System for administering and monitoring hydroxychloroquine prophylaxis for COVID-19 in accordance with a national advisory: preliminary experience of a tertiary care institute in India.
Identifieur interne : 000173 ( Main/Corpus ); précédent : 000172; suivant : 000174System for administering and monitoring hydroxychloroquine prophylaxis for COVID-19 in accordance with a national advisory: preliminary experience of a tertiary care institute in India.
Auteurs : Praveen Kumar-M ; Ritin Mohindra ; Ashish Bhalla ; Nusrat Shafiq ; Vikas Suri ; Deepa Kumari ; Avaneesh Kumar Pandey ; Ankur Gupta ; Parul Chawla Gupta ; Amol Patil ; Ashish Kumar Kakkar ; Samir MalhotraSource :
- Expert review of anti-infective therapy [ 1744-8336 ] ; 2021.
Abstract
BACKGROUND
Hydroxychloroquine (HCQ) was one of the earliest drugs to be recommended for tackling the COVID-19 threat leading to its widespread usage. We provide preliminary findings of the system, established in a tertiary care academic center for the administration of HCQ prophylaxis to healthcare workers (HCW) based on Indian Council of Medical Research (ICMR) advisory.
METHODS
A dedicated clinical pharmacology and internal medicine team screened for contraindications, administered informed consent, maintained compliance and monitored for adverse events.
RESULTS
Among the 194 HCWs screened for ruling out contraindications for prophylaxis, 9 were excluded and 185 were initiated on HCQ. A total of 55 adverse events were seen in 38 (20.5%) HCWs out of which 70.9%, 29.1% were mild and moderate & none were severe. Before the completion of therapy, a total of 23 participants discontinued. Change in QTc interval on day 2 was 5 (IQR: -3.75, 11) ms and the end of week 1 was 15 ms (IQR: 2, 18). Out of the 5 HCW who turned positive for COVID-19, 2 were on HCQ.
CONCLUSION
HCQ prophylaxis was found to be safe and well tolerated in HCW when administered after appropriate screening and with monitoring for adverse events.
DOI: 10.1080/14787210.2021.1909476
PubMed: 33781166
PubMed Central: PMC8054489
Links to Exploration step
pubmed:33781166Le document en format XML
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Malhotra</name><affiliation><nlm:affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33781166</idno><idno type="pmid">33781166</idno><idno type="doi">10.1080/14787210.2021.1909476</idno><idno type="pmc">PMC8054489</idno><idno type="wicri:Area/Main/Corpus">000173</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000173</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">System for administering and monitoring hydroxychloroquine prophylaxis for COVID-19 in accordance with a national advisory: preliminary experience of a tertiary care institute in India.</title><author><name sortKey="Kumar M, Praveen" sort="Kumar M, Praveen" uniqKey="Kumar M P" first="Praveen" last="Kumar-M">Praveen Kumar-M</name><affiliation><nlm:affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Mohindra, Ritin" sort="Mohindra, Ritin" uniqKey="Mohindra R" first="Ritin" last="Mohindra">Ritin Mohindra</name><affiliation><nlm:affiliation>Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Bhalla, Ashish" sort="Bhalla, Ashish" uniqKey="Bhalla A" first="Ashish" last="Bhalla">Ashish Bhalla</name><affiliation><nlm:affiliation>Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Shafiq, Nusrat" sort="Shafiq, Nusrat" uniqKey="Shafiq N" first="Nusrat" last="Shafiq">Nusrat Shafiq</name><affiliation><nlm:affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Suri, Vikas" sort="Suri, Vikas" uniqKey="Suri V" first="Vikas" last="Suri">Vikas Suri</name><affiliation><nlm:affiliation>Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Kumari, Deepa" sort="Kumari, Deepa" uniqKey="Kumari D" first="Deepa" last="Kumari">Deepa Kumari</name><affiliation><nlm:affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Pandey, Avaneesh Kumar" sort="Pandey, Avaneesh Kumar" uniqKey="Pandey A" first="Avaneesh Kumar" last="Pandey">Avaneesh Kumar Pandey</name><affiliation><nlm:affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Gupta, Ankur" sort="Gupta, Ankur" uniqKey="Gupta A" first="Ankur" last="Gupta">Ankur Gupta</name><affiliation><nlm:affiliation>Department of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Gupta, Parul Chawla" sort="Gupta, Parul Chawla" uniqKey="Gupta P" first="Parul Chawla" last="Gupta">Parul Chawla Gupta</name><affiliation><nlm:affiliation>Department of Ophthalmology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Patil, Amol" sort="Patil, Amol" uniqKey="Patil A" first="Amol" last="Patil">Amol Patil</name><affiliation><nlm:affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Kakkar, Ashish Kumar" sort="Kakkar, Ashish Kumar" uniqKey="Kakkar A" first="Ashish Kumar" last="Kakkar">Ashish Kumar Kakkar</name><affiliation><nlm:affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Malhotra, Samir" sort="Malhotra, Samir" uniqKey="Malhotra S" first="Samir" last="Malhotra">Samir Malhotra</name><affiliation><nlm:affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Expert review of anti-infective therapy</title><idno type="eISSN">1744-8336</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Hydroxychloroquine (HCQ) was one of the earliest drugs to be recommended for tackling the COVID-19 threat leading to its widespread usage. We provide preliminary findings of the system, established in a tertiary care academic center for the administration of HCQ prophylaxis to healthcare workers (HCW) based on Indian Council of Medical Research (ICMR) advisory.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A dedicated clinical pharmacology and internal medicine team screened for contraindications, administered informed consent, maintained compliance and monitored for adverse events.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Among the 194 HCWs screened for ruling out contraindications for prophylaxis, 9 were excluded and 185 were initiated on HCQ. A total of 55 adverse events were seen in 38 (20.5%) HCWs out of which 70.9%, 29.1% were mild and moderate & none were severe. Before the completion of therapy, a total of 23 participants discontinued. Change in QTc interval on day 2 was 5 (IQR: -3.75, 11) ms and the end of week 1 was 15 ms (IQR: 2, 18). Out of the 5 HCW who turned positive for COVID-19, 2 were on HCQ.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>HCQ prophylaxis was found to be safe and well tolerated in HCW when administered after appropriate screening and with monitoring for adverse events.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33781166</PMID><DateRevised><Year>2021</Year><Month>05</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1744-8336</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2021</Year><Month>Apr</Month><Day>15</Day></PubDate></JournalIssue><Title>Expert review of anti-infective therapy</Title><ISOAbbreviation>Expert Rev Anti Infect Ther</ISOAbbreviation></Journal><ArticleTitle>System for administering and monitoring hydroxychloroquine prophylaxis for COVID-19 in accordance with a national advisory: preliminary experience of a tertiary care institute in India.</ArticleTitle><Pagination><MedlinePgn>1-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/14787210.2021.1909476</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="UNASSIGNED">Hydroxychloroquine (HCQ) was one of the earliest drugs to be recommended for tackling the COVID-19 threat leading to its widespread usage. We provide preliminary findings of the system, established in a tertiary care academic center for the administration of HCQ prophylaxis to healthcare workers (HCW) based on Indian Council of Medical Research (ICMR) advisory.</AbstractText><AbstractText Label="METHODS" NlmCategory="UNASSIGNED">A dedicated clinical pharmacology and internal medicine team screened for contraindications, administered informed consent, maintained compliance and monitored for adverse events.</AbstractText><AbstractText Label="RESULTS" NlmCategory="UNASSIGNED">Among the 194 HCWs screened for ruling out contraindications for prophylaxis, 9 were excluded and 185 were initiated on HCQ. A total of 55 adverse events were seen in 38 (20.5%) HCWs out of which 70.9%, 29.1% were mild and moderate & none were severe. Before the completion of therapy, a total of 23 participants discontinued. Change in QTc interval on day 2 was 5 (IQR: -3.75, 11) ms and the end of week 1 was 15 ms (IQR: 2, 18). Out of the 5 HCW who turned positive for COVID-19, 2 were on HCQ.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="UNASSIGNED">HCQ prophylaxis was found to be safe and well tolerated in HCW when administered after appropriate screening and with monitoring for adverse events.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kumar-M</LastName><ForeName>Praveen</ForeName><Initials>P</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-9318-1167</Identifier><AffiliationInfo><Affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mohindra</LastName><ForeName>Ritin</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bhalla</LastName><ForeName>Ashish</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shafiq</LastName><ForeName>Nusrat</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suri</LastName><ForeName>Vikas</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumari</LastName><ForeName>Deepa</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pandey</LastName><ForeName>Avaneesh Kumar</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>Ankur</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>Parul Chawla</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patil</LastName><ForeName>Amol</ForeName><Initials>A</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8552-2796</Identifier><AffiliationInfo><Affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kakkar</LastName><ForeName>Ashish Kumar</ForeName><Initials>AK</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7768-7304</Identifier><AffiliationInfo><Affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malhotra</LastName><ForeName>Samir</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>04</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Expert Rev Anti Infect Ther</MedlineTA><NlmUniqueID>101181284</NlmUniqueID><ISSNLinking>1478-7210</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19 prophylaxis</Keyword><Keyword MajorTopicYN="N">HCQ</Keyword><Keyword MajorTopicYN="N">HCW</Keyword><Keyword MajorTopicYN="N">healthcare worker</Keyword><Keyword MajorTopicYN="N">hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">national advisory</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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