Janus particles: recent advances in the biomedical applications
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Auteurs : Tu C. Le [Australie] ; Jiali Zhai [Australie] ; Wei-Hsun Chiu [Australie] ; Phong A. Tran [Australie] ; Nhiem Tran [Australie]Source :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2019.
Abstract
Janus particles, which are named after the two-faced Roman god Janus, have two distinct sides with different surface features, structures, and compositions. This asymmetric structure enables the combination of different or even incompatible physical, chemical, and mechanical properties within a single particle. Much effort has been focused on the preparation of Janus particles with high homogeneity, tunable size and shape, combined functionalities, and scalability. With their unique features, Janus particles have attracted attention in a wide range of applications such as in optics, catalysis, and biomedicine. As a biomedical device, Janus particles offer opportunities to incorporate therapeutics, imaging, or sensing modalities in independent compartments of a single particle in a spatially controlled manner. This may result in synergistic actions of combined therapies and multi-level targeting not possible in isotropic systems. In this review, we summarize the latest advances in employing Janus particles as therapeutic delivery carriers, in vivo imaging probes, and biosensors. Challenges and future opportunities for these particles will also be discussed.
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DOI: 10.2147/IJN.S169030
PubMed: 31692550
PubMed Central: 6711559
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Nanomedicine</journal-id><journal-id journal-id-type="iso-abbrev">Int J Nanomedicine</journal-id><journal-id journal-id-type="publisher-id">IJN</journal-id><journal-id journal-id-type="pmc">intjnano</journal-id><journal-title-group><journal-title>International Journal of Nanomedicine</journal-title></journal-title-group><issn pub-type="ppub">1176-9114</issn><issn pub-type="epub">1178-2013</issn><publisher><publisher-name>Dove</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31692550</article-id><article-id pub-id-type="pmc">6711559</article-id><article-id pub-id-type="publisher-id">169030</article-id><article-id pub-id-type="doi">10.2147/IJN.S169030</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Janus particles: recent advances in the biomedical applications</article-title><alt-title alt-title-type="running-authors">Le et al</alt-title><alt-title alt-title-type="running-title">Le et al</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Le</surname><given-names>Tu C</given-names></name><xref ref-type="aff" rid="AFF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhai</surname><given-names>Jiali</given-names></name><xref ref-type="aff" rid="AFF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Chiu</surname><given-names>Wei-Hsun</given-names></name><xref ref-type="aff" rid="AFF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Tran</surname><given-names>Phong A</given-names></name><xref ref-type="aff" rid="AFF0003">3</xref><xref ref-type="aff" rid="AFF0004">4</xref></contrib><contrib contrib-type="author"><name><surname>Tran</surname><given-names>Nhiem</given-names></name><xref ref-type="corresp" rid="AN0001"></xref><xref ref-type="aff" rid="AFF0002">2</xref></contrib><aff id="AFF0001"><label>1</label><institution>School of Engineering, RMIT University</institution>,<addr-line>Melbourne</addr-line>,<addr-line>VIC 3001,</addr-line><country>Australia</country></aff><aff id="AFF0002"><label>2</label><institution>School of Science, RMIT University</institution>,<addr-line>Melbourne</addr-line>,<addr-line>VIC 3001,</addr-line><country>Australia</country></aff><aff id="AFF0003"><label>3</label><institution>School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology</institution>,<addr-line>Brisbane</addr-line>,<addr-line>QLD 4000</addr-line>,<country>Australia</country></aff><aff id="AFF0004"><label>4</label><institution>Interface Science and Materials Engineering group, School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology</institution>,<addr-line>Brisbane</addr-line>,<addr-line>QLD 4000</addr-line>,<country>Australia</country></aff></contrib-group><author-notes><corresp id="AN0001">Correspondence: Nhiem Tran<institution>School of Science, RMIT University</institution>, <addr-line>124 La Trobe Street</addr-line>, <addr-line>Melbourne</addr-line><addr-line>VIC 3000</addr-line>, <country>Australia</country><phone>Tel +61 3 9925 2131</phone>Email Nhiem.tran@rmit.edu.au</corresp></author-notes><pub-date pub-type="epub"><day>23</day><month>8</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>14</volume><fpage>6749</fpage><lpage>6777</lpage><history><date date-type="received"><day>19</day><month>2</month><year>2019</year></date><date date-type="accepted"><day>21</day><month>5</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 Le et al.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Le et al.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link> and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (<ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link>).</license-p></license></permissions><abstract><title>Abstract</title><p>Janus particles, which are named after the two-faced Roman god Janus, have two distinct sides with different surface features, structures, and compositions. This asymmetric structure enables the combination of different or even incompatible physical, chemical, and mechanical properties within a single particle. Much effort has been focused on the preparation of Janus particles with high homogeneity, tunable size and shape, combined functionalities, and scalability. With their unique features, Janus particles have attracted attention in a wide range of applications such as in optics, catalysis, and biomedicine. As a biomedical device, Janus particles offer opportunities to incorporate therapeutics, imaging, or sensing modalities in independent compartments of a single particle in a spatially controlled manner. This may result in synergistic actions of combined therapies and multi-level targeting not possible in isotropic systems. In this review, we summarize the latest advances in employing Janus particles as therapeutic delivery carriers, in vivo imaging probes, and biosensors. Challenges and future opportunities for these particles will also be discussed.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd>Janus particles</kwd><kwd>therapeutics</kwd><kwd>theranostics</kwd><kwd>imaging</kwd><kwd>sensing</kwd></kwd-group><counts><fig-count count="23"></fig-count><ref-count count="120"></ref-count><page-count count="29"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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