Unfavorable hydroxychloroquine COVID-19 research associated with authors having a history of political party donations.
Identifieur interne : 000156 ( Main/Corpus ); précédent : 000155; suivant : 000157Unfavorable hydroxychloroquine COVID-19 research associated with authors having a history of political party donations.
Auteurs : Andrew C. Berry ; Russell S. Gonnering ; Ivan Rodriguez ; Qianying Zhang ; Bruce B. BerrySource :
- Reviews in cardiovascular medicine [ 1530-6550 ] ; 2021.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antimalarials, Hydroxychloroquine.
- geographic : United States.
- drug therapy : COVID-19.
- Gift Giving, Humans, Politics, Publication Bias.
Abstract
We explored the degree to which political bias in medicine and study authors could explain the stark variation in Hydroxychloroquine (HCQ)/Chloroquine (CQ) study favorability in the US compared to the rest of the world. COVID-19/SARS-CoV-2 preprint and published papers between January 1, 2020-July 26, 2020 with Hydroxychloroquine and/or Chloroquine; 267 met study criteria, 68 from the US. A control subset was selected. HCQ/CQ study result favorability (favorable, unfavorable, or neutral) was noted. First and last main authors of each US study were entered into FollowTheMoney.org Website, extracting any history of political party donation. Of all US studies (68 total), 39/68 (57.4%) were unfavorable, with only 7/68 (10.3%) of US studies yielding favorable results-compared to 199 non-US studies, 66/199 (33.2%) unfavorable, 69/199 (34.7%) favorable, and 64/199 (32.2%) neutral. Studies with at least one US main author were 20.4% (SE 0.053, P < 0.05) more likely to report unfavorable results than non-US studies. US Studies with at least one main author donating to any political party were 25.6% (SE 0.085, P < 0.01) more likely to have unfavorable results. US studies with at least one author donating to the Democratic party were 20.4% (SE 0.045, P < 0.05) more likely to have unfavorable results. US authors were more likely to publish studies with medically harmful conclusions than non-US authors. Cardiology-specific HCQ/CQ studies were 44.2% more likely to yield harmful conclusions (P < 0.01). Inaccurate propagation of HCQ/CQ cardiac adverse effects with individual scientific author political bias has contributed to unfavorable US HCQ/CQ publication patterns and political polarization of the medications.
DOI: 10.31083/j.rcm.2021.01.262
PubMed: 33792262
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Unfavorable hydroxychloroquine COVID-19 research associated with authors having a history of political party donations.</title><author><name sortKey="Berry, Andrew C" sort="Berry, Andrew C" uniqKey="Berry A" first="Andrew C" last="Berry">Andrew C. Berry</name><affiliation><nlm:affiliation>Division of Gastroenterology, Larkin Community Hospital, South Miami, 33143 FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gonnering, Russell S" sort="Gonnering, Russell S" uniqKey="Gonnering R" first="Russell S" last="Gonnering">Russell S. Gonnering</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Medical College of Wisconsin, Milwaukee, 53226 WI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez, Ivan" sort="Rodriguez, Ivan" uniqKey="Rodriguez I" first="Ivan" last="Rodriguez">Ivan Rodriguez</name><affiliation><nlm:affiliation>Department of Accounting and Finance, Gary M. Owen College of Business, Eastern Michigan University, Ypsilanti, 48197 MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Qianying" sort="Zhang, Qianying" uniqKey="Zhang Q" first="Qianying" last="Zhang">Qianying Zhang</name><affiliation><nlm:affiliation>Department of Economics and Business Administration, Hillsdale College, Hillsdale, 49242 MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Berry, Bruce B" sort="Berry, Bruce B" uniqKey="Berry B" first="Bruce B" last="Berry">Bruce B. Berry</name><affiliation><nlm:affiliation>Community Physicians, Froedtert and the Medical College of Wisconsin, Milwaukee, 53226 WI, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33792262</idno><idno type="pmid">33792262</idno><idno type="doi">10.31083/j.rcm.2021.01.262</idno><idno type="wicri:Area/Main/Corpus">000156</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000156</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Unfavorable hydroxychloroquine COVID-19 research associated with authors having a history of political party donations.</title><author><name sortKey="Berry, Andrew C" sort="Berry, Andrew C" uniqKey="Berry A" first="Andrew C" last="Berry">Andrew C. Berry</name><affiliation><nlm:affiliation>Division of Gastroenterology, Larkin Community Hospital, South Miami, 33143 FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gonnering, Russell S" sort="Gonnering, Russell S" uniqKey="Gonnering R" first="Russell S" last="Gonnering">Russell S. Gonnering</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Medical College of Wisconsin, Milwaukee, 53226 WI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez, Ivan" sort="Rodriguez, Ivan" uniqKey="Rodriguez I" first="Ivan" last="Rodriguez">Ivan Rodriguez</name><affiliation><nlm:affiliation>Department of Accounting and Finance, Gary M. Owen College of Business, Eastern Michigan University, Ypsilanti, 48197 MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Qianying" sort="Zhang, Qianying" uniqKey="Zhang Q" first="Qianying" last="Zhang">Qianying Zhang</name><affiliation><nlm:affiliation>Department of Economics and Business Administration, Hillsdale College, Hillsdale, 49242 MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Berry, Bruce B" sort="Berry, Bruce B" uniqKey="Berry B" first="Bruce B" last="Berry">Bruce B. Berry</name><affiliation><nlm:affiliation>Community Physicians, Froedtert and the Medical College of Wisconsin, Milwaukee, 53226 WI, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Reviews in cardiovascular medicine</title><idno type="ISSN">1530-6550</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antimalarials (therapeutic use)</term><term>COVID-19 (drug therapy)</term><term>Gift Giving (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (therapeutic use)</term><term>Politics (MeSH)</term><term>Publication Bias (MeSH)</term><term>United States (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antimalarials</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>United States</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gift Giving</term><term>Humans</term><term>Politics</term><term>Publication Bias</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We explored the degree to which political bias in medicine and study authors could explain the stark variation in Hydroxychloroquine (HCQ)/Chloroquine (CQ) study favorability in the US compared to the rest of the world. COVID-19/SARS-CoV-2 preprint and published papers between January 1, 2020-July 26, 2020 with Hydroxychloroquine and/or Chloroquine; 267 met study criteria, 68 from the US. A control subset was selected. HCQ/CQ study result favorability (favorable, unfavorable, or neutral) was noted. First and last main authors of each US study were entered into <i>FollowTheMoney.org</i> Website, extracting any history of political party donation. Of all US studies (68 total), 39/68 (57.4%) were unfavorable, with only 7/68 (10.3%) of US studies yielding favorable results-compared to 199 non-US studies, 66/199 (33.2%) unfavorable, 69/199 (34.7%) favorable, and 64/199 (32.2%) neutral. Studies with at least one US main author were 20.4% (SE 0.053, <i>P</i> < 0.05) more likely to report unfavorable results than non-US studies. US Studies with at least one main author donating to <i>any</i> political party were 25.6% (SE 0.085, <i>P</i> < 0.01) more likely to have unfavorable results. US studies with at least one author donating to the Democratic party were 20.4% (SE 0.045, <i>P</i> < 0.05) more likely to have unfavorable results. US authors were more likely to publish studies with medically harmful conclusions than non-US authors. Cardiology-specific HCQ/CQ studies were 44.2% more likely to yield harmful conclusions (<i>P</i> < 0.01). Inaccurate propagation of HCQ/CQ cardiac adverse effects with individual scientific author political bias has contributed to unfavorable US HCQ/CQ publication patterns and political polarization of the medications.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33792262</PMID><DateCompleted><Year>2021</Year><Month>04</Month><Day>20</Day></DateCompleted><DateRevised><Year>2021</Year><Month>04</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1530-6550</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>1</Issue><PubDate><Year>2021</Year><Month>03</Month><Day>30</Day></PubDate></JournalIssue><Title>Reviews in cardiovascular medicine</Title><ISOAbbreviation>Rev Cardiovasc Med</ISOAbbreviation></Journal><ArticleTitle>Unfavorable hydroxychloroquine COVID-19 research associated with authors having a history of political party donations.</ArticleTitle><Pagination><MedlinePgn>191-198</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.31083/j.rcm.2021.01.262</ELocationID><Abstract><AbstractText>We explored the degree to which political bias in medicine and study authors could explain the stark variation in Hydroxychloroquine (HCQ)/Chloroquine (CQ) study favorability in the US compared to the rest of the world. COVID-19/SARS-CoV-2 preprint and published papers between January 1, 2020-July 26, 2020 with Hydroxychloroquine and/or Chloroquine; 267 met study criteria, 68 from the US. A control subset was selected. HCQ/CQ study result favorability (favorable, unfavorable, or neutral) was noted. First and last main authors of each US study were entered into <i>FollowTheMoney.org</i> Website, extracting any history of political party donation. Of all US studies (68 total), 39/68 (57.4%) were unfavorable, with only 7/68 (10.3%) of US studies yielding favorable results-compared to 199 non-US studies, 66/199 (33.2%) unfavorable, 69/199 (34.7%) favorable, and 64/199 (32.2%) neutral. Studies with at least one US main author were 20.4% (SE 0.053, <i>P</i> < 0.05) more likely to report unfavorable results than non-US studies. US Studies with at least one main author donating to <i>any</i> political party were 25.6% (SE 0.085, <i>P</i> < 0.01) more likely to have unfavorable results. US studies with at least one author donating to the Democratic party were 20.4% (SE 0.045, <i>P</i> < 0.05) more likely to have unfavorable results. US authors were more likely to publish studies with medically harmful conclusions than non-US authors. Cardiology-specific HCQ/CQ studies were 44.2% more likely to yield harmful conclusions (<i>P</i> < 0.01). Inaccurate propagation of HCQ/CQ cardiac adverse effects with individual scientific author political bias has contributed to unfavorable US HCQ/CQ publication patterns and political polarization of the medications.</AbstractText><CopyrightInformation>© 2021 The Authors. Published by IMR Press.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Berry</LastName><ForeName>Andrew C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Larkin Community Hospital, South Miami, 33143 FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gonnering</LastName><ForeName>Russell S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Sciences, The Medical College of Wisconsin, Milwaukee, 53226 WI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodriguez</LastName><ForeName>Ivan</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Accounting and Finance, Gary M. Owen College of Business, Eastern Michigan University, Ypsilanti, 48197 MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Qianying</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Economics and Business Administration, Hillsdale College, Hillsdale, 49242 MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berry</LastName><ForeName>Bruce B</ForeName><Initials>BB</Initials><AffiliationInfo><Affiliation>Community Physicians, Froedtert and the Medical College of Wisconsin, Milwaukee, 53226 WI, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Rev Cardiovasc Med</MedlineTA><NlmUniqueID>100960007</NlmUniqueID><ISSNLinking>1530-6550</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D037921" MajorTopicYN="Y">Gift Giving</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011057" MajorTopicYN="Y">Politics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017594" MajorTopicYN="Y">Publication Bias</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">Cardiac</Keyword><Keyword MajorTopicYN="Y">Chloroquine</Keyword><Keyword MajorTopicYN="Y">Donations</Keyword><Keyword MajorTopicYN="Y">Hydroxychloroquine</Keyword><Keyword MajorTopicYN="Y">Political bias</Keyword><Keyword MajorTopicYN="Y">Political party</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword></KeywordList><CoiStatement>The authors declare no financial or political conflicts of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>11</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>12</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2021</Year><Month>01</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>4</Month><Day>1</Day><Hour>10</Hour><Minute>20</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>4</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33792262</ArticleId><ArticleId IdType="pii">1617068681011-1593459803</ArticleId><ArticleId IdType="doi">10.31083/j.rcm.2021.01.262</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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