Chloroquine treatment of interstitial lung disease in children.
Identifieur interne : 000524 ( PubMed/Curation ); précédent : 000523; suivant : 000525Chloroquine treatment of interstitial lung disease in children.
Auteurs : A. Avital [Israël] ; S. Godfrey ; C. Maayan ; Y. Diamant ; C. SpringerSource :
- Pediatric pulmonology [ 8755-6863 ] ; 1994.
Descripteurs français
- KwdFr :
- Association de médicaments, Chloroquine (usage thérapeutique), Enfant, Enfant d'âge préscolaire, Humains, Nourrisson, Pneumopathies interstitielles (diagnostic), Pneumopathies interstitielles (traitement médicamenteux), Prednisone (usage thérapeutique), Résultat thérapeutique, Tests de la fonction respiratoire, Épreuve d'effort, Études de suivi.
- MESH :
- diagnostic : Pneumopathies interstitielles.
- traitement médicamenteux : Pneumopathies interstitielles.
- usage thérapeutique : Chloroquine, Prednisone.
- Association de médicaments, Enfant, Enfant d'âge préscolaire, Humains, Nourrisson, Résultat thérapeutique, Tests de la fonction respiratoire, Épreuve d'effort, Études de suivi.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Chloroquine, Prednisone.
- diagnosis : Lung Diseases, Interstitial.
- drug therapy : Lung Diseases, Interstitial.
- Child, Child, Preschool, Drug Therapy, Combination, Exercise Test, Follow-Up Studies, Humans, Infant, Respiratory Function Tests, Treatment Outcome.
Abstract
Seven children aged 3 months to 11 years with histologically confirmed interstitial lung disease (ILD) [6 with desquamative interstitial pneumonitis (DIP) and 1 with chronic interstitial pneumonitis] were treated with chloroquine, 10 mg/kg/day. One patient, diagnosed late in the course of the disease, died after three weeks of treatment, despite the addition of systemic corticosteroids. Another patient responded to combined therapy with chloroquine and prednisone and had a normal lung biopsy after 6 months of treatment. He underwent surgical repair of mitral valve stenosis and died after extensive brain infarction. The other 5 patients responded well to chloroquine therapy with major improvement in oxygenation within a few weeks and in lung function over the next few months. They remained well clinically and physiologically, including a normal response to incremental exercise, during a mean follow-up period of 9.8 years (range 3.5 to 15.7 years). None of the patients has developed retinopathy or any other ocular complication. Bronchoalveolar lavage was a useful tool for evaluation of the activity of the disease (predominance of neutrophils) in 3 out of 4 patients. We suggest that chloroquine should be considered as an effective treatment in ILD in children. Incremental exercise test may be helpful for routine follow-up and evaluation of the efficacy of a specific treatment.
DOI: 10.1002/ppul.1950180603
PubMed: 7892069
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000524
Links to Exploration step
pubmed:7892069Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chloroquine treatment of interstitial lung disease in children.</title><author><name sortKey="Avital, A" sort="Avital, A" uniqKey="Avital A" first="A" last="Avital">A. Avital</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pulmonology, Hadassah University Hospital, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Institute of Pulmonology, Hadassah University Hospital, Jerusalem</wicri:regionArea></affiliation></author><author><name sortKey="Godfrey, S" sort="Godfrey, S" uniqKey="Godfrey S" first="S" last="Godfrey">S. Godfrey</name></author><author><name sortKey="Maayan, C" sort="Maayan, C" uniqKey="Maayan C" first="C" last="Maayan">C. Maayan</name></author><author><name sortKey="Diamant, Y" sort="Diamant, Y" uniqKey="Diamant Y" first="Y" last="Diamant">Y. Diamant</name></author><author><name sortKey="Springer, C" sort="Springer, C" uniqKey="Springer C" first="C" last="Springer">C. Springer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:7892069</idno><idno type="pmid">7892069</idno><idno type="doi">10.1002/ppul.1950180603</idno><idno type="wicri:Area/PubMed/Corpus">000524</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000524</idno><idno type="wicri:Area/PubMed/Curation">000524</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000524</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chloroquine treatment of interstitial lung disease in children.</title><author><name sortKey="Avital, A" sort="Avital, A" uniqKey="Avital A" first="A" last="Avital">A. Avital</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pulmonology, Hadassah University Hospital, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Institute of Pulmonology, Hadassah University Hospital, Jerusalem</wicri:regionArea></affiliation></author><author><name sortKey="Godfrey, S" sort="Godfrey, S" uniqKey="Godfrey S" first="S" last="Godfrey">S. Godfrey</name></author><author><name sortKey="Maayan, C" sort="Maayan, C" uniqKey="Maayan C" first="C" last="Maayan">C. Maayan</name></author><author><name sortKey="Diamant, Y" sort="Diamant, Y" uniqKey="Diamant Y" first="Y" last="Diamant">Y. Diamant</name></author><author><name sortKey="Springer, C" sort="Springer, C" uniqKey="Springer C" first="C" last="Springer">C. Springer</name></author></analytic><series><title level="j">Pediatric pulmonology</title><idno type="ISSN">8755-6863</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Child, Preschool</term><term>Chloroquine (therapeutic use)</term><term>Drug Therapy, Combination</term><term>Exercise Test</term><term>Follow-Up Studies</term><term>Humans</term><term>Infant</term><term>Lung Diseases, Interstitial (diagnosis)</term><term>Lung Diseases, Interstitial (drug therapy)</term><term>Prednisone (therapeutic use)</term><term>Respiratory Function Tests</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Association de médicaments</term><term>Chloroquine (usage thérapeutique)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Humains</term><term>Nourrisson</term><term>Pneumopathies interstitielles (diagnostic)</term><term>Pneumopathies interstitielles (traitement médicamenteux)</term><term>Prednisone (usage thérapeutique)</term><term>Résultat thérapeutique</term><term>Tests de la fonction respiratoire</term><term>Épreuve d'effort</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Chloroquine</term><term>Prednisone</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Pneumopathies interstitielles</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Pneumopathies interstitielles</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Chloroquine</term><term>Prednisone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Child, Preschool</term><term>Drug Therapy, Combination</term><term>Exercise Test</term><term>Follow-Up Studies</term><term>Humans</term><term>Infant</term><term>Respiratory Function Tests</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Association de médicaments</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Humains</term><term>Nourrisson</term><term>Résultat thérapeutique</term><term>Tests de la fonction respiratoire</term><term>Épreuve d'effort</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Seven children aged 3 months to 11 years with histologically confirmed interstitial lung disease (ILD) [6 with desquamative interstitial pneumonitis (DIP) and 1 with chronic interstitial pneumonitis] were treated with chloroquine, 10 mg/kg/day. One patient, diagnosed late in the course of the disease, died after three weeks of treatment, despite the addition of systemic corticosteroids. Another patient responded to combined therapy with chloroquine and prednisone and had a normal lung biopsy after 6 months of treatment. He underwent surgical repair of mitral valve stenosis and died after extensive brain infarction. The other 5 patients responded well to chloroquine therapy with major improvement in oxygenation within a few weeks and in lung function over the next few months. They remained well clinically and physiologically, including a normal response to incremental exercise, during a mean follow-up period of 9.8 years (range 3.5 to 15.7 years). None of the patients has developed retinopathy or any other ocular complication. Bronchoalveolar lavage was a useful tool for evaluation of the activity of the disease (predominance of neutrophils) in 3 out of 4 patients. We suggest that chloroquine should be considered as an effective treatment in ILD in children. Incremental exercise test may be helpful for routine follow-up and evaluation of the efficacy of a specific treatment.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7892069</PMID><DateCompleted><Year>1995</Year><Month>04</Month><Day>20</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">8755-6863</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>6</Issue><PubDate><Year>1994</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Pediatric pulmonology</Title><ISOAbbreviation>Pediatr. Pulmonol.</ISOAbbreviation></Journal><ArticleTitle>Chloroquine treatment of interstitial lung disease in children.</ArticleTitle><Pagination><MedlinePgn>356-60</MedlinePgn></Pagination><Abstract><AbstractText>Seven children aged 3 months to 11 years with histologically confirmed interstitial lung disease (ILD) [6 with desquamative interstitial pneumonitis (DIP) and 1 with chronic interstitial pneumonitis] were treated with chloroquine, 10 mg/kg/day. One patient, diagnosed late in the course of the disease, died after three weeks of treatment, despite the addition of systemic corticosteroids. Another patient responded to combined therapy with chloroquine and prednisone and had a normal lung biopsy after 6 months of treatment. He underwent surgical repair of mitral valve stenosis and died after extensive brain infarction. The other 5 patients responded well to chloroquine therapy with major improvement in oxygenation within a few weeks and in lung function over the next few months. They remained well clinically and physiologically, including a normal response to incremental exercise, during a mean follow-up period of 9.8 years (range 3.5 to 15.7 years). None of the patients has developed retinopathy or any other ocular complication. Bronchoalveolar lavage was a useful tool for evaluation of the activity of the disease (predominance of neutrophils) in 3 out of 4 patients. We suggest that chloroquine should be considered as an effective treatment in ILD in children. Incremental exercise test may be helpful for routine follow-up and evaluation of the efficacy of a specific treatment.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Avital</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Pulmonology, Hadassah University Hospital, Jerusalem, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Godfrey</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Maayan</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Diamant</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Springer</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pediatr Pulmonol</MedlineTA><NlmUniqueID>8510590</NlmUniqueID><ISSNLinking>1099-0496</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>VB0R961HZT</RegistryNumber><NameOfSubstance UI="D011241">Prednisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005080" MajorTopicYN="N">Exercise Test</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017563" MajorTopicYN="N">Lung Diseases, Interstitial</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011241" MajorTopicYN="N">Prednisone</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012129" MajorTopicYN="N">Respiratory Function Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1994</Year><Month>12</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1994</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1994</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7892069</ArticleId><ArticleId IdType="doi">10.1002/ppul.1950180603</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000524 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000524 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:7892069
|texte= Chloroquine treatment of interstitial lung disease in children.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:7892069" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |