Emerging role of γδ T cells in vaccine‐mediated protection from infectious diseases
Identifieur interne : 000787 ( Pmc/Checkpoint ); précédent : 000786; suivant : 000788Emerging role of γδ T cells in vaccine‐mediated protection from infectious diseases
Auteurs : Kathleen W. Dantzler ; Lauren De La Parte ; Prasanna JagannathanSource :
- Clinical & Translational Immunology [ 2050-0068 ] ; 2019.
Abstract
γδ T cells are fascinating cells that bridge the innate and adaptive immune systems. They have long been known to proliferate rapidly following infection; however, the identity of the specific γδ T cell subsets proliferating and the role of this expansion in protection from disease have only been explored more recently. Several recent studies have investigated γδ T‐cell responses to vaccines targeting infections such as
Url:
DOI: 10.1002/cti2.1072
PubMed: 31485329
PubMed Central: 6712516
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>γδ T cells are fascinating cells that bridge the innate and adaptive immune systems. They have long been known to proliferate rapidly following infection; however, the identity of the specific γδ T cell subsets proliferating and the role of this expansion in protection from disease have only been explored more recently. Several recent studies have investigated γδ T‐cell responses to vaccines targeting infections such as <italic>Mycobacterium</italic>
,<italic> Plasmodium</italic>
and influenza, and studies in animal models have provided further insight into the association of these responses with improved clinical outcomes. In this review, we examine the evidence for a role for γδ T cells in vaccine‐induced protection against various bacterial, protozoan and viral infections. We further discuss results suggesting potential mechanisms for protection, including cytokine‐mediated direct and indirect killing of infected cells, and highlight remaining open questions in the field. Finally, building on current efforts to integrate strategies targeting γδ T cells into immunotherapies for cancer, we discuss potential approaches to improve vaccines for infectious diseases by inducing γδ T‐cell activation and cytotoxicity.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Transl Immunology</journal-id>
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<title-group><article-title>Emerging role of γδ T cells in vaccine‐mediated protection from infectious diseases</article-title>
<alt-title alt-title-type="left-running-head">KW Dantzler <italic>et al</italic>
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<given-names>Kathleen W</given-names>
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<xref ref-type="aff" rid="cti21072-aff-0001"><sup>1</sup>
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<contrib id="cti21072-cr-0002" contrib-type="author"><name><surname>de la Parte</surname>
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<xref ref-type="aff" rid="cti21072-aff-0001"><sup>1</sup>
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<contrib id="cti21072-cr-0003" contrib-type="author" corresp="yes"><name><surname>Jagannathan</surname>
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<named-content content-type="country-part">CA</named-content>
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<author-notes><corresp id="correspondenceTo"><label>*</label>
<bold>Correspondence</bold>
<break></break>
P Jagannathan, Department of Medicine, Stanford University, 300 Pasteur Drive, Lane Building, Suite L154, Stanford, CA 94305, USA.<break></break>
E‐mail: <email>prasj@stanford.edu</email>
<break></break>
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<pub-date pub-type="epub"><day>28</day>
<month>8</month>
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<month>4</month>
<year>2019</year>
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<date date-type="rev-recd"><day>04</day>
<month>7</month>
<year>2019</year>
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<date date-type="accepted"><day>14</day>
<month>7</month>
<year>2019</year>
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<permissions><pmc-comment> © 2019 Australian and New Zealand Society for Immunology Inc. </pmc-comment>
<copyright-statement content-type="article-copyright">© 2019 The Authors. <italic>Clinical & Translational Immunology</italic>
published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology Inc.</copyright-statement>
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<abstract id="cti21072-abs-0001"><title>Abstract</title>
<p>γδ T cells are fascinating cells that bridge the innate and adaptive immune systems. They have long been known to proliferate rapidly following infection; however, the identity of the specific γδ T cell subsets proliferating and the role of this expansion in protection from disease have only been explored more recently. Several recent studies have investigated γδ T‐cell responses to vaccines targeting infections such as <italic>Mycobacterium</italic>
,<italic> Plasmodium</italic>
and influenza, and studies in animal models have provided further insight into the association of these responses with improved clinical outcomes. In this review, we examine the evidence for a role for γδ T cells in vaccine‐induced protection against various bacterial, protozoan and viral infections. We further discuss results suggesting potential mechanisms for protection, including cytokine‐mediated direct and indirect killing of infected cells, and highlight remaining open questions in the field. Finally, building on current efforts to integrate strategies targeting γδ T cells into immunotherapies for cancer, we discuss potential approaches to improve vaccines for infectious diseases by inducing γδ T‐cell activation and cytotoxicity.</p>
</abstract>
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<funding-group><award-group><funding-source>Pilot Project Grant</funding-source>
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