQ/HCQ, a reposition of AAMs either alone/combinedly could be rationalised as an antiviral approach to nCoV.
DOI: 10.1016/j.mehy.2020.110046
PubMed: 33254480
PubMed Central: PMC7321662
Links to Exploration step
pubmed:33254480Le document en format XML
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<author><name sortKey="Bhattacharyya, Dipankar" sort="Bhattacharyya, Dipankar" uniqKey="Bhattacharyya D" first="Dipankar" last="Bhattacharyya">Dipankar Bhattacharyya</name>
<affiliation><nlm:affiliation>Chichuria Institute of Medical Science & Research, Thakurpara, Chichuria, Bethuadahari-II (XVI), Nadia, West Bengal 741 126, India. Electronic address: bhattacharyya952@gmail.com.</nlm:affiliation>
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<affiliation><nlm:affiliation>Chichuria Institute of Medical Science & Research, Thakurpara, Chichuria, Bethuadahari-II (XVI), Nadia, West Bengal 741 126, India. Electronic address: bhattacharyya952@gmail.com.</nlm:affiliation>
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<term>Anti-Asthmatic Agents (therapeutic use)</term>
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<term>COVID-19 (drug therapy)</term>
<term>Cetirizine (therapeutic use)</term>
<term>Clinical Trials as Topic (MeSH)</term>
<term>Drug Repositioning (MeSH)</term>
<term>Histamine H1 Antagonists, Non-Sedating (therapeutic use)</term>
<term>Humans (MeSH)</term>
<term>Hypersensitivity (drug therapy)</term>
<term>Models, Theoretical (MeSH)</term>
<term>Patient Safety (MeSH)</term>
<term>Quinolines (therapeutic use)</term>
<term>Taste (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Acetates</term>
<term>Anti-Asthmatic Agents</term>
<term>Antiviral Agents</term>
<term>Cetirizine</term>
<term>Histamine H1 Antagonists, Non-Sedating</term>
<term>Quinolines</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term>
<term>Hypersensitivity</term>
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<keywords scheme="MESH" xml:lang="en"><term>Clinical Trials as Topic</term>
<term>Drug Repositioning</term>
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<front><div type="abstract" xml:lang="en">It has been hypothesised that antiallergic medications (AAMs) like montelukast and levocetirizine both the two bitter chloro compounds could be repurposed either alone or combinedly as an antiviral against SARS-CoV-2, like chloroquine/hydroxychloroquine (CQ/HCQ), another two bitter chloro compounds. Both AAMs and CQ/HCQ are bitter tasted chloro compounds. Depending on their these two similar physical properties and the safety and efficacy of AAMs by controlling over post viral episodes as comparing with viral inhibitory activities including SARS-CoV-2 by CQ/HCQ, a reposition of AAMs either alone/combinedly could be rationalised as an antiviral approach to nCoV.</div>
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<Abstract><AbstractText>It has been hypothesised that antiallergic medications (AAMs) like montelukast and levocetirizine both the two bitter chloro compounds could be repurposed either alone or combinedly as an antiviral against SARS-CoV-2, like chloroquine/hydroxychloroquine (CQ/HCQ), another two bitter chloro compounds. Both AAMs and CQ/HCQ are bitter tasted chloro compounds. Depending on their these two similar physical properties and the safety and efficacy of AAMs by controlling over post viral episodes as comparing with viral inhibitory activities including SARS-CoV-2 by CQ/HCQ, a reposition of AAMs either alone/combinedly could be rationalised as an antiviral approach to nCoV.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation>
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<AffiliationInfo><Affiliation>Chichuria Institute of Medical Science & Research, Thakurpara, Chichuria, Bethuadahari-II (XVI), Nadia, West Bengal 741 126, India. Electronic address: bhattacharyya952@gmail.com.</Affiliation>
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