Morphometric analysis of the effect of chloroquine on rat foetal lung maturation.
Identifieur interne : 000540 ( PubMed/Corpus ); précédent : 000539; suivant : 000541Morphometric analysis of the effect of chloroquine on rat foetal lung maturation.
Auteurs : A O Okanlawon ; A B Ejiwunmi ; M O Dada ; O A AshiruSource :
- East African medical journal [ 0012-835X ] ; 1993.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Antimalarials, Chloroquine.
- chemical , analogs & derivatives : Chloroquine.
- anatomy & histology : Lung.
- drug effects : Lung.
- embryology : Lung.
- Animals, Drug Evaluation, Preclinical, Female, Fetal Organ Maturity, Organ Size, Pregnancy, Rats, Rats, Sprague-Dawley.
Abstract
Pregnant Sprague-Dawley rats were injected with chloroquine phosphate (40mg/kg b. wt 1.p) in the late canalicular (day 20) and early terminal-sac (day 21) and sacrificed in the late terminal sac (day 22 = term) stage of foetal lung development. The control animal received normal saline. Morphometric evaluation of the lungs by light microscopy revealed three important exposure-related lesions. They were: (a) reduction in the volume density of parenchyma and saccular space, (b) reduction in the volume of an average saccule and, (c) an increase in the number of saccules per unit volume (Numerical Density). The observations suggest that chloroquine retards foetal lung maturation by reducing the saccular expansion which takes place immediately preterm. However, the possible practical implications are unclear.
PubMed: 8513751
Links to Exploration step
pubmed:8513751Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Morphometric analysis of the effect of chloroquine on rat foetal lung maturation.</title><author><name sortKey="Okanlawon, A O" sort="Okanlawon, A O" uniqKey="Okanlawon A" first="A O" last="Okanlawon">A O Okanlawon</name><affiliation><nlm:affiliation>Department of Anatomy, College of Medicine, University of Lagos, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Ejiwunmi, A B" sort="Ejiwunmi, A B" uniqKey="Ejiwunmi A" first="A B" last="Ejiwunmi">A B Ejiwunmi</name></author><author><name sortKey="Dada, M O" sort="Dada, M O" uniqKey="Dada M" first="M O" last="Dada">M O Dada</name></author><author><name sortKey="Ashiru, O A" sort="Ashiru, O A" uniqKey="Ashiru O" first="O A" last="Ashiru">O A Ashiru</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1993">1993</date><idno type="RBID">pubmed:8513751</idno><idno type="pmid">8513751</idno><idno type="wicri:Area/PubMed/Corpus">000540</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000540</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Morphometric analysis of the effect of chloroquine on rat foetal lung maturation.</title><author><name sortKey="Okanlawon, A O" sort="Okanlawon, A O" uniqKey="Okanlawon A" first="A O" last="Okanlawon">A O Okanlawon</name><affiliation><nlm:affiliation>Department of Anatomy, College of Medicine, University of Lagos, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Ejiwunmi, A B" sort="Ejiwunmi, A B" uniqKey="Ejiwunmi A" first="A B" last="Ejiwunmi">A B Ejiwunmi</name></author><author><name sortKey="Dada, M O" sort="Dada, M O" uniqKey="Dada M" first="M O" last="Dada">M O Dada</name></author><author><name sortKey="Ashiru, O A" sort="Ashiru, O A" uniqKey="Ashiru O" first="O A" last="Ashiru">O A Ashiru</name></author></analytic><series><title level="j">East African medical journal</title><idno type="ISSN">0012-835X</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antimalarials (adverse effects)</term><term>Chloroquine (adverse effects)</term><term>Chloroquine (analogs & derivatives)</term><term>Drug Evaluation, Preclinical</term><term>Female</term><term>Fetal Organ Maturity</term><term>Lung (anatomy & histology)</term><term>Lung (drug effects)</term><term>Lung (embryology)</term><term>Organ Size</term><term>Pregnancy</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antimalarials</term><term>Chloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Evaluation, Preclinical</term><term>Female</term><term>Fetal Organ Maturity</term><term>Organ Size</term><term>Pregnancy</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pregnant Sprague-Dawley rats were injected with chloroquine phosphate (40mg/kg b. wt 1.p) in the late canalicular (day 20) and early terminal-sac (day 21) and sacrificed in the late terminal sac (day 22 = term) stage of foetal lung development. The control animal received normal saline. Morphometric evaluation of the lungs by light microscopy revealed three important exposure-related lesions. They were: (a) reduction in the volume density of parenchyma and saccular space, (b) reduction in the volume of an average saccule and, (c) an increase in the number of saccules per unit volume (Numerical Density). The observations suggest that chloroquine retards foetal lung maturation by reducing the saccular expansion which takes place immediately preterm. However, the possible practical implications are unclear.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8513751</PMID><DateCompleted><Year>1993</Year><Month>07</Month><Day>21</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0012-835X</ISSN><JournalIssue CitedMedium="Print"><Volume>70</Volume><Issue>2</Issue><PubDate><Year>1993</Year><Month>Feb</Month></PubDate></JournalIssue><Title>East African medical journal</Title><ISOAbbreviation>East Afr Med J</ISOAbbreviation></Journal><ArticleTitle>Morphometric analysis of the effect of chloroquine on rat foetal lung maturation.</ArticleTitle><Pagination><MedlinePgn>98-100</MedlinePgn></Pagination><Abstract><AbstractText>Pregnant Sprague-Dawley rats were injected with chloroquine phosphate (40mg/kg b. wt 1.p) in the late canalicular (day 20) and early terminal-sac (day 21) and sacrificed in the late terminal sac (day 22 = term) stage of foetal lung development. The control animal received normal saline. Morphometric evaluation of the lungs by light microscopy revealed three important exposure-related lesions. They were: (a) reduction in the volume density of parenchyma and saccular space, (b) reduction in the volume of an average saccule and, (c) an increase in the number of saccules per unit volume (Numerical Density). The observations suggest that chloroquine retards foetal lung maturation by reducing the saccular expansion which takes place immediately preterm. However, the possible practical implications are unclear.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Okanlawon</LastName><ForeName>A O</ForeName><Initials>AO</Initials><AffiliationInfo><Affiliation>Department of Anatomy, College of Medicine, University of Lagos, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ejiwunmi</LastName><ForeName>A B</ForeName><Initials>AB</Initials></Author><Author ValidYN="Y"><LastName>Dada</LastName><ForeName>M O</ForeName><Initials>MO</Initials></Author><Author ValidYN="Y"><LastName>Ashiru</LastName><ForeName>O A</ForeName><Initials>OA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Kenya</Country><MedlineTA>East Afr Med J</MedlineTA><NlmUniqueID>0372766</NlmUniqueID><ISSNLinking>0012-835X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical><Chemical><RegistryNumber>6E17K3343P</RegistryNumber><NameOfSubstance UI="C023676">chloroquine diphosphate</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004353" MajorTopicYN="N">Drug Evaluation, Preclinical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005325" MajorTopicYN="N">Fetal Organ Maturity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000033" MajorTopicYN="N">anatomy & histology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000196" MajorTopicYN="Y">embryology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009929" MajorTopicYN="N">Organ Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1993</Year><Month>2</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1993</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1993</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8513751</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000540 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000540 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:8513751
|texte= Morphometric analysis of the effect of chloroquine on rat foetal lung maturation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:8513751" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |