Molecular pathobiology of scleritis and its therapeutic implications
Identifieur interne : 000859 ( Pmc/Corpus ); précédent : 000858; suivant : 000860Molecular pathobiology of scleritis and its therapeutic implications
Auteurs : Undurti N. DasSource :
- International Journal of Ophthalmology [ 2222-3959 ] ; 2020.
Abstract
Scleritis and other autoimmune diseases are characterized by an imbalance in the levels of pro-inflammatory and anti-inflammatory molecules with the balance tilted more towards the former due to the failure of recognition of self. The triggering of inflammatory process could be ascribed to the presence of cytoplasmic DNA/chromatin that leads to activation of cytosolic DNA-sensing cGAS-STING (cyclic GMP-AMP synthase linked to stimulator of interferon genes) pathway and enhanced expression of NF-κB that results in an increase in the production of pro-inflammatory bioactive lipids. Bioactive lipids gamma-linolenic acid (GLA), dihomo-GLA (DGLA), prostaglandin E1 (PGE1), prostacyclin (PGI2) and lipoxin A4, resolvins, protectins and maresins have anti-inflammatory actions, bind to DNA to render it non-antigenic and are decreased in autoimmune diseases. These results suggest that efforts designed to enhance the production of anti-inflammatory bioactive lipids may form a new approach to autoimmune diseases. Local injection or infusion of lipoxins, resolvins, protectins and maresins or their precursors such as arachidonic acid may be exploited in the prevention and management of autoimmune diseases including scleritis, uveitis and lupus/rheumatoid arthritis.
Url:
DOI: 10.18240/ijo.2020.01.23
PubMed: 31956585
PubMed Central: 6942945
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PMC:6942945Le document en format XML
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<affiliation><nlm:aff id="aff2"><addr-line>BioScience Research Centre and Department of Medicine, GVP Medical College and Hospital, Visakhapatnam 530048, India</addr-line>
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<front><div type="abstract" xml:lang="en"><p>Scleritis and other autoimmune diseases are characterized by an imbalance in the levels of pro-inflammatory and anti-inflammatory molecules with the balance tilted more towards the former due to the failure of recognition of self. The triggering of inflammatory process could be ascribed to the presence of cytoplasmic DNA/chromatin that leads to activation of cytosolic DNA-sensing cGAS-STING (cyclic GMP-AMP synthase linked to stimulator of interferon genes) pathway and enhanced expression of NF-κB that results in an increase in the production of pro-inflammatory bioactive lipids. Bioactive lipids gamma-linolenic acid (GLA), dihomo-GLA (DGLA), prostaglandin E1 (PGE1), prostacyclin (PGI2) and lipoxin A4, resolvins, protectins and maresins have anti-inflammatory actions, bind to DNA to render it non-antigenic and are decreased in autoimmune diseases. These results suggest that efforts designed to enhance the production of anti-inflammatory bioactive lipids may form a new approach to autoimmune diseases. Local injection or infusion of lipoxins, resolvins, protectins and maresins or their precursors such as arachidonic acid may be exploited in the prevention and management of autoimmune diseases including scleritis, uveitis and lupus/rheumatoid arthritis.</p>
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<pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Ophthalmol</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject>
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<title-group><article-title>Molecular pathobiology of scleritis and its therapeutic implications</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Das</surname>
<given-names>Undurti N</given-names>
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<xref ref-type="aff" rid="aff1">1</xref>
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<addr-line>UND Life Sciences, Battle Ground, WA 98604, USA</addr-line>
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<addr-line>BioScience Research Centre and Department of Medicine, GVP Medical College and Hospital, Visakhapatnam 530048, India</addr-line>
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<author-notes><corresp><bold>Correspondence to:</bold>
Undurti N Das. UND Life Sciences, 2221 NW 5<sup>th</sup>
St, Battle Ground, WA 98604, USA. <email>Undurti@hotmail.com</email>
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<volume>13</volume>
<issue>1</issue>
<fpage>163</fpage>
<lpage>175</lpage>
<history><date date-type="received"><day>10</day>
<month>5</month>
<year>2019</year>
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<date date-type="accepted"><day>12</day>
<month>9</month>
<year>2019</year>
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<permissions><copyright-statement>International Journal of Ophthalmology Press</copyright-statement>
<copyright-year>2020</copyright-year>
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<abstract><p>Scleritis and other autoimmune diseases are characterized by an imbalance in the levels of pro-inflammatory and anti-inflammatory molecules with the balance tilted more towards the former due to the failure of recognition of self. The triggering of inflammatory process could be ascribed to the presence of cytoplasmic DNA/chromatin that leads to activation of cytosolic DNA-sensing cGAS-STING (cyclic GMP-AMP synthase linked to stimulator of interferon genes) pathway and enhanced expression of NF-κB that results in an increase in the production of pro-inflammatory bioactive lipids. Bioactive lipids gamma-linolenic acid (GLA), dihomo-GLA (DGLA), prostaglandin E1 (PGE1), prostacyclin (PGI2) and lipoxin A4, resolvins, protectins and maresins have anti-inflammatory actions, bind to DNA to render it non-antigenic and are decreased in autoimmune diseases. These results suggest that efforts designed to enhance the production of anti-inflammatory bioactive lipids may form a new approach to autoimmune diseases. Local injection or infusion of lipoxins, resolvins, protectins and maresins or their precursors such as arachidonic acid may be exploited in the prevention and management of autoimmune diseases including scleritis, uveitis and lupus/rheumatoid arthritis.</p>
</abstract>
<kwd-group><kwd>scleritis</kwd>
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<kwd>bioactive lipids</kwd>
<kwd>inflammation</kwd>
<kwd>micronucleus</kwd>
<kwd>cytokines</kwd>
<kwd>resolution of inflammation</kwd>
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