Autophagy Activation in Asthma Airways Remodeling.
Identifieur interne : 000076 ( PubMed/Curation ); précédent : 000075; suivant : 000077Autophagy Activation in Asthma Airways Remodeling.
Auteurs : Kielan D. Mcalinden ; Deepak A. Deshpande [États-Unis] ; Saeid Ghavami [Canada] ; Dia Xenaki [Australie] ; Sukhwinder Singh Sohal [Australie] ; Brian G. Oliver [Australie] ; Mehra Haghi ; Pawan Sharma [Australie]Source :
- American journal of respiratory cell and molecular biology [ 1535-4989 ] ; 2019.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antiasthmatiques (pharmacologie), Asthme (anatomopathologie), Asthme (génétique), Asthme (métabolisme), Asthme (traitement médicamenteux), Autophagie (), Autophagie (génétique), Bécline-1 (antagonistes et inhibiteurs), Bécline-1 (génétique), Bécline-1 (métabolisme), Chloroquine (pharmacologie), Cils vibratiles (), Cils vibratiles (anatomopathologie), Cils vibratiles (métabolisme), Culture primaire de cellules, Femelle, Humains, Modèles animaux de maladie humaine, Muqueuse respiratoire (), Muqueuse respiratoire (anatomopathologie), Muqueuse respiratoire (métabolisme), Muscles lisses (), Muscles lisses (anatomopathologie), Muscles lisses (métabolisme), Myocytes du muscle lisse (), Myocytes du muscle lisse (anatomopathologie), Myocytes du muscle lisse (métabolisme), Mâle, Poumon (), Poumon (anatomopathologie), Poumon (métabolisme), Protéine-5 associée à l'autophagie (antagonistes et inhibiteurs), Protéine-5 associée à l'autophagie (génétique), Protéine-5 associée à l'autophagie (métabolisme), Remodelage des voies aériennes (), Régulation de l'expression des gènes, Souris, Souris de lignée BALB C, Sujet âgé, Sujet âgé de 80 ans ou plus, Séquestosome-1 (génétique), Séquestosome-1 (métabolisme), Transduction du signal, Études cas-témoins.
- MESH :
- anatomopathologie : Asthme, Cils vibratiles, Muqueuse respiratoire, Muscles lisses, Myocytes du muscle lisse, Poumon.
- antagonistes et inhibiteurs : Bécline-1, Protéine-5 associée à l'autophagie.
- génétique : Asthme, Autophagie, Bécline-1, Protéine-5 associée à l'autophagie, Séquestosome-1.
- métabolisme : Asthme, Bécline-1, Cils vibratiles, Muqueuse respiratoire, Muscles lisses, Myocytes du muscle lisse, Poumon, Protéine-5 associée à l'autophagie, Séquestosome-1.
- pharmacologie : Antiasthmatiques, Chloroquine.
- traitement médicamenteux : Asthme.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Autophagie, Cils vibratiles, Culture primaire de cellules, Femelle, Humains, Modèles animaux de maladie humaine, Muqueuse respiratoire, Muscles lisses, Myocytes du muscle lisse, Mâle, Poumon, Remodelage des voies aériennes, Régulation de l'expression des gènes, Souris, Souris de lignée BALB C, Sujet âgé, Sujet âgé de 80 ans ou plus, Transduction du signal, Études cas-témoins.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Airway Remodeling (drug effects), Animals, Anti-Asthmatic Agents (pharmacology), Asthma (drug therapy), Asthma (genetics), Asthma (metabolism), Asthma (pathology), Autophagy (drug effects), Autophagy (genetics), Autophagy-Related Protein 5 (antagonists & inhibitors), Autophagy-Related Protein 5 (genetics), Autophagy-Related Protein 5 (metabolism), Beclin-1 (antagonists & inhibitors), Beclin-1 (genetics), Beclin-1 (metabolism), Case-Control Studies, Chloroquine (pharmacology), Cilia (drug effects), Cilia (metabolism), Cilia (pathology), Disease Models, Animal, Female, Gene Expression Regulation, Humans, Lung (drug effects), Lung (metabolism), Lung (pathology), Male, Mice, Mice, Inbred BALB C, Middle Aged, Muscle, Smooth (drug effects), Muscle, Smooth (metabolism), Muscle, Smooth (pathology), Myocytes, Smooth Muscle (drug effects), Myocytes, Smooth Muscle (metabolism), Myocytes, Smooth Muscle (pathology), Primary Cell Culture, Respiratory Mucosa (drug effects), Respiratory Mucosa (metabolism), Respiratory Mucosa (pathology), Sequestosome-1 Protein (genetics), Sequestosome-1 Protein (metabolism), Signal Transduction.
- MESH :
- chemical , antagonists & inhibitors : Autophagy-Related Protein 5, Beclin-1.
- chemical , genetics : Autophagy-Related Protein 5, Beclin-1, Sequestosome-1 Protein.
- chemical , metabolism : Autophagy-Related Protein 5, Beclin-1, Sequestosome-1 Protein.
- chemical , pharmacology : Anti-Asthmatic Agents, Chloroquine.
- drug effects : Airway Remodeling, Autophagy, Cilia, Lung, Muscle, Smooth, Myocytes, Smooth Muscle, Respiratory Mucosa.
- drug therapy : Asthma.
- genetics : Asthma, Autophagy.
- metabolism : Asthma, Cilia, Lung, Muscle, Smooth, Myocytes, Smooth Muscle, Respiratory Mucosa.
- pathology : Asthma, Cilia, Lung, Muscle, Smooth, Myocytes, Smooth Muscle, Respiratory Mucosa.
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Case-Control Studies, Disease Models, Animal, Female, Gene Expression Regulation, Humans, Male, Mice, Mice, Inbred BALB C, Middle Aged, Primary Cell Culture, Signal Transduction.
Abstract
Current asthma therapies fail to target airway remodeling that correlates with asthma severity driving disease progression that ultimately leads to loss of lung function. Macroautophagy (hereinafter "autophagy") is a fundamental cell-recycling mechanism in all eukaryotic cells; emerging evidence suggests that it is dysregulated in asthma. We investigated the interrelationship between autophagy and airway remodeling and assessed preclinical efficacy of a known autophagy inhibitor in murine models of asthma. Human asthmatic and nonasthmatic lung tissues were histologically evaluated and were immunostained for key autophagy markers. The percentage area of positive staining was quantified in the epithelium and airway smooth muscle bundles using ImageJ software. Furthermore, the autophagy inhibitor chloroquine was tested intranasally in prophylactic (3 wk) and treatment (5 wk) models of allergic asthma in mice. Human asthmatic tissues showed greater tissue inflammation and demonstrated hallmark features of airway remodeling, displaying thickened epithelium (P < 0.001) and reticular basement membrane (P < 0.0001), greater lamina propria depth (P < 0.005), and increased airway smooth muscle bundles (P < 0.001) with higher expression of Beclin-1 (P < 0.01) and ATG5 (autophagy-related gene 5) (P < 0.05) together with reduced p62 (P < 0.05) compared with nonasthmatic control tissues. Beclin-1 expression was significantly higher in asthmatic epithelium and ciliated cells (P < 0.05), suggesting a potential role of ciliophagy in asthma. Murine asthma models demonstrated effective preclinical efficacy (reduced key features of allergic asthma: airway inflammation, airway hyperresponsiveness, and airway remodeling) of the autophagy inhibitor chloroquine. Our data demonstrate cell context-dependent and selective activation of autophagy in structural cells in asthma. Furthermore, this pathway can be effectively targeted to ameliorate airway remodeling in asthma.
DOI: 10.1165/rcmb.2018-0169OC
PubMed: 30383396
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000076
Links to Exploration step
pubmed:30383396Curation
No country items
Kielan D. Mcalinden<affiliation><nlm:affiliation>1 Graduate School of Health and.</nlm:affiliation>
<wicri:noCountry code="no comma">1 Graduate School of Health and.</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>1 Graduate School of Health and.</nlm:affiliation>
<wicri:noCountry code="no comma">1 Graduate School of Health and.</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Autophagy Activation in Asthma Airways Remodeling.</title>
<author><name sortKey="Mcalinden, Kielan D" sort="Mcalinden, Kielan D" uniqKey="Mcalinden K" first="Kielan D" last="Mcalinden">Kielan D. Mcalinden</name>
<affiliation><nlm:affiliation>1 Graduate School of Health and.</nlm:affiliation>
<wicri:noCountry code="no comma">1 Graduate School of Health and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Deshpande, Deepak A" sort="Deshpande, Deepak A" uniqKey="Deshpande D" first="Deepak A" last="Deshpande">Deepak A. Deshpande</name>
<affiliation wicri:level="2"><nlm:affiliation>4 Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>4 Center for Translational Medicine, Thomas Jefferson University, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ghavami, Saeid" sort="Ghavami, Saeid" uniqKey="Ghavami S" first="Saeid" last="Ghavami">Saeid Ghavami</name>
<affiliation wicri:level="4"><nlm:affiliation>5 Department of Anatomy & Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada; and.</nlm:affiliation>
<orgName type="university">Université du Manitoba</orgName>
<country>Canada</country>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xenaki, Dia" sort="Xenaki, Dia" uniqKey="Xenaki D" first="Dia" last="Xenaki">Dia Xenaki</name>
<affiliation wicri:level="1"><nlm:affiliation>2 Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>2 Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sohal, Sukhwinder Singh" sort="Sohal, Sukhwinder Singh" uniqKey="Sohal S" first="Sukhwinder Singh" last="Sohal">Sukhwinder Singh Sohal</name>
<affiliation wicri:level="1"><nlm:affiliation>6 Respiratory Translational Research Group, Department of Laboratory Medicine, University of Tasmania, Launceston, Tasmania, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>6 Respiratory Translational Research Group, Department of Laboratory Medicine, University of Tasmania, Launceston, Tasmania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oliver, Brian G" sort="Oliver, Brian G" uniqKey="Oliver B" first="Brian G" last="Oliver">Brian G. Oliver</name>
<affiliation wicri:level="1"><nlm:affiliation>3 School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>3 School of Life Sciences, University of Technology Sydney, Sydney, New South Wales</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haghi, Mehra" sort="Haghi, Mehra" uniqKey="Haghi M" first="Mehra" last="Haghi">Mehra Haghi</name>
<affiliation><nlm:affiliation>1 Graduate School of Health and.</nlm:affiliation>
<wicri:noCountry code="no comma">1 Graduate School of Health and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sharma, Pawan" sort="Sharma, Pawan" uniqKey="Sharma P" first="Pawan" last="Sharma">Pawan Sharma</name>
<affiliation wicri:level="1"><nlm:affiliation>3 School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>3 School of Life Sciences, University of Technology Sydney, Sydney, New South Wales</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:30383396</idno>
<idno type="pmid">30383396</idno>
<idno type="doi">10.1165/rcmb.2018-0169OC</idno>
<idno type="wicri:Area/PubMed/Corpus">000076</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000076</idno>
<idno type="wicri:Area/PubMed/Curation">000076</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000076</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Autophagy Activation in Asthma Airways Remodeling.</title>
<author><name sortKey="Mcalinden, Kielan D" sort="Mcalinden, Kielan D" uniqKey="Mcalinden K" first="Kielan D" last="Mcalinden">Kielan D. Mcalinden</name>
<affiliation><nlm:affiliation>1 Graduate School of Health and.</nlm:affiliation>
<wicri:noCountry code="no comma">1 Graduate School of Health and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Deshpande, Deepak A" sort="Deshpande, Deepak A" uniqKey="Deshpande D" first="Deepak A" last="Deshpande">Deepak A. Deshpande</name>
<affiliation wicri:level="2"><nlm:affiliation>4 Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>4 Center for Translational Medicine, Thomas Jefferson University, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ghavami, Saeid" sort="Ghavami, Saeid" uniqKey="Ghavami S" first="Saeid" last="Ghavami">Saeid Ghavami</name>
<affiliation wicri:level="4"><nlm:affiliation>5 Department of Anatomy & Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada; and.</nlm:affiliation>
<orgName type="university">Université du Manitoba</orgName>
<country>Canada</country>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xenaki, Dia" sort="Xenaki, Dia" uniqKey="Xenaki D" first="Dia" last="Xenaki">Dia Xenaki</name>
<affiliation wicri:level="1"><nlm:affiliation>2 Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>2 Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sohal, Sukhwinder Singh" sort="Sohal, Sukhwinder Singh" uniqKey="Sohal S" first="Sukhwinder Singh" last="Sohal">Sukhwinder Singh Sohal</name>
<affiliation wicri:level="1"><nlm:affiliation>6 Respiratory Translational Research Group, Department of Laboratory Medicine, University of Tasmania, Launceston, Tasmania, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>6 Respiratory Translational Research Group, Department of Laboratory Medicine, University of Tasmania, Launceston, Tasmania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oliver, Brian G" sort="Oliver, Brian G" uniqKey="Oliver B" first="Brian G" last="Oliver">Brian G. Oliver</name>
<affiliation wicri:level="1"><nlm:affiliation>3 School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>3 School of Life Sciences, University of Technology Sydney, Sydney, New South Wales</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haghi, Mehra" sort="Haghi, Mehra" uniqKey="Haghi M" first="Mehra" last="Haghi">Mehra Haghi</name>
<affiliation><nlm:affiliation>1 Graduate School of Health and.</nlm:affiliation>
<wicri:noCountry code="no comma">1 Graduate School of Health and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sharma, Pawan" sort="Sharma, Pawan" uniqKey="Sharma P" first="Pawan" last="Sharma">Pawan Sharma</name>
<affiliation wicri:level="1"><nlm:affiliation>3 School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>3 School of Life Sciences, University of Technology Sydney, Sydney, New South Wales</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">American journal of respiratory cell and molecular biology</title>
<idno type="eISSN">1535-4989</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Airway Remodeling (drug effects)</term>
<term>Animals</term>
<term>Anti-Asthmatic Agents (pharmacology)</term>
<term>Asthma (drug therapy)</term>
<term>Asthma (genetics)</term>
<term>Asthma (metabolism)</term>
<term>Asthma (pathology)</term>
<term>Autophagy (drug effects)</term>
<term>Autophagy (genetics)</term>
<term>Autophagy-Related Protein 5 (antagonists & inhibitors)</term>
<term>Autophagy-Related Protein 5 (genetics)</term>
<term>Autophagy-Related Protein 5 (metabolism)</term>
<term>Beclin-1 (antagonists & inhibitors)</term>
<term>Beclin-1 (genetics)</term>
<term>Beclin-1 (metabolism)</term>
<term>Case-Control Studies</term>
<term>Chloroquine (pharmacology)</term>
<term>Cilia (drug effects)</term>
<term>Cilia (metabolism)</term>
<term>Cilia (pathology)</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Lung (drug effects)</term>
<term>Lung (metabolism)</term>
<term>Lung (pathology)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Middle Aged</term>
<term>Muscle, Smooth (drug effects)</term>
<term>Muscle, Smooth (metabolism)</term>
<term>Muscle, Smooth (pathology)</term>
<term>Myocytes, Smooth Muscle (drug effects)</term>
<term>Myocytes, Smooth Muscle (metabolism)</term>
<term>Myocytes, Smooth Muscle (pathology)</term>
<term>Primary Cell Culture</term>
<term>Respiratory Mucosa (drug effects)</term>
<term>Respiratory Mucosa (metabolism)</term>
<term>Respiratory Mucosa (pathology)</term>
<term>Sequestosome-1 Protein (genetics)</term>
<term>Sequestosome-1 Protein (metabolism)</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Antiasthmatiques (pharmacologie)</term>
<term>Asthme (anatomopathologie)</term>
<term>Asthme (génétique)</term>
<term>Asthme (métabolisme)</term>
<term>Asthme (traitement médicamenteux)</term>
<term>Autophagie ()</term>
<term>Autophagie (génétique)</term>
<term>Bécline-1 (antagonistes et inhibiteurs)</term>
<term>Bécline-1 (génétique)</term>
<term>Bécline-1 (métabolisme)</term>
<term>Chloroquine (pharmacologie)</term>
<term>Cils vibratiles ()</term>
<term>Cils vibratiles (anatomopathologie)</term>
<term>Cils vibratiles (métabolisme)</term>
<term>Culture primaire de cellules</term>
<term>Femelle</term>
<term>Humains</term>
<term>Modèles animaux de maladie humaine</term>
<term>Muqueuse respiratoire ()</term>
<term>Muqueuse respiratoire (anatomopathologie)</term>
<term>Muqueuse respiratoire (métabolisme)</term>
<term>Muscles lisses ()</term>
<term>Muscles lisses (anatomopathologie)</term>
<term>Muscles lisses (métabolisme)</term>
<term>Myocytes du muscle lisse ()</term>
<term>Myocytes du muscle lisse (anatomopathologie)</term>
<term>Myocytes du muscle lisse (métabolisme)</term>
<term>Mâle</term>
<term>Poumon ()</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (métabolisme)</term>
<term>Protéine-5 associée à l'autophagie (antagonistes et inhibiteurs)</term>
<term>Protéine-5 associée à l'autophagie (génétique)</term>
<term>Protéine-5 associée à l'autophagie (métabolisme)</term>
<term>Remodelage des voies aériennes ()</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Séquestosome-1 (génétique)</term>
<term>Séquestosome-1 (métabolisme)</term>
<term>Transduction du signal</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Autophagy-Related Protein 5</term>
<term>Beclin-1</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Autophagy-Related Protein 5</term>
<term>Beclin-1</term>
<term>Sequestosome-1 Protein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Autophagy-Related Protein 5</term>
<term>Beclin-1</term>
<term>Sequestosome-1 Protein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Asthmatic Agents</term>
<term>Chloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Asthme</term>
<term>Cils vibratiles</term>
<term>Muqueuse respiratoire</term>
<term>Muscles lisses</term>
<term>Myocytes du muscle lisse</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Bécline-1</term>
<term>Protéine-5 associée à l'autophagie</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Airway Remodeling</term>
<term>Autophagy</term>
<term>Cilia</term>
<term>Lung</term>
<term>Muscle, Smooth</term>
<term>Myocytes, Smooth Muscle</term>
<term>Respiratory Mucosa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Asthma</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asthma</term>
<term>Autophagy</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Asthme</term>
<term>Autophagie</term>
<term>Bécline-1</term>
<term>Protéine-5 associée à l'autophagie</term>
<term>Séquestosome-1</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Asthma</term>
<term>Cilia</term>
<term>Lung</term>
<term>Muscle, Smooth</term>
<term>Myocytes, Smooth Muscle</term>
<term>Respiratory Mucosa</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Asthme</term>
<term>Bécline-1</term>
<term>Cils vibratiles</term>
<term>Muqueuse respiratoire</term>
<term>Muscles lisses</term>
<term>Myocytes du muscle lisse</term>
<term>Poumon</term>
<term>Protéine-5 associée à l'autophagie</term>
<term>Séquestosome-1</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Asthma</term>
<term>Cilia</term>
<term>Lung</term>
<term>Muscle, Smooth</term>
<term>Myocytes, Smooth Muscle</term>
<term>Respiratory Mucosa</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiasthmatiques</term>
<term>Chloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Asthme</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Case-Control Studies</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Middle Aged</term>
<term>Primary Cell Culture</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Autophagie</term>
<term>Cils vibratiles</term>
<term>Culture primaire de cellules</term>
<term>Femelle</term>
<term>Humains</term>
<term>Modèles animaux de maladie humaine</term>
<term>Muqueuse respiratoire</term>
<term>Muscles lisses</term>
<term>Myocytes du muscle lisse</term>
<term>Mâle</term>
<term>Poumon</term>
<term>Remodelage des voies aériennes</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Transduction du signal</term>
<term>Études cas-témoins</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Current asthma therapies fail to target airway remodeling that correlates with asthma severity driving disease progression that ultimately leads to loss of lung function. Macroautophagy (hereinafter "autophagy") is a fundamental cell-recycling mechanism in all eukaryotic cells; emerging evidence suggests that it is dysregulated in asthma. We investigated the interrelationship between autophagy and airway remodeling and assessed preclinical efficacy of a known autophagy inhibitor in murine models of asthma. Human asthmatic and nonasthmatic lung tissues were histologically evaluated and were immunostained for key autophagy markers. The percentage area of positive staining was quantified in the epithelium and airway smooth muscle bundles using ImageJ software. Furthermore, the autophagy inhibitor chloroquine was tested intranasally in prophylactic (3 wk) and treatment (5 wk) models of allergic asthma in mice. Human asthmatic tissues showed greater tissue inflammation and demonstrated hallmark features of airway remodeling, displaying thickened epithelium (<i>P</i>
< 0.001) and reticular basement membrane (<i>P</i>
< 0.0001), greater lamina propria depth (<i>P</i>
< 0.005), and increased airway smooth muscle bundles (<i>P</i>
< 0.001) with higher expression of Beclin-1 (<i>P</i>
< 0.01) and ATG5 (autophagy-related gene 5) (<i>P</i>
< 0.05) together with reduced p62 (<i>P</i>
< 0.05) compared with nonasthmatic control tissues. Beclin-1 expression was significantly higher in asthmatic epithelium and ciliated cells (<i>P</i>
< 0.05), suggesting a potential role of ciliophagy in asthma. Murine asthma models demonstrated effective preclinical efficacy (reduced key features of allergic asthma: airway inflammation, airway hyperresponsiveness, and airway remodeling) of the autophagy inhibitor chloroquine. Our data demonstrate cell context-dependent and selective activation of autophagy in structural cells in asthma. Furthermore, this pathway can be effectively targeted to ameliorate airway remodeling in asthma.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30383396</PMID>
<DateCompleted><Year>2019</Year>
<Month>12</Month>
<Day>27</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1535-4989</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>60</Volume>
<Issue>5</Issue>
<PubDate><Year>2019</Year>
<Month>05</Month>
</PubDate>
</JournalIssue>
<Title>American journal of respiratory cell and molecular biology</Title>
<ISOAbbreviation>Am. J. Respir. Cell Mol. Biol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Autophagy Activation in Asthma Airways Remodeling.</ArticleTitle>
<Pagination><MedlinePgn>541-553</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1165/rcmb.2018-0169OC</ELocationID>
<Abstract><AbstractText>Current asthma therapies fail to target airway remodeling that correlates with asthma severity driving disease progression that ultimately leads to loss of lung function. Macroautophagy (hereinafter "autophagy") is a fundamental cell-recycling mechanism in all eukaryotic cells; emerging evidence suggests that it is dysregulated in asthma. We investigated the interrelationship between autophagy and airway remodeling and assessed preclinical efficacy of a known autophagy inhibitor in murine models of asthma. Human asthmatic and nonasthmatic lung tissues were histologically evaluated and were immunostained for key autophagy markers. The percentage area of positive staining was quantified in the epithelium and airway smooth muscle bundles using ImageJ software. Furthermore, the autophagy inhibitor chloroquine was tested intranasally in prophylactic (3 wk) and treatment (5 wk) models of allergic asthma in mice. Human asthmatic tissues showed greater tissue inflammation and demonstrated hallmark features of airway remodeling, displaying thickened epithelium (<i>P</i>
< 0.001) and reticular basement membrane (<i>P</i>
< 0.0001), greater lamina propria depth (<i>P</i>
< 0.005), and increased airway smooth muscle bundles (<i>P</i>
< 0.001) with higher expression of Beclin-1 (<i>P</i>
< 0.01) and ATG5 (autophagy-related gene 5) (<i>P</i>
< 0.05) together with reduced p62 (<i>P</i>
< 0.05) compared with nonasthmatic control tissues. Beclin-1 expression was significantly higher in asthmatic epithelium and ciliated cells (<i>P</i>
< 0.05), suggesting a potential role of ciliophagy in asthma. Murine asthma models demonstrated effective preclinical efficacy (reduced key features of allergic asthma: airway inflammation, airway hyperresponsiveness, and airway remodeling) of the autophagy inhibitor chloroquine. Our data demonstrate cell context-dependent and selective activation of autophagy in structural cells in asthma. Furthermore, this pathway can be effectively targeted to ameliorate airway remodeling in asthma.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McAlinden</LastName>
<ForeName>Kielan D</ForeName>
<Initials>KD</Initials>
<AffiliationInfo><Affiliation>1 Graduate School of Health and.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>3 School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>2 Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deshpande</LastName>
<ForeName>Deepak A</ForeName>
<Initials>DA</Initials>
<AffiliationInfo><Affiliation>4 Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ghavami</LastName>
<ForeName>Saeid</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>5 Department of Anatomy & Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xenaki</LastName>
<ForeName>Dia</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>2 Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sohal</LastName>
<ForeName>Sukhwinder Singh</ForeName>
<Initials>SS</Initials>
<AffiliationInfo><Affiliation>6 Respiratory Translational Research Group, Department of Laboratory Medicine, University of Tasmania, Launceston, Tasmania, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oliver</LastName>
<ForeName>Brian G</ForeName>
<Initials>BG</Initials>
<AffiliationInfo><Affiliation>3 School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>2 Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Haghi</LastName>
<ForeName>Mehra</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>1 Graduate School of Health and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sharma</LastName>
<ForeName>Pawan</ForeName>
<Initials>P</Initials>
<Identifier Source="ORCID">0000-0002-2904-2306</Identifier>
<AffiliationInfo><Affiliation>3 School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>2 Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 HL137030</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Am J Respir Cell Mol Biol</MedlineTA>
<NlmUniqueID>8917225</NlmUniqueID>
<ISSNLinking>1044-1549</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C502778">ATG5 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018927">Anti-Asthmatic Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000071187">Autophagy-Related Protein 5</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C491997">BECN1 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000071186">Beclin-1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C099718">SQSTM1 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000071456">Sequestosome-1 Protein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>886U3H6UFF</RegistryNumber>
<NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Am J Respir Cell Mol Biol. 2019 May;60(5):494-496</RefSource>
<PMID Version="1">30423254</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056151" MajorTopicYN="N">Airway Remodeling</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018927" MajorTopicYN="N">Anti-Asthmatic Agents</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001249" MajorTopicYN="N">Asthma</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000071187" MajorTopicYN="N">Autophagy-Related Protein 5</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000071186" MajorTopicYN="N">Beclin-1</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002923" MajorTopicYN="N">Cilia</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009130" MajorTopicYN="N">Muscle, Smooth</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032389" MajorTopicYN="N">Myocytes, Smooth Muscle</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061251" MajorTopicYN="N">Primary Cell Culture</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020545" MajorTopicYN="N">Respiratory Mucosa</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000071456" MajorTopicYN="N">Sequestosome-1 Protein</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Beclin-1</Keyword>
<Keyword MajorTopicYN="Y">asthma</Keyword>
<Keyword MajorTopicYN="Y">autophagy</Keyword>
<Keyword MajorTopicYN="Y">immunohistochemistry</Keyword>
<Keyword MajorTopicYN="Y">remodeling</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pmc-release"><Year>2020</Year>
<Month>05</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>11</Month>
<Day>2</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>12</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>11</Month>
<Day>2</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30383396</ArticleId>
<ArticleId IdType="doi">10.1165/rcmb.2018-0169OC</ArticleId>
<ArticleId IdType="pmc">PMC6503620</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Sci Rep. 2017 Oct 17;7(1):13392</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29042607</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Methods Enzymol. 2009;452:181-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19200883</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2012;7(4):e33454</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22536318</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Respir Cell Mol Biol. 2011 Feb;44(2):127-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20525803</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Allergy Clin Immunol. 2012 Feb;129(2):569-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22040902</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Hepatology. 2007 Sep;46(3):851-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17685470</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2013 Feb 14;368(7):651-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23406030</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Allergy Clin Immunol. 2003 Jun;111(6):1293-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12789232</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Respir Crit Care Med. 2012 May 15;185(10):1058-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22403800</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Opin Cell Biol. 2008 Oct;20(5):583-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18573652</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Arch Ophthalmol. 1964 Feb;71:238-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14089397</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Methods Mol Biol. 2019;1854:87-103</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29101677</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2010 Apr 2;285(14):10850-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20123989</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Autophagy. 2012 Apr;8(4):694-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22498476</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell. 2008 Jan 11;132(1):27-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18191218</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Can J Physiol Pharmacol. 2015 Mar;93(3):195-202</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25692961</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 1994 Feb 18;269(7):5241-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8106507</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Respir Crit Care Med. 2003 Jan 1;167(1):78-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12502479</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Gastroenterology. 2012 Apr;142(4):938-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22240484</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 1972 Jan 7;235(5332):50-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4550396</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Pathol. 2010 Aug;177(2):632-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20616344</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mol Cell Endocrinol. 2012 Apr 4;351(2):167-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22266540</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochim Biophys Acta. 2011 Jan;1812(1):23-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20637865</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Respir Crit Care Med. 1999 Sep;160(3):1035-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10471638</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Cell Sci. 2008 Aug 15;121(Pt 16):2685-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18653543</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Eur Respir J. 2006 Jan;27(1):208-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16387953</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Autophagy. 2012 Apr;8(4):445-544</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22966490</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):749-768</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29481833</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Cell Biol. 2010 Sep;12(9):823-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20811354</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Front Immunol. 2017 Mar 29;8:355</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28424691</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Antibiot (Tokyo). 1984 Feb;37(2):110-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6423597</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Pathol. 2014 Aug;184(8):2146-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24976620</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Autophagy. 2014 Mar;10(3):532-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24401596</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Eur J Pharmacol. 2017 Apr 5;800:40-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28216048</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>EMBO Rep. 2001 Apr;2(4):330-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11306555</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):642-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9279252</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Br J Pharmacol. 2012 Oct;167(3):548-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22551156</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Respir Cell Mol Biol. 2011 Mar;44(3):394-403</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20463291</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Med. 2010 Nov;16(11):1299-304</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20972434</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Respirology. 2010 Aug;15(6):930-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20630030</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1982 Mar;79(6):1889-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6952238</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L27-L40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28473327</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Respir Crit Care Med. 2003 May 15;167(10):1360-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12531777</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biochem. 2002 May;131(5):647-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11983070</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Respirology. 2017 Aug;22(6):1125-1132</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28326668</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Eur J Biochem. 1997 Jan 15;243(1-2):240-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9030745</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell Death Dis. 2015 Mar 19;6:e1696</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25789971</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Cell Sci. 2010 Sep 15;123(Pt 18):3061-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20736308</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Ann Allergy. 1990 Jul;65(1):53-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2195922</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2014 Jul 23;9(7):e102737</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25054970</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000076 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000076 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:30383396 |texte= Autophagy Activation in Asthma Airways Remodeling. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:30383396" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |