ChloroquineV1, PubMed, Checkpoint, bibRecord, 000512

Morphometric analysis of the effect of chloroquine on rat foetal lung maturation.

Identifieur interne : 000512 ( PubMed/Checkpoint ); précédent : 000511; suivant : 000513

Morphometric analysis of the effect of chloroquine on rat foetal lung maturation.

Auteurs : A O Okanlawon [Nigeria] ; A B Ejiwunmi ; M O Dada ; O A Ashiru

Source :

East African medical journal [ 0012-835X ] ; 1993.

RBID : pubmed:8513751

Descripteurs français

KwdFr :
- Animaux, Antipaludiques (effets indésirables), Chloroquine (analogues et dérivés), Chloroquine (effets indésirables), Femelle, Grossesse, Maturité foetale, Poumon (), Poumon (anatomie et histologie), Poumon (embryologie), Rat Sprague-Dawley, Rats, Taille d'organe, Évaluation préclinique de médicament.
MESH :
- analogues et dérivés : Chloroquine.
- anatomie et histologie : Poumon.
- effets indésirables : Antipaludiques, Chloroquine.
- embryologie : Poumon.
- Animaux, Femelle, Grossesse, Maturité foetale, Poumon, Rat Sprague-Dawley, Rats, Taille d'organe, Évaluation préclinique de médicament.

English descriptors

KwdEn :
- Animals, Antimalarials (adverse effects), Chloroquine (adverse effects), Chloroquine (analogs & derivatives), Drug Evaluation, Preclinical, Female, Fetal Organ Maturity, Lung (anatomy & histology), Lung (drug effects), Lung (embryology), Organ Size, Pregnancy, Rats, Rats, Sprague-Dawley.
MESH :
- chemical , adverse effects : Antimalarials, Chloroquine.
- chemical , analogs & derivatives : Chloroquine.
- anatomy & histology : Lung.
- drug effects : Lung.
- embryology : Lung.
- Animals, Drug Evaluation, Preclinical, Female, Fetal Organ Maturity, Organ Size, Pregnancy, Rats, Rats, Sprague-Dawley.

Abstract

Pregnant Sprague-Dawley rats were injected with chloroquine phosphate (40mg/kg b. wt 1.p) in the late canalicular (day 20) and early terminal-sac (day 21) and sacrificed in the late terminal sac (day 22 = term) stage of foetal lung development. The control animal received normal saline. Morphometric evaluation of the lungs by light microscopy revealed three important exposure-related lesions. They were: (a) reduction in the volume density of parenchyma and saccular space, (b) reduction in the volume of an average saccule and, (c) an increase in the number of saccules per unit volume (Numerical Density). The observations suggest that chloroquine retards foetal lung maturation by reducing the saccular expansion which takes place immediately preterm. However, the possible practical implications are unclear.

PubMed: 8513751

Affiliations:

Nigeria

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Le document en format XML

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<author><name sortKey="Okanlawon, A O" sort="Okanlawon, A O" uniqKey="Okanlawon A" first="A O" last="Okanlawon">A O Okanlawon</name>
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<term>Chloroquine (analogs & derivatives)</term>
<term>Drug Evaluation, Preclinical</term>
<term>Female</term>
<term>Fetal Organ Maturity</term>
<term>Lung (anatomy & histology)</term>
<term>Lung (drug effects)</term>
<term>Lung (embryology)</term>
<term>Organ Size</term>
<term>Pregnancy</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antipaludiques (effets indésirables)</term>
<term>Chloroquine (analogues et dérivés)</term>
<term>Chloroquine (effets indésirables)</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Maturité foetale</term>
<term>Poumon ()</term>
<term>Poumon (anatomie et histologie)</term>
<term>Poumon (embryologie)</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Taille d'organe</term>
<term>Évaluation préclinique de médicament</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antimalarials</term>
<term>Chloroquine</term>
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<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Chloroquine</term>
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<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Chloroquine</term>
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<keywords scheme="MESH" qualifier="anatomie et histologie" xml:lang="fr"><term>Poumon</term>
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<keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Lung</term>
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<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antipaludiques</term>
<term>Chloroquine</term>
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<term>Poumon</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Taille d'organe</term>
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<front><div type="abstract" xml:lang="en">Pregnant Sprague-Dawley rats were injected with chloroquine phosphate (40mg/kg b. wt 1.p) in the late canalicular (day 20) and early terminal-sac (day 21) and sacrificed in the late terminal sac (day 22 = term) stage of foetal lung development. The control animal received normal saline. Morphometric evaluation of the lungs by light microscopy revealed three important exposure-related lesions. They were: (a) reduction in the volume density of parenchyma and saccular space, (b) reduction in the volume of an average saccule and, (c) an increase in the number of saccules per unit volume (Numerical Density). The observations suggest that chloroquine retards foetal lung maturation by reducing the saccular expansion which takes place immediately preterm. However, the possible practical implications are unclear.</div>
</front>
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<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
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<JournalIssue CitedMedium="Print"><Volume>70</Volume>
<Issue>2</Issue>
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<Title>East African medical journal</Title>
<ISOAbbreviation>East Afr Med J</ISOAbbreviation>
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<ArticleTitle>Morphometric analysis of the effect of chloroquine on rat foetal lung maturation.</ArticleTitle>
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<Abstract><AbstractText>Pregnant Sprague-Dawley rats were injected with chloroquine phosphate (40mg/kg b. wt 1.p) in the late canalicular (day 20) and early terminal-sac (day 21) and sacrificed in the late terminal sac (day 22 = term) stage of foetal lung development. The control animal received normal saline. Morphometric evaluation of the lungs by light microscopy revealed three important exposure-related lesions. They were: (a) reduction in the volume density of parenchyma and saccular space, (b) reduction in the volume of an average saccule and, (c) an increase in the number of saccules per unit volume (Numerical Density). The observations suggest that chloroquine retards foetal lung maturation by reducing the saccular expansion which takes place immediately preterm. However, the possible practical implications are unclear.</AbstractText>
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Morphometric analysis of the effect of chloroquine on rat foetal lung maturation.

Morphometric analysis of the effect of chloroquine on rat foetal lung maturation.

Source :

Descripteurs français

English descriptors

Abstract

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