Hydroxychloroquine/Chloroquine as Therapeutics for COVID-19: Truth under the Mystery.
Identifieur interne : 000074 ( Main/Corpus ); précédent : 000073; suivant : 000075Hydroxychloroquine/Chloroquine as Therapeutics for COVID-19: Truth under the Mystery.
Auteurs : Yao Chen ; Mei-Xiu Li ; Guo-Dong Lu ; Han-Ming Shen ; Jing ZhouSource :
- International journal of biological sciences [ 1449-2288 ] ; 2021.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antiviral Agents, Chloroquine, Hydroxychloroquine.
- drug therapy : COVID-19.
- isolation & purification : SARS-CoV-2.
- virology : COVID-19.
- Animals, Disease Models, Animal, Endocytosis, Humans.
Abstract
The outbreak of coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly evolved into a global pandemic. One major challenge in the battle against this deadly disease is to find effective therapy. Due to the availability and proven clinical record of hydroxychloroquine (HCQ) and chloroquine (CQ) in various human diseases, there have been enormous efforts in repurposing these two drugs as therapeutics for COVID-19. To date, substantial amount of work at cellular, animal models and clinical trials have been performed to verify their therapeutic potential against COVID-19. However, neither lab-based studies nor clinical trials have provided consistent and convincing evidence to support the therapeutic value of HCQ/CQ in the treatment of COVID-19. In this mini review we provide a systematic summary on this important topic and aim to reveal some truth covered by the mystery regarding the therapeutic value of HCQ/CQ in COVID-19.
DOI: 10.7150/ijbs.59547
PubMed: 33907517
PubMed Central: PMC8071775
Links to Exploration step
pubmed:33907517Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hydroxychloroquine/Chloroquine as Therapeutics for COVID-19: Truth under the Mystery.</title><author><name sortKey="Chen, Yao" sort="Chen, Yao" uniqKey="Chen Y" first="Yao" last="Chen">Yao Chen</name><affiliation><nlm:affiliation>Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Mei Xiu" sort="Li, Mei Xiu" uniqKey="Li M" first="Mei-Xiu" last="Li">Mei-Xiu Li</name><affiliation><nlm:affiliation>Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.</nlm:affiliation></affiliation></author><author><name sortKey="Lu, Guo Dong" sort="Lu, Guo Dong" uniqKey="Lu G" first="Guo-Dong" last="Lu">Guo-Dong Lu</name><affiliation><nlm:affiliation>Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.</nlm:affiliation></affiliation></author><author><name sortKey="Shen, Han Ming" sort="Shen, Han Ming" uniqKey="Shen H" first="Han-Ming" last="Shen">Han-Ming Shen</name><affiliation><nlm:affiliation>Faculty of Health Sciences, University of Macau, Taipa, Macau, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Jing" sort="Zhou, Jing" uniqKey="Zhou J" first="Jing" last="Zhou">Jing Zhou</name><affiliation><nlm:affiliation>Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33907517</idno><idno type="pmid">33907517</idno><idno type="doi">10.7150/ijbs.59547</idno><idno type="pmc">PMC8071775</idno><idno type="wicri:Area/Main/Corpus">000074</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000074</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hydroxychloroquine/Chloroquine as Therapeutics for COVID-19: Truth under the Mystery.</title><author><name sortKey="Chen, Yao" sort="Chen, Yao" uniqKey="Chen Y" first="Yao" last="Chen">Yao Chen</name><affiliation><nlm:affiliation>Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Mei Xiu" sort="Li, Mei Xiu" uniqKey="Li M" first="Mei-Xiu" last="Li">Mei-Xiu Li</name><affiliation><nlm:affiliation>Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.</nlm:affiliation></affiliation></author><author><name sortKey="Lu, Guo Dong" sort="Lu, Guo Dong" uniqKey="Lu G" first="Guo-Dong" last="Lu">Guo-Dong Lu</name><affiliation><nlm:affiliation>Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.</nlm:affiliation></affiliation></author><author><name sortKey="Shen, Han Ming" sort="Shen, Han Ming" uniqKey="Shen H" first="Han-Ming" last="Shen">Han-Ming Shen</name><affiliation><nlm:affiliation>Faculty of Health Sciences, University of Macau, Taipa, Macau, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Jing" sort="Zhou, Jing" uniqKey="Zhou J" first="Jing" last="Zhou">Jing Zhou</name><affiliation><nlm:affiliation>Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author></analytic><series><title level="j">International journal of biological sciences</title><idno type="eISSN">1449-2288</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antiviral Agents (therapeutic use)</term><term>COVID-19 (drug therapy)</term><term>COVID-19 (virology)</term><term>Chloroquine (therapeutic use)</term><term>Disease Models, Animal (MeSH)</term><term>Endocytosis (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (therapeutic use)</term><term>SARS-CoV-2 (isolation & purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Chloroquine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS-CoV-2</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Endocytosis</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The outbreak of coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly evolved into a global pandemic. One major challenge in the battle against this deadly disease is to find effective therapy. Due to the availability and proven clinical record of hydroxychloroquine (HCQ) and chloroquine (CQ) in various human diseases, there have been enormous efforts in repurposing these two drugs as therapeutics for COVID-19. To date, substantial amount of work at cellular, animal models and clinical trials have been performed to verify their therapeutic potential against COVID-19. However, neither lab-based studies nor clinical trials have provided consistent and convincing evidence to support the therapeutic value of HCQ/CQ in the treatment of COVID-19. In this mini review we provide a systematic summary on this important topic and aim to reveal some truth covered by the mystery regarding the therapeutic value of HCQ/CQ in COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33907517</PMID><DateCompleted><Year>2021</Year><Month>05</Month><Day>20</Day></DateCompleted><DateRevised><Year>2021</Year><Month>05</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1449-2288</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>6</Issue><PubDate><Year>2021</Year></PubDate></JournalIssue><Title>International journal of biological sciences</Title><ISOAbbreviation>Int J Biol Sci</ISOAbbreviation></Journal><ArticleTitle>Hydroxychloroquine/Chloroquine as Therapeutics for COVID-19: Truth under the Mystery.</ArticleTitle><Pagination><MedlinePgn>1538-1546</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.7150/ijbs.59547</ELocationID><Abstract><AbstractText>The outbreak of coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly evolved into a global pandemic. One major challenge in the battle against this deadly disease is to find effective therapy. Due to the availability and proven clinical record of hydroxychloroquine (HCQ) and chloroquine (CQ) in various human diseases, there have been enormous efforts in repurposing these two drugs as therapeutics for COVID-19. To date, substantial amount of work at cellular, animal models and clinical trials have been performed to verify their therapeutic potential against COVID-19. However, neither lab-based studies nor clinical trials have provided consistent and convincing evidence to support the therapeutic value of HCQ/CQ in the treatment of COVID-19. In this mini review we provide a systematic summary on this important topic and aim to reveal some truth covered by the mystery regarding the therapeutic value of HCQ/CQ in COVID-19.</AbstractText><CopyrightInformation>© The author(s).</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yao</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Mei-Xiu</ForeName><Initials>MX</Initials><AffiliationInfo><Affiliation>Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Guo-Dong</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>Han-Ming</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>Faculty of Health Sciences, University of Macau, Taipa, Macau, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>04</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Australia</Country><MedlineTA>Int J Biol Sci</MedlineTA><NlmUniqueID>101235568</NlmUniqueID><ISSNLinking>1449-2288</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" 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