“Iron free” zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis
Identifieur interne : 001017 ( Ncbi/Merge ); précédent : 001016; suivant : 001018“Iron free” zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis
Auteurs : Changping Zhang [République populaire de Chine] ; Zixuan Liu [République populaire de Chine] ; Yuhao Zhang [République populaire de Chine] ; Liang Ma [République populaire de Chine] ; Erqun Song [République populaire de Chine] ; Yang Song [République populaire de Chine]Source :
- Cell Death & Disease [ 2041-4889 ] ; 2020.
Abstract
Exposure to nanomaterials (NMs) is an emerging threat to human health, and the understanding of their intracellular behavior and related toxic effects is urgently needed. Ferroptosis is a newly discovered, iron-mediated cell death that is distinctive from apoptosis or other cell-death pathways. No evidence currently exists for the effect of “iron free” engineered NMs on ferroptosis. We showed by several approaches that (1) zinc oxide nanoparticles (ZnO NPs)-induced cell death involves ferroptosis; (2) ZnO NPs-triggered ferroptosis is associated with elevation of reactive oxygen species (ROS) and lipid peroxidation, along with depletion of glutathione (GSH) and downregulation of glutathione peroxidase 4 (GPx4); (3) ZnO NPs disrupt intracellular iron homeostasis by orchestrating iron uptake, storage and export; (4) p53 largely participates in ZnO NPs-induced ferroptosis; and (5) ZnO particle remnants and dissolved zinc ion both contribute to ferroptosis. In conclusion, our data provide a new mechanistic rationale for ferroptosis as a novel cell-death phenotype induced by engineered NMs.
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DOI: 10.1038/s41419-020-2384-5
PubMed: 32170066
PubMed Central: 7070056
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Chine</country><wicri:regionArea>Chongqing</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Zixuan" sort="Liu, Zixuan" uniqKey="Liu Z" first="Zixuan" last="Liu">Zixuan Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.263906.8</institution-id><institution>Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences,</institution><institution>Southwest University,</institution></institution-wrap>Chongqing, 400715 People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chongqing</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Yuhao" sort="Zhang, Yuhao" uniqKey="Zhang Y" first="Yuhao" last="Zhang">Yuhao Zhang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id 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China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chongqing</wicri:regionArea></affiliation></author><author><name sortKey="Song, Erqun" sort="Song, Erqun" uniqKey="Song E" first="Erqun" last="Song">Erqun Song</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.263906.8</institution-id><institution>Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences,</institution><institution>Southwest University,</institution></institution-wrap>Chongqing, 400715 People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chongqing</wicri:regionArea></affiliation></author><author><name sortKey="Song, Yang" sort="Song, Yang" uniqKey="Song Y" first="Yang" last="Song">Yang Song</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.263906.8</institution-id><institution>Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences,</institution><institution>Southwest University,</institution></institution-wrap>Chongqing, 400715 People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chongqing</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cell Death & Disease</title><idno type="eISSN">2041-4889</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Exposure to nanomaterials (NMs) is an emerging threat to human health, and the understanding of their intracellular behavior and related toxic effects is urgently needed. Ferroptosis is a newly discovered, iron-mediated cell death that is distinctive from apoptosis or other cell-death pathways. No evidence currently exists for the effect of “iron free” engineered NMs on ferroptosis. We showed by several approaches that (1) zinc oxide nanoparticles (ZnO NPs)-induced cell death involves ferroptosis; (2) ZnO NPs-triggered ferroptosis is associated with elevation of reactive oxygen species (ROS) and lipid peroxidation, along with depletion of glutathione (GSH) and downregulation of glutathione peroxidase 4 (GPx4); (3) ZnO NPs disrupt intracellular iron homeostasis by orchestrating iron uptake, storage and export; (4) p53 largely participates in ZnO NPs-induced ferroptosis; and (5) ZnO particle remnants and dissolved zinc ion both contribute to ferroptosis. In conclusion, our data provide a new mechanistic rationale for ferroptosis as a novel cell-death phenotype induced by engineered NMs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhao, F" uniqKey="Zhao F">F Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nel, A" uniqKey="Nel A">A Nel</name></author><author><name sortKey="Xia, T" uniqKey="Xia T">T Xia</name></author><author><name sortKey="Madler, L" uniqKey="Madler L">L Madler</name></author><author><name sortKey="Li, N" uniqKey="Li N">N Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dixon, Sj" uniqKey="Dixon S">SJ Dixon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dixon, Sj" uniqKey="Dixon S">SJ Dixon</name></author><author><name sortKey="Stockwell, Br" uniqKey="Stockwell B">BR Stockwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, Y" uniqKey="Xie Y">Y Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, Z" uniqKey="Shen Z">Z Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Se" uniqKey="Kim S">SE Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ou, W" uniqKey="Ou W">W Ou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szwed, M" uniqKey="Szwed M">M Szwed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gliga, Ar" uniqKey="Gliga A">AR Gliga</name></author><author><name sortKey="Skoglund, S" uniqKey="Skoglund S">S Skoglund</name></author><author><name sortKey="Wallinder, Io" uniqKey="Wallinder I">IO Wallinder</name></author><author><name sortKey="Fadeel, B" uniqKey="Fadeel B">B Fadeel</name></author><author><name sortKey="Karlsson, Hl" uniqKey="Karlsson H">HL Karlsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samet, Jm" uniqKey="Samet J">JM Samet</name></author><author><name sortKey="Dominici, F" uniqKey="Dominici F">F Dominici</name></author><author><name sortKey="Curriero, Fc" uniqKey="Curriero F">FC Curriero</name></author><author><name sortKey="Coursac, I" uniqKey="Coursac I">I Coursac</name></author><author><name sortKey="Zeger, Sl" uniqKey="Zeger S">SL Zeger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gojova, A" uniqKey="Gojova A">A Gojova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akhtar, Mj" uniqKey="Akhtar M">MJ Akhtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Bm" uniqKey="Johnson B">BM Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garciahevia, L" uniqKey="Garciahevia L">L Garcíahevia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Ws" uniqKey="Yang W">WS Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doll, S" uniqKey="Doll S">S Doll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kagan, Ve" uniqKey="Kagan V">VE Kagan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donovan, A" uniqKey="Donovan A">A Donovan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drakesmith, H" uniqKey="Drakesmith H">H Drakesmith</name></author><author><name sortKey="Nemeth, E" uniqKey="Nemeth E">E Nemeth</name></author><author><name sortKey="Ganz, T" uniqKey="Ganz T">T Ganz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marro, S" uniqKey="Marro S">S Marro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nemeth, E" uniqKey="Nemeth E">E Nemeth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleming, Re" uniqKey="Fleming R">RE Fleming</name></author><author><name sortKey="Ponka, P" uniqKey="Ponka P">P Ponka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eaton, Jw" uniqKey="Eaton J">JW Eaton</name></author><author><name sortKey="Qian, M" uniqKey="Qian M">M Qian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yagoda, N" uniqKey="Yagoda N">N Yagoda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dolma, S" uniqKey="Dolma S">S Dolma</name></author><author><name sortKey="Lessnick, Sl" uniqKey="Lessnick S">SL Lessnick</name></author><author><name sortKey="Hahn, Wc" uniqKey="Hahn W">WC Hahn</name></author><author><name sortKey="Stockwell, Br" uniqKey="Stockwell B">BR Stockwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Sj" uniqKey="Wang S">SJ Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author><author><name sortKey="Najafzadeh, M" uniqKey="Najafzadeh M">M Najafzadeh</name></author><author><name sortKey="Jacob, Bk" uniqKey="Jacob B">BK Jacob</name></author><author><name sortKey="Dhawan, A" uniqKey="Dhawan A">A Dhawan</name></author><author><name sortKey="Anderson, D" uniqKey="Anderson D">D Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, Kw" uniqKey="Ng K">KW Ng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roy, R" uniqKey="Roy R">R Roy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Setyawati, Mi" uniqKey="Setyawati M">MI Setyawati</name></author><author><name sortKey="Tay, Cy" uniqKey="Tay C">CY Tay</name></author><author><name sortKey="Leong, Dt" uniqKey="Leong D">DT Leong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stockwell, Br" uniqKey="Stockwell B">BR Stockwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ou, Y" uniqKey="Ou Y">Y Ou</name></author><author><name sortKey="Wang, Sj" uniqKey="Wang S">SJ Wang</name></author><author><name sortKey="Li, D" uniqKey="Li D">D Li</name></author><author><name sortKey="Chu, B" uniqKey="Chu B">B Chu</name></author><author><name sortKey="Gu, W" uniqKey="Gu W">W Gu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murphy, Me" uniqKey="Murphy M">ME Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Chang, Y" uniqKey="Chang Y">Y Chang</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moos, Pj" uniqKey="Moos P">PJ Moos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meeusen, Jw" uniqKey="Meeusen J">JW Meeusen</name></author><author><name sortKey="Tomasiewicz, H" uniqKey="Tomasiewicz H">H Tomasiewicz</name></author><author><name sortKey="Nowakowski, A" uniqKey="Nowakowski A">A Nowakowski</name></author><author><name sortKey="Petering, Dh" uniqKey="Petering D">DH Petering</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kao, Yy" uniqKey="Kao Y">YY Kao</name></author><author><name sortKey="Chen, Yc" uniqKey="Chen Y">YC Chen</name></author><author><name sortKey="Cheng, Tj" uniqKey="Cheng T">TJ Cheng</name></author><author><name sortKey="Chiung, Ym" uniqKey="Chiung Y">YM Chiung</name></author><author><name sortKey="Liu, Ps" uniqKey="Liu P">PS Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pasquet, J" uniqKey="Pasquet J">J Pasquet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xia, T" uniqKey="Xia T">T Xia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Ws" uniqKey="Yang W">WS Yang</name></author><author><name sortKey="Stockwell, Br" uniqKey="Stockwell B">BR Stockwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, Z" uniqKey="Shen Z">Z Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sadli, N" uniqKey="Sadli N">N Sadli</name></author><author><name sortKey="Barrow, Cj" uniqKey="Barrow C">CJ Barrow</name></author><author><name sortKey="Mcgee, S" uniqKey="Mcgee S">S McGee</name></author><author><name sortKey="Suphioglu, C" uniqKey="Suphioglu C">C Suphioglu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gazaryan, Ig" uniqKey="Gazaryan I">IG Gazaryan</name></author><author><name sortKey="Krasinskaya, Ip" uniqKey="Krasinskaya I">IP Krasinskaya</name></author><author><name sortKey="Kristal, Bs" uniqKey="Kristal B">BS Kristal</name></author><author><name sortKey="Brown, Am" uniqKey="Brown A">AM Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slepchenko, Kg" uniqKey="Slepchenko K">KG Slepchenko</name></author><author><name sortKey="Lu, Q" uniqKey="Lu Q">Q Lu</name></author><author><name sortKey="Li, Yv" uniqKey="Li Y">YV Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finney, La" uniqKey="Finney L">LA Finney</name></author><author><name sortKey="O Alloran, Tv" uniqKey="O Alloran T">TV O’Halloran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Cc" uniqKey="Huang C">CC Huang</name></author><author><name sortKey="Aronstam, Rs" uniqKey="Aronstam R">RS Aronstam</name></author><author><name sortKey="Chen, Dr" uniqKey="Chen D">DR Chen</name></author><author><name sortKey="Huang, Yw" uniqKey="Huang Y">YW Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, D" uniqKey="Guo D">D Guo</name></author><author><name sortKey="Du, Y" uniqKey="Du Y">Y Du</name></author><author><name sortKey="Wu, Q" uniqKey="Wu Q">Q Wu</name></author><author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name></author><author><name sortKey="Bi, H" uniqKey="Bi H">H Bi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vander Jagt, Ta" uniqKey="Vander Jagt T">TA Vander Jagt</name></author><author><name sortKey="Connor, Ja" uniqKey="Connor J">JA Connor</name></author><author><name sortKey="Weiss, Jh" uniqKey="Weiss J">JH Weiss</name></author><author><name sortKey="Shuttleworth, Cw" uniqKey="Shuttleworth C">CW Shuttleworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, R" uniqKey="Kang R">R Kang</name></author><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name></author><author><name sortKey="Tang, D" uniqKey="Tang D">D Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ostrakhovitch, Ea" uniqKey="Ostrakhovitch E">EA Ostrakhovitch</name></author><author><name sortKey="Cherian, Mg" uniqKey="Cherian M">MG Cherian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pagani, Ma" uniqKey="Pagani M">MA Pagani</name></author><author><name sortKey="Casamayor, A" uniqKey="Casamayor A">A Casamayor</name></author><author><name sortKey="Serrano, R" uniqKey="Serrano R">R Serrano</name></author><author><name sortKey="Atrian, S" uniqKey="Atrian S">S Atrian</name></author><author><name sortKey="Arino, J" uniqKey="Arino J">J Arino</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cell Death Dis</journal-id><journal-id journal-id-type="iso-abbrev">Cell Death Dis</journal-id><journal-title-group><journal-title>Cell Death & Disease</journal-title></journal-title-group><issn pub-type="epub">2041-4889</issn><publisher><publisher-name>Nature Publishing Group UK</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32170066</article-id><article-id pub-id-type="pmc">7070056</article-id><article-id pub-id-type="publisher-id">2384</article-id><article-id pub-id-type="doi">10.1038/s41419-020-2384-5</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>“Iron free” zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Changping</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Zixuan</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Yuhao</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Liang</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Song</surname><given-names>Erqun</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-7716-9216</contrib-id><name><surname>Song</surname><given-names>Yang</given-names></name><address><email>ysong@swu.edu.cn</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.263906.8</institution-id><institution>Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Food Science,</institution><institution>Southwest University,</institution></institution-wrap>Chongqing, 400715 People’s Republic of China</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.263906.8</institution-id><institution>Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences,</institution><institution>Southwest University,</institution></institution-wrap>Chongqing, 400715 People’s Republic of China</aff></contrib-group><pub-date pub-type="epub"><day>13</day><month>3</month><year>2020</year></pub-date><pub-date pub-type="pmc-release"><day>13</day><month>3</month><year>2020</year></pub-date><pub-date pub-type="collection"><month>3</month><year>2020</year></pub-date><volume>11</volume><issue>3</issue><elocation-id>183</elocation-id><history><date date-type="received"><day>11</day><month>11</month><year>2019</year></date><date date-type="rev-recd"><day>24</day><month>2</month><year>2020</year></date><date date-type="accepted"><day>25</day><month>2</month><year>2020</year></date></history><permissions><copyright-statement>© The Author(s) 2020</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold> This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>.</license-p></license></permissions><abstract id="Abs1"><p id="Par1">Exposure to nanomaterials (NMs) is an emerging threat to human health, and the understanding of their intracellular behavior and related toxic effects is urgently needed. Ferroptosis is a newly discovered, iron-mediated cell death that is distinctive from apoptosis or other cell-death pathways. No evidence currently exists for the effect of “iron free” engineered NMs on ferroptosis. We showed by several approaches that (1) zinc oxide nanoparticles (ZnO NPs)-induced cell death involves ferroptosis; (2) ZnO NPs-triggered ferroptosis is associated with elevation of reactive oxygen species (ROS) and lipid peroxidation, along with depletion of glutathione (GSH) and downregulation of glutathione peroxidase 4 (GPx4); (3) ZnO NPs disrupt intracellular iron homeostasis by orchestrating iron uptake, storage and export; (4) p53 largely participates in ZnO NPs-induced ferroptosis; and (5) ZnO particle remnants and dissolved zinc ion both contribute to ferroptosis. In conclusion, our data provide a new mechanistic rationale for ferroptosis as a novel cell-death phenotype induced by engineered NMs.</p></abstract><kwd-group kwd-group-type="npg-subject"><title>Subject terms</title><kwd>Biophysical chemistry</kwd><kwd>Stress signalling</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">https://doi.org/10.13039/501100001809</institution-id><institution>National Natural Science Foundation of China (National Science Foundation of China)</institution></institution-wrap></funding-source><award-id>21622704</award-id><award-id>31671881</award-id><award-id>21575118</award-id><principal-award-recipient><name><surname>Ma</surname><given-names>Liang</given-names></name><name><surname>Song</surname><given-names>Erqun</given-names></name><name><surname>Song</surname><given-names>Yang</given-names></name></principal-award-recipient></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2020</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Changping" sort="Zhang, Changping" uniqKey="Zhang C" first="Changping" last="Zhang">Changping Zhang</name></noRegion><name sortKey="Liu, Zixuan" sort="Liu, Zixuan" uniqKey="Liu Z" first="Zixuan" last="Liu">Zixuan Liu</name><name sortKey="Ma, Liang" sort="Ma, Liang" uniqKey="Ma L" first="Liang" last="Ma">Liang Ma</name><name sortKey="Song, Erqun" sort="Song, Erqun" uniqKey="Song E" first="Erqun" last="Song">Erqun Song</name><name sortKey="Song, Yang" sort="Song, Yang" uniqKey="Song Y" first="Yang" last="Song">Yang Song</name><name sortKey="Zhang, Yuhao" sort="Zhang, Yuhao" uniqKey="Zhang Y" first="Yuhao" last="Zhang">Yuhao Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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