Mitochondrial Involvement in Cisplatin Resistance
Identifieur interne : 000A18 ( Pmc/Curation ); précédent : 000A17; suivant : 000A19Mitochondrial Involvement in Cisplatin Resistance
Auteurs : Veronica Cocetta [Italie] ; Eugenio Ragazzi [Italie] ; Monica Montopoli [Italie]Source :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2019.
Abstract
Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent recurrence of resistance phenomena, it still remains the only therapeutic option for several tumors. Circumventing cisplatin resistance remains, therefore, a major goal for clinical therapy and represents a challenge for scientific research. Recent studies have brought to light the fundamental role of mitochondria in onset, progression, and metastasis of cancer, as well as its importance in the resistance to chemotherapy. The aim of this review is to give an overview of the current knowledge about the implication of mitochondria in cisplatin resistance and on the recent development in this research field. Recent studies have highlighted the role of mitochondrial DNA alterations in onset of resistance phenomena, being related both to redox balance alterations and to signal crosstalk with the nucleus, allowing a rewiring of cell metabolism. Moreover, an important role of the mitochondrial dynamics in the adaptation mechanism of cancer cells to challenging environment has been revealed. Giving bioenergetic plasticity to tumor cells, mitochondria allow cells to evade death pathways in stressful conditions, including chemotherapy. So far, even if the central role of mitochondria is recognized, little is known about the specific mechanisms implicated in the resistance. Nevertheless, mitochondria appear to be promising pharmacological targets for overcoming cisplatin resistance, but further studies are necessary.
Url:
DOI: 10.3390/ijms20143384
PubMed: 31295873
PubMed Central: 6678541
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Cocetta</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-20-03384">Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Egidio Meneghetti 2, 35131 Padua, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Egidio Meneghetti 2, 35131 Padua</wicri:regionArea></affiliation></author><author><name sortKey="Ragazzi, Eugenio" sort="Ragazzi, Eugenio" uniqKey="Ragazzi E" first="Eugenio" last="Ragazzi">Eugenio Ragazzi</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-20-03384">Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Egidio Meneghetti 2, 35131 Padua, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Egidio Meneghetti 2, 35131 Padua</wicri:regionArea></affiliation></author><author><name sortKey="Montopoli, Monica" sort="Montopoli, Monica" uniqKey="Montopoli M" first="Monica" last="Montopoli">Monica Montopoli</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-20-03384">Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Egidio Meneghetti 2, 35131 Padua, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Egidio Meneghetti 2, 35131 Padua</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijms-20-03384">Venetian Institute of Molecular Medicine (VIMM), Via Orus 2, 35129 Padua, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Venetian Institute of Molecular Medicine (VIMM), Via Orus 2, 35129 Padua</wicri:regionArea></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent recurrence of resistance phenomena, it still remains the only therapeutic option for several tumors. Circumventing cisplatin resistance remains, therefore, a major goal for clinical therapy and represents a challenge for scientific research. Recent studies have brought to light the fundamental role of mitochondria in onset, progression, and metastasis of cancer, as well as its importance in the resistance to chemotherapy. The aim of this review is to give an overview of the current knowledge about the implication of mitochondria in cisplatin resistance and on the recent development in this research field. Recent studies have highlighted the role of mitochondrial DNA alterations in onset of resistance phenomena, being related both to redox balance alterations and to signal crosstalk with the nucleus, allowing a rewiring of cell metabolism. Moreover, an important role of the mitochondrial dynamics in the adaptation mechanism of cancer cells to challenging environment has been revealed. Giving bioenergetic plasticity to tumor cells, mitochondria allow cells to evade death pathways in stressful conditions, including chemotherapy. So far, even if the central role of mitochondria is recognized, little is known about the specific mechanisms implicated in the resistance. Nevertheless, mitochondria appear to be promising pharmacological targets for overcoming cisplatin resistance, but further studies are necessary.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Prestayko, A W" uniqKey="Prestayko A">A.W. Prestayko</name></author><author><name sortKey="D Oust, J C" uniqKey="D Oust J">J.C. D’aoust</name></author><author><name sortKey="Issell, B F" uniqKey="Issell B">B.F. Issell</name></author><author><name sortKey="Crooke, S T" uniqKey="Crooke S">S.T. Crooke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lebwohl, D" uniqKey="Lebwohl D">D. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Mol Sci</journal-id><journal-id journal-id-type="iso-abbrev">Int J Mol Sci</journal-id><journal-id journal-id-type="publisher-id">ijms</journal-id><journal-title-group><journal-title>International Journal of Molecular Sciences</journal-title></journal-title-group><issn pub-type="epub">1422-0067</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31295873</article-id><article-id pub-id-type="pmc">6678541</article-id><article-id pub-id-type="doi">10.3390/ijms20143384</article-id><article-id pub-id-type="publisher-id">ijms-20-03384</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Mitochondrial Involvement in Cisplatin Resistance</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cocetta</surname><given-names>Veronica</given-names></name><xref ref-type="aff" rid="af1-ijms-20-03384">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-0390-6823</contrib-id><name><surname>Ragazzi</surname><given-names>Eugenio</given-names></name><xref ref-type="aff" rid="af1-ijms-20-03384">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-6182-4132</contrib-id><name><surname>Montopoli</surname><given-names>Monica</given-names></name><xref ref-type="aff" rid="af1-ijms-20-03384">1</xref><xref ref-type="aff" rid="af2-ijms-20-03384">2</xref><xref rid="c1-ijms-20-03384" ref-type="corresp">*</xref></contrib></contrib-group><aff id="af1-ijms-20-03384"><label>1</label>Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Egidio Meneghetti 2, 35131 Padua, Italy</aff><aff id="af2-ijms-20-03384"><label>2</label>Venetian Institute of Molecular Medicine (VIMM), Via Orus 2, 35129 Padua, Italy</aff><author-notes><corresp id="c1-ijms-20-03384"><label>*</label>Correspondence: <email>monica.montopoli@unipd.it</email>; Tel.: +39-049-8275076</corresp></author-notes><pub-date pub-type="epub"><day>10</day><month>7</month><year>2019</year></pub-date><pub-date pub-type="collection"><month>7</month><year>2019</year></pub-date><volume>20</volume><issue>14</issue><elocation-id>3384</elocation-id><history><date date-type="received"><day>31</day><month>5</month><year>2019</year></date><date date-type="accepted"><day>08</day><month>7</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 by the authors.</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent recurrence of resistance phenomena, it still remains the only therapeutic option for several tumors. Circumventing cisplatin resistance remains, therefore, a major goal for clinical therapy and represents a challenge for scientific research. Recent studies have brought to light the fundamental role of mitochondria in onset, progression, and metastasis of cancer, as well as its importance in the resistance to chemotherapy. The aim of this review is to give an overview of the current knowledge about the implication of mitochondria in cisplatin resistance and on the recent development in this research field. Recent studies have highlighted the role of mitochondrial DNA alterations in onset of resistance phenomena, being related both to redox balance alterations and to signal crosstalk with the nucleus, allowing a rewiring of cell metabolism. Moreover, an important role of the mitochondrial dynamics in the adaptation mechanism of cancer cells to challenging environment has been revealed. Giving bioenergetic plasticity to tumor cells, mitochondria allow cells to evade death pathways in stressful conditions, including chemotherapy. So far, even if the central role of mitochondria is recognized, little is known about the specific mechanisms implicated in the resistance. Nevertheless, mitochondria appear to be promising pharmacological targets for overcoming cisplatin resistance, but further studies are necessary.</p></abstract><kwd-group><kwd>mitochondria</kwd><kwd>cisplatin</kwd><kwd>resistance</kwd><kwd>mitochondrial dynamics</kwd><kwd>mtDNA</kwd></kwd-group></article-meta></front><floats-group><fig id="ijms-20-03384-f001" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Schematic representation of an example for mitochondrial delivery of cisplatin prodrug using liposomal formulation.</p></caption><graphic xlink:href="ijms-20-03384-g001"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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