The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes
Identifieur interne : 000A36 ( Pmc/Curation ); précédent : 000A35; suivant : 000A37The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes
Auteurs : Ying Yao [République populaire de Chine] ; Yiteng Zang [République populaire de Chine] ; Jing Qu [République populaire de Chine] ; Meng Tang [République populaire de Chine] ; Ting Zhang [République populaire de Chine]Source :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2019.
Abstract
Metallic nanoparticles (MNPs) are new engineering materials with broad prospects for biomedical applications; thus, their biosafety has drawn great concern. The liver is the main detoxification organ of vertebrates. However, many issues concerning the interactions between MNPs and biological systems (cells and tissues) are unclear, particularly the toxic effects of MNPs on hepatocytes and other liver cells. Numerous researchers have shown that some MNPs can induce decreased cell survival rate, production of reactive oxygen species (ROS), mitochondrial damage, DNA strand breaks, and even autophagy, pyroptosis, apoptosis, or other forms of cell death. Our review focuses on the recent researches on the liver toxicity of MNPs and its mechanisms at cellular and subcellular levels to provide a scientific basis for the subsequent hepatotoxicity studies of MNPs.
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DOI: 10.2147/IJN.S212907
PubMed: 31806972
PubMed Central: 6844216
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Nanomedicine</journal-id><journal-id journal-id-type="iso-abbrev">Int J Nanomedicine</journal-id><journal-id journal-id-type="publisher-id">IJN</journal-id><journal-id journal-id-type="pmc">intjnano</journal-id><journal-title-group><journal-title>International Journal of Nanomedicine</journal-title></journal-title-group><issn pub-type="ppub">1176-9114</issn><issn pub-type="epub">1178-2013</issn><publisher><publisher-name>Dove</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31806972</article-id><article-id pub-id-type="pmc">6844216</article-id><article-id pub-id-type="publisher-id">212907</article-id><article-id pub-id-type="doi">10.2147/IJN.S212907</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes</article-title><alt-title alt-title-type="running-authors">Yao et al</alt-title><alt-title alt-title-type="running-title">Yao et al</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Yao</surname><given-names>Ying</given-names></name><xref ref-type="aff" rid="AFF0001">1</xref><xref ref-type="author-notes" rid="FT0001"></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Zang</surname><given-names>Yiteng</given-names></name><xref ref-type="aff" rid="AFF0001">1</xref><xref ref-type="author-notes" rid="FT0001"></xref></contrib><contrib contrib-type="author"><name><surname>Qu</surname><given-names>Jing</given-names></name><xref ref-type="aff" rid="AFF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Tang</surname><given-names>Meng</given-names></name><xref ref-type="aff" rid="AFF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Ting</given-names></name><xref ref-type="corresp" rid="AN0001"></xref><xref ref-type="aff" rid="AFF0001">1</xref></contrib><aff id="AFF0001"><label>1</label><institution>Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University</institution>,<addr-line>Nanjing</addr-line><addr-line>210009</addr-line>,<country>People’s Republic of China</country></aff></contrib-group><author-notes><corresp id="AN0001">Correspondence: Ting Zhang <institution>Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University</institution>, <addr-line>Nanjing</addr-line><addr-line>210009</addr-line>, <country>People’s Republic of China</country><phone>Tel +86-25-83272566</phone><fax>Fax +86-25-83272566</fax> Email zhangting@seu.edu.cn</corresp><fn id="FT0001"><label>*</label><p>These authors contributed equally to this work</p></fn></author-notes><pub-date pub-type="epub"><day>07</day><month>11</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>14</volume><fpage>8787</fpage><lpage>8804</lpage><history><date date-type="received"><day>19</day><month>4</month><year>2019</year></date><date date-type="accepted"><day>21</day><month>10</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 Yao et al.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Yao et al.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link> and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (<ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link>).</license-p></license></permissions><abstract><title>Abstract</title><p>Metallic nanoparticles (MNPs) are new engineering materials with broad prospects for biomedical applications; thus, their biosafety has drawn great concern. The liver is the main detoxification organ of vertebrates. However, many issues concerning the interactions between MNPs and biological systems (cells and tissues) are unclear, particularly the toxic effects of MNPs on hepatocytes and other liver cells. Numerous researchers have shown that some MNPs can induce decreased cell survival rate, production of reactive oxygen species (ROS), mitochondrial damage, DNA strand breaks, and even autophagy, pyroptosis, apoptosis, or other forms of cell death. Our review focuses on the recent researches on the liver toxicity of MNPs and its mechanisms at cellular and subcellular levels to provide a scientific basis for the subsequent hepatotoxicity studies of MNPs.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd>metallic nanoparticles</kwd><kwd>hepatotoxicity</kwd><kwd>subcellular injury</kwd><kwd>dysfunctions</kwd><kwd>toxicity outcome</kwd></kwd-group><counts><fig-count count="1"></fig-count><table-count count="2"></table-count><ref-count count="116"></ref-count><page-count count="18"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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