Emerging role of γδ T cells in vaccine‐mediated protection from infectious diseases
Identifieur interne : 000938 ( Pmc/Curation ); précédent : 000937; suivant : 000939Emerging role of γδ T cells in vaccine‐mediated protection from infectious diseases
Auteurs : Kathleen W. Dantzler ; Lauren De La Parte ; Prasanna JagannathanSource :
- Clinical & Translational Immunology [ 2050-0068 ] ; 2019.
Abstract
γδ T cells are fascinating cells that bridge the innate and adaptive immune systems. They have long been known to proliferate rapidly following infection; however, the identity of the specific γδ T cell subsets proliferating and the role of this expansion in protection from disease have only been explored more recently. Several recent studies have investigated γδ T‐cell responses to vaccines targeting infections such as
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DOI: 10.1002/cti2.1072
PubMed: 31485329
PubMed Central: 6712516
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Dantzler</name><affiliation><nlm:aff id="cti21072-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="De La Parte, Lauren" sort="De La Parte, Lauren" uniqKey="De La Parte L" first="Lauren" last="De La Parte">Lauren De La Parte</name><affiliation><nlm:aff id="cti21072-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Jagannathan, Prasanna" sort="Jagannathan, Prasanna" uniqKey="Jagannathan P" first="Prasanna" last="Jagannathan">Prasanna Jagannathan</name><affiliation><nlm:aff id="cti21072-aff-0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31485329</idno><idno type="pmc">6712516</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712516</idno><idno type="RBID">PMC:6712516</idno><idno type="doi">10.1002/cti2.1072</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000938</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000938</idno><idno type="wicri:Area/Pmc/Curation">000938</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000938</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Emerging role of γδ T cells in vaccine‐mediated protection from infectious diseases</title><author><name sortKey="Dantzler, Kathleen W" sort="Dantzler, Kathleen W" uniqKey="Dantzler K" first="Kathleen W" last="Dantzler">Kathleen W. Dantzler</name><affiliation><nlm:aff id="cti21072-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="De La Parte, Lauren" sort="De La Parte, Lauren" uniqKey="De La Parte L" first="Lauren" last="De La Parte">Lauren De La Parte</name><affiliation><nlm:aff id="cti21072-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Jagannathan, Prasanna" sort="Jagannathan, Prasanna" uniqKey="Jagannathan P" first="Prasanna" last="Jagannathan">Prasanna Jagannathan</name><affiliation><nlm:aff id="cti21072-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Clinical & Translational Immunology</title><idno type="eISSN">2050-0068</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>γδ T cells are fascinating cells that bridge the innate and adaptive immune systems. They have long been known to proliferate rapidly following infection; however, the identity of the specific γδ T cell subsets proliferating and the role of this expansion in protection from disease have only been explored more recently. Several recent studies have investigated γδ T‐cell responses to vaccines targeting infections such as <italic>Mycobacterium</italic>,<italic> Plasmodium</italic> and influenza, and studies in animal models have provided further insight into the association of these responses with improved clinical outcomes. In this review, we examine the evidence for a role for γδ T cells in vaccine‐induced protection against various bacterial, protozoan and viral infections. We further discuss results suggesting potential mechanisms for protection, including cytokine‐mediated direct and indirect killing of infected cells, and highlight remaining open questions in the field. Finally, building on current efforts to integrate strategies targeting γδ T cells into immunotherapies for cancer, we discuss potential approaches to improve vaccines for infectious diseases by inducing γδ T‐cell activation and cytotoxicity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Transl Immunology</journal-id><journal-id journal-id-type="iso-abbrev">Clin Transl Immunology</journal-id><journal-id journal-id-type="doi">10.1002/(ISSN)2050-0068</journal-id><journal-id journal-id-type="publisher-id">CTI2</journal-id><journal-title-group><journal-title>Clinical & Translational Immunology</journal-title></journal-title-group><issn pub-type="epub">2050-0068</issn><publisher><publisher-name>John Wiley and Sons Inc.</publisher-name><publisher-loc>Hoboken</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31485329</article-id><article-id pub-id-type="pmc">6712516</article-id><article-id pub-id-type="doi">10.1002/cti2.1072</article-id><article-id pub-id-type="publisher-id">CTI21072</article-id><article-categories><subj-group subj-group-type="overline"><subject>Special Feature Review</subject></subj-group><subj-group subj-group-type="heading"><subject>Special Feature Reviews</subject></subj-group></article-categories><title-group><article-title>Emerging role of γδ T cells in vaccine‐mediated protection from infectious diseases</article-title><alt-title alt-title-type="left-running-head">KW Dantzler <italic>et al</italic>.</alt-title></title-group><contrib-group><contrib id="cti21072-cr-0001" contrib-type="author"><name><surname>Dantzler</surname><given-names>Kathleen W</given-names></name><xref ref-type="aff" rid="cti21072-aff-0001"><sup>1</sup></xref></contrib><contrib id="cti21072-cr-0002" contrib-type="author"><name><surname>de la Parte</surname><given-names>Lauren</given-names></name><xref ref-type="aff" rid="cti21072-aff-0001"><sup>1</sup></xref></contrib><contrib id="cti21072-cr-0003" contrib-type="author" corresp="yes"><name><surname>Jagannathan</surname><given-names>Prasanna</given-names></name><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6305-758X</contrib-id><address><email>prasj@stanford.edu</email></address><xref ref-type="aff" rid="cti21072-aff-0001"><sup>1</sup></xref></contrib></contrib-group><aff id="cti21072-aff-0001"><label><sup>1</sup></label><named-content content-type="organisation-division">Department of Medicine</named-content><institution>Stanford University</institution><named-content content-type="city">Stanford</named-content><named-content content-type="country-part">CA</named-content><country country="US">USA</country></aff><author-notes><corresp id="correspondenceTo"><label>*</label><bold>Correspondence</bold><break></break>P Jagannathan, Department of Medicine, Stanford University, 300 Pasteur Drive, Lane Building, Suite L154, Stanford, CA 94305, USA.<break></break>E‐mail: <email>prasj@stanford.edu</email><break></break></corresp></author-notes><pub-date pub-type="epub"><day>28</day><month>8</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>8</volume><issue>8</issue><issue-id pub-id-type="doi">10.1002/cti2.2019.8.issue-8</issue-id><elocation-id>e1072</elocation-id><history><date date-type="received"><day>08</day><month>4</month><year>2019</year></date><date date-type="rev-recd"><day>04</day><month>7</month><year>2019</year></date><date date-type="accepted"><day>14</day><month>7</month><year>2019</year></date></history><permissions><pmc-comment> © 2019 Australian and New Zealand Society for Immunology Inc. </pmc-comment>
<copyright-statement content-type="article-copyright">© 2019 The Authors. <italic>Clinical & Translational Immunology</italic> published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology Inc.</copyright-statement><license license-type="creativeCommonsBy"><license-p>This is an open access article under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link> License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="file:CTI2-8-e1072.pdf"></self-uri><abstract id="cti21072-abs-0001"><title>Abstract</title><p>γδ T cells are fascinating cells that bridge the innate and adaptive immune systems. They have long been known to proliferate rapidly following infection; however, the identity of the specific γδ T cell subsets proliferating and the role of this expansion in protection from disease have only been explored more recently. Several recent studies have investigated γδ T‐cell responses to vaccines targeting infections such as <italic>Mycobacterium</italic>,<italic> Plasmodium</italic> and influenza, and studies in animal models have provided further insight into the association of these responses with improved clinical outcomes. In this review, we examine the evidence for a role for γδ T cells in vaccine‐induced protection against various bacterial, protozoan and viral infections. We further discuss results suggesting potential mechanisms for protection, including cytokine‐mediated direct and indirect killing of infected cells, and highlight remaining open questions in the field. Finally, building on current efforts to integrate strategies targeting γδ T cells into immunotherapies for cancer, we discuss potential approaches to improve vaccines for infectious diseases by inducing γδ T‐cell activation and cytotoxicity.</p></abstract><kwd-group kwd-group-type="author-generated"><kwd id="cti21072-kwd-0001">cytokines</kwd><kwd id="cti21072-kwd-0002">infection</kwd><kwd id="cti21072-kwd-0003">proliferation</kwd><kwd id="cti21072-kwd-0004">vaccination</kwd><kwd id="cti21072-kwd-0005">Vγ9Vδ2 T cells</kwd><kwd id="cti21072-kwd-0006">γδ T cells</kwd></kwd-group><funding-group><award-group><funding-source>Pilot Project Grant</funding-source><award-id>AI 118610</award-id></award-group></funding-group><counts><fig-count count="0"></fig-count><table-count count="1"></table-count><page-count count="16"></page-count><word-count count="10561"></word-count></counts><custom-meta-group><custom-meta><meta-name>source-schema-version-number</meta-name><meta-value>2.0</meta-value></custom-meta><custom-meta><meta-name>component-id</meta-name><meta-value>cti21072</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>2019</meta-value></custom-meta><custom-meta><meta-name>details-of-publishers-convertor</meta-name><meta-value>Converter:WILEY_ML3GV2_TO_NLMPMC version:5.6.8 mode:remove_FC converted:28.08.2019</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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