Mefloquine-induced pneumonitis.
Identifieur interne : 000435 ( PubMed/Corpus ); précédent : 000434; suivant : 000436Mefloquine-induced pneumonitis.
Auteurs : Patrick Soentjens ; Marc Delanote ; Alfons Van GompelSource :
- Journal of travel medicine [ 1195-1982 ]
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Antimalarials, Mefloquine.
- chemical , adverse effects : Antimalarials, Mefloquine.
- chemically induced : Pneumonia.
- diagnosis : Pneumonia.
- prevention & control : Malaria.
- Female, Humans, Middle Aged.
Abstract
Mefloquine is indicated as oral treatment and as prophylaxis for malaria in areas where chloroquine-resistant malaria is present. Gastrointestinal and neuropsychiatric side effects of mefloquine are well known. More severe neuropsychiatric disorders such as psychosis, depression, hallucinations, and seizures are also reported in the literature. We are reporting a case of drug-induced pneumonia due to mefloquine. This diagnosis was confirmed 4 months after the adverse event, after restarting the same malaria prophylaxis, which could be considered as an unintentional provocation test. This is the third case report in the literature of acute lung injury caused by mefloquine.
DOI: 10.1111/j.1708-8305.2006.00037.x
PubMed: 16706949
Links to Exploration step
pubmed:16706949Le document en format XML
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<author><name sortKey="Soentjens, Patrick" sort="Soentjens, Patrick" uniqKey="Soentjens P" first="Patrick" last="Soentjens">Patrick Soentjens</name>
<affiliation><nlm:affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Delanote, Marc" sort="Delanote, Marc" uniqKey="Delanote M" first="Marc" last="Delanote">Marc Delanote</name>
</author>
<author><name sortKey="Van Gompel, Alfons" sort="Van Gompel, Alfons" uniqKey="Van Gompel A" first="Alfons" last="Van Gompel">Alfons Van Gompel</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Mefloquine-induced pneumonitis.</title>
<author><name sortKey="Soentjens, Patrick" sort="Soentjens, Patrick" uniqKey="Soentjens P" first="Patrick" last="Soentjens">Patrick Soentjens</name>
<affiliation><nlm:affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium.</nlm:affiliation>
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<author><name sortKey="Delanote, Marc" sort="Delanote, Marc" uniqKey="Delanote M" first="Marc" last="Delanote">Marc Delanote</name>
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<author><name sortKey="Van Gompel, Alfons" sort="Van Gompel, Alfons" uniqKey="Van Gompel A" first="Alfons" last="Van Gompel">Alfons Van Gompel</name>
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<series><title level="j">Journal of travel medicine</title>
<idno type="ISSN">1195-1982</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antimalarials (administration & dosage)</term>
<term>Antimalarials (adverse effects)</term>
<term>Female</term>
<term>Humans</term>
<term>Malaria (prevention & control)</term>
<term>Mefloquine (administration & dosage)</term>
<term>Mefloquine (adverse effects)</term>
<term>Middle Aged</term>
<term>Pneumonia (chemically induced)</term>
<term>Pneumonia (diagnosis)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antimalarials</term>
<term>Mefloquine</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antimalarials</term>
<term>Mefloquine</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Pneumonia</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Pneumonia</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Malaria</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Humans</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">Mefloquine is indicated as oral treatment and as prophylaxis for malaria in areas where chloroquine-resistant malaria is present. Gastrointestinal and neuropsychiatric side effects of mefloquine are well known. More severe neuropsychiatric disorders such as psychosis, depression, hallucinations, and seizures are also reported in the literature. We are reporting a case of drug-induced pneumonia due to mefloquine. This diagnosis was confirmed 4 months after the adverse event, after restarting the same malaria prophylaxis, which could be considered as an unintentional provocation test. This is the third case report in the literature of acute lung injury caused by mefloquine.</div>
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<DateCompleted><Year>2006</Year>
<Month>08</Month>
<Day>02</Day>
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<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">1195-1982</ISSN>
<JournalIssue CitedMedium="Print"><Volume>13</Volume>
<Issue>3</Issue>
<PubDate><MedlineDate>2006 May-Jun</MedlineDate>
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<Title>Journal of travel medicine</Title>
<ISOAbbreviation>J Travel Med</ISOAbbreviation>
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<ArticleTitle>Mefloquine-induced pneumonitis.</ArticleTitle>
<Pagination><MedlinePgn>172-4</MedlinePgn>
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<Abstract><AbstractText>Mefloquine is indicated as oral treatment and as prophylaxis for malaria in areas where chloroquine-resistant malaria is present. Gastrointestinal and neuropsychiatric side effects of mefloquine are well known. More severe neuropsychiatric disorders such as psychosis, depression, hallucinations, and seizures are also reported in the literature. We are reporting a case of drug-induced pneumonia due to mefloquine. This diagnosis was confirmed 4 months after the adverse event, after restarting the same malaria prophylaxis, which could be considered as an unintentional provocation test. This is the third case report in the literature of acute lung injury caused by mefloquine.</AbstractText>
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<MeshHeading><DescriptorName UI="D015767" MajorTopicYN="N">Mefloquine</DescriptorName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D011014" MajorTopicYN="N">Pneumonia</DescriptorName>
<QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
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