Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It
Identifieur interne : 000625 ( Pmc/Curation ); précédent : 000624; suivant : 000626Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It
Auteurs : Mikhail Ponomarenko [Russie] ; Dmitry Rasskazov ; Irina Chadaeva [Russie] ; Ekaterina Sharypova ; Irina Drachkova ; Dmitry Oshchepkov ; Petr Ponomarenko ; Ludmila Savinkova ; Evgeniya Oshchepkova ; Maria Nazarenko ; Nikolay Kolchanov [Russie]Source :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2020.
Abstract
(1) Background: The World Health Organization (WHO) regards atherosclerosis-related myocardial infarction and stroke as the main causes of death in humans. Susceptibility to atherogenesis-associated diseases is caused by single-nucleotide polymorphisms (SNPs). (2) Methods: Using our previously developed public web-service SNP_TATA_Comparator, we estimated statistical significance of the SNP-caused alterations in TATA-binding protein (TBP) binding affinity for 70 bp proximal promoter regions of the human genes clinically associated with diseases syntonic or dystonic with atherogenesis. Additionally, we did the same for several genes related to the maintenance of mitochondrial genome integrity, according to present-day active research aimed at retarding atherogenesis. (3) Results: In dbSNP, we found 1186 SNPs altering such affinity to the same extent as clinical SNP markers do (as estimated). Particularly, clinical SNP marker rs2276109 can prevent autoimmune diseases via reduced TBP affinity for the human
Url:
DOI: 10.3390/ijms21031045
PubMed: 32033288
PubMed Central: 7037642
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000625
Links to Exploration step
PMC:7037642Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It</title>
<author><name sortKey="Ponomarenko, Mikhail" sort="Ponomarenko, Mikhail" uniqKey="Ponomarenko M" first="Mikhail" last="Ponomarenko">Mikhail Ponomarenko</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-ijms-21-01045">Novosibirsk State University, Novosibirsk 630090, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Novosibirsk State University, Novosibirsk 630090</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rasskazov, Dmitry" sort="Rasskazov, Dmitry" uniqKey="Rasskazov D" first="Dmitry" last="Rasskazov">Dmitry Rasskazov</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chadaeva, Irina" sort="Chadaeva, Irina" uniqKey="Chadaeva I" first="Irina" last="Chadaeva">Irina Chadaeva</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-ijms-21-01045">Novosibirsk State University, Novosibirsk 630090, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Novosibirsk State University, Novosibirsk 630090</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sharypova, Ekaterina" sort="Sharypova, Ekaterina" uniqKey="Sharypova E" first="Ekaterina" last="Sharypova">Ekaterina Sharypova</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Drachkova, Irina" sort="Drachkova, Irina" uniqKey="Drachkova I" first="Irina" last="Drachkova">Irina Drachkova</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oshchepkov, Dmitry" sort="Oshchepkov, Dmitry" uniqKey="Oshchepkov D" first="Dmitry" last="Oshchepkov">Dmitry Oshchepkov</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ponomarenko, Petr" sort="Ponomarenko, Petr" uniqKey="Ponomarenko P" first="Petr" last="Ponomarenko">Petr Ponomarenko</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Savinkova, Ludmila" sort="Savinkova, Ludmila" uniqKey="Savinkova L" first="Ludmila" last="Savinkova">Ludmila Savinkova</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oshchepkova, Evgeniya" sort="Oshchepkova, Evgeniya" uniqKey="Oshchepkova E" first="Evgeniya" last="Oshchepkova">Evgeniya Oshchepkova</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nazarenko, Maria" sort="Nazarenko, Maria" uniqKey="Nazarenko M" first="Maria" last="Nazarenko">Maria Nazarenko</name>
<affiliation><nlm:aff id="af3-ijms-21-01045">Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk 634009, Russia;<email>maria.nazarenko@medgenetics.ru</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kolchanov, Nikolay" sort="Kolchanov, Nikolay" uniqKey="Kolchanov N" first="Nikolay" last="Kolchanov">Nikolay Kolchanov</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-ijms-21-01045">Novosibirsk State University, Novosibirsk 630090, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Novosibirsk State University, Novosibirsk 630090</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">32033288</idno>
<idno type="pmc">7037642</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037642</idno>
<idno type="RBID">PMC:7037642</idno>
<idno type="doi">10.3390/ijms21031045</idno>
<date when="2020">2020</date>
<idno type="wicri:Area/Pmc/Corpus">000625</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000625</idno>
<idno type="wicri:Area/Pmc/Curation">000625</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000625</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It</title>
<author><name sortKey="Ponomarenko, Mikhail" sort="Ponomarenko, Mikhail" uniqKey="Ponomarenko M" first="Mikhail" last="Ponomarenko">Mikhail Ponomarenko</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-ijms-21-01045">Novosibirsk State University, Novosibirsk 630090, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Novosibirsk State University, Novosibirsk 630090</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rasskazov, Dmitry" sort="Rasskazov, Dmitry" uniqKey="Rasskazov D" first="Dmitry" last="Rasskazov">Dmitry Rasskazov</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chadaeva, Irina" sort="Chadaeva, Irina" uniqKey="Chadaeva I" first="Irina" last="Chadaeva">Irina Chadaeva</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-ijms-21-01045">Novosibirsk State University, Novosibirsk 630090, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Novosibirsk State University, Novosibirsk 630090</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sharypova, Ekaterina" sort="Sharypova, Ekaterina" uniqKey="Sharypova E" first="Ekaterina" last="Sharypova">Ekaterina Sharypova</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Drachkova, Irina" sort="Drachkova, Irina" uniqKey="Drachkova I" first="Irina" last="Drachkova">Irina Drachkova</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oshchepkov, Dmitry" sort="Oshchepkov, Dmitry" uniqKey="Oshchepkov D" first="Dmitry" last="Oshchepkov">Dmitry Oshchepkov</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ponomarenko, Petr" sort="Ponomarenko, Petr" uniqKey="Ponomarenko P" first="Petr" last="Ponomarenko">Petr Ponomarenko</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Savinkova, Ludmila" sort="Savinkova, Ludmila" uniqKey="Savinkova L" first="Ludmila" last="Savinkova">Ludmila Savinkova</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oshchepkova, Evgeniya" sort="Oshchepkova, Evgeniya" uniqKey="Oshchepkova E" first="Evgeniya" last="Oshchepkova">Evgeniya Oshchepkova</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nazarenko, Maria" sort="Nazarenko, Maria" uniqKey="Nazarenko M" first="Maria" last="Nazarenko">Maria Nazarenko</name>
<affiliation><nlm:aff id="af3-ijms-21-01045">Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk 634009, Russia;<email>maria.nazarenko@medgenetics.ru</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kolchanov, Nikolay" sort="Kolchanov, Nikolay" uniqKey="Kolchanov N" first="Nikolay" last="Kolchanov">Nikolay Kolchanov</name>
<affiliation><nlm:aff id="af1-ijms-21-01045">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-ijms-21-01045">Novosibirsk State University, Novosibirsk 630090, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Novosibirsk State University, Novosibirsk 630090</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">International Journal of Molecular Sciences</title>
<idno type="eISSN">1422-0067</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>(1) Background: The World Health Organization (WHO) regards atherosclerosis-related myocardial infarction and stroke as the main causes of death in humans. Susceptibility to atherogenesis-associated diseases is caused by single-nucleotide polymorphisms (SNPs). (2) Methods: Using our previously developed public web-service SNP_TATA_Comparator, we estimated statistical significance of the SNP-caused alterations in TATA-binding protein (TBP) binding affinity for 70 bp proximal promoter regions of the human genes clinically associated with diseases syntonic or dystonic with atherogenesis. Additionally, we did the same for several genes related to the maintenance of mitochondrial genome integrity, according to present-day active research aimed at retarding atherogenesis. (3) Results: In dbSNP, we found 1186 SNPs altering such affinity to the same extent as clinical SNP markers do (as estimated). Particularly, clinical SNP marker rs2276109 can prevent autoimmune diseases via reduced TBP affinity for the human <italic>MMP12</italic>
gene promoter and therefore macrophage elastase deficiency, which is a well-known physiological marker of accelerated atherogenesis that could be retarded nutritionally using dairy fermented by lactobacilli. (4) Conclusions: Our results uncovered SNPs near clinical SNP markers as the basis of neutral drift accelerating atherogenesis and SNPs of genes encoding proteins related to mitochondrial genome integrity and microRNA genes associated with instability of the atherosclerotic plaque as a basis of directional natural selection slowing atherogenesis. Their sum may be stabilizing the natural selection that sets the normal level of atherogenesis.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Barquera, S" uniqKey="Barquera S">S. Barquera</name>
</author>
<author><name sortKey="Pedroza Tobias, A" uniqKey="Pedroza Tobias A">A. Pedroza-Tobias</name>
</author>
<author><name sortKey="Medina, C" uniqKey="Medina C">C. Medina</name>
</author>
<author><name sortKey="Hernandez Barrera, L" uniqKey="Hernandez Barrera L">L. Hernandez-Barrera</name>
</author>
<author><name sortKey="Bibbins Domingo, K" uniqKey="Bibbins Domingo K">K. Bibbins-Domingo</name>
</author>
<author><name sortKey="Lozano, R" uniqKey="Lozano R">R. Lozano</name>
</author>
<author><name sortKey="Moran, A E" uniqKey="Moran A">A.E. Moran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Libby, P" uniqKey="Libby P">P. Libby</name>
</author>
<author><name sortKey="Buring, J" uniqKey="Buring J">J. Buring</name>
</author>
<author><name sortKey="Badimon, L" uniqKey="Badimon L">L. Badimon</name>
</author>
<author><name sortKey="Hansson, G" uniqKey="Hansson G">G. Hansson</name>
</author>
<author><name sortKey="Deanfield, J" uniqKey="Deanfield J">J. Deanfield</name>
</author>
<author><name sortKey="Bittencourt, M" uniqKey="Bittencourt M">M. Bittencourt</name>
</author>
<author><name sortKey="Tokgozoglu, L" uniqKey="Tokgozoglu L">L. Tokgozoglu</name>
</author>
<author><name sortKey="Lewis, E" uniqKey="Lewis E">E. Lewis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, A C" uniqKey="Li A">A.C. Li</name>
</author>
<author><name sortKey="Glass, C K" uniqKey="Glass C">C.K. Glass</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lusis, A J" uniqKey="Lusis A">A.J. Lusis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Glass, C K" uniqKey="Glass C">C.K. Glass</name>
</author>
<author><name sortKey="Witztum, J L" uniqKey="Witztum J">J.L. Witztum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hirayama, S" uniqKey="Hirayama S">S. Hirayama</name>
</author>
<author><name sortKey="Soda, S" uniqKey="Soda S">S. Soda</name>
</author>
<author><name sortKey="Ito, Y" uniqKey="Ito Y">Y. Ito</name>
</author>
<author><name sortKey="Matsui, H" uniqKey="Matsui H">H. Matsui</name>
</author>
<author><name sortKey="Ueno, T" uniqKey="Ueno T">T. Ueno</name>
</author>
<author><name sortKey="Fukushima, Y" uniqKey="Fukushima Y">Y. Fukushima</name>
</author>
<author><name sortKey="Ohmura, H" uniqKey="Ohmura H">H. Ohmura</name>
</author>
<author><name sortKey="Hanyu, O" uniqKey="Hanyu O">O. Hanyu</name>
</author>
<author><name sortKey="Aizawa, Y" uniqKey="Aizawa Y">Y. Aizawa</name>
</author>
<author><name sortKey="Miida, T" uniqKey="Miida T">T. Miida</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lathe, R" uniqKey="Lathe R">R. Lathe</name>
</author>
<author><name sortKey="Sapronova, A" uniqKey="Sapronova A">A. Sapronova</name>
</author>
<author><name sortKey="Kotelevtsev, Y" uniqKey="Kotelevtsev Y">Y. Kotelevtsev</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Napoli, C" uniqKey="Napoli C">C. Napoli</name>
</author>
<author><name sortKey="D Rmiento, F" uniqKey="D Rmiento F">F. D’Armiento</name>
</author>
<author><name sortKey="Mancini, F" uniqKey="Mancini F">F. Mancini</name>
</author>
<author><name sortKey="Postiglione, A" uniqKey="Postiglione A">A. Postiglione</name>
</author>
<author><name sortKey="Witztum, J" uniqKey="Witztum J">J. Witztum</name>
</author>
<author><name sortKey="Palumbo, G" uniqKey="Palumbo G">G. Palumbo</name>
</author>
<author><name sortKey="Palinski, W" uniqKey="Palinski W">W. Palinski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trovato, G M" uniqKey="Trovato G">G.M. Trovato</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Telenti, A" uniqKey="Telenti A">A. Telenti</name>
</author>
<author><name sortKey="Pierce, L" uniqKey="Pierce L">L. Pierce</name>
</author>
<author><name sortKey="Biggs, W" uniqKey="Biggs W">W. Biggs</name>
</author>
<author><name sortKey="Di Iulio, J" uniqKey="Di Iulio J">J. di Iulio</name>
</author>
<author><name sortKey="Wong, E" uniqKey="Wong E">E. Wong</name>
</author>
<author><name sortKey="Fabani, M" uniqKey="Fabani M">M. Fabani</name>
</author>
<author><name sortKey="Kirkness, E" uniqKey="Kirkness E">E. Kirkness</name>
</author>
<author><name sortKey="Moustafa, A" uniqKey="Moustafa A">A. Moustafa</name>
</author>
<author><name sortKey="Shah, N" uniqKey="Shah N">N. Shah</name>
</author>
<author><name sortKey="Xie, C" uniqKey="Xie C">C. Xie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zerbino, D" uniqKey="Zerbino D">D. Zerbino</name>
</author>
<author><name sortKey="Wilder, S" uniqKey="Wilder S">S. Wilder</name>
</author>
<author><name sortKey="Johnson, N" uniqKey="Johnson N">N. Johnson</name>
</author>
<author><name sortKey="Juettemann, T" uniqKey="Juettemann T">T. Juettemann</name>
</author>
<author><name sortKey="Flicek, P" uniqKey="Flicek P">P. Flicek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sherry, S" uniqKey="Sherry S">S. Sherry</name>
</author>
<author><name sortKey="Ward, M" uniqKey="Ward M">M. Ward</name>
</author>
<author><name sortKey="Kholodov, M" uniqKey="Kholodov M">M. Kholodov</name>
</author>
<author><name sortKey="Baker, J" uniqKey="Baker J">J. Baker</name>
</author>
<author><name sortKey="Phan, L" uniqKey="Phan L">L. Phan</name>
</author>
<author><name sortKey="Smigielski, E" uniqKey="Smigielski E">E. Smigielski</name>
</author>
<author><name sortKey="Sirotkin, K" uniqKey="Sirotkin K">K. Sirotkin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haeussler, M" uniqKey="Haeussler M">M. Haeussler</name>
</author>
<author><name sortKey="Raney, B" uniqKey="Raney B">B. Raney</name>
</author>
<author><name sortKey="Hinrichs, A" uniqKey="Hinrichs A">A. Hinrichs</name>
</author>
<author><name sortKey="Clawson, H" uniqKey="Clawson H">H. Clawson</name>
</author>
<author><name sortKey="Zweig, A" uniqKey="Zweig A">A. Zweig</name>
</author>
<author><name sortKey="Karolchik, D" uniqKey="Karolchik D">D. Karolchik</name>
</author>
<author><name sortKey="Casper, J" uniqKey="Casper J">J. Casper</name>
</author>
<author><name sortKey="Speir, M" uniqKey="Speir M">M. Speir</name>
</author>
<author><name sortKey="Haussler, D" uniqKey="Haussler D">D. Haussler</name>
</author>
<author><name sortKey="Kent, W" uniqKey="Kent W">W. Kent</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, J" uniqKey="Wu J">J. Wu</name>
</author>
<author><name sortKey="Wu, M" uniqKey="Wu M">M. Wu</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L. Li</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name>
</author>
<author><name sortKey="Zeng, W" uniqKey="Zeng W">W. Zeng</name>
</author>
<author><name sortKey="Jiang, R" uniqKey="Jiang R">R. Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Landrum, M" uniqKey="Landrum M">M. Landrum</name>
</author>
<author><name sortKey="Lee, J" uniqKey="Lee J">J. Lee</name>
</author>
<author><name sortKey="Riley, G" uniqKey="Riley G">G. Riley</name>
</author>
<author><name sortKey="Jang, W" uniqKey="Jang W">W. Jang</name>
</author>
<author><name sortKey="Rubinstein, W" uniqKey="Rubinstein W">W. Rubinstein</name>
</author>
<author><name sortKey="Church, D" uniqKey="Church D">D. Church</name>
</author>
<author><name sortKey="Maglott, D" uniqKey="Maglott D">D. Maglott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amberger, J" uniqKey="Amberger J">J. Amberger</name>
</author>
<author><name sortKey="Bocchini, C" uniqKey="Bocchini C">C. Bocchini</name>
</author>
<author><name sortKey="Schiettecatte, F" uniqKey="Schiettecatte F">F. Schiettecatte</name>
</author>
<author><name sortKey="Scott, A" uniqKey="Scott A">A. Scott</name>
</author>
<author><name sortKey="Hamosh, A" uniqKey="Hamosh A">A. Hamosh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitsuyasu, H" uniqKey="Mitsuyasu H">H. Mitsuyasu</name>
</author>
<author><name sortKey="Izuhara, K" uniqKey="Izuhara K">K. Izuhara</name>
</author>
<author><name sortKey="Mao, X" uniqKey="Mao X">X. Mao</name>
</author>
<author><name sortKey="Gao, P" uniqKey="Gao P">P. Gao</name>
</author>
<author><name sortKey="Arinobu, Y" uniqKey="Arinobu Y">Y. Arinobu</name>
</author>
<author><name sortKey="Enomoto, T" uniqKey="Enomoto T">T. Enomoto</name>
</author>
<author><name sortKey="Kawai, M" uniqKey="Kawai M">M. Kawai</name>
</author>
<author><name sortKey="Sasaki, S" uniqKey="Sasaki S">S. Sasaki</name>
</author>
<author><name sortKey="Dake, Y" uniqKey="Dake Y">Y. Dake</name>
</author>
<author><name sortKey="Hamasaki, N" uniqKey="Hamasaki N">N. Hamasaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deplancke, B" uniqKey="Deplancke B">B. Deplancke</name>
</author>
<author><name sortKey="Alpern, D" uniqKey="Alpern D">D. Alpern</name>
</author>
<author><name sortKey="Gardeux, V" uniqKey="Gardeux V">V. Gardeux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Drachkova, I" uniqKey="Drachkova I">I. Drachkova</name>
</author>
<author><name sortKey="Lysova, M" uniqKey="Lysova M">M. Lysova</name>
</author>
<author><name sortKey="Arshinova, T" uniqKey="Arshinova T">T. Arshinova</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mogno, I" uniqKey="Mogno I">I. Mogno</name>
</author>
<author><name sortKey="Vallania, F" uniqKey="Vallania F">F. Vallania</name>
</author>
<author><name sortKey="Mitra, R D" uniqKey="Mitra R">R.D. Mitra</name>
</author>
<author><name sortKey="Cohen, B" uniqKey="Cohen B">B. Cohen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Mironova, V" uniqKey="Mironova V">V. Mironova</name>
</author>
<author><name sortKey="Gunbin, K" uniqKey="Gunbin K">K. Gunbin</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Varzari, A" uniqKey="Varzari A">A. Varzari</name>
</author>
<author><name sortKey="Deyneko, I" uniqKey="Deyneko I">I. Deyneko</name>
</author>
<author><name sortKey="Tudor, E" uniqKey="Tudor E">E. Tudor</name>
</author>
<author><name sortKey="Turcan, S" uniqKey="Turcan S">S. Turcan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pocai, B" uniqKey="Pocai B">B. Pocai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kimura, M" uniqKey="Kimura M">M. Kimura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haldane, J B S" uniqKey="Haldane J">J.B.S. Haldane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yoo, S" uniqKey="Yoo S">S. Yoo</name>
</author>
<author><name sortKey="Jin, C" uniqKey="Jin C">C. Jin</name>
</author>
<author><name sortKey="Jung, D" uniqKey="Jung D">D. Jung</name>
</author>
<author><name sortKey="Choi, Y" uniqKey="Choi Y">Y. Choi</name>
</author>
<author><name sortKey="Choi, J" uniqKey="Choi J">J. Choi</name>
</author>
<author><name sortKey="Lee, W" uniqKey="Lee W">W. Lee</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S. Lee</name>
</author>
<author><name sortKey="Lee, J" uniqKey="Lee J">J. Lee</name>
</author>
<author><name sortKey="Cha, S" uniqKey="Cha S">S. Cha</name>
</author>
<author><name sortKey="Kim, C" uniqKey="Kim C">C. Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deyneko, I V" uniqKey="Deyneko I">I.V. Deyneko</name>
</author>
<author><name sortKey="Kalybaeva, Y" uniqKey="Kalybaeva Y">Y. Kalybaeva</name>
</author>
<author><name sortKey="Kel, A E" uniqKey="Kel A">A.E. Kel</name>
</author>
<author><name sortKey="Blocker, H" uniqKey="Blocker H">H. Blocker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boyle, A" uniqKey="Boyle A">A. Boyle</name>
</author>
<author><name sortKey="Hong, E" uniqKey="Hong E">E. Hong</name>
</author>
<author><name sortKey="Hariharan, M" uniqKey="Hariharan M">M. Hariharan</name>
</author>
<author><name sortKey="Cheng, Y" uniqKey="Cheng Y">Y. Cheng</name>
</author>
<author><name sortKey="Schaub, M" uniqKey="Schaub M">M. Schaub</name>
</author>
<author><name sortKey="Kasowski, M" uniqKey="Kasowski M">M. Kasowski</name>
</author>
<author><name sortKey="Karczewski, K" uniqKey="Karczewski K">K. Karczewski</name>
</author>
<author><name sortKey="Park, J" uniqKey="Park J">J. Park</name>
</author>
<author><name sortKey="Hitz, B" uniqKey="Hitz B">B. Hitz</name>
</author>
<author><name sortKey="Weng, S" uniqKey="Weng S">S. Weng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mathelier, A" uniqKey="Mathelier A">A. Mathelier</name>
</author>
<author><name sortKey="Fornes, O" uniqKey="Fornes O">O. Fornes</name>
</author>
<author><name sortKey="Arenillas, D" uniqKey="Arenillas D">D. Arenillas</name>
</author>
<author><name sortKey="Chen, C" uniqKey="Chen C">C. Chen</name>
</author>
<author><name sortKey="Denay, G" uniqKey="Denay G">G. Denay</name>
</author>
<author><name sortKey="Lee, J" uniqKey="Lee J">J. Lee</name>
</author>
<author><name sortKey="Shi, W" uniqKey="Shi W">W. Shi</name>
</author>
<author><name sortKey="Shyr, C" uniqKey="Shyr C">C. Shyr</name>
</author>
<author><name sortKey="Tan, G" uniqKey="Tan G">G. Tan</name>
</author>
<author><name sortKey="Worsley Hunt, R" uniqKey="Worsley Hunt R">R. Worsley-Hunt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yevshin, I" uniqKey="Yevshin I">I. Yevshin</name>
</author>
<author><name sortKey="Sharipov, R" uniqKey="Sharipov R">R. Sharipov</name>
</author>
<author><name sortKey="Valeev, T" uniqKey="Valeev T">T. Valeev</name>
</author>
<author><name sortKey="Kel, A" uniqKey="Kel A">A. Kel</name>
</author>
<author><name sortKey="Kolpakov, F" uniqKey="Kolpakov F">F. Kolpakov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kulakovskiy, I" uniqKey="Kulakovskiy I">I. Kulakovskiy</name>
</author>
<author><name sortKey="Vorontsov, I" uniqKey="Vorontsov I">I. Vorontsov</name>
</author>
<author><name sortKey="Yevshin, I" uniqKey="Yevshin I">I. Yevshin</name>
</author>
<author><name sortKey="Sharipov, R" uniqKey="Sharipov R">R. Sharipov</name>
</author>
<author><name sortKey="Fedorova, A" uniqKey="Fedorova A">A. Fedorova</name>
</author>
<author><name sortKey="Rumynskiy, E" uniqKey="Rumynskiy E">E. Rumynskiy</name>
</author>
<author><name sortKey="Medvedeva, Y" uniqKey="Medvedeva Y">Y. Medvedeva</name>
</author>
<author><name sortKey="Magana Mora, A" uniqKey="Magana Mora A">A. Magana-Mora</name>
</author>
<author><name sortKey="Bajic, V" uniqKey="Bajic V">V. Bajic</name>
</author>
<author><name sortKey="Papatsenko, D" uniqKey="Papatsenko D">D. Papatsenko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levitsky, V" uniqKey="Levitsky V">V. Levitsky</name>
</author>
<author><name sortKey="Zemlyanskaya, E" uniqKey="Zemlyanskaya E">E. Zemlyanskaya</name>
</author>
<author><name sortKey="Oshchepkov, D" uniqKey="Oshchepkov D">D. Oshchepkov</name>
</author>
<author><name sortKey="Podkolodnaya, O" uniqKey="Podkolodnaya O">O. Podkolodnaya</name>
</author>
<author><name sortKey="Ignatieva, E" uniqKey="Ignatieva E">E. Ignatieva</name>
</author>
<author><name sortKey="Grosse, I" uniqKey="Grosse I">I. Grosse</name>
</author>
<author><name sortKey="Mironova, V" uniqKey="Mironova V">V. Mironova</name>
</author>
<author><name sortKey="Merkulova, T" uniqKey="Merkulova T">T. Merkulova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sokolenko, A" uniqKey="Sokolenko A">A. Sokolenko</name>
</author>
<author><name sortKey="Sandomirskii, I" uniqKey="Sandomirskii I">I. Sandomirskii</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Ponomarenko, J" uniqKey="Ponomarenko J">J. Ponomarenko</name>
</author>
<author><name sortKey="Frolov, A" uniqKey="Frolov A">A. Frolov</name>
</author>
<author><name sortKey="Podkolodny, N" uniqKey="Podkolodny N">N. Podkolodny</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
<author><name sortKey="Overton, G" uniqKey="Overton G">G. Overton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Drachkova, I" uniqKey="Drachkova I">I. Drachkova</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Lysova, M" uniqKey="Lysova M">M. Lysova</name>
</author>
<author><name sortKey="Arshinova, T" uniqKey="Arshinova T">T. Arshinova</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Drachkova, I" uniqKey="Drachkova I">I. Drachkova</name>
</author>
<author><name sortKey="Lysova, M" uniqKey="Lysova M">M. Lysova</name>
</author>
<author><name sortKey="Arshinova, T" uniqKey="Arshinova T">T. Arshinova</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delgadillo, R" uniqKey="Delgadillo R">R. Delgadillo</name>
</author>
<author><name sortKey="Whittington, J" uniqKey="Whittington J">J. Whittington</name>
</author>
<author><name sortKey="Parkhurst, L" uniqKey="Parkhurst L">L. Parkhurst</name>
</author>
<author><name sortKey="Parkhurst, L" uniqKey="Parkhurst L">L. Parkhurst</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, Z" uniqKey="Lu Z">Z. Lu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Suslov, V" uniqKey="Suslov V">V. Suslov</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Drachkova, I" uniqKey="Drachkova I">I. Drachkova</name>
</author>
<author><name sortKey="Arshinova, T" uniqKey="Arshinova T">T. Arshinova</name>
</author>
<author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drachkova, I" uniqKey="Drachkova I">I. Drachkova</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Arshinova, T" uniqKey="Arshinova T">T. Arshinova</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Peltek, S" uniqKey="Peltek S">S. Peltek</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drachkova, I" uniqKey="Drachkova I">I. Drachkova</name>
</author>
<author><name sortKey="Shekhovtsov, S" uniqKey="Shekhovtsov S">S. Shekhovtsov</name>
</author>
<author><name sortKey="Peltek, S" uniqKey="Peltek S">S. Peltek</name>
</author>
<author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Arshinova, T" uniqKey="Arshinova T">T. Arshinova</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Merkulova, T" uniqKey="Merkulova T">T. Merkulova</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arkova, O" uniqKey="Arkova O">O. Arkova</name>
</author>
<author><name sortKey="Kuznetsov, N" uniqKey="Kuznetsov N">N. Kuznetsov</name>
</author>
<author><name sortKey="Fedorova, O" uniqKey="Fedorova O">O. Fedorova</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arkova, O" uniqKey="Arkova O">O. Arkova</name>
</author>
<author><name sortKey="Kuznetsov, N" uniqKey="Kuznetsov N">N. Kuznetsov</name>
</author>
<author><name sortKey="Fedorova, O" uniqKey="Fedorova O">O. Fedorova</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Rasskazov, D" uniqKey="Rasskazov D">D. Rasskazov</name>
</author>
<author><name sortKey="Arkova, O" uniqKey="Arkova O">O. Arkova</name>
</author>
<author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Suslov, V" uniqKey="Suslov V">V. Suslov</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Rasskazov, D" uniqKey="Rasskazov D">D. Rasskazov</name>
</author>
<author><name sortKey="Chadaeva, I" uniqKey="Chadaeva I">I. Chadaeva</name>
</author>
<author><name sortKey="Sharypova, E" uniqKey="Sharypova E">E. Sharypova</name>
</author>
<author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Arkova, O" uniqKey="Arkova O">O. Arkova</name>
</author>
<author><name sortKey="Kashina, E" uniqKey="Kashina E">E. Kashina</name>
</author>
<author><name sortKey="Ivanisenko, N" uniqKey="Ivanisenko N">N. Ivanisenko</name>
</author>
<author><name sortKey="Zhechev, D" uniqKey="Zhechev D">D. Zhechev</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Turnaev, I" uniqKey="Turnaev I">I. Turnaev</name>
</author>
<author><name sortKey="Rasskazov, D" uniqKey="Rasskazov D">D. Rasskazov</name>
</author>
<author><name sortKey="Arkova, O" uniqKey="Arkova O">O. Arkova</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arkova, O" uniqKey="Arkova O">O. Arkova</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Rasskazov, D" uniqKey="Rasskazov D">D. Rasskazov</name>
</author>
<author><name sortKey="Drachkova, I" uniqKey="Drachkova I">I. Drachkova</name>
</author>
<author><name sortKey="Arshinova, T" uniqKey="Arshinova T">T. Arshinova</name>
</author>
<author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Arkova, O" uniqKey="Arkova O">O. Arkova</name>
</author>
<author><name sortKey="Rasskazov, D" uniqKey="Rasskazov D">D. Rasskazov</name>
</author>
<author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Chadaeva, I" uniqKey="Chadaeva I">I. Chadaeva</name>
</author>
<author><name sortKey="Rasskazov, D" uniqKey="Rasskazov D">D. Rasskazov</name>
</author>
<author><name sortKey="Sharypova, E" uniqKey="Sharypova E">E. Sharypova</name>
</author>
<author><name sortKey="Kashina, E" uniqKey="Kashina E">E. Kashina</name>
</author>
<author><name sortKey="Drachkova, I" uniqKey="Drachkova I">I. Drachkova</name>
</author>
<author><name sortKey="Zhechev, D" uniqKey="Zhechev D">D. Zhechev</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Rasskazov, D" uniqKey="Rasskazov D">D. Rasskazov</name>
</author>
<author><name sortKey="Suslov, V" uniqKey="Suslov V">V. Suslov</name>
</author>
<author><name sortKey="Sharypova, E" uniqKey="Sharypova E">E. Sharypova</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Podkolodnaya, O" uniqKey="Podkolodnaya O">O. Podkolodnaya</name>
</author>
<author><name sortKey="Podkolodny, N" uniqKey="Podkolodny N">N. Podkolodny</name>
</author>
<author><name sortKey="Tverdokhleb, N" uniqKey="Tverdokhleb N">N. Tverdokhleb</name>
</author>
<author><name sortKey="Chadaeva, I" uniqKey="Chadaeva I">I. Chadaeva</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chadaeva, I" uniqKey="Chadaeva I">I. Chadaeva</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Rasskazov, D" uniqKey="Rasskazov D">D. Rasskazov</name>
</author>
<author><name sortKey="Sharypova, E" uniqKey="Sharypova E">E. Sharypova</name>
</author>
<author><name sortKey="Kashina, E" uniqKey="Kashina E">E. Kashina</name>
</author>
<author><name sortKey="Matveeva, M" uniqKey="Matveeva M">M. Matveeva</name>
</author>
<author><name sortKey="Arshinova, T" uniqKey="Arshinova T">T. Arshinova</name>
</author>
<author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Arkova, O" uniqKey="Arkova O">O. Arkova</name>
</author>
<author><name sortKey="Bondar, N" uniqKey="Bondar N">N. Bondar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chadaeva, I" uniqKey="Chadaeva I">I. Chadaeva</name>
</author>
<author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Rasskazov, D" uniqKey="Rasskazov D">D. Rasskazov</name>
</author>
<author><name sortKey="Sharypova, E" uniqKey="Sharypova E">E. Sharypova</name>
</author>
<author><name sortKey="Kashina, E" uniqKey="Kashina E">E. Kashina</name>
</author>
<author><name sortKey="Zhechev, D" uniqKey="Zhechev D">D. Zhechev</name>
</author>
<author><name sortKey="Drachkova, I" uniqKey="Drachkova I">I. Drachkova</name>
</author>
<author><name sortKey="Arkova, O" uniqKey="Arkova O">O. Arkova</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chadaeva, I" uniqKey="Chadaeva I">I. Chadaeva</name>
</author>
<author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Rasskazov, D" uniqKey="Rasskazov D">D. Rasskazov</name>
</author>
<author><name sortKey="Sharypova, E" uniqKey="Sharypova E">E. Sharypova</name>
</author>
<author><name sortKey="Kashina, E" uniqKey="Kashina E">E. Kashina</name>
</author>
<author><name sortKey="Kleshchev, M" uniqKey="Kleshchev M">M. Kleshchev</name>
</author>
<author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Naumenko, V" uniqKey="Naumenko V">V. Naumenko</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponomarenko, M" uniqKey="Ponomarenko M">M. Ponomarenko</name>
</author>
<author><name sortKey="Rasskazov, D" uniqKey="Rasskazov D">D. Rasskazov</name>
</author>
<author><name sortKey="Chadaeva, I" uniqKey="Chadaeva I">I. Chadaeva</name>
</author>
<author><name sortKey="Sharypova, E" uniqKey="Sharypova E">E. Sharypova</name>
</author>
<author><name sortKey="Drachkova, I" uniqKey="Drachkova I">I. Drachkova</name>
</author>
<author><name sortKey="Ponomarenko, P" uniqKey="Ponomarenko P">P. Ponomarenko</name>
</author>
<author><name sortKey="Oshchepkova, E" uniqKey="Oshchepkova E">E. Oshchepkova</name>
</author>
<author><name sortKey="Savinkova, L" uniqKey="Savinkova L">L. Savinkova</name>
</author>
<author><name sortKey="Kolchanov, N" uniqKey="Kolchanov N">N. Kolchanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vasileiou, P" uniqKey="Vasileiou P">P. Vasileiou</name>
</author>
<author><name sortKey="Mourouzis, I" uniqKey="Mourouzis I">I. Mourouzis</name>
</author>
<author><name sortKey="Pantos, C" uniqKey="Pantos C">C. Pantos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koroleva, I" uniqKey="Koroleva I">I. Koroleva</name>
</author>
<author><name sortKey="Nazarenko, M" uniqKey="Nazarenko M">M. Nazarenko</name>
</author>
<author><name sortKey="Kucher, A" uniqKey="Kucher A">A. Kucher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Plengpanich, W" uniqKey="Plengpanich W">W. Plengpanich</name>
</author>
<author><name sortKey="Le Goff, W" uniqKey="Le Goff W">W. Le Goff</name>
</author>
<author><name sortKey="Poolsuk, S" uniqKey="Poolsuk S">S. Poolsuk</name>
</author>
<author><name sortKey="Julia, Z" uniqKey="Julia Z">Z. Julia</name>
</author>
<author><name sortKey="Guerin, M" uniqKey="Guerin M">M. Guerin</name>
</author>
<author><name sortKey="Khovidhunkit, W" uniqKey="Khovidhunkit W">W. Khovidhunkit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Waardenberg, A" uniqKey="Waardenberg A">A. Waardenberg</name>
</author>
<author><name sortKey="Basset, S" uniqKey="Basset S">S. Basset</name>
</author>
<author><name sortKey="Bouveret, R" uniqKey="Bouveret R">R. Bouveret</name>
</author>
<author><name sortKey="Harvey, R" uniqKey="Harvey R">R. Harvey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, T" uniqKey="Chen T">T. Chen</name>
</author>
<author><name sortKey="Sun, M" uniqKey="Sun M">M. Sun</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name>
</author>
<author><name sortKey="Cui, J" uniqKey="Cui J">J. Cui</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name>
</author>
<author><name sortKey="Yu, B" uniqKey="Yu B">B. Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Casquero, A" uniqKey="Casquero A">A. Casquero</name>
</author>
<author><name sortKey="Berti, J" uniqKey="Berti J">J. Berti</name>
</author>
<author><name sortKey="Teixeira, L" uniqKey="Teixeira L">L. Teixeira</name>
</author>
<author><name sortKey="De Oliveira, H" uniqKey="De Oliveira H">H. de Oliveira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kasowski, M" uniqKey="Kasowski M">M. Kasowski</name>
</author>
<author><name sortKey="Grubert, F" uniqKey="Grubert F">F. Grubert</name>
</author>
<author><name sortKey="Heffelfinger, C" uniqKey="Heffelfinger C">C. Heffelfinger</name>
</author>
<author><name sortKey="Hariharan, M" uniqKey="Hariharan M">M. Hariharan</name>
</author>
<author><name sortKey="Asabere, A" uniqKey="Asabere A">A. Asabere</name>
</author>
<author><name sortKey="Waszak, S" uniqKey="Waszak S">S. Waszak</name>
</author>
<author><name sortKey="Habegger, L" uniqKey="Habegger L">L. Habegger</name>
</author>
<author><name sortKey="Rozowsky, J" uniqKey="Rozowsky J">J. Rozowsky</name>
</author>
<author><name sortKey="Shi, M" uniqKey="Shi M">M. Shi</name>
</author>
<author><name sortKey="Urban, A" uniqKey="Urban A">A. Urban</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abecasis, G" uniqKey="Abecasis G">G. Abecasis</name>
</author>
<author><name sortKey="Auton, A" uniqKey="Auton A">A. Auton</name>
</author>
<author><name sortKey="Brooks, L" uniqKey="Brooks L">L. Brooks</name>
</author>
<author><name sortKey="Depristo, M" uniqKey="Depristo M">M. DePristo</name>
</author>
<author><name sortKey="Durbin, R" uniqKey="Durbin R">R. Durbin</name>
</author>
<author><name sortKey="Handsaker, R" uniqKey="Handsaker R">R. Handsaker</name>
</author>
<author><name sortKey="Kang, H" uniqKey="Kang H">H. Kang</name>
</author>
<author><name sortKey="Marth, G" uniqKey="Marth G">G. Marth</name>
</author>
<author><name sortKey="Mcvean, G" uniqKey="Mcvean G">G. McVean</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cervera, A" uniqKey="Cervera A">A. Cervera</name>
</author>
<author><name sortKey="Planas, A M" uniqKey="Planas A">A.M. Planas</name>
</author>
<author><name sortKey="Justicia, C" uniqKey="Justicia C">C. Justicia</name>
</author>
<author><name sortKey="Urra, X" uniqKey="Urra X">X. Urra</name>
</author>
<author><name sortKey="Jensenius, J" uniqKey="Jensenius J">J. Jensenius</name>
</author>
<author><name sortKey="Torres, F" uniqKey="Torres F">F. Torres</name>
</author>
<author><name sortKey="Lozano, F" uniqKey="Lozano F">F. Lozano</name>
</author>
<author><name sortKey="Chamorro, A" uniqKey="Chamorro A">A. Chamorro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sziller, I" uniqKey="Sziller I">I. Sziller</name>
</author>
<author><name sortKey="Babula, O" uniqKey="Babula O">O. Babula</name>
</author>
<author><name sortKey="Hupuczi, P" uniqKey="Hupuczi P">P. Hupuczi</name>
</author>
<author><name sortKey="Nagy, B" uniqKey="Nagy B">B. Nagy</name>
</author>
<author><name sortKey="Rigo, B" uniqKey="Rigo B">B. Rigo</name>
</author>
<author><name sortKey="Szabo, G" uniqKey="Szabo G">G. Szabo</name>
</author>
<author><name sortKey="Papp, Z" uniqKey="Papp Z">Z. Papp</name>
</author>
<author><name sortKey="Linhares, I" uniqKey="Linhares I">I. Linhares</name>
</author>
<author><name sortKey="Witkin, S" uniqKey="Witkin S">S. Witkin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boldt, A" uniqKey="Boldt A">A. Boldt</name>
</author>
<author><name sortKey="Culpi, L" uniqKey="Culpi L">L. Culpi</name>
</author>
<author><name sortKey="Tsuneto, L" uniqKey="Tsuneto L">L. Tsuneto</name>
</author>
<author><name sortKey="De Souza, I" uniqKey="De Souza I">I. de Souza</name>
</author>
<author><name sortKey="Kun, J" uniqKey="Kun J">J. Kun</name>
</author>
<author><name sortKey="Petzl Erler, M" uniqKey="Petzl Erler M">M. Petzl-Erler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Losin, I" uniqKey="Losin I">I. Losin</name>
</author>
<author><name sortKey="Shakhnovich, R" uniqKey="Shakhnovich R">R. Shakhnovich</name>
</author>
<author><name sortKey="Zykov, K" uniqKey="Zykov K">K. Zykov</name>
</author>
<author><name sortKey="Ruda, M" uniqKey="Ruda M">M. Ruda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Troelsen, L" uniqKey="Troelsen L">L. Troelsen</name>
</author>
<author><name sortKey="Garred, P" uniqKey="Garred P">P. Garred</name>
</author>
<author><name sortKey="Christiansen, B" uniqKey="Christiansen B">B. Christiansen</name>
</author>
<author><name sortKey="Torp Pedersen, C" uniqKey="Torp Pedersen C">C. Torp-Pedersen</name>
</author>
<author><name sortKey="Christensen, I" uniqKey="Christensen I">I. Christensen</name>
</author>
<author><name sortKey="Narvestad, E" uniqKey="Narvestad E">E. Narvestad</name>
</author>
<author><name sortKey="Jacobsen, S" uniqKey="Jacobsen S">S. Jacobsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matthijsen, R" uniqKey="Matthijsen R">R. Matthijsen</name>
</author>
<author><name sortKey="De Winther, M" uniqKey="De Winther M">M. de Winther</name>
</author>
<author><name sortKey="Kuipers, D" uniqKey="Kuipers D">D. Kuipers</name>
</author>
<author><name sortKey="Van Der Made, I" uniqKey="Van Der Made I">I. van der Made</name>
</author>
<author><name sortKey="Weber, C" uniqKey="Weber C">C. Weber</name>
</author>
<author><name sortKey="Herias, M" uniqKey="Herias M">M. Herias</name>
</author>
<author><name sortKey="Gijbels, M" uniqKey="Gijbels M">M. Gijbels</name>
</author>
<author><name sortKey="Buurman, W" uniqKey="Buurman W">W. Buurman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arnaud, E" uniqKey="Arnaud E">E. Arnaud</name>
</author>
<author><name sortKey="Barbalat, V" uniqKey="Barbalat V">V. Barbalat</name>
</author>
<author><name sortKey="Nicaud, V" uniqKey="Nicaud V">V. Nicaud</name>
</author>
<author><name sortKey="Cambien, F" uniqKey="Cambien F">F. Cambien</name>
</author>
<author><name sortKey="Evans, A" uniqKey="Evans A">A. Evans</name>
</author>
<author><name sortKey="Morrison, C" uniqKey="Morrison C">C. Morrison</name>
</author>
<author><name sortKey="Arveiler, D" uniqKey="Arveiler D">D. Arveiler</name>
</author>
<author><name sortKey="Luc, G" uniqKey="Luc G">G. Luc</name>
</author>
<author><name sortKey="Ruidavets, J" uniqKey="Ruidavets J">J. Ruidavets</name>
</author>
<author><name sortKey="Emmerich, J" uniqKey="Emmerich J">J. Emmerich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hasenstab, D" uniqKey="Hasenstab D">D. Hasenstab</name>
</author>
<author><name sortKey="Lea, H" uniqKey="Lea H">H. Lea</name>
</author>
<author><name sortKey="Hart, C" uniqKey="Hart C">C. Hart</name>
</author>
<author><name sortKey="Lok, S" uniqKey="Lok S">S. Lok</name>
</author>
<author><name sortKey="Clowes, A" uniqKey="Clowes A">A. Clowes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, H" uniqKey="Lin H">H. Lin</name>
</author>
<author><name sortKey="Yen, H" uniqKey="Yen H">H. Yen</name>
</author>
<author><name sortKey="Hsieh, S" uniqKey="Hsieh S">S. Hsieh</name>
</author>
<author><name sortKey="An, L" uniqKey="An L">L. An</name>
</author>
<author><name sortKey="Shen, K" uniqKey="Shen K">K. Shen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ebert, J" uniqKey="Ebert J">J. Ebert</name>
</author>
<author><name sortKey="Wilgenbus, P" uniqKey="Wilgenbus P">P. Wilgenbus</name>
</author>
<author><name sortKey="Teiber, J" uniqKey="Teiber J">J. Teiber</name>
</author>
<author><name sortKey="Jurk, K" uniqKey="Jurk K">K. Jurk</name>
</author>
<author><name sortKey="Schwierczek, K" uniqKey="Schwierczek K">K. Schwierczek</name>
</author>
<author><name sortKey="Dohrmann, M" uniqKey="Dohrmann M">M. Dohrmann</name>
</author>
<author><name sortKey="Xia, N" uniqKey="Xia N">N. Xia</name>
</author>
<author><name sortKey="Li, H" uniqKey="Li H">H. Li</name>
</author>
<author><name sortKey="Spiecker, L" uniqKey="Spiecker L">L. Spiecker</name>
</author>
<author><name sortKey="Ruf, W" uniqKey="Ruf W">W. Ruf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watanabe, M" uniqKey="Watanabe M">M. Watanabe</name>
</author>
<author><name sortKey="Zingg, B" uniqKey="Zingg B">B. Zingg</name>
</author>
<author><name sortKey="Mohrenweiser, H" uniqKey="Mohrenweiser H">H. Mohrenweiser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vives Corrons, J" uniqKey="Vives Corrons J">J. Vives-Corrons</name>
</author>
<author><name sortKey="Rubinson Skala, H" uniqKey="Rubinson Skala H">H. Rubinson-Skala</name>
</author>
<author><name sortKey="Mateo, M" uniqKey="Mateo M">M. Mateo</name>
</author>
<author><name sortKey="Estella, J" uniqKey="Estella J">J. Estella</name>
</author>
<author><name sortKey="Feliu, E" uniqKey="Feliu E">E. Feliu</name>
</author>
<author><name sortKey="Dreyfus, J" uniqKey="Dreyfus J">J. Dreyfus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balla, G" uniqKey="Balla G">G. Balla</name>
</author>
<author><name sortKey="Vercellotti, G" uniqKey="Vercellotti G">G. Vercellotti</name>
</author>
<author><name sortKey="Eaton, J" uniqKey="Eaton J">J. Eaton</name>
</author>
<author><name sortKey="Jacob, H" uniqKey="Jacob H">H. Jacob</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kioumourtzoglou, M" uniqKey="Kioumourtzoglou M">M. Kioumourtzoglou</name>
</author>
<author><name sortKey="Seals, R" uniqKey="Seals R">R. Seals</name>
</author>
<author><name sortKey="Gredal, O" uniqKey="Gredal O">O. Gredal</name>
</author>
<author><name sortKey="Mittleman, M" uniqKey="Mittleman M">M. Mittleman</name>
</author>
<author><name sortKey="Hansen, J" uniqKey="Hansen J">J. Hansen</name>
</author>
<author><name sortKey="Weisskopf, M" uniqKey="Weisskopf M">M. Weisskopf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martiney, J" uniqKey="Martiney J">J. Martiney</name>
</author>
<author><name sortKey="Cerami, A" uniqKey="Cerami A">A. Cerami</name>
</author>
<author><name sortKey="Slater, A" uniqKey="Slater A">A. Slater</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name>
</author>
<author><name sortKey="Luo, W" uniqKey="Luo W">W. Luo</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name>
</author>
<author><name sortKey="Guo, C" uniqKey="Guo C">C. Guo</name>
</author>
<author><name sortKey="Wolffe, S" uniqKey="Wolffe S">S. Wolffe</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name>
</author>
<author><name sortKey="Sun, E" uniqKey="Sun E">E. Sun</name>
</author>
<author><name sortKey="Bradley, K" uniqKey="Bradley K">K. Bradley</name>
</author>
<author><name sortKey="Campbell, A" uniqKey="Campbell A">A. Campbell</name>
</author>
<author><name sortKey="Eitzman, D" uniqKey="Eitzman D">D. Eitzman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Collins, F" uniqKey="Collins F">F. Collins</name>
</author>
<author><name sortKey="Weissman, S" uniqKey="Weissman S">S. Weissman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gall, T" uniqKey="Gall T">T. Gall</name>
</author>
<author><name sortKey="Petho, D" uniqKey="Petho D">D. Petho</name>
</author>
<author><name sortKey="Nagy, A" uniqKey="Nagy A">A. Nagy</name>
</author>
<author><name sortKey="Hendrik, Z" uniqKey="Hendrik Z">Z. Hendrik</name>
</author>
<author><name sortKey="Mehes, G" uniqKey="Mehes G">G. Mehes</name>
</author>
<author><name sortKey="Potor, L" uniqKey="Potor L">L. Potor</name>
</author>
<author><name sortKey="Gram, M" uniqKey="Gram M">M. Gram</name>
</author>
<author><name sortKey=" Kerstrom, B" uniqKey=" Kerstrom B">B. Åkerstrom</name>
</author>
<author><name sortKey="Smith, A" uniqKey="Smith A">A. Smith</name>
</author>
<author><name sortKey="Nagy, P" uniqKey="Nagy P">P. Nagy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nalls, M" uniqKey="Nalls M">M. Nalls</name>
</author>
<author><name sortKey="Wilson, J" uniqKey="Wilson J">J. Wilson</name>
</author>
<author><name sortKey="Patterson, N" uniqKey="Patterson N">N. Patterson</name>
</author>
<author><name sortKey="Tandon, A" uniqKey="Tandon A">A. Tandon</name>
</author>
<author><name sortKey="Zmuda, J" uniqKey="Zmuda J">J. Zmuda</name>
</author>
<author><name sortKey="Huntsman, S" uniqKey="Huntsman S">S. Huntsman</name>
</author>
<author><name sortKey="Garcia, M" uniqKey="Garcia M">M. Garcia</name>
</author>
<author><name sortKey="Hu, D" uniqKey="Hu D">D. Hu</name>
</author>
<author><name sortKey="Li, R" uniqKey="Li R">R. Li</name>
</author>
<author><name sortKey="Beamer, B" uniqKey="Beamer B">B. Beamer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Michon, P" uniqKey="Michon P">P. Michon</name>
</author>
<author><name sortKey="Woolley, I" uniqKey="Woolley I">I. Woolley</name>
</author>
<author><name sortKey="Wood, E M" uniqKey="Wood E">E.M. Wood</name>
</author>
<author><name sortKey="Kastens, W" uniqKey="Kastens W">W. Kastens</name>
</author>
<author><name sortKey="Zimmerman, P" uniqKey="Zimmerman P">P. Zimmerman</name>
</author>
<author><name sortKey="Adams, J" uniqKey="Adams J">J. Adams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wan, W" uniqKey="Wan W">W. Wan</name>
</author>
<author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name>
</author>
<author><name sortKey="Lionakis, M" uniqKey="Lionakis M">M. Lionakis</name>
</author>
<author><name sortKey="Marino, A" uniqKey="Marino A">A. Marino</name>
</author>
<author><name sortKey="Anderson, S" uniqKey="Anderson S">S. Anderson</name>
</author>
<author><name sortKey="Swamydas, M" uniqKey="Swamydas M">M. Swamydas</name>
</author>
<author><name sortKey="Murphy, P" uniqKey="Murphy P">P. Murphy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gencer, S" uniqKey="Gencer S">S. Gencer</name>
</author>
<author><name sortKey="Van Der Vorst, E P C" uniqKey="Van Der Vorst E">E.P.C. van der Vorst</name>
</author>
<author><name sortKey="Aslani, M" uniqKey="Aslani M">M. Aslani</name>
</author>
<author><name sortKey="Weber, C" uniqKey="Weber C">C. Weber</name>
</author>
<author><name sortKey="Doring, Y" uniqKey="Doring Y">Y. Doring</name>
</author>
<author><name sortKey="Duchene, J" uniqKey="Duchene J">J. Duchene</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hobbs, M" uniqKey="Hobbs M">M. Hobbs</name>
</author>
<author><name sortKey="Udhayakumar, V" uniqKey="Udhayakumar V">V. Udhayakumar</name>
</author>
<author><name sortKey="Levesque, M" uniqKey="Levesque M">M. Levesque</name>
</author>
<author><name sortKey="Booth, J" uniqKey="Booth J">J. Booth</name>
</author>
<author><name sortKey="Roberts, J" uniqKey="Roberts J">J. Roberts</name>
</author>
<author><name sortKey="Tkachuk, A" uniqKey="Tkachuk A">A. Tkachuk</name>
</author>
<author><name sortKey="Pole, A" uniqKey="Pole A">A. Pole</name>
</author>
<author><name sortKey="Coon, H" uniqKey="Coon H">H. Coon</name>
</author>
<author><name sortKey="Kariuki, S" uniqKey="Kariuki S">S. Kariuki</name>
</author>
<author><name sortKey="Nahlen, B" uniqKey="Nahlen B">B. Nahlen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clark, I" uniqKey="Clark I">I. Clark</name>
</author>
<author><name sortKey="Rockett, K" uniqKey="Rockett K">K. Rockett</name>
</author>
<author><name sortKey="Burgner, D" uniqKey="Burgner D">D. Burgner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name>
</author>
<author><name sortKey="Shyue, S" uniqKey="Shyue S">S. Shyue</name>
</author>
<author><name sortKey="Lin, S" uniqKey="Lin S">S. Lin</name>
</author>
<author><name sortKey="Wei, J" uniqKey="Wei J">J. Wei</name>
</author>
<author><name sortKey="Lee, T" uniqKey="Lee T">T. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jovanovic, A" uniqKey="Jovanovic A">A. Jovanovic</name>
</author>
<author><name sortKey="Sudar Milovanovic, E" uniqKey="Sudar Milovanovic E">E. Sudar-Milovanovic</name>
</author>
<author><name sortKey="Obradovic, M" uniqKey="Obradovic M">M. Obradovic</name>
</author>
<author><name sortKey="Pitt, S" uniqKey="Pitt S">S. Pitt</name>
</author>
<author><name sortKey="Stewart, A" uniqKey="Stewart A">A. Stewart</name>
</author>
<author><name sortKey="Zafirovic, S" uniqKey="Zafirovic S">S. Zafirovic</name>
</author>
<author><name sortKey="Stanimirovic, J" uniqKey="Stanimirovic J">J. Stanimirovic</name>
</author>
<author><name sortKey="Radak, D" uniqKey="Radak D">D. Radak</name>
</author>
<author><name sortKey="Isenovic, E" uniqKey="Isenovic E">E. Isenovic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponnuswamy, P" uniqKey="Ponnuswamy P">P. Ponnuswamy</name>
</author>
<author><name sortKey="Ostermeier, E" uniqKey="Ostermeier E">E. Ostermeier</name>
</author>
<author><name sortKey="Schrottle, A" uniqKey="Schrottle A">A. Schrottle</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name>
</author>
<author><name sortKey="Huang, P" uniqKey="Huang P">P. Huang</name>
</author>
<author><name sortKey="Ertl, G" uniqKey="Ertl G">G. Ertl</name>
</author>
<author><name sortKey="Nieswandt, B" uniqKey="Nieswandt B">B. Nieswandt</name>
</author>
<author><name sortKey="Kuhlencordt, P" uniqKey="Kuhlencordt P">P. Kuhlencordt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kavlie, A" uniqKey="Kavlie A">A. Kavlie</name>
</author>
<author><name sortKey="Hiltunen, L" uniqKey="Hiltunen L">L. Hiltunen</name>
</author>
<author><name sortKey="Rasi, V" uniqKey="Rasi V">V. Rasi</name>
</author>
<author><name sortKey="Prydz, H" uniqKey="Prydz H">H. Prydz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zacharski, L" uniqKey="Zacharski L">L. Zacharski</name>
</author>
<author><name sortKey="Delprete, S" uniqKey="Delprete S">S. Delprete</name>
</author>
<author><name sortKey="Kisiel, W" uniqKey="Kisiel W">W. Kisiel</name>
</author>
<author><name sortKey="Hunt, J" uniqKey="Hunt J">J. Hunt</name>
</author>
<author><name sortKey="Cornell, C" uniqKey="Cornell C">C. Cornell</name>
</author>
<author><name sortKey="Marrin, C" uniqKey="Marrin C">C. Marrin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roche, H" uniqKey="Roche H">H. Roche</name>
</author>
<author><name sortKey="Zampelas, A" uniqKey="Zampelas A">A. Zampelas</name>
</author>
<author><name sortKey="Knapper, J" uniqKey="Knapper J">J. Knapper</name>
</author>
<author><name sortKey="Webb, D" uniqKey="Webb D">D. Webb</name>
</author>
<author><name sortKey="Brooks, C" uniqKey="Brooks C">C. Brooks</name>
</author>
<author><name sortKey="Jackson, K" uniqKey="Jackson K">K. Jackson</name>
</author>
<author><name sortKey="Wright, J" uniqKey="Wright J">J. Wright</name>
</author>
<author><name sortKey="Gould, B" uniqKey="Gould B">B. Gould</name>
</author>
<author><name sortKey="Kafatos, A" uniqKey="Kafatos A">A. Kafatos</name>
</author>
<author><name sortKey="Gibney, M" uniqKey="Gibney M">M. Gibney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitropoulos, K" uniqKey="Mitropoulos K">K. Mitropoulos</name>
</author>
<author><name sortKey="Esnouf, M" uniqKey="Esnouf M">M. Esnouf</name>
</author>
<author><name sortKey="Meade, T" uniqKey="Meade T">T. Meade</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Setorki, M" uniqKey="Setorki M">M. Setorki</name>
</author>
<author><name sortKey="Rafieian Kopaei, M" uniqKey="Rafieian Kopaei M">M. Rafieian-Kopaei</name>
</author>
<author><name sortKey="Merikhi, A" uniqKey="Merikhi A">A. Merikhi</name>
</author>
<author><name sortKey="Heidarian, E" uniqKey="Heidarian E">E. Heidarian</name>
</author>
<author><name sortKey="Shahinfard, N" uniqKey="Shahinfard N">N. Shahinfard</name>
</author>
<author><name sortKey="Ansari, R" uniqKey="Ansari R">R. Ansari</name>
</author>
<author><name sortKey="Nasri, H" uniqKey="Nasri H">H. Nasri</name>
</author>
<author><name sortKey="Esmael, N" uniqKey="Esmael N">N. Esmael</name>
</author>
<author><name sortKey="Baradaran, A" uniqKey="Baradaran A">A. Baradaran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Niemann, S" uniqKey="Niemann S">S. Niemann</name>
</author>
<author><name sortKey="Broom, W" uniqKey="Broom W">W. Broom</name>
</author>
<author><name sortKey="Brown, R H" uniqKey="Brown R">R.H. Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Turner, M" uniqKey="Turner M">M. Turner</name>
</author>
<author><name sortKey="Goldacre, R" uniqKey="Goldacre R">R. Goldacre</name>
</author>
<author><name sortKey="Ramagopalan, S" uniqKey="Ramagopalan S">S. Ramagopalan</name>
</author>
<author><name sortKey="Talbot, K" uniqKey="Talbot K">K. Talbot</name>
</author>
<author><name sortKey="Goldacre, M" uniqKey="Goldacre M">M. Goldacre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ende, N" uniqKey="Ende N">N. Ende</name>
</author>
<author><name sortKey="Weinstein, F" uniqKey="Weinstein F">F. Weinstein</name>
</author>
<author><name sortKey="Chen, R" uniqKey="Chen R">R. Chen</name>
</author>
<author><name sortKey="Ende, M" uniqKey="Ende M">M. Ende</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Charles, B" uniqKey="Charles B">B. Charles</name>
</author>
<author><name sortKey="Hsieh, M" uniqKey="Hsieh M">M. Hsieh</name>
</author>
<author><name sortKey="Adeyemo, A" uniqKey="Adeyemo A">A. Adeyemo</name>
</author>
<author><name sortKey="Shriner, D" uniqKey="Shriner D">D. Shriner</name>
</author>
<author><name sortKey="Ramos, E" uniqKey="Ramos E">E. Ramos</name>
</author>
<author><name sortKey="Chin, K" uniqKey="Chin K">K. Chin</name>
</author>
<author><name sortKey="Srivastava, K" uniqKey="Srivastava K">K. Srivastava</name>
</author>
<author><name sortKey="Zakai, N" uniqKey="Zakai N">N. Zakai</name>
</author>
<author><name sortKey="Cushman, M" uniqKey="Cushman M">M. Cushman</name>
</author>
<author><name sortKey="Mcclure, L" uniqKey="Mcclure L">L. McClure</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simmons, G" uniqKey="Simmons G">G. Simmons</name>
</author>
<author><name sortKey="Padilla, J" uniqKey="Padilla J">J. Padilla</name>
</author>
<author><name sortKey="Jenkins, N" uniqKey="Jenkins N">N. Jenkins</name>
</author>
<author><name sortKey="Laughlin, M" uniqKey="Laughlin M">M. Laughlin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name>
</author>
<author><name sortKey="Tang, C" uniqKey="Tang C">C. Tang</name>
</author>
<author><name sortKey="Jin, H" uniqKey="Jin H">H. Jin</name>
</author>
<author><name sortKey="Du, J" uniqKey="Du J">J. Du</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name>
</author>
<author><name sortKey="Zhou, L" uniqKey="Zhou L">L. Zhou</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name>
</author>
<author><name sortKey="Roberts, L J" uniqKey="Roberts L">L.J. Roberts</name>
</author>
<author><name sortKey="Lin, X" uniqKey="Lin X">X. Lin</name>
</author>
<author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name>
</author>
<author><name sortKey="Guo, Z" uniqKey="Guo Z">Z. Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, W" uniqKey="Cao W">W. Cao</name>
</author>
<author><name sortKey="Ning, J" uniqKey="Ning J">J. Ning</name>
</author>
<author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name>
</author>
<author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z. Zhou</name>
</author>
<author><name sortKey="Huang, G" uniqKey="Huang G">G. Huang</name>
</author>
<author><name sortKey="Xiao, Y" uniqKey="Xiao Y">Y. Xiao</name>
</author>
<author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name>
</author>
<author><name sortKey="Liu, C" uniqKey="Liu C">C. Liu</name>
</author>
<author><name sortKey="Na, R" uniqKey="Na R">R. Na</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Badin, J" uniqKey="Badin J">J. Badin</name>
</author>
<author><name sortKey="Kole, A" uniqKey="Kole A">A. Kole</name>
</author>
<author><name sortKey="Stivers, B" uniqKey="Stivers B">B. Stivers</name>
</author>
<author><name sortKey="Progar, V" uniqKey="Progar V">V. Progar</name>
</author>
<author><name sortKey="Pareddy, A" uniqKey="Pareddy A">A. Pareddy</name>
</author>
<author><name sortKey="Alloosh, M" uniqKey="Alloosh M">M. Alloosh</name>
</author>
<author><name sortKey="Sturek, M" uniqKey="Sturek M">M. Sturek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferguson, J" uniqKey="Ferguson J">J. Ferguson</name>
</author>
<author><name sortKey="Ryan, M" uniqKey="Ryan M">M. Ryan</name>
</author>
<author><name sortKey="Gibney, E" uniqKey="Gibney E">E. Gibney</name>
</author>
<author><name sortKey="Brennan, L" uniqKey="Brennan L">L. Brennan</name>
</author>
<author><name sortKey="Roche, H" uniqKey="Roche H">H. Roche</name>
</author>
<author><name sortKey="Reilly, M" uniqKey="Reilly M">M. Reilly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Starodubtseva, N" uniqKey="Starodubtseva N">N. Starodubtseva</name>
</author>
<author><name sortKey="Sobolev, V" uniqKey="Sobolev V">V. Sobolev</name>
</author>
<author><name sortKey="Soboleva, A" uniqKey="Soboleva A">A. Soboleva</name>
</author>
<author><name sortKey="Nikolaev, A" uniqKey="Nikolaev A">A. Nikolaev</name>
</author>
<author><name sortKey="Bruskin, S" uniqKey="Bruskin S">S. Bruskin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manetti, M" uniqKey="Manetti M">M. Manetti</name>
</author>
<author><name sortKey="Ibba Manneschi, L" uniqKey="Ibba Manneschi L">L. Ibba-Manneschi</name>
</author>
<author><name sortKey="Fatini, C" uniqKey="Fatini C">C. Fatini</name>
</author>
<author><name sortKey="Guiducci, S" uniqKey="Guiducci S">S. Guiducci</name>
</author>
<author><name sortKey="Cuomo, G" uniqKey="Cuomo G">G. Cuomo</name>
</author>
<author><name sortKey="Bonino, C" uniqKey="Bonino C">C. Bonino</name>
</author>
<author><name sortKey="Bazzichi, L" uniqKey="Bazzichi L">L. Bazzichi</name>
</author>
<author><name sortKey="Liakouli, V" uniqKey="Liakouli V">V. Liakouli</name>
</author>
<author><name sortKey="Giacomelli, R" uniqKey="Giacomelli R">R. Giacomelli</name>
</author>
<author><name sortKey="Abbate, R" uniqKey="Abbate R">R. Abbate</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hunninghake, G" uniqKey="Hunninghake G">G. Hunninghake</name>
</author>
<author><name sortKey="Cho, M" uniqKey="Cho M">M. Cho</name>
</author>
<author><name sortKey="Tesfaigzi, Y" uniqKey="Tesfaigzi Y">Y. Tesfaigzi</name>
</author>
<author><name sortKey="Soto Quiros, M" uniqKey="Soto Quiros M">M. Soto-Quiros</name>
</author>
<author><name sortKey="Avila, L" uniqKey="Avila L">L. Avila</name>
</author>
<author><name sortKey="Lasky Su, J" uniqKey="Lasky Su J">J. Lasky-Su</name>
</author>
<author><name sortKey="Stidley, C" uniqKey="Stidley C">C. Stidley</name>
</author>
<author><name sortKey="Melen, E" uniqKey="Melen E">E. Melen</name>
</author>
<author><name sortKey="Soderhall, C" uniqKey="Soderhall C">C. Soderhall</name>
</author>
<author><name sortKey="Hallberg, J" uniqKey="Hallberg J">J. Hallberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hemminki, K" uniqKey="Hemminki K">K. Hemminki</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
<author><name sortKey="Sundquist, J" uniqKey="Sundquist J">J. Sundquist</name>
</author>
<author><name sortKey="Sundquist, K" uniqKey="Sundquist K">K. Sundquist</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Motterle, A" uniqKey="Motterle A">A. Motterle</name>
</author>
<author><name sortKey="Xiao, Q" uniqKey="Xiao Q">Q. Xiao</name>
</author>
<author><name sortKey="Kiechl, S" uniqKey="Kiechl S">S. Kiechl</name>
</author>
<author><name sortKey="Pender, S" uniqKey="Pender S">S. Pender</name>
</author>
<author><name sortKey="Morris, G" uniqKey="Morris G">G. Morris</name>
</author>
<author><name sortKey="Willeit, J" uniqKey="Willeit J">J. Willeit</name>
</author>
<author><name sortKey="Caulfield, M" uniqKey="Caulfield M">M. Caulfield</name>
</author>
<author><name sortKey="Ye, S" uniqKey="Ye S">S. Ye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bukowska, H" uniqKey="Bukowska H">H. Bukowska</name>
</author>
<author><name sortKey="Pieczul Mroz, J" uniqKey="Pieczul Mroz J">J. Pieczul-Mroz</name>
</author>
<author><name sortKey="Jastrzebska, M" uniqKey="Jastrzebska M">M. Jastrzebska</name>
</author>
<author><name sortKey="Chelstowski, K" uniqKey="Chelstowski K">K. Chelstowski</name>
</author>
<author><name sortKey="Naruszewicz, M" uniqKey="Naruszewicz M">M. Naruszewicz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liang, J" uniqKey="Liang J">J. Liang</name>
</author>
<author><name sortKey="Liu, E" uniqKey="Liu E">E. Liu</name>
</author>
<author><name sortKey="Yu, Y" uniqKey="Yu Y">Y. Yu</name>
</author>
<author><name sortKey="Kitajima, S" uniqKey="Kitajima S">S. Kitajima</name>
</author>
<author><name sortKey="Koike, T" uniqKey="Koike T">T. Koike</name>
</author>
<author><name sortKey="Jin, Y" uniqKey="Jin Y">Y. Jin</name>
</author>
<author><name sortKey="Morimoto, M" uniqKey="Morimoto M">M. Morimoto</name>
</author>
<author><name sortKey="Hatakeyama, K" uniqKey="Hatakeyama K">K. Hatakeyama</name>
</author>
<author><name sortKey="Asada, Y" uniqKey="Asada Y">Y. Asada</name>
</author>
<author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T. Watanabe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name>
</author>
<author><name sortKey="Bajpai, A" uniqKey="Bajpai A">A. Bajpai</name>
</author>
<author><name sortKey="Hawthorne, E" uniqKey="Hawthorne E">E. Hawthorne</name>
</author>
<author><name sortKey="Bae, Y" uniqKey="Bae Y">Y. Bae</name>
</author>
<author><name sortKey="Castagnino, P" uniqKey="Castagnino P">P. Castagnino</name>
</author>
<author><name sortKey="Monslow, J" uniqKey="Monslow J">J. Monslow</name>
</author>
<author><name sortKey="Pure, E" uniqKey="Pure E">E. Pure</name>
</author>
<author><name sortKey="Spiller, K" uniqKey="Spiller K">K. Spiller</name>
</author>
<author><name sortKey="Assoian, R" uniqKey="Assoian R">R. Assoian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yoshikawa, H" uniqKey="Yoshikawa H">H. Yoshikawa</name>
</author>
<author><name sortKey="Kawai, K" uniqKey="Kawai K">K. Kawai</name>
</author>
<author><name sortKey="Inoue, S" uniqKey="Inoue S">S. Inoue</name>
</author>
<author><name sortKey="Murayama, Y" uniqKey="Murayama Y">Y. Murayama</name>
</author>
<author><name sortKey="Fujieda, K" uniqKey="Fujieda K">K. Fujieda</name>
</author>
<author><name sortKey="Kuzuya, N" uniqKey="Kuzuya N">N. Kuzuya</name>
</author>
<author><name sortKey="Fujita, T" uniqKey="Fujita T">T. Fujita</name>
</author>
<author><name sortKey="Koide, Y" uniqKey="Koide Y">Y. Koide</name>
</author>
<author><name sortKey="Yamashita, K" uniqKey="Yamashita K">K. Yamashita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="White, J" uniqKey="White J">J. White</name>
</author>
<author><name sortKey="Saunders, G" uniqKey="Saunders G">G. Saunders</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hubbard, R" uniqKey="Hubbard R">R. Hubbard</name>
</author>
<author><name sortKey="Kosch, C" uniqKey="Kosch C">C. Kosch</name>
</author>
<author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A. Sanchez</name>
</author>
<author><name sortKey="Sabate, J" uniqKey="Sabate J">J. Sabate</name>
</author>
<author><name sortKey="Berk, L" uniqKey="Berk L">L. Berk</name>
</author>
<author><name sortKey="Shavlik, G" uniqKey="Shavlik G">G. Shavlik</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galassetti, P" uniqKey="Galassetti P">P. Galassetti</name>
</author>
<author><name sortKey="Larson, J" uniqKey="Larson J">J. Larson</name>
</author>
<author><name sortKey="Iwanaga, K" uniqKey="Iwanaga K">K. Iwanaga</name>
</author>
<author><name sortKey="Salsberg, S" uniqKey="Salsberg S">S. Salsberg</name>
</author>
<author><name sortKey="Eliakim, A" uniqKey="Eliakim A">A. Eliakim</name>
</author>
<author><name sortKey="Pontello, A" uniqKey="Pontello A">A. Pontello</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Proenca, R" uniqKey="Proenca R">R. Proenca</name>
</author>
<author><name sortKey="Maffei, M" uniqKey="Maffei M">M. Maffei</name>
</author>
<author><name sortKey="Barone, M" uniqKey="Barone M">M. Barone</name>
</author>
<author><name sortKey="Leopold, L" uniqKey="Leopold L">L. Leopold</name>
</author>
<author><name sortKey="Friedman, J M" uniqKey="Friedman J">J.M. Friedman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Skrypnik, K" uniqKey="Skrypnik K">K. Skrypnik</name>
</author>
<author><name sortKey="Suliburska, J" uniqKey="Suliburska J">J. Suliburska</name>
</author>
<author><name sortKey="Skrypnik, D" uniqKey="Skrypnik D">D. Skrypnik</name>
</author>
<author><name sortKey="Pilarski, L" uniqKey="Pilarski L">L. Pilarski</name>
</author>
<author><name sortKey="Regula, J" uniqKey="Regula J">J. Regula</name>
</author>
<author><name sortKey="Bogdanski, P" uniqKey="Bogdanski P">P. Bogdanski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jun, J" uniqKey="Jun J">J. Jun</name>
</author>
<author><name sortKey="Ma, Z" uniqKey="Ma Z">Z. Ma</name>
</author>
<author><name sortKey="Pyla, R" uniqKey="Pyla R">R. Pyla</name>
</author>
<author><name sortKey="Segar, L" uniqKey="Segar L">L. Segar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matsunaga, A" uniqKey="Matsunaga A">A. Matsunaga</name>
</author>
<author><name sortKey="Sasaki, J" uniqKey="Sasaki J">J. Sasaki</name>
</author>
<author><name sortKey="Han, H" uniqKey="Han H">H. Han</name>
</author>
<author><name sortKey="Huang, W" uniqKey="Huang W">W. Huang</name>
</author>
<author><name sortKey="Kugi, M" uniqKey="Kugi M">M. Kugi</name>
</author>
<author><name sortKey="Koga, T" uniqKey="Koga T">T. Koga</name>
</author>
<author><name sortKey="Ichiki, S" uniqKey="Ichiki S">S. Ichiki</name>
</author>
<author><name sortKey="Shinkawa, T" uniqKey="Shinkawa T">T. Shinkawa</name>
</author>
<author><name sortKey="Arakawa, K" uniqKey="Arakawa K">K. Arakawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reimers, G" uniqKey="Reimers G">G. Reimers</name>
</author>
<author><name sortKey="Jackson, C" uniqKey="Jackson C">C. Jackson</name>
</author>
<author><name sortKey="Rickards, J" uniqKey="Rickards J">J. Rickards</name>
</author>
<author><name sortKey="Chan, P" uniqKey="Chan P">P. Chan</name>
</author>
<author><name sortKey="Cohn, J" uniqKey="Cohn J">J. Cohn</name>
</author>
<author><name sortKey="Rye, K" uniqKey="Rye K">K. Rye</name>
</author>
<author><name sortKey="Barter, P" uniqKey="Barter P">P. Barter</name>
</author>
<author><name sortKey="Rodgers, K" uniqKey="Rodgers K">K. Rodgers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vermeulen, A" uniqKey="Vermeulen A">A. Vermeulen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Priyadarshini, S" uniqKey="Priyadarshini S">S. Priyadarshini</name>
</author>
<author><name sortKey="Pradhan, B" uniqKey="Pradhan B">B. Pradhan</name>
</author>
<author><name sortKey="Griebel, P" uniqKey="Griebel P">P. Griebel</name>
</author>
<author><name sortKey="Aich, P" uniqKey="Aich P">P. Aich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lord, C" uniqKey="Lord C">C. Lord</name>
</author>
<author><name sortKey="Wyler, S" uniqKey="Wyler S">S. Wyler</name>
</author>
<author><name sortKey="Wan, R" uniqKey="Wan R">R. Wan</name>
</author>
<author><name sortKey="Castorena, C" uniqKey="Castorena C">C. Castorena</name>
</author>
<author><name sortKey="Ahmed, N" uniqKey="Ahmed N">N. Ahmed</name>
</author>
<author><name sortKey="Mathew, D" uniqKey="Mathew D">D. Mathew</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S. Lee</name>
</author>
<author><name sortKey="Liu, C" uniqKey="Liu C">C. Liu</name>
</author>
<author><name sortKey="Elmquist, J" uniqKey="Elmquist J">J. Elmquist</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Strandberg, L" uniqKey="Strandberg L">L. Strandberg</name>
</author>
<author><name sortKey="Mellstrom, D" uniqKey="Mellstrom D">D. Mellstrom</name>
</author>
<author><name sortKey="Ljunggren, O" uniqKey="Ljunggren O">O. Ljunggren</name>
</author>
<author><name sortKey="Grundberg, E" uniqKey="Grundberg E">E. Grundberg</name>
</author>
<author><name sortKey="Karlsson, M" uniqKey="Karlsson M">M. Karlsson</name>
</author>
<author><name sortKey="Holmberg, A" uniqKey="Holmberg A">A. Holmberg</name>
</author>
<author><name sortKey="Orwoll, E" uniqKey="Orwoll E">E. Orwoll</name>
</author>
<author><name sortKey="Eriksson, A" uniqKey="Eriksson A">A. Eriksson</name>
</author>
<author><name sortKey="Svedberg, J" uniqKey="Svedberg J">J. Svedberg</name>
</author>
<author><name sortKey="Bengtsson, M" uniqKey="Bengtsson M">M. Bengtsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hayashi, F" uniqKey="Hayashi F">F. Hayashi</name>
</author>
<author><name sortKey="Watanabe, M" uniqKey="Watanabe M">M. Watanabe</name>
</author>
<author><name sortKey="Nanba, T" uniqKey="Nanba T">T. Nanba</name>
</author>
<author><name sortKey="Inoue, N" uniqKey="Inoue N">N. Inoue</name>
</author>
<author><name sortKey="Akamizu, T" uniqKey="Akamizu T">T. Akamizu</name>
</author>
<author><name sortKey="Iwatani, Y" uniqKey="Iwatani Y">Y. Iwatani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Borkowska, P" uniqKey="Borkowska P">P. Borkowska</name>
</author>
<author><name sortKey="Kucia, K" uniqKey="Kucia K">K. Kucia</name>
</author>
<author><name sortKey="Rzezniczek, S" uniqKey="Rzezniczek S">S. Rzezniczek</name>
</author>
<author><name sortKey="Paul Samojedny, M" uniqKey="Paul Samojedny M">M. Paul-Samojedny</name>
</author>
<author><name sortKey="Kowalczyk, M" uniqKey="Kowalczyk M">M. Kowalczyk</name>
</author>
<author><name sortKey="Owczarek, A" uniqKey="Owczarek A">A. Owczarek</name>
</author>
<author><name sortKey="Suchanek, R" uniqKey="Suchanek R">R. Suchanek</name>
</author>
<author><name sortKey="Medrala, T" uniqKey="Medrala T">T. Medrala</name>
</author>
<author><name sortKey="Kowalski, J" uniqKey="Kowalski J">J. Kowalski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, K" uniqKey="Wu K">K. Wu</name>
</author>
<author><name sortKey="Zhou, X" uniqKey="Zhou X">X. Zhou</name>
</author>
<author><name sortKey="Zheng, F" uniqKey="Zheng F">F. Zheng</name>
</author>
<author><name sortKey="Xu, X" uniqKey="Xu X">X. Xu</name>
</author>
<author><name sortKey="Lin, Y" uniqKey="Lin Y">Y. Lin</name>
</author>
<author><name sortKey="Yang, J" uniqKey="Yang J">J. Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
<author><name sortKey="Kato, N" uniqKey="Kato N">N. Kato</name>
</author>
<author><name sortKey="Hoshida, Y" uniqKey="Hoshida Y">Y. Hoshida</name>
</author>
<author><name sortKey="Yoshida, H" uniqKey="Yoshida H">H. Yoshida</name>
</author>
<author><name sortKey="Taniguchi, H" uniqKey="Taniguchi H">H. Taniguchi</name>
</author>
<author><name sortKey="Goto, T" uniqKey="Goto T">T. Goto</name>
</author>
<author><name sortKey="Moriyama, M" uniqKey="Moriyama M">M. Moriyama</name>
</author>
<author><name sortKey="Otsuka, M" uniqKey="Otsuka M">M. Otsuka</name>
</author>
<author><name sortKey="Shiina, S" uniqKey="Shiina S">S. Shiina</name>
</author>
<author><name sortKey="Shiratori, Y" uniqKey="Shiratori Y">Y. Shiratori</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Omar, E" uniqKey="El Omar E">E. El-Omar</name>
</author>
<author><name sortKey="Carrington, M" uniqKey="Carrington M">M. Carrington</name>
</author>
<author><name sortKey="Chow, W" uniqKey="Chow W">W. Chow</name>
</author>
<author><name sortKey="Mccoll, K" uniqKey="Mccoll K">K. McColl</name>
</author>
<author><name sortKey="Bream, J" uniqKey="Bream J">J. Bream</name>
</author>
<author><name sortKey="Young, H" uniqKey="Young H">H. Young</name>
</author>
<author><name sortKey="Herrera, J" uniqKey="Herrera J">J. Herrera</name>
</author>
<author><name sortKey="Lissowska, J" uniqKey="Lissowska J">J. Lissowska</name>
</author>
<author><name sortKey="Yuan, C" uniqKey="Yuan C">C. Yuan</name>
</author>
<author><name sortKey="Rothman, N" uniqKey="Rothman N">N. Rothman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martinez Carrillo, D" uniqKey="Martinez Carrillo D">D. Martinez-Carrillo</name>
</author>
<author><name sortKey="Garza Gonzalez, E" uniqKey="Garza Gonzalez E">E. Garza-Gonzalez</name>
</author>
<author><name sortKey="Betancourt Linares, R" uniqKey="Betancourt Linares R">R. Betancourt-Linares</name>
</author>
<author><name sortKey="Monico Manzano, T" uniqKey="Monico Manzano T">T. Monico-Manzano</name>
</author>
<author><name sortKey="Antunez Rivera, C" uniqKey="Antunez Rivera C">C. Antunez-Rivera</name>
</author>
<author><name sortKey="Roman Roman, A" uniqKey="Roman Roman A">A. Roman-Roman</name>
</author>
<author><name sortKey="Flores Alfaro, E" uniqKey="Flores Alfaro E">E. Flores-Alfaro</name>
</author>
<author><name sortKey="Illades Aguiar, B" uniqKey="Illades Aguiar B">B. Illades-Aguiar</name>
</author>
<author><name sortKey="Fernandez Tilapa, G" uniqKey="Fernandez Tilapa G">G. Fernandez-Tilapa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cochain, C" uniqKey="Cochain C">C. Cochain</name>
</author>
<author><name sortKey="Vafadarnejad, E" uniqKey="Vafadarnejad E">E. Vafadarnejad</name>
</author>
<author><name sortKey="Arampatzi, P" uniqKey="Arampatzi P">P. Arampatzi</name>
</author>
<author><name sortKey="Pelisek, J" uniqKey="Pelisek J">J. Pelisek</name>
</author>
<author><name sortKey="Winkels, H" uniqKey="Winkels H">H. Winkels</name>
</author>
<author><name sortKey="Ley, K" uniqKey="Ley K">K. Ley</name>
</author>
<author><name sortKey="Wolf, D" uniqKey="Wolf D">D. Wolf</name>
</author>
<author><name sortKey="Saliba, A" uniqKey="Saliba A">A. Saliba</name>
</author>
<author><name sortKey="Zernecke, A" uniqKey="Zernecke A">A. Zernecke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q. Zhou</name>
</author>
<author><name sortKey="Han, X" uniqKey="Han X">X. Han</name>
</author>
<author><name sortKey="Li, R" uniqKey="Li R">R. Li</name>
</author>
<author><name sortKey="Zhao, W" uniqKey="Zhao W">W. Zhao</name>
</author>
<author><name sortKey="Bai, B" uniqKey="Bai B">B. Bai</name>
</author>
<author><name sortKey="Yan, C" uniqKey="Yan C">C. Yan</name>
</author>
<author><name sortKey="Dong, X" uniqKey="Dong X">X. Dong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giunzioni, I" uniqKey="Giunzioni I">I. Giunzioni</name>
</author>
<author><name sortKey="Bonomo, A" uniqKey="Bonomo A">A. Bonomo</name>
</author>
<author><name sortKey="Bishop, E" uniqKey="Bishop E">E. Bishop</name>
</author>
<author><name sortKey="Castiglioni, S" uniqKey="Castiglioni S">S. Castiglioni</name>
</author>
<author><name sortKey="Corsini, A" uniqKey="Corsini A">A. Corsini</name>
</author>
<author><name sortKey="Bellosta, S" uniqKey="Bellosta S">S. Bellosta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abbas, A" uniqKey="Abbas A">A. Abbas</name>
</author>
<author><name sortKey="Lechevrel, M" uniqKey="Lechevrel M">M. Lechevrel</name>
</author>
<author><name sortKey="Sichel, F" uniqKey="Sichel F">F. Sichel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lainas, P" uniqKey="Lainas P">P. Lainas</name>
</author>
<author><name sortKey="Fuks, D" uniqKey="Fuks D">D. Fuks</name>
</author>
<author><name sortKey="Gaujoux, S" uniqKey="Gaujoux S">S. Gaujoux</name>
</author>
<author><name sortKey="Machroub, Z" uniqKey="Machroub Z">Z. Machroub</name>
</author>
<author><name sortKey="Fregeville, A" uniqKey="Fregeville A">A. Fregeville</name>
</author>
<author><name sortKey="Perniceni, T" uniqKey="Perniceni T">T. Perniceni</name>
</author>
<author><name sortKey="Mal, F" uniqKey="Mal F">F. Mal</name>
</author>
<author><name sortKey="Dousset, B" uniqKey="Dousset B">B. Dousset</name>
</author>
<author><name sortKey="Gayet, B" uniqKey="Gayet B">B. Gayet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peltoketo, H" uniqKey="Peltoketo H">H. Peltoketo</name>
</author>
<author><name sortKey="Piao, Y" uniqKey="Piao Y">Y. Piao</name>
</author>
<author><name sortKey="Mannermaa, A" uniqKey="Mannermaa A">A. Mannermaa</name>
</author>
<author><name sortKey="Ponder, B" uniqKey="Ponder B">B. Ponder</name>
</author>
<author><name sortKey="Isomaa, V" uniqKey="Isomaa V">V. Isomaa</name>
</author>
<author><name sortKey="Poutanen, M" uniqKey="Poutanen M">M. Poutanen</name>
</author>
<author><name sortKey="Winqvist, R" uniqKey="Winqvist R">R. Winqvist</name>
</author>
<author><name sortKey="Vihko, R" uniqKey="Vihko R">R. Vihko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, A" uniqKey="Ma A">A. Ma</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name>
</author>
<author><name sortKey="An, Y" uniqKey="An Y">Y. An</name>
</author>
<author><name sortKey="Fang, W" uniqKey="Fang W">W. Fang</name>
</author>
<author><name sortKey="Zhu, H" uniqKey="Zhu H">H. Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, W" uniqKey="He W">W. He</name>
</author>
<author><name sortKey="Gauri, M" uniqKey="Gauri M">M. Gauri</name>
</author>
<author><name sortKey="Li, T" uniqKey="Li T">T. Li</name>
</author>
<author><name sortKey="Wang, R" uniqKey="Wang R">R. Wang</name>
</author>
<author><name sortKey="Lin, S" uniqKey="Lin S">S. Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chistiakov, D" uniqKey="Chistiakov D">D. Chistiakov</name>
</author>
<author><name sortKey="Sobenin, I" uniqKey="Sobenin I">I. Sobenin</name>
</author>
<author><name sortKey="Bobryshev, Y" uniqKey="Bobryshev Y">Y. Bobryshev</name>
</author>
<author><name sortKey="Orekhov, A" uniqKey="Orekhov A">A. Orekhov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cervelli, T" uniqKey="Cervelli T">T. Cervelli</name>
</author>
<author><name sortKey="Borghini, A" uniqKey="Borghini A">A. Borghini</name>
</author>
<author><name sortKey="Galli, A" uniqKey="Galli A">A. Galli</name>
</author>
<author><name sortKey="Andreassi, M" uniqKey="Andreassi M">M. Andreassi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coxhead, J" uniqKey="Coxhead J">J. Coxhead</name>
</author>
<author><name sortKey="Williams, E" uniqKey="Williams E">E. Williams</name>
</author>
<author><name sortKey="Mathers, J" uniqKey="Mathers J">J. Mathers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name>
</author>
<author><name sortKey="Qu, X" uniqKey="Qu X">X. Qu</name>
</author>
<author><name sortKey="Yuan, F" uniqKey="Yuan F">F. Yuan</name>
</author>
<author><name sortKey="Zhang, M" uniqKey="Zhang M">M. Zhang</name>
</author>
<author><name sortKey="Fang, W" uniqKey="Fang W">W. Fang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Philips, S" uniqKey="Philips S">S. Philips</name>
</author>
<author><name sortKey="Richter, A" uniqKey="Richter A">A. Richter</name>
</author>
<author><name sortKey="Oesterreich, S" uniqKey="Oesterreich S">S. Oesterreich</name>
</author>
<author><name sortKey="Rae, J" uniqKey="Rae J">J. Rae</name>
</author>
<author><name sortKey="Flockhart, D" uniqKey="Flockhart D">D. Flockhart</name>
</author>
<author><name sortKey="Perumal, N" uniqKey="Perumal N">N. Perumal</name>
</author>
<author><name sortKey="Skaar, T" uniqKey="Skaar T">T. Skaar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcrobb, L S" uniqKey="Mcrobb L">L.S. McRobb</name>
</author>
<author><name sortKey="Mcgrath, K C Y" uniqKey="Mcgrath K">K.C.Y. McGrath</name>
</author>
<author><name sortKey="Tsatralis, T" uniqKey="Tsatralis T">T. Tsatralis</name>
</author>
<author><name sortKey="Liong, E C" uniqKey="Liong E">E.C. Liong</name>
</author>
<author><name sortKey="Tan, J T M" uniqKey="Tan J">J.T.M. Tan</name>
</author>
<author><name sortKey="Hughes, G" uniqKey="Hughes G">G. Hughes</name>
</author>
<author><name sortKey="Handelsman, D J" uniqKey="Handelsman D">D.J. Handelsman</name>
</author>
<author><name sortKey="Heather, A K" uniqKey="Heather A">A.K. Heather</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anderson, J J" uniqKey="Anderson J">J.J. Anderson</name>
</author>
<author><name sortKey="Kruszka, B" uniqKey="Kruszka B">B. Kruszka</name>
</author>
<author><name sortKey="Delaney, J A" uniqKey="Delaney J">J.A. Delaney</name>
</author>
<author><name sortKey="He, K" uniqKey="He K">K. He</name>
</author>
<author><name sortKey="Burke, G L" uniqKey="Burke G">G.L. Burke</name>
</author>
<author><name sortKey="Alonso, A" uniqKey="Alonso A">A. Alonso</name>
</author>
<author><name sortKey="Bild, D E" uniqKey="Bild D">D.E. Bild</name>
</author>
<author><name sortKey="Budoff, M" uniqKey="Budoff M">M. Budoff</name>
</author>
<author><name sortKey="Michos, E D" uniqKey="Michos E">E.D. Michos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Shakfa, F" uniqKey="Al Shakfa F">F. Al-Shakfa</name>
</author>
<author><name sortKey="Dulucq, S" uniqKey="Dulucq S">S. Dulucq</name>
</author>
<author><name sortKey="Brukner, I" uniqKey="Brukner I">I. Brukner</name>
</author>
<author><name sortKey="Milacic, I" uniqKey="Milacic I">I. Milacic</name>
</author>
<author><name sortKey="Ansari, M" uniqKey="Ansari M">M. Ansari</name>
</author>
<author><name sortKey="Beaulieu, P" uniqKey="Beaulieu P">P. Beaulieu</name>
</author>
<author><name sortKey="Moghrabi, A" uniqKey="Moghrabi A">A. Moghrabi</name>
</author>
<author><name sortKey="Laverdiere, C" uniqKey="Laverdiere C">C. Laverdiere</name>
</author>
<author><name sortKey="Sallan, S" uniqKey="Sallan S">S. Sallan</name>
</author>
<author><name sortKey="Silverman, L" uniqKey="Silverman L">L. Silverman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harrison, D" uniqKey="Harrison D">D. Harrison</name>
</author>
<author><name sortKey="Chen, W" uniqKey="Chen W">W. Chen</name>
</author>
<author><name sortKey="Dikalov, S" uniqKey="Dikalov S">S. Dikalov</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Okumura, K" uniqKey="Okumura K">K. Okumura</name>
</author>
<author><name sortKey="Tsukamoto, H" uniqKey="Tsukamoto H">H. Tsukamoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilhelmson, A" uniqKey="Wilhelmson A">A. Wilhelmson</name>
</author>
<author><name sortKey="Bourghardt Fagman, J" uniqKey="Bourghardt Fagman J">J. Bourghardt-Fagman</name>
</author>
<author><name sortKey="Gogos, J" uniqKey="Gogos J">J. Gogos</name>
</author>
<author><name sortKey="Fogelstrand, P" uniqKey="Fogelstrand P">P. Fogelstrand</name>
</author>
<author><name sortKey="Tivesten, A" uniqKey="Tivesten A">A. Tivesten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lievens, D" uniqKey="Lievens D">D. Lievens</name>
</author>
<author><name sortKey="Habets, K" uniqKey="Habets K">K. Habets</name>
</author>
<author><name sortKey="Robertson, A" uniqKey="Robertson A">A. Robertson</name>
</author>
<author><name sortKey="Laouar, Y" uniqKey="Laouar Y">Y. Laouar</name>
</author>
<author><name sortKey="Winkels, H" uniqKey="Winkels H">H. Winkels</name>
</author>
<author><name sortKey="Rademakers, T" uniqKey="Rademakers T">T. Rademakers</name>
</author>
<author><name sortKey="Beckers, L" uniqKey="Beckers L">L. Beckers</name>
</author>
<author><name sortKey="Wijnands, E" uniqKey="Wijnands E">E. Wijnands</name>
</author>
<author><name sortKey="Boon, L" uniqKey="Boon L">L. Boon</name>
</author>
<author><name sortKey="Mosaheb, M" uniqKey="Mosaheb M">M. Mosaheb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lou, J" uniqKey="Lou J">J. Lou</name>
</author>
<author><name sortKey="Zhao, D" uniqKey="Zhao D">D. Zhao</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name>
</author>
<author><name sortKey="Song, S" uniqKey="Song S">S. Song</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
<author><name sortKey="Sun, F" uniqKey="Sun F">F. Sun</name>
</author>
<author><name sortKey="Ding, X" uniqKey="Ding X">X. Ding</name>
</author>
<author><name sortKey="Yu, C" uniqKey="Yu C">C. Yu</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
<author><name sortKey="Liu, M" uniqKey="Liu M">M. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dol Gleizes, F" uniqKey="Dol Gleizes F">F. Dol-Gleizes</name>
</author>
<author><name sortKey="Delesque Touchard, N" uniqKey="Delesque Touchard N">N. Delesque-Touchard</name>
</author>
<author><name sortKey="Mares, A" uniqKey="Mares A">A. Mares</name>
</author>
<author><name sortKey="Nestor, A" uniqKey="Nestor A">A. Nestor</name>
</author>
<author><name sortKey="Schaeffer, P" uniqKey="Schaeffer P">P. Schaeffer</name>
</author>
<author><name sortKey="Bono, F" uniqKey="Bono F">F. Bono</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, D" uniqKey="Yu D">D. Yu</name>
</author>
<author><name sortKey="Rui, X" uniqKey="Rui X">X. Rui</name>
</author>
<author><name sortKey="He, S" uniqKey="He S">S. He</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hartgerink, J" uniqKey="Hartgerink J">J. Hartgerink</name>
</author>
<author><name sortKey="Cramm, J" uniqKey="Cramm J">J. Cramm</name>
</author>
<author><name sortKey="De Vos, A" uniqKey="De Vos A">A. de Vos</name>
</author>
<author><name sortKey="Bakker, T" uniqKey="Bakker T">T. Bakker</name>
</author>
<author><name sortKey="Steyerberg, E" uniqKey="Steyerberg E">E. Steyerberg</name>
</author>
<author><name sortKey="Mackenbach, J" uniqKey="Mackenbach J">J. Mackenbach</name>
</author>
<author><name sortKey="Nieboer, A" uniqKey="Nieboer A">A. Nieboer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, E" uniqKey="Yu E">E. Yu</name>
</author>
<author><name sortKey="Calvert, P" uniqKey="Calvert P">P. Calvert</name>
</author>
<author><name sortKey="Mercer, J" uniqKey="Mercer J">J. Mercer</name>
</author>
<author><name sortKey="Harrison, J" uniqKey="Harrison J">J. Harrison</name>
</author>
<author><name sortKey="Baker, L" uniqKey="Baker L">L. Baker</name>
</author>
<author><name sortKey="Figg, N" uniqKey="Figg N">N. Figg</name>
</author>
<author><name sortKey="Kumar, S" uniqKey="Kumar S">S. Kumar</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name>
</author>
<author><name sortKey="Hurst, L" uniqKey="Hurst L">L. Hurst</name>
</author>
<author><name sortKey="Obaid, D" uniqKey="Obaid D">D. Obaid</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hu, Q" uniqKey="Hu Q">Q. Hu</name>
</author>
<author><name sortKey="Ren, J" uniqKey="Ren J">J. Ren</name>
</author>
<author><name sortKey="Li, G" uniqKey="Li G">G. Li</name>
</author>
<author><name sortKey="Wu, J" uniqKey="Wu J">J. Wu</name>
</author>
<author><name sortKey="Wu, X" uniqKey="Wu X">X. Wu</name>
</author>
<author><name sortKey="Wang, G" uniqKey="Wang G">G. Wang</name>
</author>
<author><name sortKey="Gu, G" uniqKey="Gu G">G. Gu</name>
</author>
<author><name sortKey="Ren, H" uniqKey="Ren H">H. Ren</name>
</author>
<author><name sortKey="Hong, Z" uniqKey="Hong Z">Z. Hong</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cioffi, F" uniqKey="Cioffi F">F. Cioffi</name>
</author>
<author><name sortKey="Senese, R" uniqKey="Senese R">R. Senese</name>
</author>
<author><name sortKey="Lasala, P" uniqKey="Lasala P">P. Lasala</name>
</author>
<author><name sortKey="Ziello, A" uniqKey="Ziello A">A. Ziello</name>
</author>
<author><name sortKey="Mazzoli, A" uniqKey="Mazzoli A">A. Mazzoli</name>
</author>
<author><name sortKey="Crescenzo, R" uniqKey="Crescenzo R">R. Crescenzo</name>
</author>
<author><name sortKey="Liverini, G" uniqKey="Liverini G">G. Liverini</name>
</author>
<author><name sortKey="Lanni, A" uniqKey="Lanni A">A. Lanni</name>
</author>
<author><name sortKey="Goglia, F" uniqKey="Goglia F">F. Goglia</name>
</author>
<author><name sortKey="Iossa, S" uniqKey="Iossa S">S. Iossa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reddyvari, H" uniqKey="Reddyvari H">H. Reddyvari</name>
</author>
<author><name sortKey="Govatati, S" uniqKey="Govatati S">S. Govatati</name>
</author>
<author><name sortKey="Matha, S" uniqKey="Matha S">S. Matha</name>
</author>
<author><name sortKey="Korla, S" uniqKey="Korla S">S. Korla</name>
</author>
<author><name sortKey="Malempati, S" uniqKey="Malempati S">S. Malempati</name>
</author>
<author><name sortKey="Pasupuleti, S" uniqKey="Pasupuleti S">S. Pasupuleti</name>
</author>
<author><name sortKey="Bhanoori, M" uniqKey="Bhanoori M">M. Bhanoori</name>
</author>
<author><name sortKey="Nallanchakravarthula, V" uniqKey="Nallanchakravarthula V">V. Nallanchakravarthula</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stein, S" uniqKey="Stein S">S. Stein</name>
</author>
<author><name sortKey="Lohmann, C" uniqKey="Lohmann C">C. Lohmann</name>
</author>
<author><name sortKey="Handschin, C" uniqKey="Handschin C">C. Handschin</name>
</author>
<author><name sortKey="Stenfeldt, E" uniqKey="Stenfeldt E">E. Stenfeldt</name>
</author>
<author><name sortKey="Boren, J" uniqKey="Boren J">J. Boren</name>
</author>
<author><name sortKey="Luscher, T" uniqKey="Luscher T">T. Luscher</name>
</author>
<author><name sortKey="Matter, C" uniqKey="Matter C">C. Matter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Q" uniqKey="Zhao Q">Q. Zhao</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vernochet, C" uniqKey="Vernochet C">C. Vernochet</name>
</author>
<author><name sortKey="Mourier, A" uniqKey="Mourier A">A. Mourier</name>
</author>
<author><name sortKey="Bezy, O" uniqKey="Bezy O">O. Bezy</name>
</author>
<author><name sortKey="Macotela, Y" uniqKey="Macotela Y">Y. Macotela</name>
</author>
<author><name sortKey="Boucher, J" uniqKey="Boucher J">J. Boucher</name>
</author>
<author><name sortKey="Rardin, M" uniqKey="Rardin M">M. Rardin</name>
</author>
<author><name sortKey="An, D" uniqKey="An D">D. An</name>
</author>
<author><name sortKey="Lee, K" uniqKey="Lee K">K. Lee</name>
</author>
<author><name sortKey="Ilkayeva, O" uniqKey="Ilkayeva O">O. Ilkayeva</name>
</author>
<author><name sortKey="Zingaretti, C" uniqKey="Zingaretti C">C. Zingaretti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yoshida, T" uniqKey="Yoshida T">T. Yoshida</name>
</author>
<author><name sortKey="Azuma, H" uniqKey="Azuma H">H. Azuma</name>
</author>
<author><name sortKey="Aihara, K" uniqKey="Aihara K">K. Aihara</name>
</author>
<author><name sortKey="Fujimura, M" uniqKey="Fujimura M">M. Fujimura</name>
</author>
<author><name sortKey="Akaike, M" uniqKey="Akaike M">M. Akaike</name>
</author>
<author><name sortKey="Mitsui, T" uniqKey="Mitsui T">T. Mitsui</name>
</author>
<author><name sortKey="Matsumoto, T" uniqKey="Matsumoto T">T. Matsumoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Han, D" uniqKey="Han D">D. Han</name>
</author>
<author><name sortKey="Johnson, H" uniqKey="Johnson H">H. Johnson</name>
</author>
<author><name sortKey="Rao, M" uniqKey="Rao M">M. Rao</name>
</author>
<author><name sortKey="Martin, G" uniqKey="Martin G">G. Martin</name>
</author>
<author><name sortKey="Sancheti, H" uniqKey="Sancheti H">H. Sancheti</name>
</author>
<author><name sortKey="Silkwood, K" uniqKey="Silkwood K">K. Silkwood</name>
</author>
<author><name sortKey="Decker, C" uniqKey="Decker C">C. Decker</name>
</author>
<author><name sortKey="Nguyen, K" uniqKey="Nguyen K">K. Nguyen</name>
</author>
<author><name sortKey="Casian, J" uniqKey="Casian J">J. Casian</name>
</author>
<author><name sortKey="Cadenas, E" uniqKey="Cadenas E">E. Cadenas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mercer, J" uniqKey="Mercer J">J. Mercer</name>
</author>
<author><name sortKey="Cheng, K" uniqKey="Cheng K">K. Cheng</name>
</author>
<author><name sortKey="Figg, N" uniqKey="Figg N">N. Figg</name>
</author>
<author><name sortKey="Gorenne, I" uniqKey="Gorenne I">I. Gorenne</name>
</author>
<author><name sortKey="Mahmoudi, M" uniqKey="Mahmoudi M">M. Mahmoudi</name>
</author>
<author><name sortKey="Griffin, J" uniqKey="Griffin J">J. Griffin</name>
</author>
<author><name sortKey="Vidal Puig, A" uniqKey="Vidal Puig A">A. Vidal-Puig</name>
</author>
<author><name sortKey="Logan, A" uniqKey="Logan A">A. Logan</name>
</author>
<author><name sortKey="Murphy, M" uniqKey="Murphy M">M. Murphy</name>
</author>
<author><name sortKey="Bennett, M" uniqKey="Bennett M">M. Bennett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mercer, J" uniqKey="Mercer J">J. Mercer</name>
</author>
<author><name sortKey="Yu, E" uniqKey="Yu E">E. Yu</name>
</author>
<author><name sortKey="Figg, N" uniqKey="Figg N">N. Figg</name>
</author>
<author><name sortKey="Cheng, K" uniqKey="Cheng K">K. Cheng</name>
</author>
<author><name sortKey="Prime, T" uniqKey="Prime T">T. Prime</name>
</author>
<author><name sortKey="Griffin, J" uniqKey="Griffin J">J. Griffin</name>
</author>
<author><name sortKey="Masoodi, M" uniqKey="Masoodi M">M. Masoodi</name>
</author>
<author><name sortKey="Vidal Puig, A" uniqKey="Vidal Puig A">A. Vidal-Puig</name>
</author>
<author><name sortKey="Murphy, M" uniqKey="Murphy M">M. Murphy</name>
</author>
<author><name sortKey="Bennett, M" uniqKey="Bennett M">M. Bennett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L. Liu</name>
</author>
<author><name sortKey="Nagai, I" uniqKey="Nagai I">I. Nagai</name>
</author>
<author><name sortKey="Gao, Y" uniqKey="Gao Y">Y. Gao</name>
</author>
<author><name sortKey="Matsushima, Y" uniqKey="Matsushima Y">Y. Matsushima</name>
</author>
<author><name sortKey="Kawai, Y" uniqKey="Kawai Y">Y. Kawai</name>
</author>
<author><name sortKey="Sayama, K" uniqKey="Sayama K">K. Sayama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Razani, B" uniqKey="Razani B">B. Razani</name>
</author>
<author><name sortKey="Feng, C" uniqKey="Feng C">C. Feng</name>
</author>
<author><name sortKey="Semenkovich, C" uniqKey="Semenkovich C">C. Semenkovich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nair, V D" uniqKey="Nair V">V.D. Nair</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stamatelopoulos, K" uniqKey="Stamatelopoulos K">K. Stamatelopoulos</name>
</author>
<author><name sortKey="Karatzi, K" uniqKey="Karatzi K">K. Karatzi</name>
</author>
<author><name sortKey="Sidossis, L" uniqKey="Sidossis L">L. Sidossis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Teng, I" uniqKey="Teng I">I. Teng</name>
</author>
<author><name sortKey="Tsai, M" uniqKey="Tsai M">M. Tsai</name>
</author>
<author><name sortKey="Shih, S" uniqKey="Shih S">S. Shih</name>
</author>
<author><name sortKey="Tsuei, B" uniqKey="Tsuei B">B. Tsuei</name>
</author>
<author><name sortKey="Chang, H" uniqKey="Chang H">H. Chang</name>
</author>
<author><name sortKey="Chuang, Y" uniqKey="Chuang Y">Y. Chuang</name>
</author>
<author><name sortKey="Lin, C" uniqKey="Lin C">C. Lin</name>
</author>
<author><name sortKey="Chern, C" uniqKey="Chern C">C. Chern</name>
</author>
<author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liang, H" uniqKey="Liang H">H. Liang</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name>
</author>
<author><name sortKey="Liu, D" uniqKey="Liu D">D. Liu</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, S" uniqKey="Kumar S">S. Kumar</name>
</author>
<author><name sortKey="Kim, C" uniqKey="Kim C">C. Kim</name>
</author>
<author><name sortKey="Simmons, R" uniqKey="Simmons R">R. Simmons</name>
</author>
<author><name sortKey="Jo, H" uniqKey="Jo H">H. Jo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hergenreider, E" uniqKey="Hergenreider E">E. Hergenreider</name>
</author>
<author><name sortKey="Heydt, S" uniqKey="Heydt S">S. Heydt</name>
</author>
<author><name sortKey="Treguer, K" uniqKey="Treguer K">K. Treguer</name>
</author>
<author><name sortKey="Boettger, T" uniqKey="Boettger T">T. Boettger</name>
</author>
<author><name sortKey="Horrevoets, A" uniqKey="Horrevoets A">A. Horrevoets</name>
</author>
<author><name sortKey="Zeiher, A" uniqKey="Zeiher A">A. Zeiher</name>
</author>
<author><name sortKey="Scheffer, M" uniqKey="Scheffer M">M. Scheffer</name>
</author>
<author><name sortKey="Frangakis, A" uniqKey="Frangakis A">A. Frangakis</name>
</author>
<author><name sortKey="Yin, X" uniqKey="Yin X">X. Yin</name>
</author>
<author><name sortKey="Mayr, M" uniqKey="Mayr M">M. Mayr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Castiglioni, S" uniqKey="Castiglioni S">S. Castiglioni</name>
</author>
<author><name sortKey="Monti, M" uniqKey="Monti M">M. Monti</name>
</author>
<author><name sortKey="Arnaboldi, L" uniqKey="Arnaboldi L">L. Arnaboldi</name>
</author>
<author><name sortKey="Canavesi, M" uniqKey="Canavesi M">M. Canavesi</name>
</author>
<author><name sortKey="Ainis Buscherini, G" uniqKey="Ainis Buscherini G">G. Ainis Buscherini</name>
</author>
<author><name sortKey="Calabresi, L" uniqKey="Calabresi L">L. Calabresi</name>
</author>
<author><name sortKey="Corsini, A" uniqKey="Corsini A">A. Corsini</name>
</author>
<author><name sortKey="Bellosta, S" uniqKey="Bellosta S">S. Bellosta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
<author><name sortKey="Cao, C" uniqKey="Cao C">C. Cao</name>
</author>
<author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name>
</author>
<author><name sortKey="Ma, S" uniqKey="Ma S">S. Ma</name>
</author>
<author><name sortKey="Han, X" uniqKey="Han X">X. Han</name>
</author>
<author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name>
</author>
<author><name sortKey="Yang, A" uniqKey="Yang A">A. Yang</name>
</author>
<author><name sortKey="Tian, J" uniqKey="Tian J">J. Tian</name>
</author>
<author><name sortKey="Xu, H" uniqKey="Xu H">H. Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, K" uniqKey="Liu K">K. Liu</name>
</author>
<author><name sortKey="Xuekelati, S" uniqKey="Xuekelati S">S. Xuekelati</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Yin, Y" uniqKey="Yin Y">Y. Yin</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
<author><name sortKey="Chai, R" uniqKey="Chai R">R. Chai</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
<author><name sortKey="Peng, Y" uniqKey="Peng Y">Y. Peng</name>
</author>
<author><name sortKey="Wu, J" uniqKey="Wu J">J. Wu</name>
</author>
<author><name sortKey="Guo, X" uniqKey="Guo X">X. Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hahn, S" uniqKey="Hahn S">S. Hahn</name>
</author>
<author><name sortKey="Buratowski, S" uniqKey="Buratowski S">S. Buratowski</name>
</author>
<author><name sortKey="Sharp, P" uniqKey="Sharp P">P. Sharp</name>
</author>
<author><name sortKey="Guarente, L" uniqKey="Guarente L">L. Guarente</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bucher, P" uniqKey="Bucher P">P. Bucher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karas, H" uniqKey="Karas H">H. Karas</name>
</author>
<author><name sortKey="Knuppel, R" uniqKey="Knuppel R">R. Knuppel</name>
</author>
<author><name sortKey="Schulz, W" uniqKey="Schulz W">W. Schulz</name>
</author>
<author><name sortKey="Sklenar, H" uniqKey="Sklenar H">H. Sklenar</name>
</author>
<author><name sortKey="Wingender, E" uniqKey="Wingender E">E. Wingender</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pugh, B" uniqKey="Pugh B">B. Pugh</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Mol Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Mol Sci</journal-id>
<journal-id journal-id-type="publisher-id">ijms</journal-id>
<journal-title-group><journal-title>International Journal of Molecular Sciences</journal-title>
</journal-title-group>
<issn pub-type="epub">1422-0067</issn>
<publisher><publisher-name>MDPI</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32033288</article-id>
<article-id pub-id-type="pmc">7037642</article-id>
<article-id pub-id-type="doi">10.3390/ijms21031045</article-id>
<article-id pub-id-type="publisher-id">ijms-21-01045</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-1663-318X</contrib-id>
<name><surname>Ponomarenko</surname>
<given-names>Mikhail</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-21-01045">1</xref>
<xref ref-type="aff" rid="af2-ijms-21-01045">2</xref>
<xref rid="c1-ijms-21-01045" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rasskazov</surname>
<given-names>Dmitry</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-21-01045">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chadaeva</surname>
<given-names>Irina</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-21-01045">1</xref>
<xref ref-type="aff" rid="af2-ijms-21-01045">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sharypova</surname>
<given-names>Ekaterina</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-21-01045">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Drachkova</surname>
<given-names>Irina</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-21-01045">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oshchepkov</surname>
<given-names>Dmitry</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-21-01045">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ponomarenko</surname>
<given-names>Petr</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-21-01045">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Savinkova</surname>
<given-names>Ludmila</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-21-01045">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oshchepkova</surname>
<given-names>Evgeniya</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-21-01045">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nazarenko</surname>
<given-names>Maria</given-names>
</name>
<xref ref-type="aff" rid="af3-ijms-21-01045">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kolchanov</surname>
<given-names>Nikolay</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-21-01045">1</xref>
<xref ref-type="aff" rid="af2-ijms-21-01045">2</xref>
</contrib>
</contrib-group>
<aff id="af1-ijms-21-01045"><label>1</label>
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia;<email>rassk@bionet.nsc.ru</email>
(D.R.);<email>ichadaeva@bionet.nsc.ru</email>
(I.C.);<email>sharypova@bionet.nsc.ru</email>
(E.S.);<email>drachkova@bionet.nsc.ru</email>
(I.D.);<email>diman@bionet.nsc.ru</email>
(D.O.);<email>pon_petr@mail.ru</email>
(P.P.);<email>lksav@bionet.nsc.ru</email>
(L.S.);<email>nzhenia@bionet.nsc.ru</email>
(E.O.);</aff>
<aff id="af2-ijms-21-01045"><label>2</label>
Novosibirsk State University, Novosibirsk 630090, Russia</aff>
<aff id="af3-ijms-21-01045"><label>3</label>
Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk 634009, Russia;<email>maria.nazarenko@medgenetics.ru</email>
</aff>
<author-notes><corresp id="c1-ijms-21-01045"><label>*</label>
Correspondence: <email>pon@bionet.nsc.ru</email>
; Tel.: +7-(383)-363-49-63 (ext. 1311)</corresp>
</author-notes>
<pub-date pub-type="epub"><day>05</day>
<month>2</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="collection"><month>2</month>
<year>2020</year>
</pub-date>
<volume>21</volume>
<issue>3</issue>
<elocation-id>1045</elocation-id>
<history><date date-type="received"><day>30</day>
<month>12</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>04</day>
<month>2</month>
<year>2020</year>
</date>
</history>
<permissions><copyright-statement>© 2020 by the authors.</copyright-statement>
<copyright-year>2020</copyright-year>
<license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p>(1) Background: The World Health Organization (WHO) regards atherosclerosis-related myocardial infarction and stroke as the main causes of death in humans. Susceptibility to atherogenesis-associated diseases is caused by single-nucleotide polymorphisms (SNPs). (2) Methods: Using our previously developed public web-service SNP_TATA_Comparator, we estimated statistical significance of the SNP-caused alterations in TATA-binding protein (TBP) binding affinity for 70 bp proximal promoter regions of the human genes clinically associated with diseases syntonic or dystonic with atherogenesis. Additionally, we did the same for several genes related to the maintenance of mitochondrial genome integrity, according to present-day active research aimed at retarding atherogenesis. (3) Results: In dbSNP, we found 1186 SNPs altering such affinity to the same extent as clinical SNP markers do (as estimated). Particularly, clinical SNP marker rs2276109 can prevent autoimmune diseases via reduced TBP affinity for the human <italic>MMP12</italic>
gene promoter and therefore macrophage elastase deficiency, which is a well-known physiological marker of accelerated atherogenesis that could be retarded nutritionally using dairy fermented by lactobacilli. (4) Conclusions: Our results uncovered SNPs near clinical SNP markers as the basis of neutral drift accelerating atherogenesis and SNPs of genes encoding proteins related to mitochondrial genome integrity and microRNA genes associated with instability of the atherosclerotic plaque as a basis of directional natural selection slowing atherogenesis. Their sum may be stabilizing the natural selection that sets the normal level of atherogenesis.</p>
</abstract>
<kwd-group><kwd>atherosclerosis</kwd>
<kwd>human</kwd>
<kwd>gene</kwd>
<kwd>promoter</kwd>
<kwd>TATA-binding protein (TBP) TBP-binding site (TATA box)</kwd>
<kwd>single nucleotide polymorphism (SNP)</kwd>
<kwd>candidate SNP marker</kwd>
<kwd>verification in vitro</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="ijms-21-01045-f001" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>The result produced by our SNP_TATA_Comparator [<xref rid="B45-ijms-21-01045" ref-type="bibr">45</xref>
] in the case of the only known clinical SNP marker (rs1427119663) of slowed atherosclerosis in the human <italic>CETP</italic>
gene. Legend: (<bold>a</bold>
) Unannotated SNPs (analyzed in this study) in a 70 bp proximal promoter [where all proven TBP-sites (framed, □) are located (double-headed red arrow, ↔) of the human <italic>CETP</italic>
gene retrieved from the UCSC Genome Browser [<xref rid="B13-ijms-21-01045" ref-type="bibr">13</xref>
]. (<bold>b</bold>
) The description of this clinical SNP marker (rs1427119663) of retarded atherosclerosis corresponds to dbSNP build No. 151 [<xref rid="B12-ijms-21-01045" ref-type="bibr">12</xref>
]. (<bold>c</bold>
) The output of our public Web service SNP_TATA_Comparator [<xref rid="B45-ijms-21-01045" ref-type="bibr">45</xref>
] after the input of data on the clinical SNP marker rs1427119663 as depicted by arrows (i.e., the textbox Result: “deficiency: significant” in line “Decision”). (d) Our software-based calculation implementing our bioinformatics model of the three-step TBP-promoter binding (i.e., TBP slides along DNA <=> TBP stops at a TBP-site <=> the TBP-promoter complex is fixed by a 90° DNA bend [<xref rid="B36-ijms-21-01045" ref-type="bibr">36</xref>
]), based on standard bioinformatics-related software R [<xref rid="B59-ijms-21-01045" ref-type="bibr">59</xref>
], as described in detail within <xref ref-type="app" rid="app1-ijms-21-01045">Supplementary Materials</xref>
(<xref ref-type="app" rid="app1-ijms-21-01045">Supplementary File S1: Supplementary Methods</xref>
).</p>
</caption>
<graphic xlink:href="ijms-21-01045-g001"></graphic>
</fig>
<fig id="ijms-21-01045-f002" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>Examples of predictions made in this work (using our previously created Web service SNP_TATA_Comparator [<xref rid="B45-ijms-21-01045" ref-type="bibr">45</xref>
]) regarding statistically significant changes in the expression of human genes. <italic>Legend</italic>
: See the footnote of <xref ref-type="fig" rid="ijms-21-01045-f001">Figure 1</xref>
. Candidate SNP markers of accelerated and retarded atherogenesis: (<bold>a</bold>
) <italic>HBB</italic>
: rs34500389: −31C>T; (<bold>b</bold>
) <italic>SOD1</italic>
: rs7277748: −32A>G; (<bold>c</bold>
) GCG: rs183433761: −41A>G; (<bold>d</bold>
) <italic>COMT</italic>
: rs370819229: −33C>A; (<bold>e</bold>
) <italic>POLG</italic>
: rs776506626: −37A>G; (<bold>f</bold>
) <italic>MIR10B</italic>
: rs1388274194: −22G>T.</p>
</caption>
<graphic xlink:href="ijms-21-01045-g002"></graphic>
</fig>
<fig id="ijms-21-01045-f003" orientation="portrait" position="float"><label>Figure 3</label>
<caption><p>Statistically significant correlations between in silico predicted and in vitro measured values of equilibrium dissociation constant K<sub>D</sub>
of TBP-promoter complexes expressed in ln units. <italic>Legend</italic>
: (<bold>a</bold>
) Electropherograms for the wild type ancestral (WT) allele of the unannotated SNP rs183433761 in the human <italic>GCG</italic>
gene promoter as an illustrative example. The concentration of TBP was 0.3 nM in all the experiments. The concentrations of 26 bp oligodeoxyribonucleotides (ODNs) centered around the tested SNP allele are indicated. (<bold>b</bold>
) Dependences of reaction rates on ODN concentrations in cases of the ancestral alleles of the SNP in question. The KD value of the equilibrium dissociation constant was inferred from these dependences serving as input data for publicly available software GraphPad Prism 5 (<uri xlink:href="http://graphpad-prism.software.informer.com/5.01">http://graphpad-prism.software.informer.com/5.01</uri>
). (<bold>c</bold>
,<bold>d</bold>
) Graphical representation of the analyzed correlations on absolute and relative measurement scales, respectively. Solid and dashed lines denote linear regression and boundaries of its 95% confidence interval, calculated by means of software package STATISTICA (Statsoft<sup>TM</sup>
, Tulsa, USA). Arrows pinpoint the ancestral (WT) alleles of the SNP being studied (GCG:rs183433761). Statistics: r, τ, γ, and p are coefficients of Pearson’s linear correlation, Spearman’s rank correlation, Kendall’s rank correlation, and Goodman–Kruskal generalized correlation and their <italic>p</italic>
-values, respectively.</p>
</caption>
<graphic xlink:href="ijms-21-01045-g003"></graphic>
</fig>
<fig id="ijms-21-01045-f004" orientation="portrait" position="float"><label>Figure 4</label>
<caption><p>A flow chart of the keyword search for atherosclerosis as a comorbidity of hereditary diseases whose candidate SNP markers can alter TBP-sites in the human gene promoters.</p>
</caption>
<graphic xlink:href="ijms-21-01045-g004"></graphic>
</fig>
<table-wrap id="ijms-21-01045-t005" orientation="portrait" position="float"><object-id pub-id-type="pii">ijms-21-01045-t005_Table 5</object-id>
<label>Table 5</label>
<caption><p>Atherogenesis-related candidate SNP markers within the gene promoters where SNPs of TBP-sites are clinically linked with obesity.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1"><italic>Gene</italic>
</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">dbSNP ID [<xref rid="B12-ijms-21-01045" ref-type="bibr">12</xref>
] or [Ref]</th>
<th colspan="4" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">DNA, Genome Sequence</th>
<th colspan="6" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">K<sub>D</sub>
, nM</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Clinical Data or <italic>Candidate SNP Markers</italic>
</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">AS</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Ref.</th>
</tr>
<tr><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5′ flank</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">WT</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">min</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3′ flank</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">WT</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">min</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Δ</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Z</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ρ</th>
</tr>
</thead>
<tbody><tr><td rowspan="5" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>GCG</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs183433761</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gctggagagt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tataaaagca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>1</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>< </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>8</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td rowspan="5" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>hypogluca-gonemia and postprandial increased ratio [INS]:[GCG] accelerates atherogenesis</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td rowspan="5" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B115-ijms-21-01045" ref-type="bibr">115</xref>
,<xref rid="B116-ijms-21-01045" ref-type="bibr">116</xref>
,<xref rid="B117-ijms-21-01045" ref-type="bibr">117</xref>
,<xref rid="B118-ijms-21-01045" ref-type="bibr">118</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1342326265</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tataaaagca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgcgccttgg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>0.9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>1.2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>< </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs757035851</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tatataaaag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>-</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgcgccttgg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>0.9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>1.1</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>< </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs773542506</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tggagagtat</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>taaaagcagt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>1</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>< </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>14</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs984859897</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>agctggagag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>atataaaagc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>1</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>< </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td rowspan="5" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>LEP</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs201381696</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tcgggccgct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>taagaggggc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>12</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>< </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>18</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>hypoleptine-mia, obesity</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B119-ijms-21-01045" ref-type="bibr">119</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1458202641</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggggcgggca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gaggggcggg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>< </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>8</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>accelerate atherogenesis</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B120-ijms-21-01045" ref-type="bibr">120</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs34104384</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ccgctataag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggggcgggca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>> </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>slowed down atherogenesis (athero-protector)</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B121-ijms-21-01045" ref-type="bibr">121</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs200487063</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgatcgggcc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ctataagagg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>> </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1249322424</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gtgatcgggc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gctataagag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>> </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td rowspan="4" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>APOA1</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B122-ijms-21-01045" ref-type="bibr">122</xref>
]</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tgcagacata</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ataggccctg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">< </td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">hematuria, fatty liver, obesity</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B122-ijms-21-01045" ref-type="bibr">122</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1428975217</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>acataaatag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ccctgcaaga</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2.6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3.0</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>< </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>0.05</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>D</italic>
</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>accelerated atherogenesis (exogenous APOA1 is atheropro-tector)</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B123-ijms-21-01045" ref-type="bibr">123</xref>
,<xref rid="B124-ijms-21-01045" ref-type="bibr">124</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1017922094</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cagacataaa</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>aggccctgca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>< </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1297144980</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cctggctgca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6bp</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>-</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>aataggccct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>21</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>< </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>30</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td rowspan="6" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>HTR2C</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs3813929</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cccctcatcc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gcttttggcc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">73</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">56</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">> </td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">obesity com-plication of olanzapine antipsycho-tic therapy</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B15-ijms-21-01045" ref-type="bibr">15</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1348095721</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>agagcgtggt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cagattcacc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>73</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>56</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>> </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td rowspan="5" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>hypercor-tisolemia accelerates atherogenesis that can be slowed down by lorcaserin</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td rowspan="5" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B125-ijms-21-01045" ref-type="bibr">125</xref>
,<xref rid="B126-ijms-21-01045" ref-type="bibr">126</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1444133212</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>caagagcgtg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>caagagcgtg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>73</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>39</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>> </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs886838672</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ccgcttttgg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ccaagagcgt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>73</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>34</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>> </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>15</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1376972872</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tcccgctttt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gcccaagagc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>73</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>43</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>> </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1222709869</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tggctcctcc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ctcatcccgc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>73</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>50</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>> </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>8</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>IL1B</italic>
</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">rs1143627</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">ttttgaaagc</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">c</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">t</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">ataaaaacag</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">5</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">2</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">> </td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">15</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">10<sup>−6</sup>
</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">obesity, Gra-ves’ disease, depression; lung, liver, breast, and gastric cancer </td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B127-ijms-21-01045" ref-type="bibr">127</xref>
,<xref rid="B128-ijms-21-01045" ref-type="bibr">128</xref>
,<xref rid="B129-ijms-21-01045" ref-type="bibr">129</xref>
,<xref rid="B130-ijms-21-01045" ref-type="bibr">130</xref>
,<xref rid="B131-ijms-21-01045" ref-type="bibr">131</xref>
,<xref rid="B132-ijms-21-01045" ref-type="bibr">132</xref>
,<xref rid="B133-ijms-21-01045" ref-type="bibr">133</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>accelerated atherogenesis, </italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B134-ijms-21-01045" ref-type="bibr">134</xref>
] </td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs549858786</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgaaagccat</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>aaaacagcga</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>8</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">slowed down atherogenesis </td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B135-ijms-21-01045" ref-type="bibr">135</xref>
,<xref rid="B136-ijms-21-01045" ref-type="bibr">136</xref>
]</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>Genes: <italic>GCG</italic>
, glucagon; <italic>LEP</italic>
, leptin; <italic>APOA1</italic>
, apolipoprotein A1; <italic>HTR2C</italic>
, 5-hydroxytryptamine receptor 2C (synonym: serotonin receptor 2C); <italic>IL1B</italic>
, interleukin 1β. Deletions, <italic>APOA1</italic>
: 6bp = gacata.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="ijms-21-01045-t006" orientation="portrait" position="float"><object-id pub-id-type="pii">ijms-21-01045-t006_Table 6</object-id>
<label>Table 6</label>
<caption><p>Atherogenesis-related candidate SNP markers within the gene promoters where SNPs of TBP-sites are clinically linked with cancers.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Gene</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">dbSNP ID [<xref rid="B12-ijms-21-01045" ref-type="bibr">12</xref>
] or [Ref]</th>
<th colspan="4" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">DNA, Genome Sequence</th>
<th colspan="6" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">K<sub>D</sub>
, nM</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Clinical Data or Candidate SNP Markers</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">AS</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">[Ref]</th>
</tr>
<tr><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5′ flank</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">WT</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">min</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3′ flank</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">WT</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">min</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Δ</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Z</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ρ</th>
</tr>
</thead>
<tbody><tr><td rowspan="4" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>ADH7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs17537595</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gctgctgtta</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">atacaacaga</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">13</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">esophageal cancer</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B137-ijms-21-01045" ref-type="bibr">137</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs372329931</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>agctgctgtt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tatacaacag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>1</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>post-esopha-gectomy necrosis comorbid with atherogenesis</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B138-ijms-21-01045" ref-type="bibr">138</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs755152695</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>caagctgctg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tatatacaac</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>1.0</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>1.4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1238877951</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gcacaagctg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgttatatac</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>1.0</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>1.2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td rowspan="6" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>HSD17B1</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs201739205</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">aggtgatatc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agcccagagc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">13</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">18</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−3</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">B</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">breast cancer</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B139-ijms-21-01045" ref-type="bibr">139</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs748743528</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gcaggtgata</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>caagcccaga</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>28</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>biomarker of the atherogenesis slowed down by drug IMM-H007</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B140-ijms-21-01045" ref-type="bibr">140</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs779674159</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>agcaggtgat</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tcaagcccag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>35</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>18</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1282820277</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cgaagcaggt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>atatcaagcc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>accelerated atherogenesis</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B141-ijms-21-01045" ref-type="bibr">141</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs755636251</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggcgaagcag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgatatcaag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>0.05</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>D</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1332869256</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gggcgaagca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gtgatatcaa</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td rowspan="8" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>MLH1</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs63750527</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tacaacaaag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ggacttcaga</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">11</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−3</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">B</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">nonpolyposis colon cancer</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B15-ijms-21-01045" ref-type="bibr">15</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs756099600</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">atacaacaaa</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a, c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gggacttcag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">11</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.05</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">D</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs753671152</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>caaaggggac</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tcagaaatgt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>improved DNA mismatch repair can slow down atherogenesis</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td rowspan="6" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B142-ijms-21-01045" ref-type="bibr">142</xref>
,<xref rid="B143-ijms-21-01045" ref-type="bibr">143</xref>
,<xref rid="B144-ijms-21-01045" ref-type="bibr">144</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1424963586</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gatacaacaa</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggggacttca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs752622244</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cttggagggg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>atacaacaaa</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs587778905</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gcttggaggg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>21bp</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>taaa</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>agaaatgtca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>19</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>accelerated atherogenesis</italic>
, <italic>which can be slowed down by restricting alcohol and red meat intake</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs34285587</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gggggataca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g<sup>*</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>caaaggggac</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>20</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs864622145</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggagggggat</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>caacaaaggg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>27</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td rowspan="6" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>RET</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs10900296</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gccggcgctt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g, c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cctcgcttca</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">30</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">90</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">20</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">pheochro-mocytoma</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B15-ijms-21-01045" ref-type="bibr">15</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs551321384</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>agccggcgct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>acctcgcttc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>30</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>75</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>dysregulated atheroprotector pentraxin-3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td rowspan="4" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B145-ijms-21-01045" ref-type="bibr">145</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1191017949</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cagccggcgc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tacctcgctt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>30</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>48</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1237152255</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tacctcgctt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ttacctcgct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>30</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>20</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>slowed down atherogenesis</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1372293149</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cgcagccggc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cttacctcgc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>30</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>16</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs10900297</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gcgcttacct</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gcttcagtcc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">30</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">17</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">pheochro-mocytoma</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B15-ijms-21-01045" ref-type="bibr">15</xref>
]</td>
</tr>
<tr><td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>ESR2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs35036378</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cctctcggtc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ttaaaaggaa</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−3</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">B</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ESR2-deficient pT1 tumor</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B146-ijms-21-01045" ref-type="bibr">146</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs766797386</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ttaaaaggaa</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>aaggggctta</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>accelerated calcification</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B147-ijms-21-01045" ref-type="bibr">147</xref>
,<xref rid="B148-ijms-21-01045" ref-type="bibr">148</xref>
]</td>
</tr>
<tr><td rowspan="7" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>DHFR</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs10168</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ctgcacaaat</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gggacgaggg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">15</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">resistance to methotrexate</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B149-ijms-21-01045" ref-type="bibr">149</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs750793297</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgcacaaatg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggacgagggg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>15</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td rowspan="6" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>DHFR deficit is a biomarker of accelerated atherogenesis</italic>
, <italic>which can be slowed down by smoking restriction</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td rowspan="6" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B150-ijms-21-01045" ref-type="bibr">150</xref>
,<xref rid="B151-ijms-21-01045" ref-type="bibr">151</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1464445339</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggggcggggc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>35bp</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>-</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggccacaatt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>15</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>170</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>44</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs766799008</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gcctgcacaa</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tggggacgag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>15</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>19</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs764508464</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gcctgcacaa</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>-</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tggggacgag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>15</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>37</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs754122321</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ctcgcctgca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>aaatggggac</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>15</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>25</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1328822484</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cctcgcctgc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>caaatgggga</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>15</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>58</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>25</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>Genes: <italic>ADH7</italic>
, alcohol dehydrogenase 7; <italic>HSD17B1</italic>
, hydroxysteroid (17-β) dehydrogenase 1; <italic>MLH1</italic>
, DNA mismatch repair protein Mlh1; <italic>RET</italic>
, Ret proto-oncogene; <italic>ESR2</italic>
, estrogen receptor 2 (β); <italic>DHFR</italic>
, dihydrofolate reductase. Deletions, <italic>MLH1</italic>
: 21bp = ggatacaacaaaggggacttc; <italic>DHFR</italic>
: 35bp = ctcgcctgcacaaatggggacgaggggggcggggc.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="ijms-21-01045-t007" orientation="portrait" position="float"><object-id pub-id-type="pii">ijms-21-01045-t007_Table 7</object-id>
<label>Table 7</label>
<caption><p>Atherogenesis-related candidate SNP markers within the gene promoters in which SNPs of TBP-sites are clinically linked with developmental disorders.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Gene</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">dbSNP ID [<xref rid="B12-ijms-21-01045" ref-type="bibr">12</xref>
] or [Ref]</th>
<th colspan="4" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">DNA, Genome Sequence</th>
<th colspan="6" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">K<sub>D</sub>
, nM</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Clinical Data or Candidate SNP Markers</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">AS</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Ref.</th>
</tr>
<tr><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5′ flank</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">WT</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">min</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3′ flank</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">WT</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">min</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Δ</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Z</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ρ</th>
</tr>
</thead>
<tbody><tr><td rowspan="17" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">COMT</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs370819229</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ccgcccgcca</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a*</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ggcctgcgtc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">211</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">2</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.05</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">D</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">dilated car-diomyopathy</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B15-ijms-21-01045" ref-type="bibr">15</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs901020754</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">acggcctgcg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ccgccaccgg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">243</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−3</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">B</td>
<td rowspan="15" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">slowed atherogenesis due to both estradiol (substrate) and 2-metho-xy estradiol (metabolite), which are athero-protective</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td rowspan="15" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B152-ijms-21-01045" ref-type="bibr">152</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs779542396</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgccacggcc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gcgtccgcca</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">243</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−3</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">B</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs45593642</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ccaccggaag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gccctcctaa</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">115</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs45581136</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gccaccggaa</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgccctccta</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">160</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−2</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs868447575</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgtccgccac</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a, t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ggaagcgccc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">74</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">17</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1369731401</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gcgtccgcca</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cggaagcgcc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">118</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs928358205</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ctgcgtccgc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">accggaagcg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">82</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">13</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1060501404</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gcctgcgtcc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ccaccggaag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">137</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1296549321</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ggcctgcgtc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gccaccggaa</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">152</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−3</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">B</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1333679310</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cacggcctgc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tccgccaccg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">110</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs981175339</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ccacggcctg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a, t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgtccgccac</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">113</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs748298389</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gccacggcct</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgtccgccac</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">70</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">18</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1428300695</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ccgccacggc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t*</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tgcgtccgcc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">117</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs562298402</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgcccgccac</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gcctgcgtcc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">150</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−3</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">B</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1249101844</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgcaccccgc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">15bp</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">-</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ccgccaccgg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">83</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">15</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs777650793</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gtccgccacc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gaagcgccct</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">187</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">82</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">15</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cardiovascu-lar disease</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B15-ijms-21-01045" ref-type="bibr">15</xref>
]</td>
</tr>
<tr><td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">TGFBR2</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs138010137</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgcagcgctg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gttgaagttg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">29</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">39</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">aortic thora-cic aneurysm & dissection</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B15-ijms-21-01045" ref-type="bibr">15</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1300366819</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgctgagttg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agttgagtga</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">29</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">53</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">16</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">unchecked T-cell activation accelerates atherogenesis</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B153-ijms-21-01045" ref-type="bibr">153</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1310294304</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agcgctgagt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gaagttgagt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">29</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">11</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">17</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">hypertension accelerates atherogenesis</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B154-ijms-21-01045" ref-type="bibr">154</xref>
]</td>
</tr>
<tr><td rowspan="12" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">FGFR2</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs886046768</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agagcgcggt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gagagccgag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">115</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">31</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">22</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cranio-synostosis</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B15-ijms-21-01045" ref-type="bibr">15</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1212347974</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tggaggagag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gcggtggaga</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">115</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">99</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−2</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td>
<td rowspan="6" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">accelerated atherogenesis that can be slowed down by heparin-derived oligo-saccharide</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td rowspan="9" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B155-ijms-21-01045" ref-type="bibr">155</xref>
,<xref rid="B156-ijms-21-01045" ref-type="bibr">156</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1027484343</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ctggaggaga</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t*</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgcggtggag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">115</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">101</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−2</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1226640384</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ggctggagga</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agcgcggtgg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">115</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">99</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−2</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1189849606</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gcggctggag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agagcgcggt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">115</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">48</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">17</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs971411400</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">atggtggtaa</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t*</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agtcatcctg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">13</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">11</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−2</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs778187292</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cctgtatggt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gtaacagtca</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">13</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">7</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1377663539</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gggcggcggc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ggaggagagc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">115</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">139</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−2</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">slowed atherogenesis</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs751951199</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">aatcgcctgt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tggtggtaac</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">13</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">30</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">13</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−6</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs757648006</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tcttaatcgc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tgtatggtgg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">13</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">17</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10<sup>−2</sup>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">rs387906677</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">atcgcctgta</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">t</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">g</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">ggtggtaaca</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">13</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">27</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">11</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">10<sup>−6</sup>
</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">A</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">bent bone dysplasia</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B15-ijms-21-01045" ref-type="bibr">15</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>Genes: <italic>COMT</italic>
, catechol-O-methyltransferase; <italic>TGFBR2</italic>
, transforming growth factor beta receptor 2; <italic>FGFR2</italic>
, fibroblast growth factor receptor 2 (synonyms: keratinocyte growth factor receptor, bacteria-expressed kinase). Deletions, <italic>COMT</italic>
: 15bp = ccgccacggcctgcg.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="ijms-21-01045-t008" orientation="portrait" position="float"><object-id pub-id-type="pii">ijms-21-01045-t008_Table 8</object-id>
<label>Table 8</label>
<caption><p>Atherogenesis-related candidate SNP markers within promoters of the human protein-coding genes related to the maintenance of mitochondrial genome integrity.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Gene</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">dbSNP ID [<xref rid="B12-ijms-21-01045" ref-type="bibr">12</xref>
] or [Ref]</th>
<th colspan="4" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">DNA, Genome Sequence</th>
<th colspan="6" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">K<sub>D</sub>
, nM</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Clinical Data or Candidate SNP Markers</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">AS</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Ref.</th>
</tr>
<tr><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5′ flank</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">WT</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">min</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3′ flank</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">WT</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">min</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Δ</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Z</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ρ</th>
</tr>
</thead>
<tbody><tr><td rowspan="29" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>POLG</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs776506626</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gaagcgctgg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tatttaccag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>8</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td rowspan="6" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>accelerated atherogenesis</italic>
, <italic>which can be slowed down by antioxidant MitoQ</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td rowspan="29" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B158-ijms-21-01045" ref-type="bibr">158</xref>
,<xref rid="B159-ijms-21-01045" ref-type="bibr">159</xref>
,<xref rid="B160-ijms-21-01045" ref-type="bibr">160</xref>
,<xref rid="B161-ijms-21-01045" ref-type="bibr">161</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs142347031</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gagcgcttac</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>aatgcagttt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs888362291</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggacaccatg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gcatgcacat</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>41</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>53</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1460331646</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cctggacacc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgagcatgca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>41</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>53</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs760935752</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cgtttcctgg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>caccatgagc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>41</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>53</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1266453407:g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ttggcggccc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cctattggtc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>24</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>30</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1266453407:a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ttggcggccc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cctattggtc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>24</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>20</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td rowspan="23" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>slowed atherogenesis</italic>
, <italic>while fructose-rich diet can accelerate mitochondrial DNA damage as atherogenic nutrition</italic>
, <italic>as can alcohol</italic>
, <italic>the effect of which could be reversed by green tea</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1257127556</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ccctcctatt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gtcgcgctgg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>24</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>22</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1210506140</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gccctcctat</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggtcgcgctg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>24</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>8</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>16</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs3176154</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tggcggccct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ctattggtcg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>24</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>14</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1024469208</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cctcacagac</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tcggcccctg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>35</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>29</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs747270023</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cccccaccct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t *</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>acagacctcg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>35</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>15</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs2307434</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cccccaccct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>-</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>acagacctcg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>35</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>21</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>8</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs983016336</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cttcccccac</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ctcacagacc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>35</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>25</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1318374817</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgattgtctt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ccccaccctc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>35</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>22</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs768707883</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gctcctgatt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tcttccccca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>35</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>20</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs974500502</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tctcctgctc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgattgtctt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>35</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>23</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>8</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs142460560</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgaagcgctg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>atatttacca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs769410130</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cagggctaag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t *</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>agcttccagc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>41</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>23</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs749799663</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggccatctca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggctaagcag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>41</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>33</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs769104909</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>acatggccat</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tcagggctaa</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>41</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>16</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>16</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1309549222</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gcatgcacat</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gccatctcag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>41</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>15</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs767895645</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ccatgagcat</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a *</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cacatggcca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>41</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>20</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs144068243</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>acaccatgag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>atgcacatgg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>41</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>18</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1206132846</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gtttcctgga</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>accatgagca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>41</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>28</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs766414821</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gcatgcgttt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ctggacacca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>41</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>35</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1333954036</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tggtgttcga</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gtggaggtct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>62</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>36</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs953495957</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gggggaggcc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
, <italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tacccgtggc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>62</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>43</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs961105910</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tccagccagt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>aaagaagcca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>16</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td rowspan="4" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>PGC1A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1254748756</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggactgtagt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>agacaggtgc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>18</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>18</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td rowspan="4" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>slowed atherogenesis</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B162-ijms-21-01045" ref-type="bibr">162</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1206245736</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgtttggatg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gtaaatgcag</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs772816414</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gtttggatgt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>taaatgcagg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B163-ijms-21-01045" ref-type="bibr">163</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1334636034</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gtgtttggat</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tgtaaatgca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td rowspan="14" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>TFAM</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1349790536</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gcccccatct</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ccgaccggat</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>18</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>25</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td rowspan="7" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>slowed atherogenesis</italic>
, <italic>while chronic alcohol intake upregulates TFAM as pro-atherogenic risk factor</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
<td rowspan="7" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B164-ijms-21-01045" ref-type="bibr">164</xref>
,<xref rid="B166-ijms-21-01045" ref-type="bibr">166</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1442727766</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cccgccccca</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ctaccgaccg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>18</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>25</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs756889032</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">catgtggggc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t *</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tgctgagtgc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>39</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>44</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>0.05</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>D</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs200473819</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ctccgaagca</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gtggggcgtg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>39</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>50</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1247582808</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tctccgaagc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tgtggggcgt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>39</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>50</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1468597986</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tcccgttact</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tttctgaact</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>9</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1036018716</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cctctcccgt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">actatttctg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs943871999</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cccatctacc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">accggatgtt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>18</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>14</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td rowspan="7" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>propensity to intimal thickening of an artery or vein related to accelerated atherogenesis</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
<td rowspan="7" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B165-ijms-21-01045" ref-type="bibr">165</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs571704530</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ccccatctac</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gaccggatgt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>18</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs911015016</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cccccatcta</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgaccggatg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>18</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>15</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1355238441</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tccgaagcat</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tggggcgtgc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>39</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>18</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1350851808</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tttctccgaa</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">catgtggggc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>39</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>34</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>0.05</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>D</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1448492458</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gatggcgttt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tccgaagcat</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>39</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>30</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1337389336</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gagcgatggc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a *</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tttctccgaa</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>39</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>32</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td rowspan="30" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>ATM</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs540204119</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgggagtagg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agctgcgtgg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>12</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>15</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td rowspan="14" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>accelerated atherogenesis</italic>
, <italic>which can be slowed down by anti-malarial drug chloroquine when p53 expression is normal</italic>
, <italic>as can mitochondria-targeted antioxidant MitoQ regardless of p53 level</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
<td rowspan="30" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B167-ijms-21-01045" ref-type="bibr">167</xref>
,<xref rid="B168-ijms-21-01045" ref-type="bibr">168</xref>
,<xref rid="B169-ijms-21-01045" ref-type="bibr">169</xref>
,<xref rid="B170-ijms-21-01045" ref-type="bibr">170</xref>
,<xref rid="B171-ijms-21-01045" ref-type="bibr">171</xref>
,<xref rid="B172-ijms-21-01045" ref-type="bibr">172</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs960185644</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">aagcgggagt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ggtagctgcg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>12</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>15</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs758371056</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gtatttagta</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ttttagtcag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1424898053</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tctctcgtat</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tagtactttt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>8</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1418169685</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ctctctcgta</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ttagtacttt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1439694580</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tgatctctct</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tcgtatttag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1461551448</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgggtccaat</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">accctccatc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>23</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>45</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>12</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1479937619</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agccgggtcc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ataaccctcc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>23</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>29</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1179356361</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ccagcatagc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gggtccaata</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>23</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>26</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>0.05</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>D</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1290688759</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ttcacagata</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">aaaatattaa</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>12</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs778072373</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gttcacagat</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">taaaatatta</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1162474448</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">aacggaagtt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">atatgatcat</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>14</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>12</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs951064054</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gccgcggttg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tactactttg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs773550815:g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gccgggtcca</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">taaccctcca</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>23</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>33</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↑</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs773550815:t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gccgggtcca</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">taaccctcca</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>23</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>21</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>0.05</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>D</italic>
</td>
<td rowspan="16" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>slowed atherogenesis</italic>
, <italic>while caffeine (ATM inhibi-tor) can post-prandially in-crease arterial stiffness for up to 3 h per cup of coffee as pro-atherogenic factor unlike mixtures of caffeine & catechins in tea as athero-protectors</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs976385260</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">acgacgaggg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a *</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gaagagggtg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>69</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>50</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1440912817</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gacgacgagg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cgaagagggt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>69</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>51</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1382260245</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ggaggacgac</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agggcgaaga</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>69</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>36</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>12</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs942361620</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gcggggagga</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gacgagggcg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>69</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>49</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1457610144</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gggcggggag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">acgacgaggg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>69</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>61</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>0.05</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>D</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs973002497</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agacttggag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">15bp</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">-</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gggcggggag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>69</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>56</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1222755392</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ggcggggatg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ggagggcggg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>69</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>53</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1242858005</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ggaggggcgg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gatgaggagg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>69</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>57</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1235571571</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gcgggagtag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tagctgcgtg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>12</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1254449321</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agcgggagta</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">a</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gtagctgcgt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>12</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>8</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs763320013</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ggtccaataa</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cctccatccc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>23</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>19</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs373553992</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tccttctgtc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">agcatagccg</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>23</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>16</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1397272250</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gacgttcaca</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">atataaaata</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>1</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1401830174</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tcgaaacagt</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ataacggaag</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs1310604038</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ccaccgccgc</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">g</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">c, t</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">gttgatacta</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>2</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>0.05</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>D</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>↓</italic>
</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>Genes: <italic>POLG</italic>
, catalytic subunit of DNA polymerase γ; <italic>PGC1A</italic>
, peroxisome proliferator-activated receptor γ coactivator 1α (synonym: PPARGC1A); <italic>TFAM</italic>
, mitochondrial transcription factor A; <italic>ATM</italic>
, ATM serine/threonine kinase. Deletions, <italic>ATM</italic>
: 15bp = gggcggggatgagga.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="ijms-21-01045-t009" orientation="portrait" position="float"><object-id pub-id-type="pii">ijms-21-01045-t009_Table 9</object-id>
<label>Table 9</label>
<caption><p>Atherogenesis-related candidate SNP markers within the promoters of miRNA genes associated with instability of the atherosclerotic plaque.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Gene</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">dbSNP ID [<xref rid="B12-ijms-21-01045" ref-type="bibr">12</xref>
] or [Ref]</th>
<th colspan="4" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">DNA, Genome Sequence</th>
<th colspan="6" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">K<sub>D</sub>
, nM</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Clinical Data or Candidate SNP Markers</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">AS</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Ref.</th>
</tr>
<tr><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5′ flank</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">WT</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">min</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3′ flank</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">WT</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">min</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Δ</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Z</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ρ</th>
</tr>
</thead>
<tbody><tr><td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>MIR10B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1388274194</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cagcgaccta</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cagcgaccta</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>14</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>4</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>14</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ABCA1 over-inhibition that accelerates atherogenesis</italic>
, <italic>which can be slowed down by dietary supplements of berberine</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B173-ijms-21-01045" ref-type="bibr">173</xref>
,<xref rid="B174-ijms-21-01045" ref-type="bibr">174</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs564940769</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cggcagcgac</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g *</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>taggtacctc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>14</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>25</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>8</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>slowed atherogenesis</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td rowspan="4" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>MIR21</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs752908264</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gtgacatctc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>atggctgtac</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>33</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>11</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td rowspan="4" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>reduced calcification of atherosclerotic plaque</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td rowspan="4" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B175-ijms-21-01045" ref-type="bibr">175</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs781007656</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>atcgtgacat</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tccatggctg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>33</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>20</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs368618785</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ctaccatcgt</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>acatctccat</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>33</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>20</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs772840282</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>actgtctgct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>gttttgccta</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>33</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>22</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>7</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td rowspan="7" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>MIR143</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs369969688</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cctctaacac</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ccttctcctg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>13</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td rowspan="4" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>prevented transformation of cells over-loaded with cholesterol in-to foam cells slows down atherogenesis</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
<td rowspan="4" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B176-ijms-21-01045" ref-type="bibr">176</xref>
,<xref rid="B177-ijms-21-01045" ref-type="bibr">177</xref>
,<xref rid="B178-ijms-21-01045" ref-type="bibr">178</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs142037609</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tcccctctaa</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>accccttctc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1035277319</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>caggtcccct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>taacacccct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>16</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs999653534</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ccaggtcccc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ctaacacccc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>14</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−2</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>C</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1369382070</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>caccccttct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>-</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cctggccagg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>22</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>accelerated atherogenesis</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B179-ijms-21-01045" ref-type="bibr">179</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs568314295</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ccctctaaca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>g</italic>
, <italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cccttctcct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>21</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs1033081876</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cccctctaac</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ccccttctcc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>17</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>44</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>16</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>A</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
</tr>
<tr><td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>MIR145</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs909856793</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cagctggtcc</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tagggacacg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>45</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>56</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic><</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−3</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">accelerated atherogenesis</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↑</td>
<td rowspan="3" align="center" valign="middle" style="border-bottom:solid thin" colspan="1">[<xref rid="B177-ijms-21-01045" ref-type="bibr">177</xref>
,<xref rid="B178-ijms-21-01045" ref-type="bibr">178</xref>
,<xref rid="B180-ijms-21-01045" ref-type="bibr">180</xref>
]</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs746241408</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>cttagggaca</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>a</italic>
, <italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>ggcggccttg</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>45</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>38</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>3</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>0.05</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>D</italic>
</td>
<td rowspan="2" align="center" valign="middle" style="border-bottom:solid thin" colspan="1"><italic>prevented transformation of cells over-loaded with cholesterol in-to foam cells slows down atherogenesis</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>rs778670319</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>tccttaggga</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>c</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>t</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>acggcggcct</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>45</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>32</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>></italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>5</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>10<sup>−6</sup>
</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>D</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">↓</td>
</tr>
</tbody>
</table>
</table-wrap>
</floats-group>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000625 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000625 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:7037642 |texte= Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:32033288" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |