Immunoadsorption and autologous transplantation for life-threatening primary antiphospholipid syndrome
Identifieur interne : 000695 ( Pmc/Checkpoint ); précédent : 000694; suivant : 000696Immunoadsorption and autologous transplantation for life-threatening primary antiphospholipid syndrome
Auteurs : Anne Angelillo-Scherrer ; Behrouz Mansouri Taleghani ; Frauke Förger ; Gabriela M. Baerlocher ; Thomas Pabst ; Alexander Pöllinger ; Yara Banz ; Thomas Geiser [Suisse] ; Johanna A. Kremer Hovinga ; Alicia RovSource :
- Blood Advances [ 2473-9529 ] ; 2019.
Abstract
Reduction of APL antibodies by immunoadsorption may be a lifesaving therapy for the management of DAH with high titer of APL antibodies. Autologous HSCT may be a valid treatment option in patients with primary APS and no response to standard immunosuppressive therapy.
Url:
DOI: 10.1182/bloodadvances.2019000465
PubMed: 31506284
PubMed Central: 6737408
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immunoadsorption and autologous transplantation for life-threatening primary antiphospholipid syndrome</title>
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<affiliation><nlm:aff id="aff2">Department for BioMedical Research,</nlm:aff>
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<wicri:noCountry code="subfield">Bern University Hospital</wicri:noCountry>
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<wicri:noCountry code="subfield">Bern University Hospital</wicri:noCountry>
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<author><name sortKey="Pollinger, Alexander" sort="Pollinger, Alexander" uniqKey="Pollinger A" first="Alexander" last="Pöllinger">Alexander Pöllinger</name>
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<wicri:noCountry code="subfield">Bern University Hospital</wicri:noCountry>
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<wicri:noCountry code="subfield">Bern University Hospital</wicri:noCountry>
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<author><name sortKey="Rov, Alicia" sort="Rov, Alicia" uniqKey="Rov A" first="Alicia" last="Rov">Alicia Rov</name>
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<wicri:noCountry code="subfield">Bern University Hospital</wicri:noCountry>
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<series><title level="j">Blood Advances</title>
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<front><div type="abstract" xml:lang="en"><title>Key Points</title>
<p><list list-type="bullet"><list-item><p>Reduction of APL antibodies by immunoadsorption may be a lifesaving therapy for the management of DAH with high titer of APL antibodies.</p>
</list-item>
<list-item><p>Autologous HSCT may be a valid treatment option in patients with primary APS and no response to standard immunosuppressive therapy.</p>
</list-item>
</list>
</p>
</div>
</front>
</TEI>
<pmc article-type="case-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood Adv</journal-id>
<journal-id journal-id-type="iso-abbrev">Blood Adv</journal-id>
<journal-id journal-id-type="hwp">bloodoa</journal-id>
<journal-id journal-id-type="pmc">Blood Adv</journal-id>
<journal-id journal-id-type="publisher-id">Blood Advances</journal-id>
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<issn pub-type="ppub">2473-9529</issn>
<issn pub-type="epub">2473-9537</issn>
<publisher><publisher-name>American Society of Hematology</publisher-name>
<publisher-loc>Washington, DC</publisher-loc>
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<article-id pub-id-type="pmc">6737408</article-id>
<article-id pub-id-type="publisher-id">2019/ADV2019000465</article-id>
<article-id pub-id-type="doi">10.1182/bloodadvances.2019000465</article-id>
<article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>1</subject>
<subject>20</subject>
<subject>29</subject>
<subject>31</subject>
</subj-group>
<subj-group subj-group-type="heading"><subject>Exceptional Case Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Immunoadsorption and autologous transplantation for life-threatening primary antiphospholipid syndrome</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-2872-4863</contrib-id>
<name><surname>Angelillo-Scherrer</surname>
<given-names>Anne</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mansouri Taleghani</surname>
<given-names>Behrouz</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
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<contrib contrib-type="author"><name><surname>Förger</surname>
<given-names>Frauke</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baerlocher</surname>
<given-names>Gabriela M.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pabst</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pöllinger</surname>
<given-names>Alexander</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Banz</surname>
<given-names>Yara</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Geiser</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-1300-7135</contrib-id>
<name><surname>Kremer Hovinga</surname>
<given-names>Johanna A.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rovó</surname>
<given-names>Alicia</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<aff id="aff1"><label>1</label>
Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital,</aff>
<aff id="aff2"><label>2</label>
Department for BioMedical Research,</aff>
<aff id="aff3"><label>3</label>
Department of Rheumatology, Immunology, Allergology, Inselspital, Bern University Hospital,</aff>
<aff id="aff4"><label>4</label>
Department of Medical Oncology, Inselspital, Bern University Hospital,</aff>
<aff id="aff5"><label>5</label>
Department of Diagnostic, Interventional and Pediatrics Radiology, Bern University Hospital,</aff>
<aff id="aff6"><label>6</label>
Institute of Pathology, and</aff>
<aff id="aff7"><label>7</label>
Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland</aff>
</contrib-group>
<pub-date pub-type="collection"><day>10</day>
<month>9</month>
<year>2019</year>
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<pub-date pub-type="epub"><day>10</day>
<month>9</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>10</day>
<month>9</month>
<year>2019</year>
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<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the . </pmc-comment>
<volume>3</volume>
<issue>17</issue>
<fpage>2664</fpage>
<lpage>2667</lpage>
<history><date date-type="received"><day>19</day>
<month>5</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>23</day>
<month>7</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© 2019 by The American Society of Hematology</copyright-statement>
<copyright-year>2019</copyright-year>
<ali:free_to_read></ali:free_to_read>
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<self-uri xlink:title="pdf" xlink:href="advancesADV2019000465.pdf"></self-uri>
<abstract abstract-type="executive-summary"><title>Key Points</title>
<p><list list-type="bullet"><list-item><p>Reduction of APL antibodies by immunoadsorption may be a lifesaving therapy for the management of DAH with high titer of APL antibodies.</p>
</list-item>
<list-item><p>Autologous HSCT may be a valid treatment option in patients with primary APS and no response to standard immunosuppressive therapy.</p>
</list-item>
</list>
</p>
</abstract>
<counts><page-count count="4"></page-count>
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<affiliations><list><country><li>Suisse</li>
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<region><li>Canton de Berne</li>
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<settlement><li>Berne</li>
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<tree><noCountry><name sortKey="Angelillo Scherrer, Anne" sort="Angelillo Scherrer, Anne" uniqKey="Angelillo Scherrer A" first="Anne" last="Angelillo-Scherrer">Anne Angelillo-Scherrer</name>
<name sortKey="Baerlocher, Gabriela M" sort="Baerlocher, Gabriela M" uniqKey="Baerlocher G" first="Gabriela M." last="Baerlocher">Gabriela M. Baerlocher</name>
<name sortKey="Banz, Yara" sort="Banz, Yara" uniqKey="Banz Y" first="Yara" last="Banz">Yara Banz</name>
<name sortKey="Forger, Frauke" sort="Forger, Frauke" uniqKey="Forger F" first="Frauke" last="Förger">Frauke Förger</name>
<name sortKey="Kremer Hovinga, Johanna A" sort="Kremer Hovinga, Johanna A" uniqKey="Kremer Hovinga J" first="Johanna A." last="Kremer Hovinga">Johanna A. Kremer Hovinga</name>
<name sortKey="Mansouri Taleghani, Behrouz" sort="Mansouri Taleghani, Behrouz" uniqKey="Mansouri Taleghani B" first="Behrouz" last="Mansouri Taleghani">Behrouz Mansouri Taleghani</name>
<name sortKey="Pabst, Thomas" sort="Pabst, Thomas" uniqKey="Pabst T" first="Thomas" last="Pabst">Thomas Pabst</name>
<name sortKey="Pollinger, Alexander" sort="Pollinger, Alexander" uniqKey="Pollinger A" first="Alexander" last="Pöllinger">Alexander Pöllinger</name>
<name sortKey="Rov, Alicia" sort="Rov, Alicia" uniqKey="Rov A" first="Alicia" last="Rov">Alicia Rov</name>
</noCountry>
<country name="Suisse"><region name="Canton de Berne"><name sortKey="Geiser, Thomas" sort="Geiser, Thomas" uniqKey="Geiser T" first="Thomas" last="Geiser">Thomas Geiser</name>
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