Role of tumor and host autophagy in cancer metabolism
Identifieur interne : 000858 ( Pmc/Corpus ); précédent : 000857; suivant : 000859Role of tumor and host autophagy in cancer metabolism
Auteurs : Laura Poillet-Perez ; Eileen WhiteSource :
- Genes & Development [ 0890-9369 ] ; 2019.
Abstract
In this review, Poillet-Perez et al. discuss how understanding the underlying mechanisms by which autophagy functions in cancer can guide its development as an anticancer approach.
Url:
DOI: 10.1101/gad.325514.119
PubMed: 31160394
PubMed Central: 6546058
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PMC:6546058Le document en format XML
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<author><name sortKey="Poillet Perez, Laura" sort="Poillet Perez, Laura" uniqKey="Poillet Perez L" first="Laura" last="Poillet-Perez">Laura Poillet-Perez</name>
<affiliation><nlm:aff id="af1">Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="White, Eileen" sort="White, Eileen" uniqKey="White E" first="Eileen" last="White">Eileen White</name>
<affiliation><nlm:aff id="af1">Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af2">Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of tumor and host autophagy in cancer metabolism</title>
<author><name sortKey="Poillet Perez, Laura" sort="Poillet Perez, Laura" uniqKey="Poillet Perez L" first="Laura" last="Poillet-Perez">Laura Poillet-Perez</name>
<affiliation><nlm:aff id="af1">Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA;</nlm:aff>
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<author><name sortKey="White, Eileen" sort="White, Eileen" uniqKey="White E" first="Eileen" last="White">Eileen White</name>
<affiliation><nlm:aff id="af1">Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA;</nlm:aff>
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<affiliation><nlm:aff id="af2">Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA</nlm:aff>
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<series><title level="j">Genes & Development</title>
<idno type="ISSN">0890-9369</idno>
<idno type="eISSN">1549-5477</idno>
<imprint><date when="2019">2019</date>
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<front><div type="abstract" xml:lang="en"><p>In this review, Poillet-Perez et al. discuss how understanding the underlying mechanisms by which autophagy functions in cancer can guide its development as an anticancer approach.</p>
</div>
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<pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Genes Dev</journal-id>
<journal-id journal-id-type="iso-abbrev">Genes Dev</journal-id>
<journal-id journal-id-type="hwp">genesdev</journal-id>
<journal-id journal-id-type="pmc">genesdev</journal-id>
<journal-id journal-id-type="publisher-id">GAD</journal-id>
<journal-title-group><journal-title>Genes & Development</journal-title>
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<issn pub-type="ppub">0890-9369</issn>
<issn pub-type="epub">1549-5477</issn>
<publisher><publisher-name>Cold Spring Harbor Laboratory Press</publisher-name>
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<article-id pub-id-type="medline">8711660</article-id>
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<article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>7</subject>
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<subj-group subj-group-type="hwp-journal-coll"><subject>4</subject>
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<subj-group subj-group-type="heading"><subject>Review</subject>
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<title-group><article-title>Role of tumor and host autophagy in cancer metabolism</article-title>
<alt-title alt-title-type="left-running">Poillet-Perez and White</alt-title>
<alt-title alt-title-type="right-running">Role of autophagy in cancer metabolism</alt-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Poillet-Perez</surname>
<given-names>Laura</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>White</surname>
<given-names>Eileen</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af2">2</xref>
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<aff id="af1"><label>1</label>
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA;</aff>
<aff id="af2"><label>2</label>
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA</aff>
<author-notes><corresp>Corresponding author: <email>epwhite@cinj.rutgers.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>1</day>
<month>6</month>
<year>2019</year>
</pub-date>
<volume>33</volume>
<issue>11-12</issue>
<fpage>610</fpage>
<lpage>619</lpage>
<permissions><copyright-statement><ext-link ext-link-type="uri" xlink:href="http://genesdev.cshlp.org/site/misc/terms.xhtml">© 2019 Poillet-Perez and White; Published by Cold Spring Harbor Laboratory Press</ext-link>
</copyright-statement>
<copyright-year>2019</copyright-year>
<license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see <ext-link ext-link-type="uri" xlink:href="http://genesdev.cshlp.org/site/misc/terms.xhtml">http://genesdev.cshlp.org/site/misc/terms.xhtml</ext-link>
). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>
.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="610.pdf"></self-uri>
<abstract abstract-type="precis"><p>In this review, Poillet-Perez et al. discuss how understanding the underlying mechanisms by which autophagy functions in cancer can guide its development as an anticancer approach.</p>
</abstract>
<abstract><p>Macroautophagy (referred to here as autophagy) degrades and recycles cytoplasmic constituents to sustain cellular and mammalian metabolism and survival during starvation. Deregulation of autophagy is involved in numerous diseases, such as cancer. Cancers up-regulate autophagy and depend on it for survival, growth, and malignancy in a tumor cell-autonomous fashion. Recently, it has become apparent that autophagy in host tissues as well as the tumor cells themselves contribute to tumor growth. Understanding how autophagy regulates metabolism and tumor growth has revealed new essential tumor nutrients, where they come from, and how they are supplied and used, which can now be targeted for cancer therapy.</p>
</abstract>
<kwd-group><kwd>autophagy</kwd>
<kwd>cancer</kwd>
<kwd>metabolism</kwd>
</kwd-group>
<funding-group><award-group id="funding-1"><funding-source><institution-wrap><institution>National Institutes of Health </institution>
<institution-id institution-id-type="open-funder-registry">10.13039/100000002</institution-id>
</institution-wrap>
</funding-source>
<award-id>R01CA163591</award-id>
</award-group>
<award-group id="funding-2"><funding-source>New Jersey Commission for Cancer Research</funding-source>
<award-id>DHFS16PPC034</award-id>
</award-group>
</funding-group>
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