Cardiovascular disease in rheumatoid arthritis: medications and risk factors in China.
Identifieur interne : 000170 ( PubMed/Curation ); précédent : 000169; suivant : 000171Cardiovascular disease in rheumatoid arthritis: medications and risk factors in China.
Auteurs : Chun Li [République populaire de Chine] ; X R Wang [République populaire de Chine] ; H J Ji [République populaire de Chine] ; X Y Zhang [République populaire de Chine] ; X F Li [République populaire de Chine] ; L Z Wang [République populaire de Chine] ; C H Wang [République populaire de Chine] ; Y F Wang [République populaire de Chine] ; Rong Yang [République populaire de Chine] ; G C Wang [République populaire de Chine] ; Xin Lu [République populaire de Chine] ; Ping Zhu [République populaire de Chine] ; L N Chen [République populaire de Chine] ; H T Jin [République populaire de Chine] ; J T Liu [République populaire de Chine] ; X Y Liu [République populaire de Chine] ; Lin Sun [République populaire de Chine] ; H Y Chen [République populaire de Chine] ; Ping Wei [République populaire de Chine] ; J X Wang [République populaire de Chine] ; L F Cui [République populaire de Chine] ; Rong Shu [République populaire de Chine] ; B L Liu [République populaire de Chine] ; Z L Zhang [République populaire de Chine] ; G T Li [République populaire de Chine] ; Z B Li [République populaire de Chine] ; Jing Yang [République populaire de Chine] ; J F Li [République populaire de Chine] ; Bin Jia [République populaire de Chine] ; F X Zhang [République populaire de Chine] ; J M Tao [République populaire de Chine] ; S L Han [République populaire de Chine] ; J Y Lin [République populaire de Chine] ; M Q Wei [République populaire de Chine] ; X M Liu [République populaire de Chine] ; Dan Ke [République populaire de Chine] ; S X Hu [République populaire de Chine] ; Cong Ye [République populaire de Chine] ; X Y Yang [République populaire de Chine] ; Hao Li [République populaire de Chine] ; C B Huang [République populaire de Chine] ; Ming Gao [République populaire de Chine] ; Bei Lai [République populaire de Chine] ; X F Li [République populaire de Chine] ; L J Song [République populaire de Chine] ; Yi Wang [République populaire de Chine] ; X Y Wang [République populaire de Chine] ; Y D Tang [République populaire de Chine] ; Yin Su [République populaire de Chine] ; Rong Mu [République populaire de Chine] ; Z G Li [République populaire de Chine]Source :
- Clinical rheumatology [ 1434-9949 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Antirhumatismaux (usage thérapeutique), Chine (épidémiologie), Enfant, Facteurs de risque, Femelle, Humains, Incidence, Jeune adulte, Maladies cardiovasculaires (), Maladies cardiovasculaires (épidémiologie), Maladies cardiovasculaires (étiologie), Mâle, Polyarthrite rhumatoïde (), Polyarthrite rhumatoïde (traitement médicamenteux), Polyarthrite rhumatoïde (épidémiologie), Prévalence, Sujet âgé, Sujet âgé de 80 ans ou plus, Surveillance de la population (), Études de suivi, Études rétrospectives, Études transversales, Évaluation des risques, Évolution de la maladie.
- MESH :
- traitement médicamenteux : Polyarthrite rhumatoïde.
- usage thérapeutique : Antirhumatismaux.
- épidémiologie : Chine, Maladies cardiovasculaires, Polyarthrite rhumatoïde.
- étiologie : Maladies cardiovasculaires.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Facteurs de risque, Femelle, Humains, Incidence, Jeune adulte, Maladies cardiovasculaires, Mâle, Polyarthrite rhumatoïde, Prévalence, Sujet âgé, Sujet âgé de 80 ans ou plus, Surveillance de la population, Études de suivi, Études rétrospectives, Études transversales, Évaluation des risques, Évolution de la maladie.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antirheumatic Agents (therapeutic use), Arthritis, Rheumatoid (complications), Arthritis, Rheumatoid (drug therapy), Arthritis, Rheumatoid (epidemiology), Cardiovascular Diseases (epidemiology), Cardiovascular Diseases (etiology), Cardiovascular Diseases (prevention & control), Child, China (epidemiology), Cross-Sectional Studies, Disease Progression, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Population Surveillance (methods), Prevalence, Retrospective Studies, Risk Assessment, Risk Factors, Young Adult.
- MESH :
- chemical , therapeutic use : Antirheumatic Agents.
- complications : Arthritis, Rheumatoid.
- drug therapy : Arthritis, Rheumatoid.
- epidemiology : Arthritis, Rheumatoid, Cardiovascular Diseases, China.
- etiology : Cardiovascular Diseases.
- methods : Population Surveillance.
- prevention & control : Cardiovascular Diseases.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Cross-Sectional Studies, Disease Progression, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Prevalence, Retrospective Studies, Risk Assessment, Risk Factors, Young Adult.
Abstract
This study aims to assess the risk factors of cardiovascular disease (CVD) and to determine the association of traditional and biologic disease-modifying anti-rheumatic drugs (DMARDs) with risk for CVD in Chinese rheumatoid arthritis (RA) patients. A cross-sectional cohort of 2013 RA patients from 21 hospitals around China was established. Medical history of CVD was documented. The patients' social background, clinical manifestations, comorbidities, and medications were also collected. Of the 2013 patients, 256 had CVD with an incidence of 12.7%. Compared with non-CVD controls, RA patients with CVD had a significantly advanced age, long-standing median disease duration, more often male and more deformity joints. Patients with CVD also had higher rates of smoking, rheumatoid nodules, interstitial lung disease, and anemia. The prevalence of comorbidities, including hypothyroidism, diabetes mellitus (DM), hypertension, and hyperlipidemia, was also significant higher in the CVD group. In contrast, patients treated with methotrexate, hydroxychloroquine (HCQ), and TNF blockers had lower incidence of CVD. The multivariate analysis showed that the use of HCQ was a protective factor of CVD, while hypertension, hyperlipidemia, and interstitial lung disease were independent risk factors of CVD. Our study shows that the independent risk factors of CVD include hypertension, hyperlipidemia, and interstitial lung disease. HCQ reduces the risk of CVD in patients with RA.
DOI: 10.1007/s10067-017-3596-7
PubMed: 28342151
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China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University Shougang Hospital, 9 Jinyuanzhuang Street, Beijing, 100144</wicri:regionArea></affiliation></author><author><name sortKey="Ji, H J" sort="Ji, H J" uniqKey="Ji H" first="H J" last="Ji">H J Ji</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, X Y" sort="Zhang, X Y" uniqKey="Zhang X" first="X Y" last="Zhang">X Y Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044</wicri:regionArea></affiliation></author><author><name sortKey="Li, X F" sort="Li, X F" uniqKey="Li X" first="X F" last="Li">X F Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001</wicri:regionArea></affiliation></author><author><name sortKey="Wang, L Z" sort="Wang, L Z" uniqKey="Wang L" first="L Z" last="Wang">L Z Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001</wicri:regionArea></affiliation></author><author><name sortKey="Wang, C H" sort="Wang, C H" uniqKey="Wang C" first="C H" last="Wang">C H Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Y F" sort="Wang, Y F" uniqKey="Wang Y" first="Y F" last="Wang">Y F Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The First Affiliated Hospital, Baotou Medical College, 41 Linyin Road, Baotou, 014010, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The First Affiliated Hospital, Baotou Medical College, 41 Linyin Road, Baotou, 014010</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Rong" sort="Yang, Rong" uniqKey="Yang R" first="Rong" last="Yang">Rong Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The First Affiliated Hospital, Baotou Medical College, 41 Linyin Road, Baotou, 014010, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The First Affiliated Hospital, Baotou Medical College, 41 Linyin Road, Baotou, 014010</wicri:regionArea></affiliation></author><author><name sortKey="Wang, G C" sort="Wang, G C" uniqKey="Wang G" first="G C" last="Wang">G C Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029</wicri:regionArea></affiliation></author><author><name sortKey="Lu, Xin" sort="Lu, Xin" uniqKey="Lu X" first="Xin" last="Lu">Xin Lu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Ping" sort="Zhu, Ping" uniqKey="Zhu P" first="Ping" last="Zhu">Ping Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Xijing Hospital, 15 Changle Road, Xian, 710032, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Xijing Hospital, 15 Changle Road, Xian, 710032</wicri:regionArea></affiliation></author><author><name sortKey="Chen, L N" sort="Chen, L N" uniqKey="Chen L" first="L N" last="Chen">L N Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Xijing Hospital, 15 Changle Road, Xian, 710032, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Xijing Hospital, 15 Changle Road, Xian, 710032</wicri:regionArea></affiliation></author><author><name sortKey="Jin, H T" sort="Jin, H T" uniqKey="Jin H" first="H T" last="Jin">H T Jin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000</wicri:regionArea></affiliation></author><author><name sortKey="Liu, J T" sort="Liu, J T" uniqKey="Liu J" first="J T" last="Liu">J T Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000</wicri:regionArea></affiliation></author><author><name sortKey="Liu, X Y" sort="Liu, X Y" uniqKey="Liu X" first="X Y" last="Liu">X Y Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University Third Hospital, 49 North Garden Rd, Beijing, 100191, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University Third Hospital, 49 North Garden Rd, Beijing, 100191</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Lin" sort="Sun, Lin" uniqKey="Sun L" first="Lin" last="Sun">Lin Sun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University Third Hospital, 49 North Garden Rd, Beijing, 100191, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University Third Hospital, 49 North Garden Rd, Beijing, 100191</wicri:regionArea></affiliation></author><author><name sortKey="Chen, H Y" sort="Chen, H Y" uniqKey="Chen H" first="H Y" last="Chen">H Y Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000</wicri:regionArea></affiliation></author><author><name sortKey="Wei, Ping" sort="Wei, Ping" uniqKey="Wei P" first="Ping" last="Wei">Ping Wei</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000</wicri:regionArea></affiliation></author><author><name sortKey="Wang, J X" sort="Wang, J X" uniqKey="Wang J" first="J X" last="Wang">J X Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000</wicri:regionArea></affiliation></author><author><name sortKey="Cui, L F" sort="Cui, L F" uniqKey="Cui L" first="L F" last="Cui">L F Cui</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000</wicri:regionArea></affiliation></author><author><name sortKey="Shu, Rong" sort="Shu, Rong" uniqKey="Shu R" first="Rong" last="Shu">Rong Shu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000</wicri:regionArea></affiliation></author><author><name sortKey="Liu, B L" sort="Liu, B L" uniqKey="Liu B" first="B L" last="Liu">B L Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Z L" sort="Zhang, Z L" uniqKey="Zhang Z" first="Z L" last="Zhang">Z L Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University First Hospital, 8 Xishiku Road, Beijing, 100034, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University First Hospital, 8 Xishiku Road, Beijing, 100034</wicri:regionArea></affiliation></author><author><name sortKey="Li, G T" sort="Li, G T" uniqKey="Li G" first="G T" last="Li">G T Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University First Hospital, 8 Xishiku Road, Beijing, 100034, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University First Hospital, 8 Xishiku Road, Beijing, 100034</wicri:regionArea></affiliation></author><author><name sortKey="Li, Z B" sort="Li, Z B" uniqKey="Li Z" first="Z B" last="Li">Z B Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peace Hospital, 398 West Zhongshan Rd, Shijiazhuang, 050082, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peace Hospital, 398 West Zhongshan Rd, Shijiazhuang, 050082</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Jing" sort="Yang, Jing" uniqKey="Yang J" first="Jing" last="Yang">Jing Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peace Hospital, 398 West Zhongshan Rd, Shijiazhuang, 050082, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peace Hospital, 398 West Zhongshan Rd, Shijiazhuang, 050082</wicri:regionArea></affiliation></author><author><name sortKey="Li, J F" sort="Li, J F" uniqKey="Li J" first="J F" last="Li">J F Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Hebei Handan Central Hospital, 311 Heping Rd, Handan, 056001, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Hebei Handan Central Hospital, 311 Heping Rd, Handan, 056001</wicri:regionArea></affiliation></author><author><name sortKey="Jia, Bin" sort="Jia, Bin" uniqKey="Jia B" first="Bin" last="Jia">Bin Jia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Hebei Handan Central Hospital, 311 Heping Rd, Handan, 056001, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Hebei Handan Central Hospital, 311 Heping Rd, Handan, 056001</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, F X" sort="Zhang, F X" uniqKey="Zhang F" first="F X" last="Zhang">F X Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Hebei People's Hospital, 348 West Heping Rd, Shijiazhuang, 050051, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Hebei People's Hospital, 348 West Heping Rd, Shijiazhuang, 050051</wicri:regionArea></affiliation></author><author><name sortKey="Tao, J M" sort="Tao, J M" uniqKey="Tao J" first="J M" last="Tao">J M Tao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Hebei People's Hospital, 348 West Heping Rd, Shijiazhuang, 050051, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Hebei People's Hospital, 348 West Heping Rd, Shijiazhuang, 050051</wicri:regionArea></affiliation></author><author><name sortKey="Han, S L" sort="Han, S L" uniqKey="Han S" first="S L" last="Han">S L Han</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University Shougang Hospital, 9 Jinyuanzhuang Street, Beijing, 100144, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University Shougang Hospital, 9 Jinyuanzhuang Street, Beijing, 100144</wicri:regionArea></affiliation></author><author><name sortKey="Lin, J Y" sort="Lin, J Y" uniqKey="Lin J" first="J Y" last="Lin">J Y Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Rd, Nanning, 530021, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Rd, Nanning, 530021</wicri:regionArea></affiliation></author><author><name sortKey="Wei, M Q" sort="Wei, M Q" uniqKey="Wei M" first="M Q" last="Wei">M Q Wei</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Rd, Nanning, 530021, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Rd, Nanning, 530021</wicri:regionArea></affiliation></author><author><name sortKey="Liu, X M" sort="Liu, X M" uniqKey="Liu X" first="X M" last="Liu">X M Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Beijing Shunyi Hospital of China Medical University, 3 South Guangming Rd, Beijing, 101300, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Beijing Shunyi Hospital of China Medical University, 3 South Guangming Rd, Beijing, 101300</wicri:regionArea></affiliation></author><author><name sortKey="Ke, Dan" sort="Ke, Dan" uniqKey="Ke D" first="Dan" last="Ke">Dan Ke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Beijing Shunyi Hospital of China Medical University, 3 South Guangming Rd, Beijing, 101300, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Beijing Shunyi Hospital of China Medical University, 3 South Guangming Rd, Beijing, 101300</wicri:regionArea></affiliation></author><author><name sortKey="Hu, S X" sort="Hu, S X" uniqKey="Hu S" first="S X" last="Hu">S X Hu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Tongji Medical College Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Tongji Medical College Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030</wicri:regionArea></affiliation></author><author><name sortKey="Ye, Cong" sort="Ye, Cong" uniqKey="Ye C" first="Cong" last="Ye">Cong Ye</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Tongji Medical College Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Tongji Medical College Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030</wicri:regionArea></affiliation></author><author><name sortKey="Yang, X Y" sort="Yang, X Y" uniqKey="Yang X" first="X Y" last="Yang">X Y Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, First Affiliated Hospital of Sun Yat-sen University, 58 Second Zhongshan Rd, Guangzhou, 510080, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, First Affiliated Hospital of Sun Yat-sen University, 58 Second Zhongshan Rd, Guangzhou, 510080</wicri:regionArea></affiliation></author><author><name sortKey="Li, Hao" sort="Li, Hao" uniqKey="Li H" first="Hao" last="Li">Hao Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, First Affiliated Hospital of Sun Yat-sen University, 58 Second Zhongshan Rd, Guangzhou, 510080, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, First Affiliated Hospital of Sun Yat-sen University, 58 Second Zhongshan Rd, Guangzhou, 510080</wicri:regionArea></affiliation></author><author><name sortKey="Huang, C B" sort="Huang, C B" uniqKey="Huang C" first="C B" last="Huang">C B Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Ming" sort="Gao, Ming" uniqKey="Gao M" first="Ming" last="Gao">Ming Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730</wicri:regionArea></affiliation></author><author><name sortKey="Lai, Bei" sort="Lai, Bei" uniqKey="Lai B" first="Bei" last="Lai">Bei Lai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730</wicri:regionArea></affiliation></author><author><name sortKey="Li, X F" sort="Li, X F" uniqKey="Li X" first="X F" last="Li">X F Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Qilu Hospital of Shandong University, 107 Jinan Culture Road, Jinan, 250012, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Qilu Hospital of Shandong University, 107 Jinan Culture Road, Jinan, 250012</wicri:regionArea></affiliation></author><author><name sortKey="Song, L J" sort="Song, L J" uniqKey="Song L" first="L J" last="Song">L J Song</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Qilu Hospital of Shandong University, 107 Jinan Culture Road, Jinan, 250012, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Qilu Hospital of Shandong University, 107 Jinan Culture Road, Jinan, 250012</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Yi" sort="Wang, Yi" uniqKey="Wang Y" first="Yi" last="Wang">Yi Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Second Hospital of Lanzhou University, 82 Cuiyingmen Rd, Lanzhou, 730030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Second Hospital of Lanzhou University, 82 Cuiyingmen Rd, Lanzhou, 730030</wicri:regionArea></affiliation></author><author><name sortKey="Wang, X Y" sort="Wang, X Y" uniqKey="Wang X" first="X Y" last="Wang">X Y Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Second Hospital of Lanzhou University, 82 Cuiyingmen Rd, Lanzhou, 730030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Second Hospital of Lanzhou University, 82 Cuiyingmen Rd, Lanzhou, 730030</wicri:regionArea></affiliation></author><author><name sortKey="Tang, Y D" sort="Tang, Y D" uniqKey="Tang Y" first="Y D" last="Tang">Y D Tang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Fuwai Hospital, North Lishi Road, Beijing, 100037, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Fuwai Hospital, North Lishi Road, Beijing, 100037</wicri:regionArea></affiliation></author><author><name sortKey="Su, Yin" sort="Su, Yin" uniqKey="Su Y" first="Yin" last="Su">Yin Su</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044</wicri:regionArea></affiliation></author><author><name sortKey="Mu, Rong" sort="Mu, Rong" uniqKey="Mu R" first="Rong" last="Mu">Rong Mu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China. murong@pkuph.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044</wicri:regionArea></affiliation></author><author><name sortKey="Li, Z G" sort="Li, Z G" uniqKey="Li Z" first="Z G" last="Li">Z G Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China. li99@bjmu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28342151</idno><idno type="pmid">28342151</idno><idno type="doi">10.1007/s10067-017-3596-7</idno><idno type="wicri:Area/PubMed/Corpus">000170</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000170</idno><idno type="wicri:Area/PubMed/Curation">000170</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000170</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cardiovascular disease in rheumatoid arthritis: medications and risk factors in China.</title><author><name sortKey="Li, Chun" sort="Li, Chun" uniqKey="Li C" first="Chun" last="Li">Chun Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044</wicri:regionArea></affiliation></author><author><name sortKey="Wang, X R" sort="Wang, X R" uniqKey="Wang X" first="X R" last="Wang">X R Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University Shougang Hospital, 9 Jinyuanzhuang Street, Beijing, 100144, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University Shougang Hospital, 9 Jinyuanzhuang Street, Beijing, 100144</wicri:regionArea></affiliation></author><author><name sortKey="Ji, H J" sort="Ji, H J" uniqKey="Ji H" first="H J" last="Ji">H J Ji</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, X Y" sort="Zhang, X Y" uniqKey="Zhang X" first="X Y" last="Zhang">X Y Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044</wicri:regionArea></affiliation></author><author><name sortKey="Li, X F" sort="Li, X F" uniqKey="Li X" first="X F" last="Li">X F Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001</wicri:regionArea></affiliation></author><author><name sortKey="Wang, L Z" sort="Wang, L Z" uniqKey="Wang L" first="L Z" last="Wang">L Z Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001</wicri:regionArea></affiliation></author><author><name sortKey="Wang, C H" sort="Wang, C H" uniqKey="Wang C" first="C H" last="Wang">C H Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Y F" sort="Wang, Y F" uniqKey="Wang Y" first="Y F" last="Wang">Y F Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The First Affiliated Hospital, Baotou Medical College, 41 Linyin Road, Baotou, 014010, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The First Affiliated Hospital, Baotou Medical College, 41 Linyin Road, Baotou, 014010</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Rong" sort="Yang, Rong" uniqKey="Yang R" first="Rong" last="Yang">Rong Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The First Affiliated Hospital, Baotou Medical College, 41 Linyin Road, Baotou, 014010, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The First Affiliated Hospital, Baotou Medical College, 41 Linyin Road, Baotou, 014010</wicri:regionArea></affiliation></author><author><name sortKey="Wang, G C" sort="Wang, G C" uniqKey="Wang G" first="G C" last="Wang">G C Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029</wicri:regionArea></affiliation></author><author><name sortKey="Lu, Xin" sort="Lu, Xin" uniqKey="Lu X" first="Xin" last="Lu">Xin Lu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Ping" sort="Zhu, Ping" uniqKey="Zhu P" first="Ping" last="Zhu">Ping Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Xijing Hospital, 15 Changle Road, Xian, 710032, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Xijing Hospital, 15 Changle Road, Xian, 710032</wicri:regionArea></affiliation></author><author><name sortKey="Chen, L N" sort="Chen, L N" uniqKey="Chen L" first="L N" last="Chen">L N Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Xijing Hospital, 15 Changle Road, Xian, 710032, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Xijing Hospital, 15 Changle Road, Xian, 710032</wicri:regionArea></affiliation></author><author><name sortKey="Jin, H T" sort="Jin, H T" uniqKey="Jin H" first="H T" last="Jin">H T Jin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000</wicri:regionArea></affiliation></author><author><name sortKey="Liu, J T" sort="Liu, J T" uniqKey="Liu J" first="J T" last="Liu">J T Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000</wicri:regionArea></affiliation></author><author><name sortKey="Liu, X Y" sort="Liu, X Y" uniqKey="Liu X" first="X Y" last="Liu">X Y Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University Third Hospital, 49 North Garden Rd, Beijing, 100191, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University Third Hospital, 49 North Garden Rd, Beijing, 100191</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Lin" sort="Sun, Lin" uniqKey="Sun L" first="Lin" last="Sun">Lin Sun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University Third Hospital, 49 North Garden Rd, Beijing, 100191, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University Third Hospital, 49 North Garden Rd, Beijing, 100191</wicri:regionArea></affiliation></author><author><name sortKey="Chen, H Y" sort="Chen, H Y" uniqKey="Chen H" first="H Y" last="Chen">H Y Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000</wicri:regionArea></affiliation></author><author><name sortKey="Wei, Ping" sort="Wei, Ping" uniqKey="Wei P" first="Ping" last="Wei">Ping Wei</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000</wicri:regionArea></affiliation></author><author><name sortKey="Wang, J X" sort="Wang, J X" uniqKey="Wang J" first="J X" last="Wang">J X Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000</wicri:regionArea></affiliation></author><author><name sortKey="Cui, L F" sort="Cui, L F" uniqKey="Cui L" first="L F" last="Cui">L F Cui</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000</wicri:regionArea></affiliation></author><author><name sortKey="Shu, Rong" sort="Shu, Rong" uniqKey="Shu R" first="Rong" last="Shu">Rong Shu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000</wicri:regionArea></affiliation></author><author><name sortKey="Liu, B L" sort="Liu, B L" uniqKey="Liu B" first="B L" last="Liu">B L Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Z L" sort="Zhang, Z L" uniqKey="Zhang Z" first="Z L" last="Zhang">Z L Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University First Hospital, 8 Xishiku Road, Beijing, 100034, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University First Hospital, 8 Xishiku Road, Beijing, 100034</wicri:regionArea></affiliation></author><author><name sortKey="Li, G T" sort="Li, G T" uniqKey="Li G" first="G T" last="Li">G T Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University First Hospital, 8 Xishiku Road, Beijing, 100034, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University First Hospital, 8 Xishiku Road, Beijing, 100034</wicri:regionArea></affiliation></author><author><name sortKey="Li, Z B" sort="Li, Z B" uniqKey="Li Z" first="Z B" last="Li">Z B Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peace Hospital, 398 West Zhongshan Rd, Shijiazhuang, 050082, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peace Hospital, 398 West Zhongshan Rd, Shijiazhuang, 050082</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Jing" sort="Yang, Jing" uniqKey="Yang J" first="Jing" last="Yang">Jing Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peace Hospital, 398 West Zhongshan Rd, Shijiazhuang, 050082, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peace Hospital, 398 West Zhongshan Rd, Shijiazhuang, 050082</wicri:regionArea></affiliation></author><author><name sortKey="Li, J F" sort="Li, J F" uniqKey="Li J" first="J F" last="Li">J F Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Hebei Handan Central Hospital, 311 Heping Rd, Handan, 056001, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Hebei Handan Central Hospital, 311 Heping Rd, Handan, 056001</wicri:regionArea></affiliation></author><author><name sortKey="Jia, Bin" sort="Jia, Bin" uniqKey="Jia B" first="Bin" last="Jia">Bin Jia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Hebei Handan Central Hospital, 311 Heping Rd, Handan, 056001, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Hebei Handan Central Hospital, 311 Heping Rd, Handan, 056001</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, F X" sort="Zhang, F X" uniqKey="Zhang F" first="F X" last="Zhang">F X Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Hebei People's Hospital, 348 West Heping Rd, Shijiazhuang, 050051, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Hebei People's Hospital, 348 West Heping Rd, Shijiazhuang, 050051</wicri:regionArea></affiliation></author><author><name sortKey="Tao, J M" sort="Tao, J M" uniqKey="Tao J" first="J M" last="Tao">J M Tao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Hebei People's Hospital, 348 West Heping Rd, Shijiazhuang, 050051, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Hebei People's Hospital, 348 West Heping Rd, Shijiazhuang, 050051</wicri:regionArea></affiliation></author><author><name sortKey="Han, S L" sort="Han, S L" uniqKey="Han S" first="S L" last="Han">S L Han</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University Shougang Hospital, 9 Jinyuanzhuang Street, Beijing, 100144, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University Shougang Hospital, 9 Jinyuanzhuang Street, Beijing, 100144</wicri:regionArea></affiliation></author><author><name sortKey="Lin, J Y" sort="Lin, J Y" uniqKey="Lin J" first="J Y" last="Lin">J Y Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Rd, Nanning, 530021, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Rd, Nanning, 530021</wicri:regionArea></affiliation></author><author><name sortKey="Wei, M Q" sort="Wei, M Q" uniqKey="Wei M" first="M Q" last="Wei">M Q Wei</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Rd, Nanning, 530021, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Rd, Nanning, 530021</wicri:regionArea></affiliation></author><author><name sortKey="Liu, X M" sort="Liu, X M" uniqKey="Liu X" first="X M" last="Liu">X M Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Beijing Shunyi Hospital of China Medical University, 3 South Guangming Rd, Beijing, 101300, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Beijing Shunyi Hospital of China Medical University, 3 South Guangming Rd, Beijing, 101300</wicri:regionArea></affiliation></author><author><name sortKey="Ke, Dan" sort="Ke, Dan" uniqKey="Ke D" first="Dan" last="Ke">Dan Ke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Beijing Shunyi Hospital of China Medical University, 3 South Guangming Rd, Beijing, 101300, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Beijing Shunyi Hospital of China Medical University, 3 South Guangming Rd, Beijing, 101300</wicri:regionArea></affiliation></author><author><name sortKey="Hu, S X" sort="Hu, S X" uniqKey="Hu S" first="S X" last="Hu">S X Hu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Tongji Medical College Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Tongji Medical College Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030</wicri:regionArea></affiliation></author><author><name sortKey="Ye, Cong" sort="Ye, Cong" uniqKey="Ye C" first="Cong" last="Ye">Cong Ye</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Tongji Medical College Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Tongji Medical College Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030</wicri:regionArea></affiliation></author><author><name sortKey="Yang, X Y" sort="Yang, X Y" uniqKey="Yang X" first="X Y" last="Yang">X Y Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, First Affiliated Hospital of Sun Yat-sen University, 58 Second Zhongshan Rd, Guangzhou, 510080, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, First Affiliated Hospital of Sun Yat-sen University, 58 Second Zhongshan Rd, Guangzhou, 510080</wicri:regionArea></affiliation></author><author><name sortKey="Li, Hao" sort="Li, Hao" uniqKey="Li H" first="Hao" last="Li">Hao Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, First Affiliated Hospital of Sun Yat-sen University, 58 Second Zhongshan Rd, Guangzhou, 510080, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, First Affiliated Hospital of Sun Yat-sen University, 58 Second Zhongshan Rd, Guangzhou, 510080</wicri:regionArea></affiliation></author><author><name sortKey="Huang, C B" sort="Huang, C B" uniqKey="Huang C" first="C B" last="Huang">C B Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Ming" sort="Gao, Ming" uniqKey="Gao M" first="Ming" last="Gao">Ming Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730</wicri:regionArea></affiliation></author><author><name sortKey="Lai, Bei" sort="Lai, Bei" uniqKey="Lai B" first="Bei" last="Lai">Bei Lai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730</wicri:regionArea></affiliation></author><author><name sortKey="Li, X F" sort="Li, X F" uniqKey="Li X" first="X F" last="Li">X F Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Qilu Hospital of Shandong University, 107 Jinan Culture Road, Jinan, 250012, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Qilu Hospital of Shandong University, 107 Jinan Culture Road, Jinan, 250012</wicri:regionArea></affiliation></author><author><name sortKey="Song, L J" sort="Song, L J" uniqKey="Song L" first="L J" last="Song">L J Song</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Qilu Hospital of Shandong University, 107 Jinan Culture Road, Jinan, 250012, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Qilu Hospital of Shandong University, 107 Jinan Culture Road, Jinan, 250012</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Yi" sort="Wang, Yi" uniqKey="Wang Y" first="Yi" last="Wang">Yi Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Second Hospital of Lanzhou University, 82 Cuiyingmen Rd, Lanzhou, 730030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Second Hospital of Lanzhou University, 82 Cuiyingmen Rd, Lanzhou, 730030</wicri:regionArea></affiliation></author><author><name sortKey="Wang, X Y" sort="Wang, X Y" uniqKey="Wang X" first="X Y" last="Wang">X Y Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Second Hospital of Lanzhou University, 82 Cuiyingmen Rd, Lanzhou, 730030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Second Hospital of Lanzhou University, 82 Cuiyingmen Rd, Lanzhou, 730030</wicri:regionArea></affiliation></author><author><name sortKey="Tang, Y D" sort="Tang, Y D" uniqKey="Tang Y" first="Y D" last="Tang">Y D Tang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Fuwai Hospital, North Lishi Road, Beijing, 100037, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Fuwai Hospital, North Lishi Road, Beijing, 100037</wicri:regionArea></affiliation></author><author><name sortKey="Su, Yin" sort="Su, Yin" uniqKey="Su Y" first="Yin" last="Su">Yin Su</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044</wicri:regionArea></affiliation></author><author><name sortKey="Mu, Rong" sort="Mu, Rong" uniqKey="Mu R" first="Rong" last="Mu">Rong Mu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China. murong@pkuph.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044</wicri:regionArea></affiliation></author><author><name sortKey="Li, Z G" sort="Li, Z G" uniqKey="Li Z" first="Z G" last="Li">Z G Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China. li99@bjmu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044</wicri:regionArea></affiliation></author></analytic><series><title level="j">Clinical rheumatology</title><idno type="eISSN">1434-9949</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antirheumatic Agents (therapeutic use)</term><term>Arthritis, Rheumatoid (complications)</term><term>Arthritis, Rheumatoid (drug therapy)</term><term>Arthritis, Rheumatoid (epidemiology)</term><term>Cardiovascular Diseases (epidemiology)</term><term>Cardiovascular Diseases (etiology)</term><term>Cardiovascular Diseases (prevention & control)</term><term>Child</term><term>China (epidemiology)</term><term>Cross-Sectional Studies</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Population Surveillance (methods)</term><term>Prevalence</term><term>Retrospective Studies</term><term>Risk Assessment</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antirhumatismaux (usage thérapeutique)</term><term>Chine (épidémiologie)</term><term>Enfant</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Maladies cardiovasculaires ()</term><term>Maladies cardiovasculaires (épidémiologie)</term><term>Maladies cardiovasculaires (étiologie)</term><term>Mâle</term><term>Polyarthrite rhumatoïde ()</term><term>Polyarthrite rhumatoïde (traitement médicamenteux)</term><term>Polyarthrite rhumatoïde (épidémiologie)</term><term>Prévalence</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Surveillance de la population ()</term><term>Études de suivi</term><term>Études rétrospectives</term><term>Études transversales</term><term>Évaluation des risques</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antirheumatic Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Cardiovascular Diseases</term><term>China</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Population Surveillance</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Polyarthrite rhumatoïde</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antirhumatismaux</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term><term>Maladies cardiovasculaires</term><term>Polyarthrite rhumatoïde</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladies cardiovasculaires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Cross-Sectional Studies</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Retrospective Studies</term><term>Risk Assessment</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Maladies cardiovasculaires</term><term>Mâle</term><term>Polyarthrite rhumatoïde</term><term>Prévalence</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Surveillance de la population</term><term>Études de suivi</term><term>Études rétrospectives</term><term>Études transversales</term><term>Évaluation des risques</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study aims to assess the risk factors of cardiovascular disease (CVD) and to determine the association of traditional and biologic disease-modifying anti-rheumatic drugs (DMARDs) with risk for CVD in Chinese rheumatoid arthritis (RA) patients. A cross-sectional cohort of 2013 RA patients from 21 hospitals around China was established. Medical history of CVD was documented. The patients' social background, clinical manifestations, comorbidities, and medications were also collected. Of the 2013 patients, 256 had CVD with an incidence of 12.7%. Compared with non-CVD controls, RA patients with CVD had a significantly advanced age, long-standing median disease duration, more often male and more deformity joints. Patients with CVD also had higher rates of smoking, rheumatoid nodules, interstitial lung disease, and anemia. The prevalence of comorbidities, including hypothyroidism, diabetes mellitus (DM), hypertension, and hyperlipidemia, was also significant higher in the CVD group. In contrast, patients treated with methotrexate, hydroxychloroquine (HCQ), and TNF blockers had lower incidence of CVD. The multivariate analysis showed that the use of HCQ was a protective factor of CVD, while hypertension, hyperlipidemia, and interstitial lung disease were independent risk factors of CVD. Our study shows that the independent risk factors of CVD include hypertension, hyperlipidemia, and interstitial lung disease. HCQ reduces the risk of CVD in patients with RA.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28342151</PMID><DateCompleted><Year>2018</Year><Month>01</Month><Day>26</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1434-9949</ISSN><JournalIssue CitedMedium="Internet"><Volume>36</Volume><Issue>5</Issue><PubDate><Year>2017</Year><Month>May</Month></PubDate></JournalIssue><Title>Clinical rheumatology</Title><ISOAbbreviation>Clin. Rheumatol.</ISOAbbreviation></Journal><ArticleTitle>Cardiovascular disease in rheumatoid arthritis: medications and risk factors in China.</ArticleTitle><Pagination><MedlinePgn>1023-1029</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10067-017-3596-7</ELocationID><Abstract><AbstractText>This study aims to assess the risk factors of cardiovascular disease (CVD) and to determine the association of traditional and biologic disease-modifying anti-rheumatic drugs (DMARDs) with risk for CVD in Chinese rheumatoid arthritis (RA) patients. A cross-sectional cohort of 2013 RA patients from 21 hospitals around China was established. Medical history of CVD was documented. The patients' social background, clinical manifestations, comorbidities, and medications were also collected. Of the 2013 patients, 256 had CVD with an incidence of 12.7%. Compared with non-CVD controls, RA patients with CVD had a significantly advanced age, long-standing median disease duration, more often male and more deformity joints. Patients with CVD also had higher rates of smoking, rheumatoid nodules, interstitial lung disease, and anemia. The prevalence of comorbidities, including hypothyroidism, diabetes mellitus (DM), hypertension, and hyperlipidemia, was also significant higher in the CVD group. In contrast, patients treated with methotrexate, hydroxychloroquine (HCQ), and TNF blockers had lower incidence of CVD. The multivariate analysis showed that the use of HCQ was a protective factor of CVD, while hypertension, hyperlipidemia, and interstitial lung disease were independent risk factors of CVD. Our study shows that the independent risk factors of CVD include hypertension, hyperlipidemia, and interstitial lung disease. HCQ reduces the risk of CVD in patients with RA.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Chun</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>X R</ForeName><Initials>XR</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peking University Shougang Hospital, 9 Jinyuanzhuang Street, Beijing, 100144, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ji</LastName><ForeName>H J</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>X Y</ForeName><Initials>XY</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>X F</ForeName><Initials>XF</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>L Z</ForeName><Initials>LZ</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>C H</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, The Second Affiliated Hospital Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Y F</ForeName><Initials>YF</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, The First Affiliated Hospital, Baotou Medical College, 41 Linyin Road, Baotou, 014010, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Rong</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, The First Affiliated Hospital, Baotou Medical College, 41 Linyin Road, Baotou, 014010, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>G C</ForeName><Initials>GC</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Xin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Ping</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Xijing Hospital, 15 Changle Road, Xian, 710032, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>L N</ForeName><Initials>LN</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Xijing Hospital, 15 Changle Road, Xian, 710032, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>H T</ForeName><Initials>HT</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>J T</ForeName><Initials>JT</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>X Y</ForeName><Initials>XY</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peking University Third Hospital, 49 North Garden Rd, Beijing, 100191, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Lin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peking University Third Hospital, 49 North Garden Rd, Beijing, 100191, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>H Y</ForeName><Initials>HY</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Ping</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>J X</ForeName><Initials>JX</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, 050000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cui</LastName><ForeName>L F</ForeName><Initials>LF</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shu</LastName><ForeName>Rong</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>B L</ForeName><Initials>BL</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Kailuan Hospital of North China Coal Hospital, 57 West Xinhua Rd, Tangshan, 063000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Z L</ForeName><Initials>ZL</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peking University First Hospital, 8 Xishiku Road, Beijing, 100034, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>G T</ForeName><Initials>GT</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peking University First Hospital, 8 Xishiku Road, Beijing, 100034, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Z B</ForeName><Initials>ZB</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peace Hospital, 398 West Zhongshan Rd, Shijiazhuang, 050082, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peace Hospital, 398 West Zhongshan Rd, Shijiazhuang, 050082, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>J F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Hebei Handan Central Hospital, 311 Heping Rd, Handan, 056001, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jia</LastName><ForeName>Bin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Hebei Handan Central Hospital, 311 Heping Rd, Handan, 056001, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>F X</ForeName><Initials>FX</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Hebei People's Hospital, 348 West Heping Rd, Shijiazhuang, 050051, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tao</LastName><ForeName>J M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Hebei People's Hospital, 348 West Heping Rd, Shijiazhuang, 050051, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>S L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peking University Shougang Hospital, 9 Jinyuanzhuang Street, Beijing, 100144, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>J Y</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Rd, Nanning, 530021, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>M Q</ForeName><Initials>MQ</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Rd, Nanning, 530021, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>X M</ForeName><Initials>XM</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Beijing Shunyi Hospital of China Medical University, 3 South Guangming Rd, Beijing, 101300, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ke</LastName><ForeName>Dan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Beijing Shunyi Hospital of China Medical University, 3 South Guangming Rd, Beijing, 101300, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>S X</ForeName><Initials>SX</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Tongji Medical College Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ye</LastName><ForeName>Cong</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Tongji Medical College Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>X Y</ForeName><Initials>XY</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, First Affiliated Hospital of Sun Yat-sen University, 58 Second Zhongshan Rd, Guangzhou, 510080, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Hao</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, First Affiliated Hospital of Sun Yat-sen University, 58 Second Zhongshan Rd, Guangzhou, 510080, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>C B</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Ming</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lai</LastName><ForeName>Bei</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Beijing Hospital, 1 Dahua Rd, Beijing, 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>X F</ForeName><Initials>XF</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Qilu Hospital of Shandong University, 107 Jinan Culture Road, Jinan, 250012, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>L J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Qilu Hospital of Shandong University, 107 Jinan Culture Road, Jinan, 250012, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Second Hospital of Lanzhou University, 82 Cuiyingmen Rd, Lanzhou, 730030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>X Y</ForeName><Initials>XY</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Second Hospital of Lanzhou University, 82 Cuiyingmen Rd, Lanzhou, 730030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Y D</ForeName><Initials>YD</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Fuwai Hospital, North Lishi Road, Beijing, 100037, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Yin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mu</LastName><ForeName>Rong</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China. murong@pkuph.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Z G</ForeName><Initials>ZG</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China. li99@bjmu.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Clin Rheumatol</MedlineTA><NlmUniqueID>8211469</NlmUniqueID><ISSNLinking>0770-3198</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018501">Antirheumatic Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" 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