Reconsidering the Use of Minocycline in the Preliminary Treatment Regime of Rheumatoid Arthritis
Identifieur interne : 000939 ( Pmc/Curation ); précédent : 000938; suivant : 000940Reconsidering the Use of Minocycline in the Preliminary Treatment Regime of Rheumatoid Arthritis
Auteurs :Source :
- Cureus [ 2168-8184 ] ; ????.
Abstract
Strong epidemiologic, clinical, and basic science studies have identified a number of factors that may lead to rheumatoid arthritis (RA) onset and progression, particularly involving the complex interplay between genomics, environmental risk factors, the breakdown of immune self-tolerance, and microbiome dysbiosis. A chronic state of inflammation established by infectious agents has long been suspected to set the stage for the development of RA. The purpose of this article is to review the contribution of the gut, lung, and oral microbiomes to the pathogenesis of RA and consider the importance of supplementing the preliminary treatment regime of RA patients with antibiotics, in particular, minocycline. Minocycline has been used in the treatment of RA due to its bacteriostatic, as well as immunomodulatory and anti-inflammatory properties. Ultimately, a short course of antibiotic treatment with minocycline may eliminate pathogenic organisms contributing to the development and progression of RA.
Url:
DOI: 10.7759/cureus.5351
PubMed: 31608186
PubMed Central: 6783212
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reconsidering the Use of Minocycline in the Preliminary Treatment Regime of Rheumatoid Arthritis</title></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31608186</idno><idno type="pmc">6783212</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783212</idno><idno type="RBID">PMC:6783212</idno><idno type="doi">10.7759/cureus.5351</idno><date when="????">????</date><idno type="wicri:Area/Pmc/Corpus">000939</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000939</idno><idno type="wicri:Area/Pmc/Curation">000939</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000939</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Reconsidering the Use of Minocycline in the Preliminary Treatment Regime of Rheumatoid Arthritis</title></analytic><series><title level="j">Cureus</title><idno type="eISSN">2168-8184</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Strong epidemiologic, clinical, and basic science studies have identified a number of factors that may lead to rheumatoid arthritis (RA) onset and progression, particularly involving the complex interplay between genomics, environmental risk factors, the breakdown of immune self-tolerance, and microbiome dysbiosis. A chronic state of inflammation established by infectious agents has long been suspected to set the stage for the development of RA. The purpose of this article is to review the contribution of the gut, lung, and oral microbiomes to the pathogenesis of RA and consider the importance of supplementing the preliminary treatment regime of RA patients with antibiotics, in particular, minocycline. Minocycline has been used in the treatment of RA due to its bacteriostatic, as well as immunomodulatory and anti-inflammatory properties. Ultimately, a short course of antibiotic treatment with minocycline may eliminate pathogenic organisms contributing to the development and progression of RA. </p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Firestein, Gs" uniqKey="Firestein G">GS Firestein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunter, Tm" uniqKey="Hunter T">TM Hunter</name></author><author><name sortKey="Boytsov, Nn" uniqKey="Boytsov N">NN Boytsov</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Schroeder, K" uniqKey="Schroeder K">K Schroeder</name></author><author><name sortKey="Michaud, K" uniqKey="Michaud K">K Michaud</name></author><author><name sortKey="Araujo, Ab" uniqKey="Araujo A">AB Araujo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turesson, C" uniqKey="Turesson C">C Turesson</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Cureus</journal-id><journal-id journal-id-type="iso-abbrev">Cureus</journal-id><journal-id journal-id-type="issn">2168-8184</journal-id><journal-title-group><journal-title>Cureus</journal-title></journal-title-group><issn pub-type="epub">2168-8184</issn><publisher><publisher-name>Cureus</publisher-name><publisher-loc>Palo Alto (CA)</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31608186</article-id><article-id pub-id-type="pmc">6783212</article-id><article-id pub-id-type="doi">10.7759/cureus.5351</article-id><article-categories><subj-group subj-group-type="heading"><subject>Allergy/Immunology</subject></subj-group><subj-group><subject>Infectious Disease</subject></subj-group><subj-group><subject>Rheumatology</subject></subj-group></article-categories><title-group><article-title>Reconsidering the Use of Minocycline in the Preliminary Treatment Regime of Rheumatoid Arthritis</article-title></title-group><contrib-group><contrib contrib-type="editor"><name><surname>Muacevic</surname><given-names>Alexander</given-names></name></contrib><contrib contrib-type="editor"><name><surname>Adler</surname><given-names>John R</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Heydari-Kamjani</surname><given-names>Milad</given-names></name><xref ref-type="aff" rid="aff-177573">1</xref></contrib><contrib contrib-type="author"><name><surname>Demory Beckler</surname><given-names>Michelle</given-names></name><xref ref-type="aff" rid="aff-177572">2</xref></contrib><contrib contrib-type="author"><name><surname>Kesselman</surname><given-names>Marc M</given-names></name><xref ref-type="aff" rid="aff-170370">3</xref></contrib></contrib-group><aff id="aff-177573"><label>1</label> Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA</aff><aff id="aff-177572"><label>2</label> Immunology, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA</aff><aff id="aff-170370"><label>3</label> Rheumatology, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA</aff><author-notes><corresp id="cor1">Milad Heydari-Kamjani <email>miladheydarik@gmail.com</email></corresp></author-notes><pub-date date-type="pub" publication-format="electronic"><day>8</day><month>8</month><year>2019</year></pub-date><pub-date date-type="collection" publication-format="electronic"><month>8</month><year>2019</year></pub-date><volume>11</volume><issue>8</issue><elocation-id>e5351</elocation-id><history><date date-type="received"><day>6</day><month>5</month><year>2019</year></date><date date-type="accepted"><day>8</day><month>8</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2019, Heydari-Kamjani et al.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Heydari-Kamjani et al.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><self-uri xlink:href="https://www.cureus.com/articles/19619-reconsidering-the-use-of-minocycline-in-the-preliminary-treatment-regime-of-rheumatoid-arthritis">This article is available from https://www.cureus.com/articles/19619-reconsidering-the-use-of-minocycline-in-the-preliminary-treatment-regime-of-rheumatoid-arthritis</self-uri><abstract><p>Strong epidemiologic, clinical, and basic science studies have identified a number of factors that may lead to rheumatoid arthritis (RA) onset and progression, particularly involving the complex interplay between genomics, environmental risk factors, the breakdown of immune self-tolerance, and microbiome dysbiosis. A chronic state of inflammation established by infectious agents has long been suspected to set the stage for the development of RA. The purpose of this article is to review the contribution of the gut, lung, and oral microbiomes to the pathogenesis of RA and consider the importance of supplementing the preliminary treatment regime of RA patients with antibiotics, in particular, minocycline. Minocycline has been used in the treatment of RA due to its bacteriostatic, as well as immunomodulatory and anti-inflammatory properties. Ultimately, a short course of antibiotic treatment with minocycline may eliminate pathogenic organisms contributing to the development and progression of RA. </p></abstract><kwd-group kwd-group-type="author"><kwd>microbiome dysbiosis</kwd><kwd>rheumatoid arthritis</kwd><kwd>antibiotics</kwd><kwd>minocycline</kwd></kwd-group></article-meta><notes><p content-type="disclaimer">The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research and reference purposes. Additionally, articles published within Cureus should not be deemed a suitable substitute for the advice of a qualified health care professional. Do not disregard or avoid professional medical advice due to content published within Cureus.</p></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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