Chloroquine treatment of interstitial lung disease in children.
Identifieur interne : 000524 ( PubMed/Corpus ); précédent : 000523; suivant : 000525Chloroquine treatment of interstitial lung disease in children.
Auteurs : A. Avital ; S. Godfrey ; C. Maayan ; Y. Diamant ; C. SpringerSource :
- Pediatric pulmonology [ 8755-6863 ] ; 1994.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Chloroquine, Prednisone.
- diagnosis : Lung Diseases, Interstitial.
- drug therapy : Lung Diseases, Interstitial.
- Child, Child, Preschool, Drug Therapy, Combination, Exercise Test, Follow-Up Studies, Humans, Infant, Respiratory Function Tests, Treatment Outcome.
Abstract
Seven children aged 3 months to 11 years with histologically confirmed interstitial lung disease (ILD) [6 with desquamative interstitial pneumonitis (DIP) and 1 with chronic interstitial pneumonitis] were treated with chloroquine, 10 mg/kg/day. One patient, diagnosed late in the course of the disease, died after three weeks of treatment, despite the addition of systemic corticosteroids. Another patient responded to combined therapy with chloroquine and prednisone and had a normal lung biopsy after 6 months of treatment. He underwent surgical repair of mitral valve stenosis and died after extensive brain infarction. The other 5 patients responded well to chloroquine therapy with major improvement in oxygenation within a few weeks and in lung function over the next few months. They remained well clinically and physiologically, including a normal response to incremental exercise, during a mean follow-up period of 9.8 years (range 3.5 to 15.7 years). None of the patients has developed retinopathy or any other ocular complication. Bronchoalveolar lavage was a useful tool for evaluation of the activity of the disease (predominance of neutrophils) in 3 out of 4 patients. We suggest that chloroquine should be considered as an effective treatment in ILD in children. Incremental exercise test may be helpful for routine follow-up and evaluation of the efficacy of a specific treatment.
DOI: 10.1002/ppul.1950180603
PubMed: 7892069
Links to Exploration step
pubmed:7892069Le document en format XML
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<author><name sortKey="Avital, A" sort="Avital, A" uniqKey="Avital A" first="A" last="Avital">A. Avital</name>
<affiliation><nlm:affiliation>Institute of Pulmonology, Hadassah University Hospital, Jerusalem, Israel.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Godfrey, S" sort="Godfrey, S" uniqKey="Godfrey S" first="S" last="Godfrey">S. Godfrey</name>
</author>
<author><name sortKey="Maayan, C" sort="Maayan, C" uniqKey="Maayan C" first="C" last="Maayan">C. Maayan</name>
</author>
<author><name sortKey="Diamant, Y" sort="Diamant, Y" uniqKey="Diamant Y" first="Y" last="Diamant">Y. Diamant</name>
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<author><name sortKey="Springer, C" sort="Springer, C" uniqKey="Springer C" first="C" last="Springer">C. Springer</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Chloroquine treatment of interstitial lung disease in children.</title>
<author><name sortKey="Avital, A" sort="Avital, A" uniqKey="Avital A" first="A" last="Avital">A. Avital</name>
<affiliation><nlm:affiliation>Institute of Pulmonology, Hadassah University Hospital, Jerusalem, Israel.</nlm:affiliation>
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<author><name sortKey="Godfrey, S" sort="Godfrey, S" uniqKey="Godfrey S" first="S" last="Godfrey">S. Godfrey</name>
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<author><name sortKey="Maayan, C" sort="Maayan, C" uniqKey="Maayan C" first="C" last="Maayan">C. Maayan</name>
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<author><name sortKey="Diamant, Y" sort="Diamant, Y" uniqKey="Diamant Y" first="Y" last="Diamant">Y. Diamant</name>
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<author><name sortKey="Springer, C" sort="Springer, C" uniqKey="Springer C" first="C" last="Springer">C. Springer</name>
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<series><title level="j">Pediatric pulmonology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term>
<term>Child, Preschool</term>
<term>Chloroquine (therapeutic use)</term>
<term>Drug Therapy, Combination</term>
<term>Exercise Test</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Infant</term>
<term>Lung Diseases, Interstitial (diagnosis)</term>
<term>Lung Diseases, Interstitial (drug therapy)</term>
<term>Prednisone (therapeutic use)</term>
<term>Respiratory Function Tests</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Chloroquine</term>
<term>Prednisone</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lung Diseases, Interstitial</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lung Diseases, Interstitial</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Child</term>
<term>Child, Preschool</term>
<term>Drug Therapy, Combination</term>
<term>Exercise Test</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Seven children aged 3 months to 11 years with histologically confirmed interstitial lung disease (ILD) [6 with desquamative interstitial pneumonitis (DIP) and 1 with chronic interstitial pneumonitis] were treated with chloroquine, 10 mg/kg/day. One patient, diagnosed late in the course of the disease, died after three weeks of treatment, despite the addition of systemic corticosteroids. Another patient responded to combined therapy with chloroquine and prednisone and had a normal lung biopsy after 6 months of treatment. He underwent surgical repair of mitral valve stenosis and died after extensive brain infarction. The other 5 patients responded well to chloroquine therapy with major improvement in oxygenation within a few weeks and in lung function over the next few months. They remained well clinically and physiologically, including a normal response to incremental exercise, during a mean follow-up period of 9.8 years (range 3.5 to 15.7 years). None of the patients has developed retinopathy or any other ocular complication. Bronchoalveolar lavage was a useful tool for evaluation of the activity of the disease (predominance of neutrophils) in 3 out of 4 patients. We suggest that chloroquine should be considered as an effective treatment in ILD in children. Incremental exercise test may be helpful for routine follow-up and evaluation of the efficacy of a specific treatment.</div>
</front>
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<DateRevised><Year>2019</Year>
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<Title>Pediatric pulmonology</Title>
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<ArticleTitle>Chloroquine treatment of interstitial lung disease in children.</ArticleTitle>
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<Abstract><AbstractText>Seven children aged 3 months to 11 years with histologically confirmed interstitial lung disease (ILD) [6 with desquamative interstitial pneumonitis (DIP) and 1 with chronic interstitial pneumonitis] were treated with chloroquine, 10 mg/kg/day. One patient, diagnosed late in the course of the disease, died after three weeks of treatment, despite the addition of systemic corticosteroids. Another patient responded to combined therapy with chloroquine and prednisone and had a normal lung biopsy after 6 months of treatment. He underwent surgical repair of mitral valve stenosis and died after extensive brain infarction. The other 5 patients responded well to chloroquine therapy with major improvement in oxygenation within a few weeks and in lung function over the next few months. They remained well clinically and physiologically, including a normal response to incremental exercise, during a mean follow-up period of 9.8 years (range 3.5 to 15.7 years). None of the patients has developed retinopathy or any other ocular complication. Bronchoalveolar lavage was a useful tool for evaluation of the activity of the disease (predominance of neutrophils) in 3 out of 4 patients. We suggest that chloroquine should be considered as an effective treatment in ILD in children. Incremental exercise test may be helpful for routine follow-up and evaluation of the efficacy of a specific treatment.</AbstractText>
</Abstract>
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<MeshHeading><DescriptorName UI="D012129" MajorTopicYN="N">Respiratory Function Tests</DescriptorName>
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