Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages.
Identifieur interne : 000525 ( PubMed/Corpus ); précédent : 000524; suivant : 000526Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages.
Auteurs : T. Lazard ; C. Perronne ; C. Truffot-Pernot ; J. Grosset ; J L Vildé ; J J PocidaloSource :
- Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [ 0962-8479 ] ; 1994.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Chloroquine, Clarithromycin.
- drug effects : Mycobacterium avium.
- growth & development : Mycobacterium avium.
- microbiology : Macrophages.
- Cells, Cultured, Colony Count, Microbial, Drug Interactions, Humans.
Abstract
Chloroquine, an alkalinizing lysosomotropic agent, enhances the intracellular activity of antibiotics against Mycobacterium tuberculosis or Coxiella burnetii.
DOI: 10.1016/0962-8479(94)90133-3
PubMed: 7949074
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pubmed:7949074Le document en format XML
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Grosset</name></author><author><name sortKey="Vilde, J L" sort="Vilde, J L" uniqKey="Vilde J" first="J L" last="Vildé">J L Vildé</name></author><author><name sortKey="Pocidalo, J J" sort="Pocidalo, J J" uniqKey="Pocidalo J" first="J J" last="Pocidalo">J J Pocidalo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:7949074</idno><idno type="pmid">7949074</idno><idno type="doi">10.1016/0962-8479(94)90133-3</idno><idno type="wicri:Area/PubMed/Corpus">000525</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000525</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages.</title><author><name sortKey="Lazard, T" sort="Lazard, T" uniqKey="Lazard T" first="T" last="Lazard">T. Lazard</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale, Hôpital Bichat-Claude Bernard, Paris.</nlm:affiliation></affiliation></author><author><name sortKey="Perronne, C" sort="Perronne, C" uniqKey="Perronne C" first="C" last="Perronne">C. Perronne</name></author><author><name sortKey="Truffot Pernot, C" sort="Truffot Pernot, C" uniqKey="Truffot Pernot C" first="C" last="Truffot-Pernot">C. Truffot-Pernot</name></author><author><name sortKey="Grosset, J" sort="Grosset, J" uniqKey="Grosset J" first="J" last="Grosset">J. Grosset</name></author><author><name sortKey="Vilde, J L" sort="Vilde, J L" uniqKey="Vilde J" first="J L" last="Vildé">J L Vildé</name></author><author><name sortKey="Pocidalo, J J" sort="Pocidalo, J J" uniqKey="Pocidalo J" first="J J" last="Pocidalo">J J Pocidalo</name></author></analytic><series><title level="j">Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease</title><idno type="ISSN">0962-8479</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cells, Cultured</term><term>Chloroquine (pharmacology)</term><term>Clarithromycin (pharmacology)</term><term>Colony Count, Microbial</term><term>Drug Interactions</term><term>Humans</term><term>Macrophages (microbiology)</term><term>Mycobacterium avium (drug effects)</term><term>Mycobacterium avium (growth & development)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Chloroquine</term><term>Clarithromycin</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Mycobacterium avium</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Mycobacterium avium</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cells, Cultured</term><term>Colony Count, Microbial</term><term>Drug Interactions</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chloroquine, an alkalinizing lysosomotropic agent, enhances the intracellular activity of antibiotics against Mycobacterium tuberculosis or Coxiella burnetii.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7949074</PMID><DateCompleted><Year>1994</Year><Month>12</Month><Day>29</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0962-8479</ISSN><JournalIssue CitedMedium="Print"><Volume>75</Volume><Issue>4</Issue><PubDate><Year>1994</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease</Title><ISOAbbreviation>Tuber. Lung Dis.</ISOAbbreviation></Journal><ArticleTitle>Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages.</ArticleTitle><Pagination><MedlinePgn>283-5</MedlinePgn></Pagination><Abstract><AbstractText Label="SETTING" NlmCategory="METHODS">Chloroquine, an alkalinizing lysosomotropic agent, enhances the intracellular activity of antibiotics against Mycobacterium tuberculosis or Coxiella burnetii.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine if chloroquine modifies the activity of clarithromycin, less effective at acidic pH, against intracellular Mycobacterium avium.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">The activity of clarithromycin (4 micrograms/ml) against the MO-1 strain of M. avium was evaluated within human macrophages in presence of chloroquine (5 micrograms/ml). The minimal inhibitory concentration of clarithromycin for the strain was 2 micrograms/ml.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">While clarithromycin alone did decrease the intracellular infection at day 7 of culture (P < 0.01), chloroquine alone did not impede the intracellular growth of M. avium, and did not enhance the activity of clarithromycin.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Chloroquine should not improve clarithromycin treatment against M. avium infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lazard</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, Hôpital Bichat-Claude Bernard, Paris.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perronne</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Truffot-Pernot</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Grosset</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Vildé</LastName><ForeName>J L</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Pocidalo</LastName><ForeName>J J</ForeName><Initials>JJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Scotland</Country><MedlineTA>Tuber Lung Dis</MedlineTA><NlmUniqueID>9212467</NlmUniqueID><ISSNLinking>0962-8479</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>H1250JIK0A</RegistryNumber><NameOfSubstance UI="D017291">Clarithromycin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017291" MajorTopicYN="N">Clarithromycin</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015169" MajorTopicYN="N">Colony Count, Microbial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004347" MajorTopicYN="N">Drug Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009162" MajorTopicYN="N">Mycobacterium avium</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1994</Year><Month>8</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1994</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1994</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7949074</ArticleId><ArticleId IdType="pii">0962-8479(94)90133-3</ArticleId><ArticleId IdType="doi">10.1016/0962-8479(94)90133-3</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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