Chloroquine and hydroxychloroquine ototoxicity; potential implications for SARS-CoV-2 treatment. A brief review of the literature.
Identifieur interne : 000174 ( Main/Corpus ); précédent : 000173; suivant : 000175Chloroquine and hydroxychloroquine ototoxicity; potential implications for SARS-CoV-2 treatment. A brief review of the literature.
Auteurs : Pietro De Luca ; Alfonso Scarpa ; Egidio De Bonis ; Matteo Cavaliere ; Pasquale Viola ; Federico Maria Gioacchini ; Massimo Ralli ; Cassandro Ettore ; Cassandro ClaudiaSource :
- American journal of otolaryngology [ 1532-818X ] ; 2020.
Abstract
INTRODUCTION
Current clinical evidences do not support any specific treatment against SARS-CoV-2. Chloroquine (CQ) and hydroxychloroquine (HCQ) are typically used in the treatment of rheumatoid arthritis, systemic lupus erythematosus and malaria; they have been considered for off-label and compassionate use in several countries against moderate to severe cases of COVID-19 and there's actually a massive demand of these two drugs. The aim of this paper is to briefly review the published literature, summarizing evidences about audiological implications after CQ and HCQ treatment.
METHODS
We conducted a review of the literature on Medline and Pubmed platforms from 27th May 2020 to 30 May 2020. We combined MeSH terms of "chloroquine", "hydroxychloroquine", "ototoxicity", "hearing loss", "tinnitus", "deafness" and "hearing". Publications with relevant data were included. Selected data (authors, country and year; sample size; study design; audiological side effects) were extracted and summarized in a table.
RESULTS
Of 45 initial studies, 14 met inclusion criteria. The authors found xix cases of HCQ ototoxicity; Tinnitus was reported in 2 cases, and it was found to be reversible or irreversible. Sensorineural hearing loss after HCQ use was reported in 7 patients; it was found to be irreversible or partially reversible after discontinuation of HCQ in 6 cases. Eight papers reporting CQ ototoxicity were; tinnitus was not reported by any authors. Sensorineural hearing loss after taking CQ was reported in 6 patients; it was found to be irreversible after discontinuation of CQ in 5 patients. One patient showed abnormal gait after a single intramuscular injection of CQ. Thirteen patients' Auditory Brainstem Response (ABR) were found to be abnormal, but they resolved after CQ discontinuation.
CONCLUSIONS
CQ and HCQ related ototoxicity is widely reported in the literature although the pathophysiological mechanism is not well known. Current data are not sufficient enough to support the use of CQ and HCQ as therapy for COVID-19, but considering the growing demand for these two drugs and the number of people around the world who have taken and will take CQ and HCQ, it must necessarily consider the clinical and social impact of long term audiological side effects.
DOI: 10.1016/j.amjoto.2020.102640
PubMed: 33780902
PubMed Central: PMC7342085
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chloroquine and hydroxychloroquine ototoxicity; potential implications for SARS-CoV-2 treatment. A brief review of the literature.</title><author><name sortKey="De Luca, Pietro" sort="De Luca, Pietro" uniqKey="De Luca P" first="Pietro" last="De Luca">Pietro De Luca</name><affiliation><nlm:affiliation>Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy. Electronic address: dr.dlp@hotmail.it.</nlm:affiliation></affiliation></author><author><name sortKey="Scarpa, Alfonso" sort="Scarpa, Alfonso" uniqKey="Scarpa A" first="Alfonso" last="Scarpa">Alfonso Scarpa</name><affiliation><nlm:affiliation>Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="De Bonis, Egidio" sort="De Bonis, Egidio" uniqKey="De Bonis E" first="Egidio" last="De Bonis">Egidio De Bonis</name><affiliation><nlm:affiliation>Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cavaliere, Matteo" sort="Cavaliere, Matteo" uniqKey="Cavaliere M" first="Matteo" last="Cavaliere">Matteo Cavaliere</name><affiliation><nlm:affiliation>Otolaryngology Department, University Hospital "San Giovanni di Dio e Ruggi D'Aragona" Salerno, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Viola, Pasquale" sort="Viola, Pasquale" uniqKey="Viola P" first="Pasquale" last="Viola">Pasquale Viola</name><affiliation><nlm:affiliation>Unit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre for Cochlear Implants and ENT Diseases, University "Magna Graecia", Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gioacchini, Federico Maria" sort="Gioacchini, Federico Maria" uniqKey="Gioacchini F" first="Federico Maria" last="Gioacchini">Federico Maria Gioacchini</name><affiliation><nlm:affiliation>ENT Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ralli, Massimo" sort="Ralli, Massimo" uniqKey="Ralli M" first="Massimo" last="Ralli">Massimo Ralli</name><affiliation><nlm:affiliation>Department of Sense Organs, University "Sapienza", Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ettore, Cassandro" sort="Ettore, Cassandro" uniqKey="Ettore C" first="Cassandro" last="Ettore">Cassandro Ettore</name><affiliation><nlm:affiliation>Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Claudia, Cassandro" sort="Claudia, Cassandro" uniqKey="Claudia C" first="Cassandro" last="Claudia">Cassandro Claudia</name><affiliation><nlm:affiliation>Department of Surgical Sciences, University of Turin, Turin, Italy.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33780902</idno><idno type="pmid">33780902</idno><idno type="doi">10.1016/j.amjoto.2020.102640</idno><idno type="pmc">PMC7342085</idno><idno type="wicri:Area/Main/Corpus">000174</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000174</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chloroquine and hydroxychloroquine ototoxicity; potential implications for SARS-CoV-2 treatment. A brief review of the literature.</title><author><name sortKey="De Luca, Pietro" sort="De Luca, Pietro" uniqKey="De Luca P" first="Pietro" last="De Luca">Pietro De Luca</name><affiliation><nlm:affiliation>Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy. Electronic address: dr.dlp@hotmail.it.</nlm:affiliation></affiliation></author><author><name sortKey="Scarpa, Alfonso" sort="Scarpa, Alfonso" uniqKey="Scarpa A" first="Alfonso" last="Scarpa">Alfonso Scarpa</name><affiliation><nlm:affiliation>Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="De Bonis, Egidio" sort="De Bonis, Egidio" uniqKey="De Bonis E" first="Egidio" last="De Bonis">Egidio De Bonis</name><affiliation><nlm:affiliation>Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cavaliere, Matteo" sort="Cavaliere, Matteo" uniqKey="Cavaliere M" first="Matteo" last="Cavaliere">Matteo Cavaliere</name><affiliation><nlm:affiliation>Otolaryngology Department, University Hospital "San Giovanni di Dio e Ruggi D'Aragona" Salerno, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Viola, Pasquale" sort="Viola, Pasquale" uniqKey="Viola P" first="Pasquale" last="Viola">Pasquale Viola</name><affiliation><nlm:affiliation>Unit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre for Cochlear Implants and ENT Diseases, University "Magna Graecia", Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gioacchini, Federico Maria" sort="Gioacchini, Federico Maria" uniqKey="Gioacchini F" first="Federico Maria" last="Gioacchini">Federico Maria Gioacchini</name><affiliation><nlm:affiliation>ENT Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ralli, Massimo" sort="Ralli, Massimo" uniqKey="Ralli M" first="Massimo" last="Ralli">Massimo Ralli</name><affiliation><nlm:affiliation>Department of Sense Organs, University "Sapienza", Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ettore, Cassandro" sort="Ettore, Cassandro" uniqKey="Ettore C" first="Cassandro" last="Ettore">Cassandro Ettore</name><affiliation><nlm:affiliation>Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Claudia, Cassandro" sort="Claudia, Cassandro" uniqKey="Claudia C" first="Cassandro" last="Claudia">Cassandro Claudia</name><affiliation><nlm:affiliation>Department of Surgical Sciences, University of Turin, Turin, Italy.</nlm:affiliation></affiliation></author></analytic><series><title level="j">American journal of otolaryngology</title><idno type="eISSN">1532-818X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Current clinical evidences do not support any specific treatment against SARS-CoV-2. Chloroquine (CQ) and hydroxychloroquine (HCQ) are typically used in the treatment of rheumatoid arthritis, systemic lupus erythematosus and malaria; they have been considered for off-label and compassionate use in several countries against moderate to severe cases of COVID-19 and there's actually a massive demand of these two drugs. The aim of this paper is to briefly review the published literature, summarizing evidences about audiological implications after CQ and HCQ treatment.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We conducted a review of the literature on Medline and Pubmed platforms from 27th May 2020 to 30 May 2020. We combined MeSH terms of "chloroquine", "hydroxychloroquine", "ototoxicity", "hearing loss", "tinnitus", "deafness" and "hearing". Publications with relevant data were included. Selected data (authors, country and year; sample size; study design; audiological side effects) were extracted and summarized in a table.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Of 45 initial studies, 14 met inclusion criteria. The authors found xix cases of HCQ ototoxicity; Tinnitus was reported in 2 cases, and it was found to be reversible or irreversible. Sensorineural hearing loss after HCQ use was reported in 7 patients; it was found to be irreversible or partially reversible after discontinuation of HCQ in 6 cases. Eight papers reporting CQ ototoxicity were; tinnitus was not reported by any authors. Sensorineural hearing loss after taking CQ was reported in 6 patients; it was found to be irreversible after discontinuation of CQ in 5 patients. One patient showed abnormal gait after a single intramuscular injection of CQ. Thirteen patients' Auditory Brainstem Response (ABR) were found to be abnormal, but they resolved after CQ discontinuation.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>CQ and HCQ related ototoxicity is widely reported in the literature although the pathophysiological mechanism is not well known. Current data are not sufficient enough to support the use of CQ and HCQ as therapy for COVID-19, but considering the growing demand for these two drugs and the number of people around the world who have taken and will take CQ and HCQ, it must necessarily consider the clinical and social impact of long term audiological side effects.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33780902</PMID><DateRevised><Year>2021</Year><Month>04</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-818X</ISSN><JournalIssue CitedMedium="Internet"><Volume>42</Volume><Issue>5</Issue><PubDate><Year>2020</Year><Month>Jul</Month><Day>08</Day></PubDate></JournalIssue><Title>American journal of otolaryngology</Title><ISOAbbreviation>Am J Otolaryngol</ISOAbbreviation></Journal><ArticleTitle>Chloroquine and hydroxychloroquine ototoxicity; potential implications for SARS-CoV-2 treatment. A brief review of the literature.</ArticleTitle><Pagination><MedlinePgn>102640</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0196-0709(20)30334-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.amjoto.2020.102640</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Current clinical evidences do not support any specific treatment against SARS-CoV-2. Chloroquine (CQ) and hydroxychloroquine (HCQ) are typically used in the treatment of rheumatoid arthritis, systemic lupus erythematosus and malaria; they have been considered for off-label and compassionate use in several countries against moderate to severe cases of COVID-19 and there's actually a massive demand of these two drugs. The aim of this paper is to briefly review the published literature, summarizing evidences about audiological implications after CQ and HCQ treatment.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a review of the literature on Medline and Pubmed platforms from 27th May 2020 to 30 May 2020. We combined MeSH terms of "chloroquine", "hydroxychloroquine", "ototoxicity", "hearing loss", "tinnitus", "deafness" and "hearing". Publications with relevant data were included. Selected data (authors, country and year; sample size; study design; audiological side effects) were extracted and summarized in a table.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 45 initial studies, 14 met inclusion criteria. The authors found xix cases of HCQ ototoxicity; Tinnitus was reported in 2 cases, and it was found to be reversible or irreversible. Sensorineural hearing loss after HCQ use was reported in 7 patients; it was found to be irreversible or partially reversible after discontinuation of HCQ in 6 cases. Eight papers reporting CQ ototoxicity were; tinnitus was not reported by any authors. Sensorineural hearing loss after taking CQ was reported in 6 patients; it was found to be irreversible after discontinuation of CQ in 5 patients. One patient showed abnormal gait after a single intramuscular injection of CQ. Thirteen patients' Auditory Brainstem Response (ABR) were found to be abnormal, but they resolved after CQ discontinuation.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">CQ and HCQ related ototoxicity is widely reported in the literature although the pathophysiological mechanism is not well known. Current data are not sufficient enough to support the use of CQ and HCQ as therapy for COVID-19, but considering the growing demand for these two drugs and the number of people around the world who have taken and will take CQ and HCQ, it must necessarily consider the clinical and social impact of long term audiological side effects.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>De Luca</LastName><ForeName>Pietro</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy. Electronic address: dr.dlp@hotmail.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scarpa</LastName><ForeName>Alfonso</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Bonis</LastName><ForeName>Egidio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cavaliere</LastName><ForeName>Matteo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Otolaryngology Department, University Hospital "San Giovanni di Dio e Ruggi D'Aragona" Salerno, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viola</LastName><ForeName>Pasquale</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Unit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre for Cochlear Implants and ENT Diseases, University "Magna Graecia", Catanzaro, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gioacchini</LastName><ForeName>Federico Maria</ForeName><Initials>FM</Initials><AffiliationInfo><Affiliation>ENT Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ralli</LastName><ForeName>Massimo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Sense Organs, University "Sapienza", Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ettore</LastName><ForeName>Cassandro</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Claudia</LastName><ForeName>Cassandro</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Surgical Sciences, University of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Otolaryngol</MedlineTA><NlmUniqueID>8000029</NlmUniqueID><ISSNLinking>0196-0709</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Chloroquine</Keyword><Keyword MajorTopicYN="N">Hearing loss</Keyword><Keyword MajorTopicYN="N">Hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">Ototoxicity</Keyword><Keyword MajorTopicYN="N">Tinnitus</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>3</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>3</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>3</Month><Day>29</Day><Hour>20</Hour><Minute>26</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33780902</ArticleId><ArticleId IdType="pii">S0196-0709(20)30334-3</ArticleId><ArticleId IdType="doi">10.1016/j.amjoto.2020.102640</ArticleId><ArticleId IdType="pmc">PMC7342085</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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