Anticancer activities of chalcone flavokawain B from Alpinia pricei Hayata in human lung adenocarcinoma (A549) cells via induction of reactive oxygen species-mediated apoptotic and autophagic cell death.
Identifieur interne : 000501 ( Ncbi/Merge ); précédent : 000500; suivant : 000502Anticancer activities of chalcone flavokawain B from Alpinia pricei Hayata in human lung adenocarcinoma (A549) cells via induction of reactive oxygen species-mediated apoptotic and autophagic cell death.
Auteurs : You-Cheng Hseu [Taïwan] ; Yu-Chi Huang [Taïwan] ; Varadharajan Thiyagarajan [Taïwan] ; Dony Chacko Mathew [Taïwan] ; Kai-Yuan Lin [Taïwan] ; Ssu-Ching Chen [Taïwan] ; Jer-Yuh Liu [Taïwan] ; Li-Sung Hsu [Taïwan] ; Mei-Ling Li [Taïwan] ; Hsin-Ling Yang [Taïwan]Source :
- Journal of cellular physiology [ 1097-4652 ] ; 2019.
Abstract
Chalcones found in fruits and vegetables have promising cancer chemopreventive properties. This study attempts to identify the anticancer efficacies of chalcone flavokawain B (FKB) in the rhizomes of Alpinia pricei Hayata by examining key molecular events in non-small-cell lung cancer (A549) cells. Our results indicated that in human A549 cells, FKB (0-15 μg/ml) decreases cell viability and colony formation, dysregulates the Bax:B-cell lymphoma 2 ratio and increases apoptotic DNA fragmentation. Mitochondrial (caspase-9/-3 and poly ADP ribose polymerase [PARP]) signaling was found to be involved in FKB-induced apoptosis. In addition, FKB-induced reactive oxygen species (ROS) generation, and N-acetylcysteine attenuated FKB-induced apoptotic cell death. Moreover, FKB triggered autophagy, as evidenced by the improved acidic vesicular organelle formation, lipidated light chain 3 (microtubule-related light chain 3) accumulation, and ATG7 expression and the decreased mammalian target of rapamycin phosphorylation. Furthermore, FKB suppressed ROS-mediated ATG4B expression. Inhibiting autophagy using 3-methyladenine/chloroquine diminished FKB-induced cell death, indicating that autophagy is triggered as a death mechanism by FKB. In summary, FKB has a crucial role in the execution and propagation of ROS-mediated apoptotic and autophagic cell death of lung adenocarcinoma cells.
DOI: 10.1002/jcp.28375
PubMed: 30847898
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Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yu Chi" sort="Huang, Yu Chi" uniqKey="Huang Y" first="Yu-Chi" last="Huang">Yu-Chi Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Thiyagarajan, Varadharajan" sort="Thiyagarajan, Varadharajan" uniqKey="Thiyagarajan V" first="Varadharajan" last="Thiyagarajan">Varadharajan Thiyagarajan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Mathew, Dony Chacko" sort="Mathew, Dony Chacko" uniqKey="Mathew D" first="Dony Chacko" last="Mathew">Dony Chacko Mathew</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Kai Yuan" sort="Lin, Kai Yuan" uniqKey="Lin K" first="Kai-Yuan" last="Lin">Kai-Yuan Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Research, Chi-Mei Medical Center, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Ssu Ching" sort="Chen, Ssu Ching" uniqKey="Chen S" first="Ssu-Ching" last="Chen">Ssu-Ching Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences, National Central University, Chung-Li, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences, National Central University, Chung-Li</wicri:regionArea><wicri:noRegion>Chung-Li</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jer Yuh" sort="Liu, Jer Yuh" uniqKey="Liu J" first="Jer-Yuh" last="Liu">Jer-Yuh Liu</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Cancer Biology, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Li Sung" sort="Hsu, Li Sung" uniqKey="Hsu L" first="Li-Sung" last="Hsu">Li-Sung Hsu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Biomedical Sciences, Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Li, Mei Ling" sort="Li, Mei Ling" uniqKey="Li M" first="Mei-Ling" last="Li">Mei-Ling Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Hsin Ling" sort="Yang, Hsin Ling" uniqKey="Yang H" first="Hsin-Ling" last="Yang">Hsin-Ling Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of cellular physiology</title><idno type="eISSN">1097-4652</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chalcones found in fruits and vegetables have promising cancer chemopreventive properties. This study attempts to identify the anticancer efficacies of chalcone flavokawain B (FKB) in the rhizomes of Alpinia pricei Hayata by examining key molecular events in non-small-cell lung cancer (A549) cells. Our results indicated that in human A549 cells, FKB (0-15 μg/ml) decreases cell viability and colony formation, dysregulates the Bax:B-cell lymphoma 2 ratio and increases apoptotic DNA fragmentation. Mitochondrial (caspase-9/-3 and poly ADP ribose polymerase [PARP]) signaling was found to be involved in FKB-induced apoptosis. In addition, FKB-induced reactive oxygen species (ROS) generation, and N-acetylcysteine attenuated FKB-induced apoptotic cell death. Moreover, FKB triggered autophagy, as evidenced by the improved acidic vesicular organelle formation, lipidated light chain 3 (microtubule-related light chain 3) accumulation, and ATG7 expression and the decreased mammalian target of rapamycin phosphorylation. Furthermore, FKB suppressed ROS-mediated ATG4B expression. Inhibiting autophagy using 3-methyladenine/chloroquine diminished FKB-induced cell death, indicating that autophagy is triggered as a death mechanism by FKB. In summary, FKB has a crucial role in the execution and propagation of ROS-mediated apoptotic and autophagic cell death of lung adenocarcinoma cells.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">30847898</PMID><DateRevised><Year>2019</Year><Month>07</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-4652</ISSN><JournalIssue CitedMedium="Internet"><Volume>234</Volume><Issue>10</Issue><PubDate><Year>2019</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Journal of cellular physiology</Title><ISOAbbreviation>J. Cell. Physiol.</ISOAbbreviation></Journal><ArticleTitle>Anticancer activities of chalcone flavokawain B from Alpinia pricei Hayata in human lung adenocarcinoma (A549) cells via induction of reactive oxygen species-mediated apoptotic and autophagic cell death.</ArticleTitle><Pagination><MedlinePgn>17514-17526</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/jcp.28375</ELocationID><Abstract><AbstractText>Chalcones found in fruits and vegetables have promising cancer chemopreventive properties. This study attempts to identify the anticancer efficacies of chalcone flavokawain B (FKB) in the rhizomes of Alpinia pricei Hayata by examining key molecular events in non-small-cell lung cancer (A549) cells. Our results indicated that in human A549 cells, FKB (0-15 μg/ml) decreases cell viability and colony formation, dysregulates the Bax:B-cell lymphoma 2 ratio and increases apoptotic DNA fragmentation. Mitochondrial (caspase-9/-3 and poly ADP ribose polymerase [PARP]) signaling was found to be involved in FKB-induced apoptosis. In addition, FKB-induced reactive oxygen species (ROS) generation, and N-acetylcysteine attenuated FKB-induced apoptotic cell death. Moreover, FKB triggered autophagy, as evidenced by the improved acidic vesicular organelle formation, lipidated light chain 3 (microtubule-related light chain 3) accumulation, and ATG7 expression and the decreased mammalian target of rapamycin phosphorylation. Furthermore, FKB suppressed ROS-mediated ATG4B expression. Inhibiting autophagy using 3-methyladenine/chloroquine diminished FKB-induced cell death, indicating that autophagy is triggered as a death mechanism by FKB. In summary, FKB has a crucial role in the execution and propagation of ROS-mediated apoptotic and autophagic cell death of lung adenocarcinoma cells.</AbstractText><CopyrightInformation>© 2019 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hseu</LastName><ForeName>You-Cheng</ForeName><Initials>YC</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-5307-6162</Identifier><AffiliationInfo><Affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Research Center of Chinese Herbal Medicine, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Yu-Chi</ForeName><Initials>YC</Initials><AffiliationInfo><Affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thiyagarajan</LastName><ForeName>Varadharajan</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mathew</LastName><ForeName>Dony Chacko</ForeName><Initials>DC</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-6822-2716</Identifier><AffiliationInfo><Affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Kai-Yuan</ForeName><Initials>KY</Initials><AffiliationInfo><Affiliation>Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Ssu-Ching</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Department of Life Sciences, National Central University, Chung-Li, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jer-Yuh</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hsu</LastName><ForeName>Li-Sung</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Mei-Ling</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Hsin-Ling</ForeName><Initials>HL</Initials><AffiliationInfo><Affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CMRC-CHM-9</GrantID><Agency>Ministry of Education (MOE), Taiwan</Agency><Country></Country></Grant><Grant><GrantID>MOST-106-2320-B-039-054-MY3</GrantID><Agency>Ministry of Science and Technology, Taiwan</Agency><Country></Country></Grant><Grant><GrantID>MOST-104-2320-B-039-040-MY</GrantID><Agency>Ministry of Science and Technology, Taiwan</Agency><Country></Country></Grant><Grant><Agency>Chinese Medicine Research Center, China Medical University</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>03</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Cell Physiol</MedlineTA><NlmUniqueID>0050222</NlmUniqueID><ISSNLinking>0021-9541</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alpinia pricei hayata</Keyword><Keyword MajorTopicYN="N">ROS</Keyword><Keyword MajorTopicYN="N">apoptosis</Keyword><Keyword MajorTopicYN="N">autophagy</Keyword><Keyword MajorTopicYN="N">chalcone flavokawain B</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>10</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>01</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>01</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>3</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>3</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>3</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30847898</ArticleId><ArticleId IdType="doi">10.1002/jcp.28375</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Hseu, You Cheng" sort="Hseu, You Cheng" uniqKey="Hseu Y" first="You-Cheng" last="Hseu">You-Cheng Hseu</name></noRegion><name sortKey="Chen, Ssu Ching" sort="Chen, Ssu Ching" uniqKey="Chen S" first="Ssu-Ching" last="Chen">Ssu-Ching Chen</name><name sortKey="Hsu, Li Sung" sort="Hsu, Li Sung" uniqKey="Hsu L" first="Li-Sung" last="Hsu">Li-Sung Hsu</name><name sortKey="Huang, Yu Chi" sort="Huang, Yu Chi" uniqKey="Huang Y" first="Yu-Chi" last="Huang">Yu-Chi Huang</name><name sortKey="Li, Mei Ling" sort="Li, Mei Ling" uniqKey="Li M" first="Mei-Ling" last="Li">Mei-Ling Li</name><name sortKey="Lin, Kai Yuan" sort="Lin, Kai Yuan" uniqKey="Lin K" first="Kai-Yuan" last="Lin">Kai-Yuan Lin</name><name sortKey="Liu, Jer Yuh" sort="Liu, Jer Yuh" uniqKey="Liu J" first="Jer-Yuh" last="Liu">Jer-Yuh Liu</name><name sortKey="Mathew, Dony Chacko" sort="Mathew, Dony Chacko" uniqKey="Mathew D" first="Dony Chacko" last="Mathew">Dony Chacko Mathew</name><name sortKey="Thiyagarajan, Varadharajan" sort="Thiyagarajan, Varadharajan" uniqKey="Thiyagarajan V" first="Varadharajan" last="Thiyagarajan">Varadharajan Thiyagarajan</name><name sortKey="Yang, Hsin Ling" sort="Yang, Hsin Ling" uniqKey="Yang H" first="Hsin-Ling" last="Yang">Hsin-Ling Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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