Lifetime Pesticide Use and Antinuclear Antibodies in Male Farmers From the Agricultural Health Study
Identifieur interne : 000636 ( Pmc/Checkpoint ); précédent : 000635; suivant : 000637Lifetime Pesticide Use and Antinuclear Antibodies in Male Farmers From the Agricultural Health Study
Auteurs : Christine G. Parks [États-Unis] ; Aline De Souza Espindola Santos [Brésil] ; Catherine C. Lerro [États-Unis] ; Curt T. Dellavalle [États-Unis] ; Mary H. Ward [États-Unis] ; Michael C. Alavanja [États-Unis] ; Sonja I. Berndt [États-Unis] ; Laura E. Beane Freeman [États-Unis] ; Dale P. Sandler [États-Unis] ; Jonathan N. Hofmann [États-Unis]Source :
- Frontiers in Immunology [ 1664-3224 ] ; 2019.
Abstract
Farming and pesticide use have been associated with systemic autoimmune diseases, and while certain organochlorine insecticides and other pesticides are suspected to influence risk, the role of specific pesticides in the development of systemic autoimmunity is not known. We measured serum antinuclear autoantibodies (ANA) by immunofluorescence on Hep-2 cells in 668 male farmers in the study of Biomarkers of Exposure and Effect in Agriculture (BEEA; 2010–2013), an Agricultural Health Study (AHS) subcohort. We examined ANA in relation to lifetime use of 46 pesticides first reported at AHS enrollment (1993–1997) and updated at intervals through BEEA enrollment. Odds ratios (OR) and 95% confidence intervals (CI) were estimated after adjusting for age, state, education, season of blood draw, current pesticide use, and correlated pesticides. Having ANA antibodies (3 or 4+ intensity at a 1:80 dilution, 21% of study participants) was associated with a reported history of seeking medical care due to exposure to pesticides (OR 2.15; 95%CI 1.17, 3.95), use of the fumigant methyl bromide (OR 3.16; 95%CI 1.05, 9.5), and use of petroleum oil/distillates (OR 1.50; 95%CI 1.00, 2.25). Using a higher threshold (3 or 4+ at a 1:160 dilution, 9%) ANA positivity was associated with the carbamate insecticide aldicarb (OR 4.82; 95%CI 1.33, 17.5) and greater combined use of four cyclodiene organochlorine insecticides (top tertile of intensity-weighted lifetime days vs. no use; OR T3 3.20; 95%CI 1.10, 9.27). By contrast, greater use of non-cyclodiene organochlorine insecticides was inversely associated with ANA (1:80 dilution 3 or 4+, OR T3 0.24; 95%CI 0.08, 0.72). Specific autoantibodies (to extractable nuclear antigens and anti-dsDNA), measured on those with ANA detected at the 1:80 dilution 3 or 4+, were seen in 15 individuals (2%), and were associated with use of two or more cyclodiene organochlorine insecticides and several other pesticides (e.g., carbofuran, ethylene dibromide). These findings suggest that specific pesticide exposures may have long-term effects on ANA prevalence and support the hypothesis that certain organochlorine insecticides may increase the risk of developing systemic autoimmunity.
Url:
DOI: 10.3389/fimmu.2019.01476
PubMed: 31354699
PubMed Central: 6637299
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Berndt</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beane Freeman, Laura E" sort="Beane Freeman, Laura E" uniqKey="Beane Freeman L" first="Laura E." last="Beane Freeman">Laura E. Beane Freeman</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale P." last="Sandler">Dale P. Sandler</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park</institution>,<addr-line>Durham, NC</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofmann, Jonathan N" sort="Hofmann, Jonathan N" uniqKey="Hofmann J" first="Jonathan N." last="Hofmann">Jonathan N. Hofmann</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Immunology</title><idno type="eISSN">1664-3224</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Farming and pesticide use have been associated with systemic autoimmune diseases, and while certain organochlorine insecticides and other pesticides are suspected to influence risk, the role of specific pesticides in the development of systemic autoimmunity is not known. We measured serum antinuclear autoantibodies (ANA) by immunofluorescence on Hep-2 cells in 668 male farmers in the study of Biomarkers of Exposure and Effect in Agriculture (BEEA; 2010–2013), an Agricultural Health Study (AHS) subcohort. We examined ANA in relation to lifetime use of 46 pesticides first reported at AHS enrollment (1993–1997) and updated at intervals through BEEA enrollment. Odds ratios (OR) and 95% confidence intervals (CI) were estimated after adjusting for age, state, education, season of blood draw, current pesticide use, and correlated pesticides. Having ANA antibodies (3 or 4+ intensity at a 1:80 dilution, 21% of study participants) was associated with a reported history of seeking medical care due to exposure to pesticides (OR 2.15; 95%CI 1.17, 3.95), use of the fumigant methyl bromide (OR 3.16; 95%CI 1.05, 9.5), and use of petroleum oil/distillates (OR 1.50; 95%CI 1.00, 2.25). Using a higher threshold (3 or 4+ at a 1:160 dilution, 9%) ANA positivity was associated with the carbamate insecticide aldicarb (OR 4.82; 95%CI 1.33, 17.5) and greater combined use of four cyclodiene organochlorine insecticides (top tertile of intensity-weighted lifetime days vs. no use; OR <sub>T3</sub> 3.20; 95%CI 1.10, 9.27). By contrast, greater use of non-cyclodiene organochlorine insecticides was inversely associated with ANA (1:80 dilution 3 or 4+, OR <sub>T3</sub> 0.24; 95%CI 0.08, 0.72). Specific autoantibodies (to extractable nuclear antigens and anti-dsDNA), measured on those with ANA detected at the 1:80 dilution 3 or 4+, were seen in 15 individuals (2%), and were associated with use of two or more cyclodiene organochlorine insecticides and several other pesticides (e.g., carbofuran, ethylene dibromide). These findings suggest that specific pesticide exposures may have long-term effects on ANA prevalence and support the hypothesis that certain organochlorine insecticides may increase the risk of developing systemic autoimmunity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gold, Ls" uniqKey="Gold L">LS Gold</name></author><author><name sortKey="Ward, Mh" uniqKey="Ward M">MH Ward</name></author><author><name sortKey="Dosemeci, M" uniqKey="Dosemeci M">M Dosemeci</name></author><author><name sortKey="De Roos, Aj" uniqKey="De Roos A">AJ De Roos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lundberg, I" uniqKey="Lundberg I">I Lundberg</name></author><author><name sortKey="Alfredsson, L" uniqKey="Alfredsson L">L Alfredsson</name></author><author><name sortKey="Plato, N" uniqKey="Plato N">N Plato</name></author><author><name sortKey="Sverdrup, B" uniqKey="Sverdrup B">B 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Immunol</journal-id><journal-id journal-id-type="iso-abbrev">Front Immunol</journal-id><journal-id journal-id-type="publisher-id">Front. Immunol.</journal-id><journal-title-group><journal-title>Frontiers in Immunology</journal-title></journal-title-group><issn pub-type="epub">1664-3224</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31354699</article-id><article-id pub-id-type="pmc">6637299</article-id><article-id pub-id-type="doi">10.3389/fimmu.2019.01476</article-id><article-categories><subj-group subj-group-type="heading"><subject>Immunology</subject><subj-group><subject>Original Research</subject></subj-group></subj-group></article-categories><title-group><article-title>Lifetime Pesticide Use and Antinuclear Antibodies in Male Farmers From the Agricultural Health Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Parks</surname><given-names>Christine G.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="c001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/306573/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Santos</surname><given-names>Aline de Souza Espindola</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/645753/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Lerro</surname><given-names>Catherine C.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>DellaValle</surname><given-names>Curt T.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ward</surname><given-names>Mary H.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Alavanja</surname><given-names>Michael C.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Berndt</surname><given-names>Sonja I.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Beane Freeman</surname><given-names>Laura E.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sandler</surname><given-names>Dale P.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hofmann</surname><given-names>Jonathan N.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/731519/overview"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park</institution>,<addr-line>Durham, NC</addr-line>,<country>United States</country></aff><aff id="aff2"><sup>2</sup><institution>Institute in Collective Health Studies, Federal University of Rio de Janeiro</institution>,<addr-line>Rio de Janeiro</addr-line>,<country>Brazil</country></aff><aff id="aff3"><sup>3</sup><institution>Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>United States</country></aff><aff id="aff4"><sup>4</sup><institution>All of Us Research Program, Office of the Director, National Institutes of Health</institution>,<addr-line>Bethesda, MD</addr-line>,<country>United States</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Kenneth Michael Pollard, The Scripps Research Institute, United States</p></fn><fn fn-type="edited-by"><p>Reviewed by: Ian P. Giles, University College London, United Kingdom; Marvin Fritzler, University of Calgary, Canada</p></fn><corresp id="c001">*Correspondence: Christine G. Parks <email>parks1@mail.nih.gov</email></corresp><fn fn-type="other" id="fn001"><p>This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology</p></fn></author-notes><pub-date pub-type="epub"><day>11</day><month>7</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>10</volume><elocation-id>1476</elocation-id><history><date date-type="received"><day>29</day><month>3</month><year>2019</year></date><date date-type="accepted"><day>13</day><month>6</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2019 Parks, Santos, Lerro, DellaValle, Ward, Alavanja, Berndt, Beane Freeman, Sandler and Hofmann.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Parks, Santos, Lerro, DellaValle, Ward, Alavanja, Berndt, Beane Freeman, Sandler and Hofmann</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Farming and pesticide use have been associated with systemic autoimmune diseases, and while certain organochlorine insecticides and other pesticides are suspected to influence risk, the role of specific pesticides in the development of systemic autoimmunity is not known. We measured serum antinuclear autoantibodies (ANA) by immunofluorescence on Hep-2 cells in 668 male farmers in the study of Biomarkers of Exposure and Effect in Agriculture (BEEA; 2010–2013), an Agricultural Health Study (AHS) subcohort. We examined ANA in relation to lifetime use of 46 pesticides first reported at AHS enrollment (1993–1997) and updated at intervals through BEEA enrollment. Odds ratios (OR) and 95% confidence intervals (CI) were estimated after adjusting for age, state, education, season of blood draw, current pesticide use, and correlated pesticides. Having ANA antibodies (3 or 4+ intensity at a 1:80 dilution, 21% of study participants) was associated with a reported history of seeking medical care due to exposure to pesticides (OR 2.15; 95%CI 1.17, 3.95), use of the fumigant methyl bromide (OR 3.16; 95%CI 1.05, 9.5), and use of petroleum oil/distillates (OR 1.50; 95%CI 1.00, 2.25). Using a higher threshold (3 or 4+ at a 1:160 dilution, 9%) ANA positivity was associated with the carbamate insecticide aldicarb (OR 4.82; 95%CI 1.33, 17.5) and greater combined use of four cyclodiene organochlorine insecticides (top tertile of intensity-weighted lifetime days vs. no use; OR <sub>T3</sub> 3.20; 95%CI 1.10, 9.27). By contrast, greater use of non-cyclodiene organochlorine insecticides was inversely associated with ANA (1:80 dilution 3 or 4+, OR <sub>T3</sub> 0.24; 95%CI 0.08, 0.72). Specific autoantibodies (to extractable nuclear antigens and anti-dsDNA), measured on those with ANA detected at the 1:80 dilution 3 or 4+, were seen in 15 individuals (2%), and were associated with use of two or more cyclodiene organochlorine insecticides and several other pesticides (e.g., carbofuran, ethylene dibromide). These findings suggest that specific pesticide exposures may have long-term effects on ANA prevalence and support the hypothesis that certain organochlorine insecticides may increase the risk of developing systemic autoimmunity.</p></abstract><kwd-group><kwd>epidemiology–analytic (risk factors)</kwd><kwd>autoantibodies</kwd><kwd>pesticides</kwd><kwd>occupational epidemiology</kwd><kwd>cohort study (or longitudinal study)</kwd></kwd-group><funding-group><award-group><funding-source id="cn001">National Institute of Environmental Health Sciences<named-content content-type="fundref-id">10.13039/100000066</named-content></funding-source><award-id rid="cn001">Z01-ES049030</award-id></award-group><award-group><funding-source id="cn002">National Cancer Institute<named-content content-type="fundref-id">10.13039/100000054</named-content></funding-source><award-id rid="cn002">Z01-CP010119</award-id></award-group></funding-group><counts><fig-count count="0"></fig-count><table-count count="5"></table-count><equation-count count="0"></equation-count><ref-count count="75"></ref-count><page-count count="13"></page-count><word-count count="10669"></word-count></counts></article-meta></front></pmc><affiliations><list><country><li>Brésil</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Parks, Christine G" sort="Parks, Christine G" uniqKey="Parks C" first="Christine G." last="Parks">Christine G. Parks</name></noRegion><name sortKey="Alavanja, Michael C" sort="Alavanja, Michael C" uniqKey="Alavanja M" first="Michael C." last="Alavanja">Michael C. Alavanja</name><name sortKey="Beane Freeman, Laura E" sort="Beane Freeman, Laura E" uniqKey="Beane Freeman L" first="Laura E." last="Beane Freeman">Laura E. Beane Freeman</name><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><name sortKey="Dellavalle, Curt T" sort="Dellavalle, Curt T" uniqKey="Dellavalle C" first="Curt T." last="Dellavalle">Curt T. Dellavalle</name><name sortKey="Hofmann, Jonathan N" sort="Hofmann, Jonathan N" uniqKey="Hofmann J" first="Jonathan N." last="Hofmann">Jonathan N. Hofmann</name><name sortKey="Lerro, Catherine C" sort="Lerro, Catherine C" uniqKey="Lerro C" first="Catherine C." last="Lerro">Catherine C. Lerro</name><name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale P." last="Sandler">Dale P. Sandler</name><name sortKey="Ward, Mary H" sort="Ward, Mary H" uniqKey="Ward M" first="Mary H." last="Ward">Mary H. Ward</name></country><country name="Brésil"><noRegion><name sortKey="Santos, Aline De Souza Espindola" sort="Santos, Aline De Souza Espindola" uniqKey="Santos A" first="Aline De Souza Espindola" last="Santos">Aline De Souza Espindola Santos</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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