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Postinfectious bronchiolitis obliterans in children: clinical and radiological profile and prognostic factors.

Identifieur interne : 000460 ( PubMed/Curation ); précédent : 000459; suivant : 000461

Postinfectious bronchiolitis obliterans in children: clinical and radiological profile and prognostic factors.

Auteurs : Ebru Yalçin [Turquie] ; Deniz Do Ru ; Mithat Halilo Lu ; U Ur Ozçelik ; Nural Kiper ; Ayhan Göçmen

Source :

RBID : pubmed:14512672

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English descriptors

Abstract

Postinfectious bronchiolitis obliterans (BO) designates a clinical syndrome of chronic airflow obstruction associated with inflammatory changes in the small airways.

DOI: 10.1159/000072900
PubMed: 14512672

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pubmed:14512672

Le document en format XML

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<nlm:affiliation>Chest Diseases Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. ebruy@hacettepe.edu.tr</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
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<name sortKey="Do Ru, Deniz" sort="Do Ru, Deniz" uniqKey="Do Ru D" first="Deniz" last="Do Ru">Deniz Do Ru</name>
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<name sortKey="Halilo Lu, Mithat" sort="Halilo Lu, Mithat" uniqKey="Halilo Lu M" first="Mithat" last="Halilo Lu">Mithat Halilo Lu</name>
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<term>Bronchiolitis Obliterans (physiopathology)</term>
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<term>Chloroquine (therapeutic use)</term>
<term>Female</term>
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<term>Infant, Newborn</term>
<term>Infections (complications)</term>
<term>Male</term>
<term>Prednisolone (therapeutic use)</term>
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<term>Infections</term>
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<term>Bronchiolitis Obliterans</term>
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<term>Bronchiolitis Obliterans</term>
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<term>Bronchiolitis Obliterans</term>
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<term>Bronchiolite oblitérante</term>
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<term>Bronchiolite oblitérante</term>
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<term>Bronchiolitis Obliterans</term>
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<term>Bronchiolite oblitérante</term>
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<term>Anti-inflammatoires</term>
<term>Chloroquine</term>
<term>Prednisolone</term>
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<term>Bronchiolite oblitérante</term>
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<term>Administration, Inhalation</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Prognosis</term>
<term>Retreatment</term>
<term>Tomography, X-Ray Computed</term>
<term>Treatment Outcome</term>
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<term>Administration par inhalation</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
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<term>Mâle</term>
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<term>Nouveau-né</term>
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<front>
<div type="abstract" xml:lang="en">Postinfectious bronchiolitis obliterans (BO) designates a clinical syndrome of chronic airflow obstruction associated with inflammatory changes in the small airways.</div>
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<PMID Version="1">14512672</PMID>
<DateCompleted>
<Year>2004</Year>
<Month>01</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised>
<Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
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<ISSN IssnType="Print">0025-7931</ISSN>
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<Volume>70</Volume>
<Issue>4</Issue>
<PubDate>
<MedlineDate>2003 Jul-Aug</MedlineDate>
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<Title>Respiration; international review of thoracic diseases</Title>
<ISOAbbreviation>Respiration</ISOAbbreviation>
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<ArticleTitle>Postinfectious bronchiolitis obliterans in children: clinical and radiological profile and prognostic factors.</ArticleTitle>
<Pagination>
<MedlinePgn>371-5</MedlinePgn>
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<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Postinfectious bronchiolitis obliterans (BO) designates a clinical syndrome of chronic airflow obstruction associated with inflammatory changes in the small airways.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The aim of this study was to determine the etiology, clinical and radiological features and define prognostic factors of postinfectious BO in children.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We undertook a review of the medical records of 20 children with postinfectious BO, who were followed up between January 1994 and August 2001.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Postinfectious BO was diagnosed in 11 boys and 9 girls with a median age of 21.5 months (6-69 months) who were followed up for a median of 23 months. Cough and wheezing persisted since the initial lung infection in all patients. Postinfectious BO was diagnosed in an average of 6 months (1-42 months) after the acute illness. Adenoviruses were the most common etiologic agents identified serologically. The diagnoses of postinfectious BO was made by thoracic high-resolution computed tomography and clinical features. Corticosteroid therapy was used in 17 patients and supportive treatment was applied in all patients. Age at initial lung infection, gender, time of starting corticosteroid treatment, presence of bronchiectasis or atelectasis and etiologic agents identified on presentation did not predict severity in our study.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Despite the prominent role of inflammation in the pathogenesis of postinfectious BO, the use of anti-inflammatory agents remains controversial. We could not identify any prognostic factors related to disease severity. In order to minimize associated complications, patients with postinfectious BO should be closely followed up and receive meticulous lung care.</AbstractText>
<CopyrightInformation>Copyright 2003 S. Karger AG, Basel</CopyrightInformation>
</Abstract>
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<LastName>Yalçin</LastName>
<ForeName>Ebru</ForeName>
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<Affiliation>Chest Diseases Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. ebruy@hacettepe.edu.tr</Affiliation>
</AffiliationInfo>
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<LastName>Doğru</LastName>
<ForeName>Deniz</ForeName>
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<LastName>Haliloğlu</LastName>
<ForeName>Mithat</ForeName>
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<ForeName>Uğur</ForeName>
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<ForeName>Nural</ForeName>
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<DescriptorName UI="D001989" MajorTopicYN="N">Bronchiolitis Obliterans</DescriptorName>
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<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
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<DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
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<DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName>
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<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<Day>28</Day>
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