Current Debates in Antiphospholipid Syndrome: The Acquired Antibody-Mediated Thrombophilia
Identifieur interne : 000250 ( an2020/Analysis ); précédent : 000249; suivant : 000251Current Debates in Antiphospholipid Syndrome: The Acquired Antibody-Mediated Thrombophilia
Auteurs : M. Akif Öztürk ; Ibrahim C. Haznedaro Lu [Turquie] ; Mehmet Turgut [Turquie] ; Hakan Göker [Turquie]Source :
- Clinical and Applied Thrombosis/Hemostasis [ 1076-0296 ] ; 2004-04.
English descriptors
- Teeft :
- Acas, Akif, Amengual, Anionic phospholipids, Annexin, Antibody, Antibody syndrome, Anticardiolipin, Anticardiolipin antibodies, Anticoagulant, Anticoagulation, Antigenic, Antiphospholipid, Antiphospholipid antibodies, Antiphospholipid antibody syndrome, Antiphospholipid syndrome, Antithrombotic, Apoptosis, Apoptotic, Apoptotic cells, Appl, Aptt, Arthritis rheum, Aspirin, Assay, Asymptomatic, Atsumi, Autoantibody, Autoimmun, Autoimmune, Beta, Bick, Cardiolipin, Cervera, Clin, Clin appl thromb hemost, Clin pathol, Clinical features, Clinical manifestations, Clinical significance, Coagulation, Coagulation cascade, Cofactor, Cohort, Confirmatory, Current debates, Drvvt, Elisa, Endothelial, Endothelial cells, Endothelium, Epitope, Erythematosus, Fetal, Fetal loss, Gharavi, Glycoprotein, Gonadotropin, Gynecol, Haematol, Haemost, Hematol, Hemost, Hemostasis, Heparin, Hypertension, Immune, Immunoglobulin, Immunol, Immunologic, Infarction, Intravenous, Invasiveness, Ischemic, Isotype, Ivig, Kaolin, Khamashta, Laboratory diagnosis, Lipid, Lipoprotein, Lmwh, Lupus, Lupus anticoagulant, Lupus anticoagulants, Miscarriage, Monoclonal, Monocyte, Myocardial infarction, Neurologic, Normal plasma, Obstet, Obstet gynecol, Obstetric, Other hand, Oxidative, Oxidized, Pathobiology, Pathogenesis, Pathol, Pathway, Phosphatidylethanolamine, Phosphatidylserine, Phospholipid, Pierangeli, Placenta, Placental, Placental thrombosis, Platelet, Platelet activation, Pregnancy loss, Primary antiphospholipid syndrome, Procoagulant, Prophylaxis, Prothrombin, Prothrombotic, Randomized, Reprod, Rheum, Rheumatol, Rheumatology, Standardization, Subgroup, Suppl, Syndrome, Syndrome patients, Systemic, Systemic lupus erythematosus, Thromb, Thromb haemost, Thrombin, Thrombocytopenia, Thromboembolism, Thrombophilia, Thromboplastin, Thrombosis, Thrombotic, Thrombotic events, Thrombus, Tissue factor, Tissue factor pathway, Triplett, Trophoblast, Venous, Venous thrombosis, Viper, Warfarin.
Abstract
Antiphospholipid (APL) syndrome is the most common form of acquired thrombophilia. It can cause significant morbidity and even mortality. The term “APL antibodies” represents a heterogeneous group of antibodies associated with this disorder. Currently no single assay can identify every APL antibody. Clinically relevant APL antibodies are mainly anticardiolipin antibodies (ACA) detected by solid phase enzyme-linked immunosorbent assay (ELISA) and lupus anticoagulants (LA) demonstrated by in vitro coagulation assay. However, there are some other antibodies associated with the APL syndrome (i.e., subgroup APL antibodies). ACAs, LAs, and subgroup APL antibodies represent intersecting, but non-identical, subsets of autoantibodies. Thus, those autoantibodies may coexist or may occur independently. Any organ system and any size of vessel can be affected during the clinical course of the disease. Therefore, the APL syndrome can manifest itself in a wide variety of clinical thrombotic features. Fetal loss and pregnancy morbidity represent a specific challenge. Despite tremendous advances in the understanding of the pathogenesis of APL syndrome during the past decade, the mainstay of management is still anticoagulation. However, there is no general agreement regarding the duration and intensity of anticoagulant therapy. In this review, we focused on the current dilemmas and their present clarifications in the wide clinicopathologic spectrum of APL syndrome and APL antibody-related distinct pathologic conditions.
Url:
DOI: 10.1177/107602960401000201
Affiliations:
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<term>Akif</term>
<term>Amengual</term>
<term>Anionic phospholipids</term>
<term>Annexin</term>
<term>Antibody</term>
<term>Antibody syndrome</term>
<term>Anticardiolipin</term>
<term>Anticardiolipin antibodies</term>
<term>Anticoagulant</term>
<term>Anticoagulation</term>
<term>Antigenic</term>
<term>Antiphospholipid</term>
<term>Antiphospholipid antibodies</term>
<term>Antiphospholipid antibody syndrome</term>
<term>Antiphospholipid syndrome</term>
<term>Antithrombotic</term>
<term>Apoptosis</term>
<term>Apoptotic</term>
<term>Apoptotic cells</term>
<term>Appl</term>
<term>Aptt</term>
<term>Arthritis rheum</term>
<term>Aspirin</term>
<term>Assay</term>
<term>Asymptomatic</term>
<term>Atsumi</term>
<term>Autoantibody</term>
<term>Autoimmun</term>
<term>Autoimmune</term>
<term>Beta</term>
<term>Bick</term>
<term>Cardiolipin</term>
<term>Cervera</term>
<term>Clin</term>
<term>Clin appl thromb hemost</term>
<term>Clin pathol</term>
<term>Clinical features</term>
<term>Clinical manifestations</term>
<term>Clinical significance</term>
<term>Coagulation</term>
<term>Coagulation cascade</term>
<term>Cofactor</term>
<term>Cohort</term>
<term>Confirmatory</term>
<term>Current debates</term>
<term>Drvvt</term>
<term>Elisa</term>
<term>Endothelial</term>
<term>Endothelial cells</term>
<term>Endothelium</term>
<term>Epitope</term>
<term>Erythematosus</term>
<term>Fetal</term>
<term>Fetal loss</term>
<term>Gharavi</term>
<term>Glycoprotein</term>
<term>Gonadotropin</term>
<term>Gynecol</term>
<term>Haematol</term>
<term>Haemost</term>
<term>Hematol</term>
<term>Hemost</term>
<term>Hemostasis</term>
<term>Heparin</term>
<term>Hypertension</term>
<term>Immune</term>
<term>Immunoglobulin</term>
<term>Immunol</term>
<term>Immunologic</term>
<term>Infarction</term>
<term>Intravenous</term>
<term>Invasiveness</term>
<term>Ischemic</term>
<term>Isotype</term>
<term>Ivig</term>
<term>Kaolin</term>
<term>Khamashta</term>
<term>Laboratory diagnosis</term>
<term>Lipid</term>
<term>Lipoprotein</term>
<term>Lmwh</term>
<term>Lupus</term>
<term>Lupus anticoagulant</term>
<term>Lupus anticoagulants</term>
<term>Miscarriage</term>
<term>Monoclonal</term>
<term>Monocyte</term>
<term>Myocardial infarction</term>
<term>Neurologic</term>
<term>Normal plasma</term>
<term>Obstet</term>
<term>Obstet gynecol</term>
<term>Obstetric</term>
<term>Other hand</term>
<term>Oxidative</term>
<term>Oxidized</term>
<term>Pathobiology</term>
<term>Pathogenesis</term>
<term>Pathol</term>
<term>Pathway</term>
<term>Phosphatidylethanolamine</term>
<term>Phosphatidylserine</term>
<term>Phospholipid</term>
<term>Pierangeli</term>
<term>Placenta</term>
<term>Placental</term>
<term>Placental thrombosis</term>
<term>Platelet</term>
<term>Platelet activation</term>
<term>Pregnancy loss</term>
<term>Primary antiphospholipid syndrome</term>
<term>Procoagulant</term>
<term>Prophylaxis</term>
<term>Prothrombin</term>
<term>Prothrombotic</term>
<term>Randomized</term>
<term>Reprod</term>
<term>Rheum</term>
<term>Rheumatol</term>
<term>Rheumatology</term>
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<term>Subgroup</term>
<term>Suppl</term>
<term>Syndrome</term>
<term>Syndrome patients</term>
<term>Systemic</term>
<term>Systemic lupus erythematosus</term>
<term>Thromb</term>
<term>Thromb haemost</term>
<term>Thrombin</term>
<term>Thrombocytopenia</term>
<term>Thromboembolism</term>
<term>Thrombophilia</term>
<term>Thromboplastin</term>
<term>Thrombosis</term>
<term>Thrombotic</term>
<term>Thrombotic events</term>
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<term>Tissue factor</term>
<term>Tissue factor pathway</term>
<term>Triplett</term>
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<term>Venous thrombosis</term>
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<front><div type="abstract" xml:lang="en">Antiphospholipid (APL) syndrome is the most common form of acquired thrombophilia. It can cause significant morbidity and even mortality. The term “APL antibodies” represents a heterogeneous group of antibodies associated with this disorder. Currently no single assay can identify every APL antibody. Clinically relevant APL antibodies are mainly anticardiolipin antibodies (ACA) detected by solid phase enzyme-linked immunosorbent assay (ELISA) and lupus anticoagulants (LA) demonstrated by in vitro coagulation assay. However, there are some other antibodies associated with the APL syndrome (i.e., subgroup APL antibodies). ACAs, LAs, and subgroup APL antibodies represent intersecting, but non-identical, subsets of autoantibodies. Thus, those autoantibodies may coexist or may occur independently. Any organ system and any size of vessel can be affected during the clinical course of the disease. Therefore, the APL syndrome can manifest itself in a wide variety of clinical thrombotic features. Fetal loss and pregnancy morbidity represent a specific challenge. Despite tremendous advances in the understanding of the pathogenesis of APL syndrome during the past decade, the mainstay of management is still anticoagulation. However, there is no general agreement regarding the duration and intensity of anticoagulant therapy. In this review, we focused on the current dilemmas and their present clarifications in the wide clinicopathologic spectrum of APL syndrome and APL antibody-related distinct pathologic conditions.</div>
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