Safety of pharmacological options for the management of COVID-19 in pregnant women: An Indian perspective.
Identifieur interne : 000567 ( Main/Corpus ); précédent : 000566; suivant : 000568Safety of pharmacological options for the management of COVID-19 in pregnant women: An Indian perspective.
Auteurs : Kavita Manchanda ; Jasbir Singh ; Ranjeev Bhagat ; Ilmjot Kaur Tiwana ; Harmanjit SinghSource :
- The International journal of risk & safety in medicine [ 1878-6847 ] ; 2021.
English descriptors
- KwdEn :
- Anti-Infective Agents (adverse effects), Anti-Infective Agents (therapeutic use), Antiviral Agents (adverse effects), Antiviral Agents (therapeutic use), COVID-19 (drug therapy), COVID-19 (epidemiology), Drugs, Investigational (MeSH), Female (MeSH), Fetus (drug effects), Humans (MeSH), Hydroxychloroquine (adverse effects), Hydroxychloroquine (therapeutic use), India (epidemiology), Off-Label Use (MeSH), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (epidemiology), Pneumonia, Viral (virology), Pregnancy (MeSH), Pregnancy Complications, Infectious (drug therapy), Pregnancy Complications, Infectious (epidemiology), Pregnancy Complications, Infectious (virology), Pregnant Women (MeSH), SARS-CoV-2 (MeSH), Steroids (adverse effects), Steroids (therapeutic use).
- MESH :
- chemical , adverse effects : Anti-Infective Agents, Antiviral Agents, Hydroxychloroquine, Steroids.
- chemical , therapeutic use : Anti-Infective Agents, Antiviral Agents, Hydroxychloroquine, Steroids.
- geographic , epidemiology : India.
- drug effects : Fetus.
- drug therapy : COVID-19, Pneumonia, Viral, Pregnancy Complications, Infectious.
- epidemiology : COVID-19, Pneumonia, Viral, Pregnancy Complications, Infectious.
- virology : Pneumonia, Viral, Pregnancy Complications, Infectious.
- chemical : Drugs, Investigational, Female, Humans, Off-Label Use, Pandemics, Pregnancy, Pregnant Women, SARS-CoV-2.
Abstract
Coronavirus disease 2019 (COVID-19) is a viral illness caused by severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) presenting with pulmonary and extra-pulmonary manifestations. The first case was reported in Wuhan, China in December 2019 and it has rapidly progressed to the form of a pandemic. The presentation is mild in about 80 percent of the cases but the disease can also progress to a severe form of respiratory illness leading to acute respiratory distress syndrome (ARDS) and sometimes multi-organ failure, especially in people with other co-morbidities. Pregnant women also appear to be at a greater risk of acquiring a severe infection due to physiological changes during pregnancy. Many drugs with in vitro activity against the virus or an immunomodulatory effect have been considered for repurposing or have been tried as off-label drugs. The safety data regarding the use of newly approved or off-label or investigational drugs in pregnant women is limited and this poses a great challenge for clinicians. Therefore, it is important to know the utility and safety of the medications to avoid untoward adverse effects on pregnant women and fetuses. In this review, we aim to provide an overview of the approved, off-label, unlicensed, new and some promising pharmacological options for their use in the treatment of COVID-19 and the safety profile in pregnancy in an Indian scenario.
DOI: 10.3233/JRS-200060
PubMed: 33386817
Links to Exploration step
pubmed:33386817Le document en format XML
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<affiliation><nlm:affiliation>Fellow in Reproductive Medicine, Milann Fertility Centre, Bangalore, India.</nlm:affiliation>
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<author><name sortKey="Singh, Jasbir" sort="Singh, Jasbir" uniqKey="Singh J" first="Jasbir" last="Singh">Jasbir Singh</name>
<affiliation><nlm:affiliation>Associate Professor, Department of Pharmacology, Government Medical College and Rajindra Hospital, Patiala, India.</nlm:affiliation>
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<author><name sortKey="Bhagat, Ranjeev" sort="Bhagat, Ranjeev" uniqKey="Bhagat R" first="Ranjeev" last="Bhagat">Ranjeev Bhagat</name>
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<term>Antiviral Agents (therapeutic use)</term>
<term>COVID-19 (drug therapy)</term>
<term>COVID-19 (epidemiology)</term>
<term>Drugs, Investigational (MeSH)</term>
<term>Female (MeSH)</term>
<term>Fetus (drug effects)</term>
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<term>Hydroxychloroquine (therapeutic use)</term>
<term>India (epidemiology)</term>
<term>Off-Label Use (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Pregnancy (MeSH)</term>
<term>Pregnancy Complications, Infectious (drug therapy)</term>
<term>Pregnancy Complications, Infectious (epidemiology)</term>
<term>Pregnancy Complications, Infectious (virology)</term>
<term>Pregnant Women (MeSH)</term>
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<front><div type="abstract" xml:lang="en">Coronavirus disease 2019 (COVID-19) is a viral illness caused by severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) presenting with pulmonary and extra-pulmonary manifestations. The first case was reported in Wuhan, China in December 2019 and it has rapidly progressed to the form of a pandemic. The presentation is mild in about 80 percent of the cases but the disease can also progress to a severe form of respiratory illness leading to acute respiratory distress syndrome (ARDS) and sometimes multi-organ failure, especially in people with other co-morbidities. Pregnant women also appear to be at a greater risk of acquiring a severe infection due to physiological changes during pregnancy. Many drugs with in vitro activity against the virus or an immunomodulatory effect have been considered for repurposing or have been tried as off-label drugs. The safety data regarding the use of newly approved or off-label or investigational drugs in pregnant women is limited and this poses a great challenge for clinicians. Therefore, it is important to know the utility and safety of the medications to avoid untoward adverse effects on pregnant women and fetuses. In this review, we aim to provide an overview of the approved, off-label, unlicensed, new and some promising pharmacological options for their use in the treatment of COVID-19 and the safety profile in pregnancy in an Indian scenario.</div>
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